Abstract：
:The inflammatory myopathies are a heterogeneous group of diseases including dermatomyositis, polymyositis, and inclusion body myositis. Few clinical trials have been conducted in myositis, making it difficult to provide clear recommendations on the treatment of these rare disorders. Although corticosteroids have not been tested in randomized controlled trials, the general expert consensus confirms their first-line use. However, in many patients, corticosteroid toxicity leads to significant disability, or these agents are ineffective, which then requires additional immunosuppression. Intravenous immunoglobulin is a reasonable short-term treatment with proven benefit in a controlled trial, but its long-term effectiveness remains unknown. The evidence for other immunosuppressive therapies has been derived mainly from case reports and open studies. These agents include methotrexate and/or azathioprine, followed by cyclosporine or tacrolimus (particularly for antisynthetase antibody-positive patients) and mycophenolate mofetil (for refractory rash). Newer therapies (eg, rituximab) are encouraging, but results from the largest randomized controlled trial studying this agent are soon to follow. The balance of evidence suggests that immunosuppressive drugs are effective in dermatomyositis and polymyositis, although randomized controlled trials are lacking.
journal_name
Curr Rheumatol Repjournal_title
Current rheumatology reportsauthors
Aggarwal R,Oddis CVdoi
10.1007/s11926-011-0172-zsubject
Has Abstractpub_date
2011-06-01 00:00:00pages
182-91issue
3eissn
1523-3774issn
1534-6307journal_volume
13pub_type
杂志文章,评审abstract：:The pediatric rheumatologist cares for children who may have a wide variety of causes of musculoskeletal pain. These include such diverse conditions as arthritis, low-back pain, hypermobility, metabolic bone pain, and amplified pain syndromes such as complex regional pain syndrome and fibromyalgia. This review examine...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-000-0072-0
更新日期：2000-08-01 00:00:00
abstract：:Biomarkers in psoriatic arthritis (PsA) may serve as surrogate end points for disease outcome and can provide insights into disease susceptibility and natural history. Biomarkers could relate to diagnosis, pathogenesis, prognosis, therapeutic response, and comorbidities. The "felt need" is, however, in the development...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-010-0107-0
更新日期：2010-08-01 00:00:00
abstract：:Osteoarthritis causes tremendous individual suffering and staggering societal costs, but due to our limited understanding of the underlying molecular and cellular mechanisms, our avenues for treating this disease are very restricted. Recent years have seen a drastic increase in the use of genetically modified mice to ...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-015-0524-1
更新日期：2015-08-01 00:00:00
abstract：:Psoriatic arthritis is a chronic, disabling disease for which therapies have been borrowed from rheumatoid arthritis and spondylitis. Traditional disease-modifying antirheumatic drugs (DMARDs) remain the first choice for the treatment of peripheral arthritis despite scarce evidence of their efficacy or ability to halt...
journal_title：Current rheumatology reports
pub_type： 杂志文章
doi：10.1007/s11926-009-0038-9
更新日期：2009-08-01 00:00:00
abstract：:Vasculitis is defined as inflammation of blood vessels and can affect multiple organs. Several classification systems exist to categorize vasculitis such as vessel size, presence of anti-neutrophil cytoplasmic antibody, pathogenesis of the inflammation, and type of inflammatory cell infiltrate. Cutaneous vasculitis oc...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-005-0037-4
更新日期：2005-08-01 00:00:00
abstract：:Psoriatic arthritis (PsA) is a chronic inflammatory joint disease associated with psoriasis that can lead to joint deformity and disability. PsA has a low likelihood of clinical remission and cure. For a long time, therapeutic options for PsA patients have been unsatisfactory, but the introduction of anti-tumor necros...
