Lung Transplantation in Patients With Systemic Sclerosis.

abstract：:Osteoarthritis (OA) is a major health problem in urgent need of better treatment. Gene therapy offers to meet this need. Of the different strategies for using gene therapy in OA, local gene transfer to synovium is in the most advanced stage of development. Local gene transfer brings several advantages, including a foc...

journal_title：Current rheumatology reports

authors： Evans CH

更新日期：2004-02-01 00:00:00

abstract：:The development of B cell-targeted biologics represents a major advance in the treatment of autoimmune rheumatic diseases. As with other immunosuppressive agents, risk of infection is a key clinical concern. This review summarises safety data from 15 years of experience of rituximab in autoimmune diseases with a parti...

journal_title：Current rheumatology reports

authors： Md Yusof MY,Vital EM,Buch MH

更新日期：2015-10-01 00:00:00

abstract：PURPOSE OF REVIEW:One justification for using expensive biologic therapy in rheumatoid arthritis (RA) has been that it can reduce future healthcare utilization such as joint surgeries and physician visits. However, the evidence to support this assertion is unclear. We conducted a review of the literature for studies wh...

journal_title：Current rheumatology reports

authors： Bansback N,Fu E,Sun H,Guh D,Zhang W,Lacaille D,Milbers K,Anis AH

更新日期：2017-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Chikungunya virus (CHIKV) infection has become increasingly prevalent in the last decade not only across the southern hemisphere but also, because of a recently documented viral mutation, in southern Europe and the USA. With the global spread of CHIKV infection, practitioners should know its epidemiol...

journal_title：Current rheumatology reports

authors： Hua C,Combe B

更新日期：2017-10-05 00:00:00

abstract：:There is a wide variation in the prevalence, incidence, and clinical manifestation of psoriatic arthritis (PsA) across countries due to genetic and environmental factors. Data on PsA in Asia are limited and come from small cross-sectional studies. The burden of PsA in Asia is high, including poor physical functioning,...

journal_title：Current rheumatology reports

authors： Leung YY,Tam LS,Li EK

更新日期：2011-08-01 00:00:00

abstract：:Psoriatic arthritis (PsA) is a chronic inflammatory joint disease associated with psoriasis that can lead to joint deformity and disability. PsA has a low likelihood of clinical remission and cure. For a long time, therapeutic options for PsA patients have been unsatisfactory, but the introduction of anti-tumor necros...

journal_title：Current rheumatology reports

authors： de Vlam K,Lories RJ

更新日期：2008-08-01 00:00:00

abstract：:Acute and chronic gout are common complications following organ transplantation. Risk factors include those shared with the general population (eg, diuretic use) and transplant-specific risk factors (eg, cyclosporine). Clinical features of gout are similar to those seen in the general population, although tophi may be...

journal_title：Current rheumatology reports

authors： Stamp LK,Chapman PT

更新日期：2012-04-01 00:00:00

abstract：:Vasculitis is defined as inflammation of blood vessels and can affect multiple organs. Several classification systems exist to categorize vasculitis such as vessel size, presence of anti-neutrophil cytoplasmic antibody, pathogenesis of the inflammation, and type of inflammatory cell infiltrate. Cutaneous vasculitis oc...

journal_title：Current rheumatology reports

authors： Hayat S,Berney SM

更新日期：2005-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Medical treatment with urate-lowering therapy (ULT) is efficacious. A recent publication suggested that surgery in gout is more prevalent than previously reported. This revelation led us to review what is known about surgical treatment of gout. RECENT FINDINGS:The Google Scholar database (January 1, ...

journal_title：Current rheumatology reports

authors： Carcione J,Bodofsky S,LaMoreaux B,Schlesinger N

更新日期：2020-11-24 00:00:00

abstract：:Genetic defects of collagen formation (the collagenopathies) affect almost every organ system and tissue in the body. They can be grouped by clinical phenotype, which usually correlates with the tissue distribution of the affected collagen subtype. Many of these conditions present in childhood; however, milder phenoty...

journal_title：Current rheumatology reports

authors： Jobling R,D'Souza R,Baker N,Lara-Corrales I,Mendoza-Londono R,Dupuis L,Savarirayan R,Ala-Kokko L,Kannu P

更新日期：2014-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this study was to provide the most up-to-date scientific evidence of the potential analgesic effects, or lack thereof, of the marijuana plant (cannabis) or cannabinoids, and of safety or tolerability of their long-term use. RECENT FINDINGS:We found that inhaled (smoked or vaporized) ca...

journal_title：Current rheumatology reports

authors： Romero-Sandoval EA,Kolano AL,Alvarado-Vázquez PA

更新日期：2017-10-05 00:00:00

abstract：PURPOSE OF REVIEW:To review progress in the field of clinical trials for SLE. RECENT FINDINGS:Treatment development for SLE has been marked by failures of many later phase studies, representing billions of dollars of lost research and development funding. Recently, more successful Phase II trials have tested reduction...

journal_title：Current rheumatology reports

authors： Thanou A,Merrill JT

更新日期：2018-05-03 00:00:00

abstract：:Health outcomes and their measures used as end points in systemic lupus erythematosus (SLE) patient care and clinical trials have been varied and are still evolving. Although significant reductions in morbidity and mortality in SLE have been achieved, the medications approved for SLE have remained the same during the ...

journal_title：Current rheumatology reports

authors： Jolly M

更新日期：2010-08-01 00:00:00

abstract：:Biomarkers in psoriatic arthritis (PsA) may serve as surrogate end points for disease outcome and can provide insights into disease susceptibility and natural history. Biomarkers could relate to diagnosis, pathogenesis, prognosis, therapeutic response, and comorbidities. The "felt need" is, however, in the development...

