Pain syndromes in children.

abstract：:Small-vessel vasculitis is a convenient descriptor for a wide range of diseases characterized by vascular inflammation of the venules, capillaries, and/or arterioles with pleomorphic clinical manifestations. The classical clinical phenotype is leukocytoclastic vasculitis with palpable purpura, but manifestations vary ...

journal_title：Current rheumatology reports

authors： Iglesias-Gamarra A,Restrepo JF,Matteson EL

更新日期：2007-08-01 00:00:00

abstract：:Optimal management for scleroderma (systemic sclerosis) is likely to require treatment of the underlying disease process, which remains incompletely understood, and also of the organ-based complications of this heterogeneous condition. Clinical trials evaluating several potential agents have been completed recently, i...

journal_title：Current rheumatology reports

authors： Denton CP,Black CM

更新日期：1999-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To review progress in the field of clinical trials for SLE. RECENT FINDINGS:Treatment development for SLE has been marked by failures of many later phase studies, representing billions of dollars of lost research and development funding. Recently, more successful Phase II trials have tested reduction...

journal_title：Current rheumatology reports

authors： Thanou A,Merrill JT

更新日期：2018-05-03 00:00:00

abstract：:Tumor-induced osteomalacia (TIO) is a paraneoplastic syndrome resulting in renal phosphate wasting and decreased bone mineralization. TIO is usually induced by small, slowly growing tumors of mesenchymal origin (phosphaturic mesenchymal tumor mixed connective tissue variant [PMTMCT]). Nonspecific symptoms including fa...

journal_title：Current rheumatology reports

authors： Hautmann AH,Hautmann MG,Kölbl O,Herr W,Fleck M

更新日期：2015-06-01 00:00:00

abstract：:Acupuncture has been used for millennia in traditional Chinese medicine as a technique believed to restore the balance of energy in the body caused by disease through the use of needles inserted into specific points or energy channels. This energy is called the de qi. The use of acupuncture for the treatment of pain i...

journal_title：Current rheumatology reports

authors： Amezaga Urruela M,Suarez-Almazor ME

更新日期：2012-12-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a chronic debilitating condition with significant impact on the musculoskeletal system. Arthroplasty may be indicated for damage related to active lupus or its treatment. As therapies for SLE have advanced, morbidity and mortality have declined, while the rate of joint replacement...

journal_title：Current rheumatology reports

authors： Kasturi S,Goodman S

更新日期：2016-09-01 00:00:00

abstract：:Apatite crystals form in physiologically calcified tissues, including the hyaline cartilage of the epiphyseal growth plate. While apatite crystals appear as unwanted deposits in other cartilage sites, more frequently, crystalline materials other than or in addition to apatite develop in dystrophic cartilage deposits. ...

journal_title：Current rheumatology reports

authors： Boskey AL

更新日期：2002-06-01 00:00:00

abstract：:The high-range estimate of 1.3% by the National Arthritis Data Workgroup for the prevalence of the entire spectrum of spondyloarthropathies (SpAs) suggests that SpAs may be more prevalent than rheumatoid arthritis (RA) in the United States. Recent surveys from many European countries using the same sample population h...

journal_title：Current rheumatology reports

authors： Akkoc N

更新日期：2008-10-01 00:00:00

abstract：:The Delphi Technique and Nominal Group Technique are two well-recognized consensus-formation methodologies specifically designed to combine judgments from a group of experts. The Delphi Technique utilizes a series of well-defined questionnaire-based surveys, whereas Nominal Group Technique is a structured face-to-face...

journal_title：Current rheumatology reports

authors： Ruperto N,Meiorin S,Iusan SM,Ravelli A,Pistorio A,Martini A

更新日期：2008-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of the study is to briefly review the molecular mechanisms that leads to structural damage in ankylosing spondylitis (AS), defined as new bone formation resulting in complete or incomplete ankylosis of the spine, and the impact of treatment with biologics to retard this process. RECENT FI...

journal_title：Current rheumatology reports

authors： Magrey MN,Khan MA

更新日期：2017-04-01 00:00:00

abstract：:Skin fibrosis occurs in a variety of human diseases, most notably systemic sclerosis (SSc). The end stage of scleroderma in human skin consists of excess collagen deposition in the dermis with loss of adnexal structures and associated adipose tissue. The initiating factors for this process and the early stages are bel...

