Abstract:
PURPOSE OF REVIEW:The effect of urate lowering treatment (ULT) on cardiovascular (CV) risk and mortality in gout has been a topic of interest. This review discusses the CV effect of ULT and comparative CV safety among ULT agents. RECENT FINDINGS:The mechanism linking gout with CV risk is not fully understood but seems multifactorial involving hyperuricemia, xanthine oxidase (XO), oxidative stress, and chronic inflammation. Conflicting data exist regarding CV benefits of ULT in adults with and without hyperuricemia. Although meta-analyses on randomized controlled trials (RCTs) suggest CV benefits with allopurinol, few high-quality RCTs have examined the CV effect of ULT among patients with hyperuricemia or gout. The recent CARES trial adds new information on comparative CV safety between two XO inhibitors (XOIs), febuxostat and allopurinol, in patients with gout. It remains unclear whether ULT reduces CV risk in patients with gout or hyperuricemia. Comparative CV safety studies of XOIs suggest that additional mechanisms beyond urate-lowering effect or XO inhibition are likely involved in CV risk modification in patients with gout. Ongoing RCTs of ULT may be able to further determine the effect of ULT on CV risk.
journal_name
Curr Rheumatol Repjournal_title
Current rheumatology reportsauthors
Kang EH,Kim SCdoi
10.1007/s11926-019-0843-8subject
Has Abstractpub_date
2019-07-24 00:00:00pages
48issue
9eissn
1523-3774issn
1534-6307pii
10.1007/s11926-019-0843-8journal_volume
21pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Ankylosing spondylitis (AS) was historically seen as a predominantly male disease. However, more recent data showed a more homogenous sex prevalence. Unfortunately, in many studies in axial spondyloarthritis (axSpA), the number of women included is low and the analyses are often not stratified for gen...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-018-0744-2
更新日期:2018-05-12 00:00:00
abstract::The investigations used to diagnose an inflammatory muscle disease include history and physical examination, evaluation of serum levels of enzymes derived from skeletal muscle, electromyography, magnetic resonance imaging, and muscle histology. The evaluation of patients who may have noninflammatory myopathy includes,...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-001-0035-0
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abstract::Recent human genetic discoveries have increased our understanding of rheumatoid arthritis (RA) susceptibility. Genome-wide association studies have expanded the number of validated RA risk loci beyond HLA-DRB1 "shared epitope" alleles to include additional major histocompatibility complex (MHC) risk alleles and more t...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-009-0050-0
更新日期:2009-10-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-999-0013-5
更新日期:1999-12-01 00:00:00
abstract::The Delphi Technique and Nominal Group Technique are two well-recognized consensus-formation methodologies specifically designed to combine judgments from a group of experts. The Delphi Technique utilizes a series of well-defined questionnaire-based surveys, whereas Nominal Group Technique is a structured face-to-face...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-008-0025-6
更新日期:2008-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Childhood arthritis is in need of a new system of classification, owing to deficiencies in the International League of Associations for Rheumatology (ILAR) criteria. We briefly review the history of classification of childhood arthritis, discuss the major criticisms of the current system, and highligh...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-020-0880-3
更新日期:2020-01-11 00:00:00
abstract::Hereditary hemochromatosis is a frequent disease in Caucasian populations. It leads to progressive iron overload in a variety of organs. The most common cause is the C282Y homozygous mutation in the HFE gene. The classical triad of skin hyperpigmentation, diabetes, and liver cirrhosis is nowadays rare but musculoskele...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-013-0393-4
更新日期:2014-01-01 00:00:00
abstract::The inflammatory myopathies are a heterogeneous group of diseases including dermatomyositis, polymyositis, and inclusion body myositis. Few clinical trials have been conducted in myositis, making it difficult to provide clear recommendations on the treatment of these rare disorders. Although corticosteroids have not b...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-011-0172-z
更新日期:2011-06-01 00:00:00
abstract::Acupuncture has been used for millennia in traditional Chinese medicine as a technique believed to restore the balance of energy in the body caused by disease through the use of needles inserted into specific points or energy channels. This energy is called the de qi. The use of acupuncture for the treatment of pain i...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-012-0295-x
更新日期:2012-12-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-002-0021-1
更新日期:2002-02-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-001-0062-x
更新日期:2001-12-01 00:00:00
abstract::Bone is not structurally normal in osteoarthritis (OA). Periarticular bone in OA has increased turnover, decreased bone mineral content and stiffness, and decreased trabecular numbers. The increased turnover of collagen, in particular, may affect the biomechanical competence of bone and is driven by a number of proces...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-003-0078-5
更新日期:2003-02-01 00:00:00
abstract::Childhood systemic lupus erythematosus (SLE) is known to have a worse prognosis than adult-onset disease, and monitoring and treatment of the disease are still a challenge. Thus, there is an urgent need for highly reliable, non-invasive biomarkers for early detection of relapses, to avoid long-term complications and t...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-012-0312-0
更新日期:2013-03-01 00:00:00
