Abstract:
:Systemic lupus erythematosus (SLE) is a chronic debilitating condition with significant impact on the musculoskeletal system. Arthroplasty may be indicated for damage related to active lupus or its treatment. As therapies for SLE have advanced, morbidity and mortality have declined, while the rate of joint replacement has increased. The age of SLE patients undergoing arthroplasty is increasing, and the indication for surgery is evolving-while avascular necrosis was previously the predominant indication for arthroplasty, osteoarthritis now accounts for a larger proportion of surgeries. Pain and functional outcomes of arthroplasty in SLE patients are comparable to those of the general population with osteoarthritis, but lupus remains an independent risk factor for post-hip arthroplasty complications and mortality. Further research is needed to characterize the impact of lupus disease activity and severity on arthroplasty outcomes.
journal_name
Curr Rheumatol Repjournal_title
Current rheumatology reportsauthors
Kasturi S,Goodman Sdoi
10.1007/s11926-016-0608-6subject
Has Abstractpub_date
2016-09-01 00:00:00pages
59issue
9eissn
1523-3774issn
1534-6307pii
10.1007/s11926-016-0608-6journal_volume
18pub_type
杂志文章,评审abstract::As the body's largest organ and first line of defense against the environment, the skin plays a vital role in host immune defense. In addition to its function as a physical barrier, the skin contains an active immune surveillance network and can mount highly specific responses to eliminate invading organisms. In this ...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-010-0158-2
更新日期:2011-04-01 00:00:00
abstract::Seronegative spondyloarthropathies comprise a group of inflammatory arthritides, which consists of ankylosing spondylitis, psoriatic arthritis, reactive arthritis (Reiter's syndrome), enteropathic arthritis, and undifferentiated spondyloarthropathy. All of them share common laboratory, clinical, and imaging findings, ...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-004-0054-8
更新日期:2004-04-01 00:00:00
abstract::While the most obvious manifestations of rheumatoid arthritis (RA) involve inflammation and damage in the synovial joints, the systemic effects of the condition are widespread and life-threatening. Of particular interest is the 'lipid paradox' of RA, where patients with a numerically equivocal starting lipid profile h...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-015-0534-z
更新日期:2015-09-01 00:00:00
abstract::Focal chondral or osteochondral lesions can be painful and disabling because they have insufficient intrinsic repair potential, and constitute one of the major extrinsic risk factors for osteoarthritis (OA). Attention has, therefore, been paid to regenerative therapeutic procedures for the early treatment of cartilagi...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-014-0452-5
更新日期:2014-10-01 00:00:00
abstract::Rheumatoid arthritis (RA) is associated with a heightened risk of cardiovascular disease (CVD) events, presumably related to a greater burden of atherosclerosis, as well as atherosclerotic plaques that tend to be inflamed and rupture prone. Many of the inflammatory pathways underlying the pathobiology of RA are also r...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-016-0578-8
更新日期:2016-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Optimal management of anxiety and mood disorders in patients with systemic lupus erythematosus (SLE) is limited by an incomplete understanding of their pathophysiology and a lack of treatment guidelines. This review aims to critically synthesize recent literature on these conditions in adults with SLE...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-018-0797-2
更新日期:2018-11-12 00:00:00
abstract::Osteoarthritis (OA), the most common type of arthritis worldwide, is a degenerative disease of diarthrodial joints resulting in pain, reduced quality of life, and socioeconomic burden. Gout, the most common form of inflammatory arthritis, is a consequence of persistently elevated levels of urate and the formation of p...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-016-0613-9
更新日期:2016-10-01 00:00:00
abstract::The classification of Spondyloarthritis (SpA) has been revised with the introduction of the ASAS classification criteria. Although this has best been described in ankylosing spondylitis and psoriatic arthritis, there are population studies evaluating the epidemiology of the different subgroups of SpA. In this paper, w...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-013-0351-1
更新日期:2013-09-01 00:00:00
abstract::Management of the pregnant patient with antiphospholipid antibody (aPL) is reviewed, with emphasis on recent randomized controlled clinical trials. These support the use of subcutaneous heparin and low dose aspirin, current standard therapy for women with aPL and a history of fetal loss. Prednisone is rarely used due ...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-001-0021-6
更新日期:2001-06-01 00:00:00
abstract::Activation of the complement system plays a fundamental role in the pathogenesis of systemic lupus erythematosus (SLE). For the past several decades, quantifying this process has focused primarily on determination of serum C3 and C4, although the utility of these assays for diagnosis and monitoring disease activity is...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-004-0012-5
更新日期:2004-10-01 00:00:00
abstract::Antiphospholipid syndrome is an important cause of neurologic morbidity. The clinical criteria for antiphospholipid syndrome include only cerebrovascular arterial and venous thrombosis, but many other neurologic manifestations have been associated with antiphospholipid antibodies (aPL). This review discusses the role ...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-007-0004-3
更新日期:2007-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Gout management is currently suboptimal despite excellent available therapy. Gout patient education has been shown to enhance medication adherence and self-management, but needs improvement. We explored the literature on gout patient education including gaps in gout patient knowledge; use of written m...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-018-0720-x
更新日期:2018-03-08 00:00:00
abstract:PURPOSE OF THE REVIEW:Polymyalgia rheumatica (PMR) is one of the most common inflammatory rheumatologic condition occurring in older adults. It is characterized by proximal pain and stiffness in the shoulders, neck, and/or pelvic girdle in individuals over 50 years of age along with evidence of an intense systemic infl...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-020-00919-2
更新日期:2020-06-19 00:00:00
abstract::Acupuncture has been used for millennia in traditional Chinese medicine as a technique believed to restore the balance of energy in the body caused by disease through the use of needles inserted into specific points or energy channels. This energy is called the de qi. The use of acupuncture for the treatment of pain i...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-012-0295-x
