Cell Senescence in Lupus.

abstract：:Genetic defects of collagen formation (the collagenopathies) affect almost every organ system and tissue in the body. They can be grouped by clinical phenotype, which usually correlates with the tissue distribution of the affected collagen subtype. Many of these conditions present in childhood; however, milder phenoty...

journal_title：Current rheumatology reports

authors： Jobling R,D'Souza R,Baker N,Lara-Corrales I,Mendoza-Londono R,Dupuis L,Savarirayan R,Ala-Kokko L,Kannu P

更新日期：2014-01-01 00:00:00

abstract：:Skin fibrosis occurs in a variety of human diseases, most notably systemic sclerosis (SSc). The end stage of scleroderma in human skin consists of excess collagen deposition in the dermis with loss of adnexal structures and associated adipose tissue. The initiating factors for this process and the early stages are bel...

journal_title：Current rheumatology reports

authors： Smith GP,Chan ES

更新日期：2010-02-01 00:00:00

abstract：:Osteoporosis and related fractures represent a major, and growing, public health concern for the United States and worldwide. The pathogenesis of osteoporosis is complex, requiring attention to the different life phases involved in growth, maintenance, and loss of bone, in addition to non-skeletal factors associated w...

journal_title：Current rheumatology reports

authors： Samelson EJ,Hannan MT

更新日期：2006-02-01 00:00:00

abstract：:Many lines of evidence suggest that autoimmune diseases result from chronic immune activation following environmental exposures in genetically susceptible individuals. A genetic basis for autoimmunity is supported by twin and family studies, candidate gene investigations, animal models, and whole genome microsatellite...

journal_title：Current rheumatology reports

authors： Shamim EA,Miller FW

更新日期：2000-06-01 00:00:00

abstract：PURPOSE OF THE REVIEW:We will address current treatment and unmet needs in psoriatic arthritis (PsA), examine existing randomized controlled trials (RCTs), and consider options for new trial designs and challenges in their implementation. RECENT FINDINGS:While therapeutic options for PsA have rapidly increased, there ...

journal_title：Current rheumatology reports

authors： Ogdie A,Coates L

更新日期：2017-04-01 00:00:00

abstract：:Seronegative spondyloarthropathies comprise a group of inflammatory arthritides, which consists of ankylosing spondylitis, psoriatic arthritis, reactive arthritis (Reiter's syndrome), enteropathic arthritis, and undifferentiated spondyloarthropathy. All of them share common laboratory, clinical, and imaging findings, ...

journal_title：Current rheumatology reports

authors： Grigoryan M,Roemer FW,Mohr A,Genant HK

更新日期：2004-04-01 00:00:00

abstract：:Interest in imaging ankylosing spondylitis (AS) and related spondyloarthropathies has increased in recent years. MRI is regarded as the most sensitive imaging modality to detect early inflammatory lesions in the sacroiliac joints and in the spine. Standard radiography plays a major role in evaluating potential disease...

journal_title：Current rheumatology reports

authors： Weber U,Kissling RO,Hodler J

更新日期：2007-10-01 00:00:00

abstract：:Osteoarthritis causes tremendous individual suffering and staggering societal costs, but due to our limited understanding of the underlying molecular and cellular mechanisms, our avenues for treating this disease are very restricted. Recent years have seen a drastic increase in the use of genetically modified mice to ...

journal_title：Current rheumatology reports

authors： Moon PM,Beier F

更新日期：2015-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Medical treatment with urate-lowering therapy (ULT) is efficacious. A recent publication suggested that surgery in gout is more prevalent than previously reported. This revelation led us to review what is known about surgical treatment of gout. RECENT FINDINGS:The Google Scholar database (January 1, ...

journal_title：Current rheumatology reports

authors： Carcione J,Bodofsky S,LaMoreaux B,Schlesinger N

更新日期：2020-11-24 00:00:00

abstract：:Traditional nonsteroidal anti-inflammatory drugs block cyclooxygenase (COX). They are the most widely used drugs for pain relief. They are indispensable for their effects but are condemned for their adverse drug reactions. Two COX inhibitors, acetaminophen and aspirin, are the most widely used over-the-counter drugs. ...

