Health-Related Quality of Life in Antiphospholipid Syndrome: Current Knowledge and Future Perspectives.

abstract：PURPOSE OF REVIEW:Macrophages play key roles in tissue homeostasis and immune surveillance, mobilizing immune activation in response to microbial invasion and promoting wound healing to repair damaged tissue. However, failure to resolve macrophage activation can lead to chronic inflammation and fibrosis, and ultimately...

journal_title：Current rheumatology reports

authors： Toledo DM,Pioli PA

更新日期：2019-05-23 00:00:00

abstract：:Ayurvedic medicine is the traditional medicine of India, which originated over 5,000 years ago. Parts of this alternative medical system have become increasingly popular worldwide as patients seek approaches to medical care that they perceive as more holistic and less toxic than those offered by conventional Western m...

journal_title：Current rheumatology reports

authors： Basnyat S,Kolasinski SL

更新日期：2014-08-01 00:00:00

abstract：:To date, most studies examining cell death during the development of osteoarthritis (OA) have focused on death of chondrocytes and have primarily examined advanced stages of the disease. Very good evidence suggests that chondrocyte death does occur at some point in the pathogenesis of OA and that it can be due to apop...

journal_title：Current rheumatology reports

authors： Del Carlo M Jr,Loeser RF

更新日期：2008-01-01 00:00:00

abstract：:The frequency of Takayasu's arteritis (TA) has been estimated to be 2.9 cases per 1 million people, with a female preponderance, although female-to-male ratio varies from different geographic areas. A high frequency of haplotype A24-B52-DR2 has been found in Japanese patients, without this association in other populat...

journal_title：Current rheumatology reports

authors： Fraga A,Medina F

更新日期：2002-02-01 00:00:00

abstract：:This study had two objectives: to describe the historical development of self-reported presenteeism instruments that can be used to identify and measure presenteeism as a result of musculoskeletal disease (MSD) and to identify if, and how many of these, presenteeism instruments are underpinned by economic theory. Syst...

journal_title：Current rheumatology reports

authors： Jones C,Payne K,Gannon B,Verstappen S

更新日期：2016-08-01 00:00:00

abstract：:Recent human genetic discoveries have increased our understanding of rheumatoid arthritis (RA) susceptibility. Genome-wide association studies have expanded the number of validated RA risk loci beyond HLA-DRB1 "shared epitope" alleles to include additional major histocompatibility complex (MHC) risk alleles and more t...

journal_title：Current rheumatology reports

authors： Plenge RM

更新日期：2009-10-01 00:00:00

abstract：:Osteoporosis and related fractures represent a major, and growing, public health concern for the United States and worldwide. The pathogenesis of osteoporosis is complex, requiring attention to the different life phases involved in growth, maintenance, and loss of bone, in addition to non-skeletal factors associated w...

journal_title：Current rheumatology reports

authors： Samelson EJ,Hannan MT

更新日期：2006-02-01 00:00:00

abstract：:Osteoporosis is a potentially preventable condition frequently encountered in patients with systemic lupus erythematosus (SLE). Bone loss in SLE is likely a multi- factorial process involving traditional osteoporosis risk factors along with lupus-related factors. Recognizing potential contributors to bone loss in pati...

journal_title：Current rheumatology reports

authors： Lee C,Ramsey-Goldman R

更新日期：2005-12-01 00:00:00

abstract：:Silicone-gel breast implant rupture is common. Silicone-gel from ruptured implants may escape the scar capsule that forms around breast implants and become "extracapsular silicone." Our previously published study found that women with extracapsular silicone gel were at higher risk of reporting that they were diagnosed...

journal_title：Current rheumatology reports

authors： Brown SL,Duggirala HJ,Pennello G

更新日期：2002-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Osteoarthritis (OA) is the most common form of arthritis and a major source of pain and disability worldwide. OA-associated pain is usually refractory to classically used analgesics, and disease-modifying therapies are still lacking. Therefore, a better understanding of mechanisms and mediators contri...