journal_title：Current rheumatology reports
pub_type： 杂志文章
doi：10.1007/s11926-008-0048-z
更新日期：2008-08-01 00:00:00
abstract：:The frequency of Takayasu's arteritis (TA) has been estimated to be 2.9 cases per 1 million people, with a female preponderance, although female-to-male ratio varies from different geographic areas. A high frequency of haplotype A24-B52-DR2 has been found in Japanese patients, without this association in other populat...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-002-0021-1
更新日期：2002-02-01 00:00:00
abstract：:The normal process of aging brings about changes in immune function, hormonal status, overall metabolism, and enhanced occurrence of neuropsychiatric disorders. These alterations are also evident at an accelerating pace in chronic inflammatory diseases. Treatment with immunosuppressive therapeutics is often not suffic...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-005-0027-6
更新日期：2005-10-01 00:00:00
abstract：PURPOSE OF REVIEW:Ankylosing spondylitis (AS) was historically seen as a predominantly male disease. However, more recent data showed a more homogenous sex prevalence. Unfortunately, in many studies in axial spondyloarthritis (axSpA), the number of women included is low and the analyses are often not stratified for gen...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-018-0744-2
更新日期：2018-05-12 00:00:00
abstract：:Psoriatic arthritis is a chronic inflammatory joint disease, seen in combination with the chronic inflammatory skin disease psoriasis and belonging to the family of spondylarthritides (SpA). A link is recognized between psoriatic arthritis and inflammatory bowel disease (IBD). Environmental factors seem to induce infl...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-013-0407-2
更新日期：2014-03-01 00:00:00
abstract：:Synovitis is the characteristic feature of inflammatory joint disease. If synovitis is localized to interphalangeal joints, rheumatoid arthritis, psoriatic arthritis, and juvenile idiopathic arthritis are among the most common differential diagnoses. The absence of pain, tenderness, and limitation of function despite ...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-014-0442-7
更新日期：2014-01-01 00:00:00
abstract：:Advanced imaging has become essential for recognition of clinically suspected early spondyloarthritis. This report summarizes recent progress towards a data-driven comprehensive definition of a positive sacroiliac joint MRI in axial spondyloarthritis, which incorporates contextual information provided by structural le...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-016-0607-7
更新日期：2016-09-01 00:00:00
abstract：:Recent human genetic discoveries have increased our understanding of rheumatoid arthritis (RA) susceptibility. Genome-wide association studies have expanded the number of validated RA risk loci beyond HLA-DRB1 "shared epitope" alleles to include additional major histocompatibility complex (MHC) risk alleles and more t...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-009-0050-0
更新日期：2009-10-01 00:00:00
abstract：PURPOSE OF THE REVIEW:Osteoarthritis (OA) is a chronic, painful joint disease that affects approximately 40% of adults over 70 year. Age is the strongest predictor of OA, while obesity is considered the primary preventable risk factor for OA. Both conditions are associated with abnormal innate immune inflammatory respo...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-017-0672-6
更新日期：2017-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Childhood arthritis is in need of a new system of classification, owing to deficiencies in the International League of Associations for Rheumatology (ILAR) criteria. We briefly review the history of classification of childhood arthritis, discuss the major criticisms of the current system, and highligh...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-020-0880-3
更新日期：2020-01-11 00:00:00
abstract：PURPOSE OF REVIEW:Chikungunya virus (CHIKV) infection has become increasingly prevalent in the last decade not only across the southern hemisphere but also, because of a recently documented viral mutation, in southern Europe and the USA. With the global spread of CHIKV infection, practitioners should know its epidemiol...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-017-0694-0
更新日期：2017-10-05 00:00:00
abstract：:Focal chondral or osteochondral lesions can be painful and disabling because they have insufficient intrinsic repair potential, and constitute one of the major extrinsic risk factors for osteoarthritis (OA). Attention has, therefore, been paid to regenerative therapeutic procedures for the early treatment of cartilagi...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-014-0452-5
更新日期：2014-10-01 00:00:00
abstract：PURPOSE OF THE REVIEW:We will address current treatment and unmet needs in psoriatic arthritis (PsA), examine existing randomized controlled trials (RCTs), and consider options for new trial designs and challenges in their implementation. RECENT FINDINGS:While therapeutic options for PsA have rapidly increased, there ...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-017-0642-z
更新日期：2017-04-01 00:00:00
abstract：:The Delphi Technique and Nominal Group Technique are two well-recognized consensus-formation methodologies specifically designed to combine judgments from a group of experts. The Delphi Technique utilizes a series of well-defined questionnaire-based surveys, whereas Nominal Group Technique is a structured face-to-face...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-008-0025-6
更新日期：2008-04-01 00:00:00
abstract：:Spondyloarthritis (SpA) is characterized by inflammation and new bone formation in the spine and entheses. The disease is the result of a complex interplay among susceptibility genes, microbial triggers, inflammation of bone marrow, and the enthesial structures and new bone formation. This article gives a conceptual o...