journal_title：Current rheumatology reports

authors： Brune K,Hinz B,Otterness I

更新日期：2009-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Gout management is currently suboptimal despite excellent available therapy. Gout patient education has been shown to enhance medication adherence and self-management, but needs improvement. We explored the literature on gout patient education including gaps in gout patient knowledge; use of written m...

journal_title：Current rheumatology reports

authors： Fields TR,Batterman A

更新日期：2018-03-08 00:00:00

abstract：:Psoriatic arthritis is a chronic inflammatory joint disease, seen in combination with the chronic inflammatory skin disease psoriasis and belonging to the family of spondylarthritides (SpA). A link is recognized between psoriatic arthritis and inflammatory bowel disease (IBD). Environmental factors seem to induce infl...

journal_title：Current rheumatology reports

authors： Eppinga H,Konstantinov SR,Peppelenbosch MP,Thio HB

更新日期：2014-03-01 00:00:00

abstract：:Uric acid nephrolithiasis is typically found in individuals with a low urine pH and a normal concentration of urinary uric acid. Patients with a history of gout are at greater risk of forming uric acid stones, as are patients with obesity, diabetes, or the complete metabolic syndrome. The unifying renal tubular abnorm...

journal_title：Current rheumatology reports

authors： Liebman SE,Taylor JG,Bushinsky DA

更新日期：2007-06-01 00:00:00

abstract：:Juvenile idiopathic arthritis (JIA) is in a majority of the cases of self-limiting, and sometimes even a self-remitting, disease. A growing amount of data suggests that active T cell regulation determines, at least partly, the clinical outcome of JIA. In experimental models of arthritis, a group of highly conserved mi...

journal_title：Current rheumatology reports

authors： Prakken B,Kuis W,van Eden W,Albani S

更新日期：2002-12-01 00:00:00

abstract：PURPOSE OF THE REVIEW:Osteoarthritis (OA) is an aging-associated and injury-induced joint disease characterized by cartilage degradation, bone sclerosis, and persistent low-grade inflammation in the joint. Aging and injury are triggers of joint pathological changes mediated by pro-inflammatory factors, some of which ar...

journal_title：Current rheumatology reports

authors： Xie C,Chen Q

更新日期：2019-12-07 00:00:00

abstract：:The distribution of the anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitides (AAV) is not uniform across geographical regions and ethnic and racial groups, suggesting that genetic and environmental factors affect the pathogenesis of these diseases. In addition, genetic factors affect not only the clin...

journal_title：Current rheumatology reports

authors： Ugarte-Gil MF,Espinoza LR

更新日期：2014-07-01 00:00:00

abstract：:TNF-blocking biologics have revolutionized the care of patients with spondyloarthritis, a group of clinically overlapping conditions that includes ankylosing spondylitis and psoriatic arthritis. However, incomplete response rates speak to the need for alternative therapeutic approaches. Over the last decade, animal mo...

journal_title：Current rheumatology reports

authors： Smith JA

更新日期：2016-06-01 00:00:00

abstract：:The inflammatory myopathies are a heterogeneous group of diseases including dermatomyositis, polymyositis, and inclusion body myositis. Few clinical trials have been conducted in myositis, making it difficult to provide clear recommendations on the treatment of these rare disorders. Although corticosteroids have not b...

journal_title：Current rheumatology reports

authors： Aggarwal R,Oddis CV

更新日期：2011-06-01 00:00:00

abstract：:Epidemiologic studies of pediatric rheumatologic disease are becoming increasingly focused on subfields of epidemiology. Genetic epidemiology is assuming an ever-greater role in the understanding of disease risks and pathogenesis. Such studies involve major histocompatibility complex, cytokine gene polymorphisms, T ce...

journal_title：Current rheumatology reports

authors： Manners PJ

更新日期：2003-12-01 00:00:00

abstract：:This study had two objectives: to describe the historical development of self-reported presenteeism instruments that can be used to identify and measure presenteeism as a result of musculoskeletal disease (MSD) and to identify if, and how many of these, presenteeism instruments are underpinned by economic theory. Syst...

journal_title：Current rheumatology reports

authors： Jones C,Payne K,Gannon B,Verstappen S

更新日期：2016-08-01 00:00:00

abstract：:Until recently, imaging evaluation of osteoarthritis has relied primarily on conventional radiography. Using radiography in clinical practice or clinical research, however, has been fraught with difficulty. Techniques for reproducibly acquiring serial radiographs of joints have improved considerably over the past seve...

