Abstract：
PURPOSE OF THE REVIEW:Osteoarthritis (OA) is an aging-associated and injury-induced joint disease characterized by cartilage degradation, bone sclerosis, and persistent low-grade inflammation in the joint. Aging and injury are triggers of joint pathological changes mediated by pro-inflammatory factors, some of which are secreted by white adipose tissue. Adipokines including adiponectin, leptin, resistin, chemerin, IL-6, and TNF-α are major players not only during inflammation but also in metabolic regulation of joint cells including chondrocytes, osteoblasts, osteoclasts as well as mesenchymal stem cells. The purpose of this review is to summarize the signal transduction pathways of adipokines in the articular joint to provide new information on potential targets for intervention of OA. RECENT FINDINGS:The risk of knee osteoarthritis is associated with adipokine gene polymorphism. While the infrapatellar fat pad is a major source of adipokines in knee synovial fluid, adipocytes also accumulate in the bone marrow during aging and obesity. Adipokines can act as SASPs (senescence associated secretory phenotype factors) that participate in cellular senescence of chondrocytes, but they also regulate energy metabolism impacting bone remodeling. Thus, adipokines are closely related to the metabolic syndrome and degenerative pathological changes in cartilage and bone during OA. Modulating the effects of adipokines on different cell types in the intra-articular joint will be a promising new option for OA intervention.
journal_name
Curr Rheumatol Repjournal_title
Current rheumatology reportsauthors
Xie C,Chen Qdoi
10.1007/s11926-019-0868-zsubject
Has Abstractpub_date
2019-12-07 00:00:00pages
71issue
12eissn
1523-3774issn
1534-6307pii
10.1007/s11926-019-0868-zjournal_volume
21pub_type
杂志文章,评审abstract：:Antiphospholipid syndrome (APS) is characterized by antiphospholipid antibodies (aPL) associated with thrombosis and/or pregnancy morbidity. However, there is a range of other manifestations associated with APS, called non-criteria manifestations that add significant morbidity to this syndrome and, some of them, repre...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-015-0502-7
更新日期：2015-04-01 00:00:00
abstract：:Large epidemiologic studies of gout can improve insight into the etiology, pathology, impact, and management of the disease. Identification of monosodium urate monohydrate crystals is considered the gold standard for diagnosis, but its application is often not possible in large studies. Therefore, under such circumsta...
journal_title：Current rheumatology reports
pub_type： 杂志文章
doi：10.1007/s11926-010-0157-3
更新日期：2011-04-01 00:00:00
abstract：:The frequency of Takayasu's arteritis (TA) has been estimated to be 2.9 cases per 1 million people, with a female preponderance, although female-to-male ratio varies from different geographic areas. A high frequency of haplotype A24-B52-DR2 has been found in Japanese patients, without this association in other populat...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-002-0021-1
更新日期：2002-02-01 00:00:00
abstract：:Small-vessel vasculitis is a convenient descriptor for a wide range of diseases characterized by vascular inflammation of the venules, capillaries, and/or arterioles with pleomorphic clinical manifestations. The classical clinical phenotype is leukocytoclastic vasculitis with palpable purpura, but manifestations vary ...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-007-0049-3
更新日期：2007-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Arthritis is a well-recognized symptom of idiopathic inflammatory myopathies (IIM). We provide a summary of available data regarding the epidemiology, clinical characteristics, and autoantibody associations of joint involvement in various forms of IIM. RECENT FINDINGS:Arthritis is reported in 18-55% ...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-019-0878-x
更新日期：2019-12-07 00:00:00
abstract：:Although exercise in the form of stretching, strength maintenance, and aerobic conditioning is generally considered beneficial to patients with fibromyalgia (FM), there is no reliable evidence to explain why exercise should help alleviate the primary symptom of FM, namely pain. Study results are varied and do not prov...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-001-0009-2
更新日期：2001-04-01 00:00:00
abstract：:Erosive osteoarthritis (OA) is a subcategory of OA in which destructive changes occur in the joints, probably as a result of a combination of inflammatory inciters and phenomena. The major changes occur in the distal and proximal interphalangeal joints, root joints of the thumb, and less commonly other hand and centri...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-001-0062-x
更新日期：2001-12-01 00:00:00
abstract：:There is a wide variation in the prevalence, incidence, and clinical manifestation of psoriatic arthritis (PsA) across countries due to genetic and environmental factors. Data on PsA in Asia are limited and come from small cross-sectional studies. The burden of PsA in Asia is high, including poor physical functioning,...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-011-0183-9
更新日期：2011-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Ankylosing spondylitis (AS) was historically seen as a predominantly male disease. However, more recent data showed a more homogenous sex prevalence. Unfortunately, in many studies in axial spondyloarthritis (axSpA), the number of women included is low and the analyses are often not stratified for gen...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-018-0744-2
更新日期：2018-05-12 00:00:00
abstract：:Traditional nonsteroidal anti-inflammatory drugs block cyclooxygenase (COX). They are the most widely used drugs for pain relief. They are indispensable for their effects but are condemned for their adverse drug reactions. Two COX inhibitors, acetaminophen and aspirin, are the most widely used over-the-counter drugs. ...