journal_title：Current rheumatology reports

authors： Smith GP,Chan ES

更新日期：2010-02-01 00:00:00

abstract：:Osteoporosis is a potentially preventable condition frequently encountered in patients with systemic lupus erythematosus (SLE). Bone loss in SLE is likely a multi- factorial process involving traditional osteoporosis risk factors along with lupus-related factors. Recognizing potential contributors to bone loss in pati...

journal_title：Current rheumatology reports

authors： Lee C,Ramsey-Goldman R

更新日期：2005-12-01 00:00:00

abstract：:Sjögren's syndrome is a chronic inflammatory process involving primarily the exocrine glands. Its association with lymphoma is well documented. A low-grade marginal-zone lymphoma related to mucosa-associated lymphoid tissue is the most common lymphoid neoplasia in Sjögren's syndrome. Among all autoimmune diseases, Sjö...

journal_title：Current rheumatology reports

authors： Voulgarelis M,Moutsopoulos HM

更新日期：2003-08-01 00:00:00

abstract：:Neonatal lupus is a disease characterized by one or more of the following findings: congenital heart block, cardiomyopathy, cutaneous lupus lesions, hepatobiliary disease, and thrombocytopenia. Accumulating evidence indicates that the disease is probably caused by maternal autoantibodies, particularly autoantibodies o...

journal_title：Current rheumatology reports

authors： Lee LA

更新日期：2001-10-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a devastating complication of systemic sclerosis (SSc). Although there are screening tests for PAH, such as carbon monoxide diffusing capacity and Doppler echocardiography, these tests are far from perfect, patients are still identified late in the course of disease, and the un...

journal_title：Current rheumatology reports

authors： Shah SJ

更新日期：2009-04-01 00:00:00

abstract：:Recent human genetic discoveries have increased our understanding of rheumatoid arthritis (RA) susceptibility. Genome-wide association studies have expanded the number of validated RA risk loci beyond HLA-DRB1 "shared epitope" alleles to include additional major histocompatibility complex (MHC) risk alleles and more t...

journal_title：Current rheumatology reports

authors： Plenge RM

更新日期：2009-10-01 00:00:00

abstract：:Silicone-gel breast implant rupture is common. Silicone-gel from ruptured implants may escape the scar capsule that forms around breast implants and become "extracapsular silicone." Our previously published study found that women with extracapsular silicone gel were at higher risk of reporting that they were diagnosed...

journal_title：Current rheumatology reports

authors： Brown SL,Duggirala HJ,Pennello G

更新日期：2002-08-01 00:00:00

abstract：:Widespread muscle pain, fatigue, and weakness are defining characteristics of patients with fibromyalgia (FM). The aim of this review is to summarize recent investigations of muscle abnormalities in FM, which can be classified as structural, metabolic, or functional in nature. Histologic muscle abnormalities of membra...

journal_title：Current rheumatology reports

authors： Park JH,Niermann KJ,Olsen N

更新日期：2000-04-01 00:00:00

abstract：:Scleroderma renal crisis (SRC) is characterized by malignant hypertension, oliguric/anuric acute renal failure, and important mortality, with a 5-year survival rate of 65%. SRC occurs in 2% to 5% of patients with systemic sclerosis (SSc), particularly those with diffuse cutaneous SSc in the first years of disease evol...

journal_title：Current rheumatology reports

authors： Bussone G,Bérezné A,Pestre V,Guillevin L,Mouthon L

更新日期：2011-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Antiphospholipid syndrome (APS) is a chronic autoimmune disease that can be seen as a burden, with consequences on patients' daily life. Health has traditionally been measured using measures of morbidity or mortality. Health-related quality of life (HRQoL) is a concept that includes quality of life th...

journal_title：Current rheumatology reports

authors： Desnoyers M,Dufrost V,Wahl D,Zuily S

更新日期：2020-05-13 00:00:00

abstract：PURPOSE OF REVIEW:Osteoarthritis (OA) is the most common form of arthritis and a major source of pain and disability worldwide. OA-associated pain is usually refractory to classically used analgesics, and disease-modifying therapies are still lacking. Therefore, a better understanding of mechanisms and mediators contri...