journal_title：Current rheumatology reports

authors： Syx D,Tran PB,Miller RE,Malfait AM

更新日期：2018-02-26 00:00:00

abstract：:Interest in imaging ankylosing spondylitis (AS) and related spondyloarthropathies has increased in recent years. MRI is regarded as the most sensitive imaging modality to detect early inflammatory lesions in the sacroiliac joints and in the spine. Standard radiography plays a major role in evaluating potential disease...

journal_title：Current rheumatology reports

authors： Weber U,Kissling RO,Hodler J

更新日期：2007-10-01 00:00:00

abstract：:Atypical femur fractures are rare but a growing concern, as they are more common in patients who use bisphosphonates. The best radiology-based studies have had access to only short-term exposure data, while the studies using prescription databases with substantial long-term data did not have access to radiology report...

journal_title：Current rheumatology reports

authors： Abrahamsen B,Clark EM

更新日期：2012-06-01 00:00:00

abstract：:Exercise is an important part of treatment in patients with idiopathic inflammatory myopathies. Improved functioning, ability to perform activities of daily living, and health-related quality of life have been reported in adult polymyositis, dermatomyositis, and also recently inclusion body myositis following differen...

journal_title：Current rheumatology reports

authors： Alexanderson H

更新日期：2012-06-01 00:00:00

abstract：:Spondyloarthritis (SpA) is characterized by inflammation and new bone formation in the spine and entheses. The disease is the result of a complex interplay among susceptibility genes, microbial triggers, inflammation of bone marrow, and the enthesial structures and new bone formation. This article gives a conceptual o...

journal_title：Current rheumatology reports

authors： Ronneberger M,Schett G

更新日期：2011-10-01 00:00:00

abstract：:Our growing understanding of the immune response mechanism has created a wave of novel biologic agents for the treatment of rheumatoid arthritis. The domain of biologic agents includes: 1) Recombinant regulatory cytokines; 2) engineered molecules and monoclonal antibodies that target proinflammatory cytokines; 3) mono...

journal_title：Current rheumatology reports

authors： Bulpitt KJ

更新日期：1999-12-01 00:00:00

abstract：:Wegener's granulomatosis (WG) is a complex autoimmune disorder that has been transformed from a uniformly lethal process to a chronic disease with a relapsing-remitting course. In the setting of frequent relapses, the need to manage cumulative disease damage and drug toxicities has spurred the identification and devel...

journal_title：Current rheumatology reports

authors： Sarraf P,Kay J,Friday RP,Reginato AM

更新日期：2006-08-01 00:00:00

abstract：:Activation of the complement system plays a fundamental role in the pathogenesis of systemic lupus erythematosus (SLE). For the past several decades, quantifying this process has focused primarily on determination of serum C3 and C4, although the utility of these assays for diagnosis and monitoring disease activity is...

journal_title：Current rheumatology reports

authors： Liu CC,Manzi S,Danchenko N,Ahearn JM

更新日期：2004-10-01 00:00:00

abstract：PURPOSE OF THE REVIEW:We will address current treatment and unmet needs in psoriatic arthritis (PsA), examine existing randomized controlled trials (RCTs), and consider options for new trial designs and challenges in their implementation. RECENT FINDINGS:While therapeutic options for PsA have rapidly increased, there ...

journal_title：Current rheumatology reports

authors： Ogdie A,Coates L

更新日期：2017-04-01 00:00:00

abstract：:Traditional nonsteroidal anti-inflammatory drugs block cyclooxygenase (COX). They are the most widely used drugs for pain relief. They are indispensable for their effects but are condemned for their adverse drug reactions. Two COX inhibitors, acetaminophen and aspirin, are the most widely used over-the-counter drugs. ...

journal_title：Current rheumatology reports

authors： Brune K,Hinz B,Otterness I

更新日期：2009-02-01 00:00:00

abstract：:Neonatal lupus is a disease characterized by one or more of the following findings: congenital heart block, cardiomyopathy, cutaneous lupus lesions, hepatobiliary disease, and thrombocytopenia. Accumulating evidence indicates that the disease is probably caused by maternal autoantibodies, particularly autoantibodies o...