更新日期:2012-12-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this study was to highlight recent findings on evaluation for lung transplantation and outcomes after transplantation in patients with systemic sclerosis (scleroderma). RECENT FINDINGS:The recognition that extra-pulmonary disease manifestations can seriously compromise post-transplant ...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-017-0650-z
更新日期:2017-05-01 00:00:00
abstract::The magnitude of placebo analgesia is influenced by environmental and perceptual factors. Environmental factors include past exposure to effective analgesic agents and verbal suggestions and cues that foster a perception of being given an effective treatment. Environmental factors, in turn, influence the proximate psy...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-006-0035-1
更新日期:2006-12-01 00:00:00
abstract::Bone is not structurally normal in osteoarthritis (OA). Periarticular bone in OA has increased turnover, decreased bone mineral content and stiffness, and decreased trabecular numbers. The increased turnover of collagen, in particular, may affect the biomechanical competence of bone and is driven by a number of proces...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-003-0078-5
更新日期:2003-02-01 00:00:00
abstract::Spondyloarthritis (SpA) is a group of inflammatory rheumatic diseases whose main clinical feature is inflammation of the axial spine. Articular, periarticular, and extra-articular manifestations can also occur, depending on the type of spondyloarthritis. The most common clinical subsets of SpA are ankylosing spondylit...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-013-0347-x
更新日期:2013-08-01 00:00:00
abstract::Psoriatic arthritis is a chronic inflammatory joint disease, seen in combination with the chronic inflammatory skin disease psoriasis and belonging to the family of spondylarthritides (SpA). A link is recognized between psoriatic arthritis and inflammatory bowel disease (IBD). Environmental factors seem to induce infl...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-013-0407-2
更新日期:2014-03-01 00:00:00
abstract::Urate is the major inert end product of purine degradation in higher primates in contrast to most other mammals because of the genetic silencing of hepatic oxidative enzyme uricase. The kidney plays a dominant role in urate elimination. The kidney excretes 70% of the daily urate production. Therefore, it is important ...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-996-0044-0
更新日期:2005-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Positron emission tomography (PET) combined with computed tomography (CT) has proven useful as a cancer screening technique in patients with inflammatory myopathy, mainly dermatomyositis. In this review, we focus on advances in this direction and other potential applications of PET/CT in patients with...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-019-0864-3
更新日期:2019-11-21 00:00:00
abstract:PURPOSE OF REVIEW:To review progress in the field of clinical trials for SLE. RECENT FINDINGS:Treatment development for SLE has been marked by failures of many later phase studies, representing billions of dollars of lost research and development funding. Recently, more successful Phase II trials have tested reduction...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-018-0745-1
更新日期:2018-05-03 00:00:00
abstract:PURPOSE OF REVIEW:One justification for using expensive biologic therapy in rheumatoid arthritis (RA) has been that it can reduce future healthcare utilization such as joint surgeries and physician visits. However, the evidence to support this assertion is unclear. We conducted a review of the literature for studies wh...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-017-0680-6
更新日期:2017-09-01 00:00:00
abstract::Dendritic cells are professional antigen-presenting cells that are most studied for their function in mediating T-cell tolerance and T-cell activation. In addition, recent evidence indicates that dendritic cells can regulate the vasculature and function of fibroblast-type cells. The potential contribution of dendritic...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-011-0215-5
更新日期:2012-02-01 00:00:00
abstract::Our growing understanding of the immune response mechanism has created a wave of novel biologic agents for the treatment of rheumatoid arthritis. The domain of biologic agents includes: 1) Recombinant regulatory cytokines; 2) engineered molecules and monoclonal antibodies that target proinflammatory cytokines; 3) mono...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-999-0013-5
更新日期:1999-12-01 00:00:00
abstract::Ayurvedic medicine is the traditional medicine of India, which originated over 5,000 years ago. Parts of this alternative medical system have become increasingly popular worldwide as patients seek approaches to medical care that they perceive as more holistic and less toxic than those offered by conventional Western m...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-014-0435-6
更新日期:2014-08-01 00:00:00
abstract::Exercise is an important part of treatment in patients with idiopathic inflammatory myopathies. Improved functioning, ability to perform activities of daily living, and health-related quality of life have been reported in adult polymyositis, dermatomyositis, and also recently inclusion body myositis following differen...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-012-0248-4
更新日期:2012-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Pain is an intense experience that can place a heavy burden on peoples' lives. The identification of psychosocial risk factors led to the development of effective pain treatments. However, effect sizes are modest. Accumulating evidence suggests that enhancing protective factors might also impact on (w...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-017-0703-3
更新日期:2017-11-09 00:00:00
abstract::Rheumatoid arthritis is a chronic inflammatory disease that results in generalized bone loss and increased fracture risk. Characteristic radiologic features of rheumatoid arthritis include periarticular osteopenia and marginal erosions. An emerging literature highlights the importance of osteoclasts as mediators of th...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-012-0253-7
更新日期:2012-06-01 00:00:00
abstract:PURPOSE OF THE REVIEW:Osteoarthritis (OA) is an aging-associated and injury-induced joint disease characterized by cartilage degradation, bone sclerosis, and persistent low-grade inflammation in the joint. Aging and injury are triggers of joint pathological changes mediated by pro-inflammatory factors, some of which ar...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-019-0868-z
更新日期:2019-12-07 00:00:00