Molecular pathogenesis of skin fibrosis: insight from animal models.

abstract：PURPOSE OF THE REVIEW:Polymyalgia rheumatica (PMR) is one of the most common inflammatory rheumatologic condition occurring in older adults. It is characterized by proximal pain and stiffness in the shoulders, neck, and/or pelvic girdle in individuals over 50 years of age along with evidence of an intense systemic infl...

journal_title：Current rheumatology reports

authors： Gazitt T,Zisman D,Gardner G

更新日期：2020-06-19 00:00:00

abstract：:Childhood systemic lupus erythematosus (SLE) is known to have a worse prognosis than adult-onset disease, and monitoring and treatment of the disease are still a challenge. Thus, there is an urgent need for highly reliable, non-invasive biomarkers for early detection of relapses, to avoid long-term complications and t...

journal_title：Current rheumatology reports

authors： Binder E,Edelbauer M

更新日期：2013-03-01 00:00:00

abstract：:Epidemiologic studies of pediatric rheumatologic disease are becoming increasingly focused on subfields of epidemiology. Genetic epidemiology is assuming an ever-greater role in the understanding of disease risks and pathogenesis. Such studies involve major histocompatibility complex, cytokine gene polymorphisms, T ce...

journal_title：Current rheumatology reports

authors： Manners PJ

更新日期：2003-12-01 00:00:00

abstract：:Management of the pregnant patient with antiphospholipid antibody (aPL) is reviewed, with emphasis on recent randomized controlled clinical trials. These support the use of subcutaneous heparin and low dose aspirin, current standard therapy for women with aPL and a history of fetal loss. Prednisone is rarely used due ...

journal_title：Current rheumatology reports

authors： Sammaritano LR

更新日期：2001-06-01 00:00:00

abstract：:Antiphospholipid antibodies are associated with a hypercoagulable state leading to a wide variety of systemic manifestations and obstetric complications. The different pathologic manifestations can be a result of arterial and venous thrombosis, microthrombotic angiopathy, embolization, obstetric disease, and non-throm...

journal_title：Current rheumatology reports

authors： DeMarco P,Singh I,Weinstein A

更新日期：2006-04-01 00:00:00

abstract：:The normal process of aging brings about changes in immune function, hormonal status, overall metabolism, and enhanced occurrence of neuropsychiatric disorders. These alterations are also evident at an accelerating pace in chronic inflammatory diseases. Treatment with immunosuppressive therapeutics is often not suffic...

journal_title：Current rheumatology reports

authors： Härle P,Straub RH

更新日期：2005-10-01 00:00:00

abstract：:Juvenile idiopathic arthritis (JIA) is in a majority of the cases of self-limiting, and sometimes even a self-remitting, disease. A growing amount of data suggests that active T cell regulation determines, at least partly, the clinical outcome of JIA. In experimental models of arthritis, a group of highly conserved mi...

journal_title：Current rheumatology reports

authors： Prakken B,Kuis W,van Eden W,Albani S

更新日期：2002-12-01 00:00:00

abstract：:Activation of the complement system plays a fundamental role in the pathogenesis of systemic lupus erythematosus (SLE). For the past several decades, quantifying this process has focused primarily on determination of serum C3 and C4, although the utility of these assays for diagnosis and monitoring disease activity is...

journal_title：Current rheumatology reports

authors： Liu CC,Manzi S,Danchenko N,Ahearn JM

更新日期：2004-10-01 00:00:00

abstract：:Osteoporosis and related fractures represent a major, and growing, public health concern for the United States and worldwide. The pathogenesis of osteoporosis is complex, requiring attention to the different life phases involved in growth, maintenance, and loss of bone, in addition to non-skeletal factors associated w...

journal_title：Current rheumatology reports

authors： Samelson EJ,Hannan MT

更新日期：2006-02-01 00:00:00

abstract：:Gout and hyperuricemia have long been suspected to be risk factors for cardiovascular disease. However, studies have frequently failed to distinguish whether these entities have an independent effect on cardiovascular risk or serve as markers for other risk factors. In vitro and animal studies suggest that uric acid i...