journal_title：Current rheumatology reports

authors： Lee LA

更新日期：2001-10-01 00:00:00

abstract：:Inflammatory joint diseases such as rheumatoid arthritis, as well as other rheumatic conditions, such as systemic lupus erythematosus (SLE) and ankylosing spondylitis, comprise a heterogeneous group of joint disorders that are all associated with extra-articular side effects, including bone loss and fractures. The con...

journal_title：Current rheumatology reports

authors： Bultink IE,Vis M,van der Horst-Bruinsma IE,Lems WF

更新日期：2012-06-01 00:00:00

abstract：:Childhood systemic lupus erythematosus (SLE) is known to have a worse prognosis than adult-onset disease, and monitoring and treatment of the disease are still a challenge. Thus, there is an urgent need for highly reliable, non-invasive biomarkers for early detection of relapses, to avoid long-term complications and t...

journal_title：Current rheumatology reports

authors： Binder E,Edelbauer M

更新日期：2013-03-01 00:00:00

abstract：:There is a wide variation in the prevalence, incidence, and clinical manifestation of psoriatic arthritis (PsA) across countries due to genetic and environmental factors. Data on PsA in Asia are limited and come from small cross-sectional studies. The burden of PsA in Asia is high, including poor physical functioning,...

journal_title：Current rheumatology reports

authors： Leung YY,Tam LS,Li EK

更新日期：2011-08-01 00:00:00

abstract：:Skin fibrosis occurs in a variety of human diseases, most notably systemic sclerosis (SSc). The end stage of scleroderma in human skin consists of excess collagen deposition in the dermis with loss of adnexal structures and associated adipose tissue. The initiating factors for this process and the early stages are bel...

journal_title：Current rheumatology reports

authors： Smith GP,Chan ES

更新日期：2010-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Several biologic drugs are available for treatment of immune-mediated diseases, and the number of children treated with biologics is increasing. This review summarises current knowledge about the safety and immunogenicity of vaccines in children treated with biologic therapy. RECENT FINDINGS:A recent...

journal_title：Current rheumatology reports

authors： Toplak N,Uziel Y

更新日期：2020-05-20 00:00:00

abstract：:The high-range estimate of 1.3% by the National Arthritis Data Workgroup for the prevalence of the entire spectrum of spondyloarthropathies (SpAs) suggests that SpAs may be more prevalent than rheumatoid arthritis (RA) in the United States. Recent surveys from many European countries using the same sample population h...

journal_title：Current rheumatology reports

authors： Akkoc N

更新日期：2008-10-01 00:00:00

abstract：:Although the pathogenesis of SLE remains poorly understood, there is consensus that it involves a combination of genetic, hormonal, and environmental factors. New technologies applied to genomic and gene expression studies have revealed novel gene mutations and cytokine alterations in this disease. Recently, advances ...

journal_title：Current rheumatology reports

authors： Stichweh D,Pascual V

更新日期：2005-12-01 00:00:00

abstract：:Systemic vasculitis can affect practically any structure in or around the eye. Although the ocular presentations of vasculitic disease are highly variable and may be quite subtle, it is important for physicians to understand some of the basic concepts, critical findings, and potential significance of ocular signs and ...

journal_title：Current rheumatology reports

authors： Shepherd JB 3rd

更新日期：2003-04-01 00:00:00

abstract：:Apatite crystals form in physiologically calcified tissues, including the hyaline cartilage of the epiphyseal growth plate. While apatite crystals appear as unwanted deposits in other cartilage sites, more frequently, crystalline materials other than or in addition to apatite develop in dystrophic cartilage deposits. ...

journal_title：Current rheumatology reports

authors： Boskey AL

更新日期：2002-06-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a chronic disease affecting the physical, social, and psychological well-being of patients. Different instruments have been developed to measure health-related quality of life, some of which are SLE-specific. Contributors to poor quality of life in patients with SLE include fatigu...

journal_title：Current rheumatology reports

authors： Kiani AN,Petri M

更新日期：2010-08-01 00:00:00