journal_title：Current rheumatology reports
pub_type： 杂志文章
doi：10.1007/s11926-011-0202-x
更新日期：2011-10-01 00:00:00
abstract：:Systemic vasculitis can affect practically any structure in or around the eye. Although the ocular presentations of vasculitic disease are highly variable and may be quite subtle, it is important for physicians to understand some of the basic concepts, critical findings, and potential significance of ocular signs and ...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-003-0037-1
更新日期：2003-04-01 00:00:00
abstract：:Rheumatoid arthritis is a chronic inflammatory disease that results in generalized bone loss and increased fracture risk. Characteristic radiologic features of rheumatoid arthritis include periarticular osteopenia and marginal erosions. An emerging literature highlights the importance of osteoclasts as mediators of th...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-012-0253-7
更新日期：2012-06-01 00:00:00
abstract：:The investigations used to diagnose an inflammatory muscle disease include history and physical examination, evaluation of serum levels of enzymes derived from skeletal muscle, electromyography, magnetic resonance imaging, and muscle histology. The evaluation of patients who may have noninflammatory myopathy includes,...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-001-0035-0
更新日期：2001-08-01 00:00:00
abstract：:Our growing understanding of the immune response mechanism has created a wave of novel biologic agents for the treatment of rheumatoid arthritis. The domain of biologic agents includes: 1) Recombinant regulatory cytokines; 2) engineered molecules and monoclonal antibodies that target proinflammatory cytokines; 3) mono...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-999-0013-5
更新日期：1999-12-01 00:00:00
abstract：:Seronegative spondyloarthropathies comprise a group of inflammatory arthritides, which consists of ankylosing spondylitis, psoriatic arthritis, reactive arthritis (Reiter's syndrome), enteropathic arthritis, and undifferentiated spondyloarthropathy. All of them share common laboratory, clinical, and imaging findings, ...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-004-0054-8
更新日期：2004-04-01 00:00:00
abstract：:Many lines of evidence suggest that autoimmune diseases result from chronic immune activation following environmental exposures in genetically susceptible individuals. A genetic basis for autoimmunity is supported by twin and family studies, candidate gene investigations, animal models, and whole genome microsatellite...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-000-0080-0
更新日期：2000-06-01 00:00:00
abstract：:Large epidemiologic studies of gout can improve insight into the etiology, pathology, impact, and management of the disease. Identification of monosodium urate monohydrate crystals is considered the gold standard for diagnosis, but its application is often not possible in large studies. Therefore, under such circumsta...
journal_title：Current rheumatology reports
pub_type： 杂志文章
doi：10.1007/s11926-010-0157-3
更新日期：2011-04-01 00:00:00
abstract：:β2-glycoprotein I (β2GPI) is the major autoantigen in the antiphospholipid syndrome. The central importance of understanding β2GPI physiology from the perspective of the rheumatologist is that it forms the foundation for understanding the pathophysiology underlying autoantibody generation, and the diverse mechanisms b...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-010-0151-9
更新日期：2011-02-01 00:00:00
abstract：:Childhood systemic lupus erythematosus (SLE) is known to have a worse prognosis than adult-onset disease, and monitoring and treatment of the disease are still a challenge. Thus, there is an urgent need for highly reliable, non-invasive biomarkers for early detection of relapses, to avoid long-term complications and t...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-012-0312-0
更新日期：2013-03-01 00:00:00
abstract：:Several entities have been carefully investigated for the symptomatic and structural management of osteoarthritis. The most compelling evidence of a potential for inhibiting the structural progression of osteoarthritis has been obtained with glucosamine sulfate, while some preliminary results also suggest that chondro...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-000-0023-9
更新日期：2000-12-01 00:00:00