journal_title：Current rheumatology reports

authors： Shah A,Keenan RT

更新日期：2010-04-01 00:00:00

abstract：:Acute and chronic gout are common complications following organ transplantation. Risk factors include those shared with the general population (eg, diuretic use) and transplant-specific risk factors (eg, cyclosporine). Clinical features of gout are similar to those seen in the general population, although tophi may be...

journal_title：Current rheumatology reports

authors： Stamp LK,Chapman PT

更新日期：2012-04-01 00:00:00

abstract：:The recent increase in the number of patients taking opioids chronically for pain has not yielded the expected benefits in reduction of symptoms and improved function. Chronic pain patients typically respond well initially to opioid medications, but regular use is associated with adverse psychological and physical eff...

journal_title：Current rheumatology reports

authors： Krashin D,Sullivan M,Ballantyne J

更新日期：2013-03-01 00:00:00

abstract：:This article attempts to evaluate the results of several recently published clinical trials of drugs used in the treatment and prevention of glucocorticoid-induced osteoporosis. Despite our lack of understanding regarding the biological mechanisms that lead to glucocorticoid-induced bone loss, effective therapy has be...

journal_title：Current rheumatology reports

authors： Boulos P,Ioannidis G,Adachi JD

更新日期：2000-02-01 00:00:00

abstract：:The high-range estimate of 1.3% by the National Arthritis Data Workgroup for the prevalence of the entire spectrum of spondyloarthropathies (SpAs) suggests that SpAs may be more prevalent than rheumatoid arthritis (RA) in the United States. Recent surveys from many European countries using the same sample population h...

journal_title：Current rheumatology reports

authors： Akkoc N

更新日期：2008-10-01 00:00:00

abstract：PURPOSE OF THE REVIEW:Idiopathic acute and recurrent pericarditis are rare diseases of unknown origin. Here, we review trigger factors, pathomechanism, and treatment options for acute and recurrent pericarditis. RECENT FINDINGS:Acute pericarditis can be triggered by viral infections, myocardial ischemia, heart cathete...

journal_title：Current rheumatology reports

authors： Blank N,Lorenz HM

更新日期：2019-03-09 00:00:00

abstract：:The pathogenic mechanisms in Behçet's syndrome are largely unknown. An autoantigen role for human leukocyte antigen B51 has been proposed. The reasons behind the thrombophilia are also not clear. Endothelial pathology could be the main culprit. The recently proposed association between familial Mediterranean fever and...

journal_title：Current rheumatology reports

authors： Yazici H

更新日期：2003-06-01 00:00:00

abstract：:Sleep disturbance is one of the most common comorbid problems for chronic pain patients. The association between the two phenomena has long been recognized, but the nature of the relationship is not well-understood. Many agree that the relationship is likely bidirectional. In this review, we focus on one side of the r...

journal_title：Current rheumatology reports

authors： Okifuji A,Hare BD

更新日期：2011-12-01 00:00:00

abstract：PURPOSE OF REVIEW:To review progress in the field of clinical trials for SLE. RECENT FINDINGS:Treatment development for SLE has been marked by failures of many later phase studies, representing billions of dollars of lost research and development funding. Recently, more successful Phase II trials have tested reduction...

journal_title：Current rheumatology reports

authors： Thanou A,Merrill JT

更新日期：2018-05-03 00:00:00

abstract：:Atypical femur fractures are rare but a growing concern, as they are more common in patients who use bisphosphonates. The best radiology-based studies have had access to only short-term exposure data, while the studies using prescription databases with substantial long-term data did not have access to radiology report...

journal_title：Current rheumatology reports

authors： Abrahamsen B,Clark EM

更新日期：2012-06-01 00:00:00

abstract：:Osteoarthritis causes tremendous individual suffering and staggering societal costs, but due to our limited understanding of the underlying molecular and cellular mechanisms, our avenues for treating this disease are very restricted. Recent years have seen a drastic increase in the use of genetically modified mice to ...