journal_title：Current rheumatology reports

authors： Peterfy C,Kothari M

更新日期：2006-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Positron emission tomography (PET) combined with computed tomography (CT) has proven useful as a cancer screening technique in patients with inflammatory myopathy, mainly dermatomyositis. In this review, we focus on advances in this direction and other potential applications of PET/CT in patients with...

journal_title：Current rheumatology reports

authors： Selva-O'Callaghan A,Gil-Vila A,Simó-Perdigó M,Trallero-Araguás E,Alvarado-Cárdenas M,Pinal-Fernandez I

更新日期：2019-11-21 00:00:00

abstract：:Tumor-induced osteomalacia (TIO) is a paraneoplastic syndrome resulting in renal phosphate wasting and decreased bone mineralization. TIO is usually induced by small, slowly growing tumors of mesenchymal origin (phosphaturic mesenchymal tumor mixed connective tissue variant [PMTMCT]). Nonspecific symptoms including fa...

journal_title：Current rheumatology reports

authors： Hautmann AH,Hautmann MG,Kölbl O,Herr W,Fleck M

更新日期：2015-06-01 00:00:00

abstract：:There is a wide variation in the prevalence, incidence, and clinical manifestation of psoriatic arthritis (PsA) across countries due to genetic and environmental factors. Data on PsA in Asia are limited and come from small cross-sectional studies. The burden of PsA in Asia is high, including poor physical functioning,...

journal_title：Current rheumatology reports

authors： Leung YY,Tam LS,Li EK

更新日期：2011-08-01 00:00:00

abstract：:The Delphi Technique and Nominal Group Technique are two well-recognized consensus-formation methodologies specifically designed to combine judgments from a group of experts. The Delphi Technique utilizes a series of well-defined questionnaire-based surveys, whereas Nominal Group Technique is a structured face-to-face...

journal_title：Current rheumatology reports

authors： Ruperto N,Meiorin S,Iusan SM,Ravelli A,Pistorio A,Martini A

更新日期：2008-04-01 00:00:00

abstract：:As the body's largest organ and first line of defense against the environment, the skin plays a vital role in host immune defense. In addition to its function as a physical barrier, the skin contains an active immune surveillance network and can mount highly specific responses to eliminate invading organisms. In this ...

journal_title：Current rheumatology reports

authors： Fuhlbrigge RC,Chaiban R

更新日期：2011-04-01 00:00:00

abstract：:Bone is not structurally normal in osteoarthritis (OA). Periarticular bone in OA has increased turnover, decreased bone mineral content and stiffness, and decreased trabecular numbers. The increased turnover of collagen, in particular, may affect the biomechanical competence of bone and is driven by a number of proces...

journal_title：Current rheumatology reports

authors： Hunter DJ,Spector TD

更新日期：2003-02-01 00:00:00

abstract：:The investigations used to diagnose an inflammatory muscle disease include history and physical examination, evaluation of serum levels of enzymes derived from skeletal muscle, electromyography, magnetic resonance imaging, and muscle histology. The evaluation of patients who may have noninflammatory myopathy includes,...

journal_title：Current rheumatology reports

authors： Wortmann RL,Vladutiu GD

更新日期：2001-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Optimal management of anxiety and mood disorders in patients with systemic lupus erythematosus (SLE) is limited by an incomplete understanding of their pathophysiology and a lack of treatment guidelines. This review aims to critically synthesize recent literature on these conditions in adults with SLE...

journal_title：Current rheumatology reports

authors： Tisseverasinghe A,Peschken C,Hitchon C

更新日期：2018-11-12 00:00:00

abstract：:Scleroderma renal crisis (SRC) is characterized by malignant hypertension, oliguric/anuric acute renal failure, and important mortality, with a 5-year survival rate of 65%. SRC occurs in 2% to 5% of patients with systemic sclerosis (SSc), particularly those with diffuse cutaneous SSc in the first years of disease evol...

journal_title：Current rheumatology reports

authors： Bussone G,Bérezné A,Pestre V,Guillevin L,Mouthon L

更新日期：2011-02-01 00:00:00