Abstract:
:Gout and hyperuricemia have long been suspected to be risk factors for cardiovascular disease. However, studies have frequently failed to distinguish whether these entities have an independent effect on cardiovascular risk or serve as markers for other risk factors. In vitro and animal studies suggest that uric acid is a biologically active compound that can increase inflammatory mediators known to lead to vascular damage. In contrast, uric acid also has potentially protective effects as a strong antioxidant, approaching the potency of vitamin C. Large clinical trials demonstrate a consistent relationship between elevated serum uric acid and a variety of cardiovascular diseases, although the strength of association varies greatly. We review the evidence for and against an independent role for hyperuricemia and/or gout in cardiovascular pathology.
journal_name
Curr Rheumatol Repjournal_title
Current rheumatology reportsauthors
Shah A,Keenan RTdoi
10.1007/s11926-010-0084-3subject
Has Abstractpub_date
2010-04-01 00:00:00pages
118-24issue
2eissn
1523-3774issn
1534-6307journal_volume
12pub_type
杂志文章,评审abstract::Several entities have been carefully investigated for the symptomatic and structural management of osteoarthritis. The most compelling evidence of a potential for inhibiting the structural progression of osteoarthritis has been obtained with glucosamine sulfate, while some preliminary results also suggest that chondro...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-000-0023-9
更新日期:2000-12-01 00:00:00
abstract::Psoriatic arthritis is a chronic, disabling disease for which therapies have been borrowed from rheumatoid arthritis and spondylitis. Traditional disease-modifying antirheumatic drugs (DMARDs) remain the first choice for the treatment of peripheral arthritis despite scarce evidence of their efficacy or ability to halt...
journal_title:Current rheumatology reports
pub_type: 杂志文章
doi:10.1007/s11926-009-0038-9
更新日期:2009-08-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章
doi:10.1007/s11926-009-0006-4
更新日期:2009-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Antiphospholipid syndrome (APS) is a chronic autoimmune disease that can be seen as a burden, with consequences on patients' daily life. Health has traditionally been measured using measures of morbidity or mortality. Health-related quality of life (HRQoL) is a concept that includes quality of life th...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-020-00900-z
更新日期:2020-05-13 00:00:00
abstract:PURPOSE OF REVIEW:Childhood arthritis is in need of a new system of classification, owing to deficiencies in the International League of Associations for Rheumatology (ILAR) criteria. We briefly review the history of classification of childhood arthritis, discuss the major criticisms of the current system, and highligh...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-020-0880-3
更新日期:2020-01-11 00:00:00
abstract:PURPOSE OF REVIEW:Several biologic drugs are available for treatment of immune-mediated diseases, and the number of children treated with biologics is increasing. This review summarises current knowledge about the safety and immunogenicity of vaccines in children treated with biologic therapy. RECENT FINDINGS:A recent...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-020-00905-8
更新日期:2020-05-20 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-019-0868-z
更新日期:2019-12-07 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-016-0578-8
更新日期:2016-05-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-017-0642-z
更新日期:2017-04-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-020-00919-2
更新日期:2020-06-19 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-012-0241-y
更新日期:2012-06-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-008-0025-6
更新日期:2008-04-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-007-0040-z
更新日期:2007-06-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-007-0049-3
更新日期:2007-08-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-005-0037-4
更新日期:2005-08-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-012-0248-4
更新日期:2012-06-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-007-0004-3
更新日期:2007-05-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-006-0051-1
更新日期:2006-04-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-006-0020-8
更新日期:2006-02-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-005-0045-4
更新日期:2005-12-01 00:00:00
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journal_title:Current rheumatology reports
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更新日期:2019-05-23 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章
doi:10.1007/s11926-007-0024-z
更新日期:2007-04-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
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更新日期:2011-12-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
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更新日期:2018-11-05 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
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更新日期:2019-11-21 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-020-00969-6
更新日期:2020-11-24 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-001-0009-2
更新日期:2001-04-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-014-0435-6
更新日期:2014-08-01 00:00:00
abstract::The risk of infection accompanies the benefits of surgery. Immunomodulatory chronic illnesses may increase the risk of surgical infections. Surgical patients with rheumatologic illness need close preoperative assessment regarding their infection risks (fixed and modifiable), which vary on the basis of the proposed pro...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-013-0379-2
更新日期:2013-12-01 00:00:00
abstract::Psoriatic arthritis (PsA) is a chronic inflammatory joint disease associated with psoriasis that can lead to joint deformity and disability. PsA has a low likelihood of clinical remission and cure. For a long time, therapeutic options for PsA patients have been unsatisfactory, but the introduction of anti-tumor necros...
journal_title:Current rheumatology reports
pub_type: 杂志文章
doi:10.1007/s11926-008-0048-z
更新日期:2008-08-01 00:00:00