journal_title：Current rheumatology reports

authors： Moon PM,Beier F

更新日期：2015-08-01 00:00:00

abstract：:Teriparatide (recombinant human parathyroid hormone ) is an anabolic agent approved for the treatment of patients at high risk for fracture. The Fracture Prevention Trial administered teriparatide to treatment-naïve patients, leading to its US Food and Drug Administration approval in 2002. Clinical trial data using an...

journal_title：Current rheumatology reports

authors： File E,Deal C

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this study was to provide the most up-to-date scientific evidence of the potential analgesic effects, or lack thereof, of the marijuana plant (cannabis) or cannabinoids, and of safety or tolerability of their long-term use. RECENT FINDINGS:We found that inhaled (smoked or vaporized) ca...

journal_title：Current rheumatology reports

authors： Romero-Sandoval EA,Kolano AL,Alvarado-Vázquez PA

更新日期：2017-10-05 00:00:00

abstract：:Tumor-induced osteomalacia (TIO) is a paraneoplastic syndrome resulting in renal phosphate wasting and decreased bone mineralization. TIO is usually induced by small, slowly growing tumors of mesenchymal origin (phosphaturic mesenchymal tumor mixed connective tissue variant [PMTMCT]). Nonspecific symptoms including fa...

journal_title：Current rheumatology reports

authors： Hautmann AH,Hautmann MG,Kölbl O,Herr W,Fleck M

更新日期：2015-06-01 00:00:00

abstract：:Clinical evaluation of patients with low bone mass attempts to determine which patients should be offered one of the effective therapies for fracture prevention. Current guidelines are primarily based on bone density. Risk factors are used, but their contribution to fracture risk is not easily assessed. The combinatio...

journal_title：Current rheumatology reports

authors： Deal CL

更新日期：2007-04-01 00:00:00

abstract：:Biomarkers in psoriatic arthritis (PsA) may serve as surrogate end points for disease outcome and can provide insights into disease susceptibility and natural history. Biomarkers could relate to diagnosis, pathogenesis, prognosis, therapeutic response, and comorbidities. The "felt need" is, however, in the development...

journal_title：Current rheumatology reports

authors： Chandran V,Gladman DD

更新日期：2010-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Childhood arthritis is in need of a new system of classification, owing to deficiencies in the International League of Associations for Rheumatology (ILAR) criteria. We briefly review the history of classification of childhood arthritis, discuss the major criticisms of the current system, and highligh...

journal_title：Current rheumatology reports

authors： Rumsey DG,Laxer RM

更新日期：2020-01-11 00:00:00

abstract：PURPOSE OF REVIEW:The concept of cellular senescence has been evolving. Although originally proposed based on studies of serum-driven replication of cell lines in vitro, it is now clear that cellular senescence occurs in vivo. It has also become clear that cellular senescence can be triggered by a number of stimuli suc...

journal_title：Current rheumatology reports

authors： Gao L,Slack M,Barnas JL,McDavid A,Anolik J,Looney RJ

更新日期：2019-01-14 00:00:00

abstract：:Upregulated adhesion molecule and cytokine expression on endothelial cells and infiltrating inflammatory cells occur in most vasculitis syndromes. These observations suggest that vasculitis is associated with pathologic activation of normal immune cell cytokine cascades. Abnormal expression of adhesion molecules and c...

journal_title：Current rheumatology reports

authors： Sundy JS,Haynes BF

更新日期：2000-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Osteoarthritis (OA) is the most common form of arthritis and a major source of pain and disability worldwide. OA-associated pain is usually refractory to classically used analgesics, and disease-modifying therapies are still lacking. Therefore, a better understanding of mechanisms and mediators contri...

journal_title：Current rheumatology reports

authors： Syx D,Tran PB,Miller RE,Malfait AM

更新日期：2018-02-26 00:00:00

abstract：:This study had two objectives: to describe the historical development of self-reported presenteeism instruments that can be used to identify and measure presenteeism as a result of musculoskeletal disease (MSD) and to identify if, and how many of these, presenteeism instruments are underpinned by economic theory. Syst...

journal_title：Current rheumatology reports

authors： Jones C,Payne K,Gannon B,Verstappen S

更新日期：2016-08-01 00:00:00