abstract::Vasculitis is defined as inflammation of blood vessels and can affect multiple organs. Several classification systems exist to categorize vasculitis such as vessel size, presence of anti-neutrophil cytoplasmic antibody, pathogenesis of the inflammation, and type of inflammatory cell infiltrate. Cutaneous vasculitis oc...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-005-0037-4
更新日期:2005-08-01 00:00:00
abstract::Recent clinical development programs for new therapeutic agents in rheumatoid arthritis have included assessment of radiographic progression comparing changes with treatment to placebo and active controls. Studies now use reliable methods of assessment and sufficient study length to detect radiographic changes. Althou...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-001-0050-1
更新日期:2001-02-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-004-0054-8
更新日期:2004-04-01 00:00:00
abstract::Sjögren's syndrome is a chronic inflammatory process involving primarily the exocrine glands. Its association with lymphoma is well documented. A low-grade marginal-zone lymphoma related to mucosa-associated lymphoid tissue is the most common lymphoid neoplasia in Sjögren's syndrome. Among all autoimmune diseases, Sjö...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-003-0011-y
更新日期:2003-08-01 00:00:00
abstract::Transforming growth factor-beta (TGF beta) plays a critical role in the development of tissue fibrosis. Its expression is consistently elevated in affected organs and correlates with increased extracellular matrix deposition. During the last few years, tremendous progress has been made in understanding the molecular a...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-002-0010-4
更新日期:2002-04-01 00:00:00
abstract::While the link between malignancy and vasculitis has been known for some time, the association of vasculitis and myelodysplastic syndrome (MDS) has only recently been reported. This article reviews the most current and landmark publications regarding MDS, as well as malignancy-associated vasculitis. We include theorie...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-012-0281-3
更新日期:2012-12-01 00:00:00
abstract:PURPOSE OF THE REVIEW:We will address current treatment and unmet needs in psoriatic arthritis (PsA), examine existing randomized controlled trials (RCTs), and consider options for new trial designs and challenges in their implementation. RECENT FINDINGS:While therapeutic options for PsA have rapidly increased, there ...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-017-0642-z
更新日期:2017-04-01 00:00:00
abstract::Optimal management for scleroderma (systemic sclerosis) is likely to require treatment of the underlying disease process, which remains incompletely understood, and also of the organ-based complications of this heterogeneous condition. Clinical trials evaluating several potential agents have been completed recently, i...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-999-0020-6
更新日期:1999-10-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-019-0848-3
更新日期:2019-07-18 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-017-0650-z
更新日期:2017-05-01 00:00:00
abstract:PURPOSE OF REVIEW:To review progress in the field of clinical trials for SLE. RECENT FINDINGS:Treatment development for SLE has been marked by failures of many later phase studies, representing billions of dollars of lost research and development funding. Recently, more successful Phase II trials have tested reduction...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-018-0745-1
更新日期:2018-05-03 00:00:00
abstract::The pediatric rheumatologist cares for children who may have a wide variety of causes of musculoskeletal pain. These include such diverse conditions as arthritis, low-back pain, hypermobility, metabolic bone pain, and amplified pain syndromes such as complex regional pain syndrome and fibromyalgia. This review examine...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-000-0072-0
更新日期:2000-08-01 00:00:00
abstract::Uric acid nephrolithiasis is typically found in individuals with a low urine pH and a normal concentration of urinary uric acid. Patients with a history of gout are at greater risk of forming uric acid stones, as are patients with obesity, diabetes, or the complete metabolic syndrome. The unifying renal tubular abnorm...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-007-0040-z
更新日期:2007-06-01 00:00:00
abstract::Psoriatic arthritis is a chronic, disabling disease for which therapies have been borrowed from rheumatoid arthritis and spondylitis. Traditional disease-modifying antirheumatic drugs (DMARDs) remain the first choice for the treatment of peripheral arthritis despite scarce evidence of their efficacy or ability to halt...
journal_title:Current rheumatology reports
pub_type: 杂志文章
doi:10.1007/s11926-009-0038-9
更新日期:2009-08-01 00:00:00
abstract::The distribution of the anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitides (AAV) is not uniform across geographical regions and ethnic and racial groups, suggesting that genetic and environmental factors affect the pathogenesis of these diseases. In addition, genetic factors affect not only the clin...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-014-0428-5
更新日期:2014-07-01 00:00:00
abstract::The development of B cell-targeted biologics represents a major advance in the treatment of autoimmune rheumatic diseases. As with other immunosuppressive agents, risk of infection is a key clinical concern. This review summarises safety data from 15 years of experience of rituximab in autoimmune diseases with a parti...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-015-0539-7
更新日期:2015-10-01 00:00:00
abstract:PURPOSE OF THE REVIEW:Idiopathic acute and recurrent pericarditis are rare diseases of unknown origin. Here, we review trigger factors, pathomechanism, and treatment options for acute and recurrent pericarditis. RECENT FINDINGS:Acute pericarditis can be triggered by viral infections, myocardial ischemia, heart cathete...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-019-0820-2
更新日期:2019-03-09 00:00:00