journal_title：Current rheumatology reports
pub_type： 杂志文章
doi：10.1007/s11926-009-0006-4
更新日期：2009-02-01 00:00:00
abstract：:Seronegative spondyloarthropathies comprise a group of inflammatory arthritides, which consists of ankylosing spondylitis, psoriatic arthritis, reactive arthritis (Reiter's syndrome), enteropathic arthritis, and undifferentiated spondyloarthropathy. All of them share common laboratory, clinical, and imaging findings, ...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-004-0054-8
更新日期：2004-04-01 00:00:00
abstract：:Osteoporosis and related fractures represent a major, and growing, public health concern for the United States and worldwide. The pathogenesis of osteoporosis is complex, requiring attention to the different life phases involved in growth, maintenance, and loss of bone, in addition to non-skeletal factors associated w...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-006-0030-6
更新日期：2006-02-01 00:00:00
abstract：:To date, most studies examining cell death during the development of osteoarthritis (OA) have focused on death of chondrocytes and have primarily examined advanced stages of the disease. Very good evidence suggests that chondrocyte death does occur at some point in the pathogenesis of OA and that it can be due to apop...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-008-0007-8
更新日期：2008-01-01 00:00:00
abstract：PURPOSE OF REVIEW:Macrophages play key roles in tissue homeostasis and immune surveillance, mobilizing immune activation in response to microbial invasion and promoting wound healing to repair damaged tissue. However, failure to resolve macrophage activation can lead to chronic inflammation and fibrosis, and ultimately...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-019-0831-z
更新日期：2019-05-23 00:00:00
abstract：:Recent clinical development programs for new therapeutic agents in rheumatoid arthritis have included assessment of radiographic progression comparing changes with treatment to placebo and active controls. Studies now use reliable methods of assessment and sufficient study length to detect radiographic changes. Althou...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-001-0050-1
更新日期：2001-02-01 00:00:00
abstract：:Apatite crystals form in physiologically calcified tissues, including the hyaline cartilage of the epiphyseal growth plate. While apatite crystals appear as unwanted deposits in other cartilage sites, more frequently, crystalline materials other than or in addition to apatite develop in dystrophic cartilage deposits. ...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-002-0072-3
更新日期：2002-06-01 00:00:00
abstract：:The recent increase in the number of patients taking opioids chronically for pain has not yielded the expected benefits in reduction of symptoms and improved function. Chronic pain patients typically respond well initially to opioid medications, but regular use is associated with adverse psychological and physical eff...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-012-0311-1
更新日期：2013-03-01 00:00:00
abstract：PURPOSE OF REVIEW:One justification for using expensive biologic therapy in rheumatoid arthritis (RA) has been that it can reduce future healthcare utilization such as joint surgeries and physician visits. However, the evidence to support this assertion is unclear. We conducted a review of the literature for studies wh...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-017-0680-6
更新日期：2017-09-01 00:00:00
abstract：PURPOSE OF REVIEW:Pain is an intense experience that can place a heavy burden on peoples' lives. The identification of psychosocial risk factors led to the development of effective pain treatments. However, effect sizes are modest. Accumulating evidence suggests that enhancing protective factors might also impact on (w...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-017-0703-3
更新日期：2017-11-09 00:00:00
abstract：:The inflammatory myopathies are a heterogeneous group of diseases including dermatomyositis, polymyositis, and inclusion body myositis. Few clinical trials have been conducted in myositis, making it difficult to provide clear recommendations on the treatment of these rare disorders. Although corticosteroids have not b...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-011-0172-z