journal_title：Current rheumatology reports

authors： Syx D,Tran PB,Miller RE,Malfait AM

更新日期：2018-02-26 00:00:00

abstract：:Spondyloarthritis (SpA) is a group of inflammatory rheumatic diseases whose main clinical feature is inflammation of the axial spine. Articular, periarticular, and extra-articular manifestations can also occur, depending on the type of spondyloarthritis. The most common clinical subsets of SpA are ankylosing spondylit...

journal_title：Current rheumatology reports

authors： O'Rielly DD,Rahman P

更新日期：2013-08-01 00:00:00

abstract：:β2-glycoprotein I (β2GPI) is the major autoantigen in the antiphospholipid syndrome. The central importance of understanding β2GPI physiology from the perspective of the rheumatologist is that it forms the foundation for understanding the pathophysiology underlying autoantibody generation, and the diverse mechanisms b...

journal_title：Current rheumatology reports

authors： Giannakopoulos B,Mirarabshahi P,Krilis SA

更新日期：2011-02-01 00:00:00

abstract：:Wegener's granulomatosis (WG) is a complex autoimmune disorder that has been transformed from a uniformly lethal process to a chronic disease with a relapsing-remitting course. In the setting of frequent relapses, the need to manage cumulative disease damage and drug toxicities has spurred the identification and devel...

journal_title：Current rheumatology reports

authors： Sarraf P,Kay J,Friday RP,Reginato AM

更新日期：2006-08-01 00:00:00

abstract：:Uric acid nephrolithiasis is typically found in individuals with a low urine pH and a normal concentration of urinary uric acid. Patients with a history of gout are at greater risk of forming uric acid stones, as are patients with obesity, diabetes, or the complete metabolic syndrome. The unifying renal tubular abnorm...

journal_title：Current rheumatology reports

authors： Liebman SE,Taylor JG,Bushinsky DA

更新日期：2007-06-01 00:00:00

abstract：:Biomarkers in psoriatic arthritis (PsA) may serve as surrogate end points for disease outcome and can provide insights into disease susceptibility and natural history. Biomarkers could relate to diagnosis, pathogenesis, prognosis, therapeutic response, and comorbidities. The "felt need" is, however, in the development...

journal_title：Current rheumatology reports

authors： Chandran V,Gladman DD

更新日期：2010-08-01 00:00:00

abstract：PURPOSE OF THE REVIEW:We will address current treatment and unmet needs in psoriatic arthritis (PsA), examine existing randomized controlled trials (RCTs), and consider options for new trial designs and challenges in their implementation. RECENT FINDINGS:While therapeutic options for PsA have rapidly increased, there ...

journal_title：Current rheumatology reports

authors： Ogdie A,Coates L

更新日期：2017-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The concept of cellular senescence has been evolving. Although originally proposed based on studies of serum-driven replication of cell lines in vitro, it is now clear that cellular senescence occurs in vivo. It has also become clear that cellular senescence can be triggered by a number of stimuli suc...

journal_title：Current rheumatology reports

authors： Gao L,Slack M,Barnas JL,McDavid A,Anolik J,Looney RJ

更新日期：2019-01-14 00:00:00

abstract：:Management of the pregnant patient with antiphospholipid antibody (aPL) is reviewed, with emphasis on recent randomized controlled clinical trials. These support the use of subcutaneous heparin and low dose aspirin, current standard therapy for women with aPL and a history of fetal loss. Prednisone is rarely used due ...

journal_title：Current rheumatology reports

authors： Sammaritano LR

更新日期：2001-06-01 00:00:00

abstract：PURPOSE OF THE REVIEW:Polymyalgia rheumatica (PMR) is one of the most common inflammatory rheumatologic condition occurring in older adults. It is characterized by proximal pain and stiffness in the shoulders, neck, and/or pelvic girdle in individuals over 50 years of age along with evidence of an intense systemic infl...

journal_title：Current rheumatology reports

authors： Gazitt T,Zisman D,Gardner G

更新日期：2020-06-19 00:00:00