更新日期：2011-06-01 00:00:00
abstract：:While the link between malignancy and vasculitis has been known for some time, the association of vasculitis and myelodysplastic syndrome (MDS) has only recently been reported. This article reviews the most current and landmark publications regarding MDS, as well as malignancy-associated vasculitis. We include theorie...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-012-0281-3
更新日期：2012-12-01 00:00:00
abstract：:Hypocomplementemic urticarial vasculitis syndrome (HUVS) is an uncommon immune complex-mediated entity characterized by urticaria with persistent acquired hypocomplementemia. First described in 1973, HUVS is associated with several systemic findings including leukocytoclastic vasculitis, severe angioedema, laryngeal e...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-009-0060-y
更新日期：2009-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Takayasu arteritis (TA) is a granulomatous inflammatory disorder that affects large vessels, especially aorta and its proximal branches. Its diagnosis can be extremely challenging due to the non-specificity of the systemic inflammatory manifestations during the early phase of the disease and usually f...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-019-0848-3
更新日期：2019-07-18 00:00:00
abstract：:Osteoporosis is a potentially preventable condition frequently encountered in patients with systemic lupus erythematosus (SLE). Bone loss in SLE is likely a multi- factorial process involving traditional osteoporosis risk factors along with lupus-related factors. Recognizing potential contributors to bone loss in pati...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-005-0056-1
更新日期：2005-12-01 00:00:00
abstract：:Psoriatic arthritis (PsA) is a chronic inflammatory joint disease associated with psoriasis that can lead to joint deformity and disability. PsA has a low likelihood of clinical remission and cure. For a long time, therapeutic options for PsA patients have been unsatisfactory, but the introduction of anti-tumor necros...
journal_title：Current rheumatology reports
pub_type： 杂志文章
doi：10.1007/s11926-008-0048-z
更新日期：2008-08-01 00:00:00
abstract：:Silicone-gel breast implant rupture is common. Silicone-gel from ruptured implants may escape the scar capsule that forms around breast implants and become "extracapsular silicone." Our previously published study found that women with extracapsular silicone gel were at higher risk of reporting that they were diagnosed...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-002-0037-6
更新日期：2002-08-01 00:00:00
abstract：:In this paper, the various systemic manifestations reported in localized scleroderma, their incidence, their relationship with systemic sclerosis, and their relationship with other autoimmune or connective tissue diseases will be analyzed. ...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-004-0020-5
更新日期：2004-12-01 00:00:00
abstract：:Rheumatoid arthritis is a chronic inflammatory disease that results in generalized bone loss and increased fracture risk. Characteristic radiologic features of rheumatoid arthritis include periarticular osteopenia and marginal erosions. An emerging literature highlights the importance of osteoclasts as mediators of th...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-012-0253-7
更新日期：2012-06-01 00:00:00
abstract：:Several entities have been carefully investigated for the symptomatic and structural management of osteoarthritis. The most compelling evidence of a potential for inhibiting the structural progression of osteoarthritis has been obtained with glucosamine sulfate, while some preliminary results also suggest that chondro...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-000-0023-9
更新日期：2000-12-01 00:00:00
abstract：:Dendritic cells are professional antigen-presenting cells that are most studied for their function in mediating T-cell tolerance and T-cell activation. In addition, recent evidence indicates that dendritic cells can regulate the vasculature and function of fibroblast-type cells. The potential contribution of dendritic...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-011-0215-5
更新日期：2012-02-01 00:00:00