journal_title：Current rheumatology reports

authors： Chandran V,Gladman DD

更新日期：2010-08-01 00:00:00

abstract：:Apatite crystals form in physiologically calcified tissues, including the hyaline cartilage of the epiphyseal growth plate. While apatite crystals appear as unwanted deposits in other cartilage sites, more frequently, crystalline materials other than or in addition to apatite develop in dystrophic cartilage deposits. ...

journal_title：Current rheumatology reports

authors： Boskey AL

更新日期：2002-06-01 00:00:00

abstract：:The normal process of aging brings about changes in immune function, hormonal status, overall metabolism, and enhanced occurrence of neuropsychiatric disorders. These alterations are also evident at an accelerating pace in chronic inflammatory diseases. Treatment with immunosuppressive therapeutics is often not suffic...

journal_title：Current rheumatology reports

authors： Härle P,Straub RH

更新日期：2005-10-01 00:00:00

abstract：:While the most obvious manifestations of rheumatoid arthritis (RA) involve inflammation and damage in the synovial joints, the systemic effects of the condition are widespread and life-threatening. Of particular interest is the 'lipid paradox' of RA, where patients with a numerically equivocal starting lipid profile h...

journal_title：Current rheumatology reports

authors： McGrath CM,Young SP

更新日期：2015-09-01 00:00:00

abstract：PURPOSE OF THE REVIEW:Polymyalgia rheumatica (PMR) is one of the most common inflammatory rheumatologic condition occurring in older adults. It is characterized by proximal pain and stiffness in the shoulders, neck, and/or pelvic girdle in individuals over 50 years of age along with evidence of an intense systemic infl...

journal_title：Current rheumatology reports

authors： Gazitt T,Zisman D,Gardner G

更新日期：2020-06-19 00:00:00

abstract：PURPOSE OF REVIEW:Ankylosing spondylitis (AS) was historically seen as a predominantly male disease. However, more recent data showed a more homogenous sex prevalence. Unfortunately, in many studies in axial spondyloarthritis (axSpA), the number of women included is low and the analyses are often not stratified for gen...

journal_title：Current rheumatology reports

authors： Rusman T,van Vollenhoven RF,van der Horst-Bruinsma IE

更新日期：2018-05-12 00:00:00

abstract：:Psoriatic arthritis is a chronic, disabling disease for which therapies have been borrowed from rheumatoid arthritis and spondylitis. Traditional disease-modifying antirheumatic drugs (DMARDs) remain the first choice for the treatment of peripheral arthritis despite scarce evidence of their efficacy or ability to halt...

journal_title：Current rheumatology reports

authors： Soriano ER,Rosa J

更新日期：2009-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Optimal management of anxiety and mood disorders in patients with systemic lupus erythematosus (SLE) is limited by an incomplete understanding of their pathophysiology and a lack of treatment guidelines. This review aims to critically synthesize recent literature on these conditions in adults with SLE...

journal_title：Current rheumatology reports

authors： Tisseverasinghe A,Peschken C,Hitchon C

更新日期：2018-11-12 00:00:00

abstract：:Sjögren's syndrome is a chronic inflammatory process involving primarily the exocrine glands. Its association with lymphoma is well documented. A low-grade marginal-zone lymphoma related to mucosa-associated lymphoid tissue is the most common lymphoid neoplasia in Sjögren's syndrome. Among all autoimmune diseases, Sjö...

journal_title：Current rheumatology reports

authors： Voulgarelis M,Moutsopoulos HM

更新日期：2003-08-01 00:00:00

abstract：:The magnitude of placebo analgesia is influenced by environmental and perceptual factors. Environmental factors include past exposure to effective analgesic agents and verbal suggestions and cues that foster a perception of being given an effective treatment. Environmental factors, in turn, influence the proximate psy...

journal_title：Current rheumatology reports

authors： Price DD,Fillingim RB,Robinson ME

更新日期：2006-12-01 00:00:00

abstract：:Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a multisystem disease, the pathogenesis of which remains undetermined. Following two microarray studies, we reported the differential expression of 88 human genes in patients with CFS; 85 of these genes were upregulated and 3 were downregulated. The top fu...

journal_title：Current rheumatology reports

authors： Kerr JR

更新日期：2008-12-01 00:00:00

abstract：:Osteoarthritis (OA), the most common type of arthritis worldwide, is a degenerative disease of diarthrodial joints resulting in pain, reduced quality of life, and socioeconomic burden. Gout, the most common form of inflammatory arthritis, is a consequence of persistently elevated levels of urate and the formation of p...

journal_title：Current rheumatology reports

authors： Yokose C,Chen M,Berhanu A,Pillinger MH,Krasnokutsky S

更新日期：2016-10-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a chronic debilitating condition with significant impact on the musculoskeletal system. Arthroplasty may be indicated for damage related to active lupus or its treatment. As therapies for SLE have advanced, morbidity and mortality have declined, while the rate of joint replacement...

journal_title：Current rheumatology reports

authors： Kasturi S,Goodman S

更新日期：2016-09-01 00:00:00

abstract：:Clinical evaluation of patients with low bone mass attempts to determine which patients should be offered one of the effective therapies for fracture prevention. Current guidelines are primarily based on bone density. Risk factors are used, but their contribution to fracture risk is not easily assessed. The combinatio...

journal_title：Current rheumatology reports

authors： Deal CL

更新日期：2007-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Macrophages play key roles in tissue homeostasis and immune surveillance, mobilizing immune activation in response to microbial invasion and promoting wound healing to repair damaged tissue. However, failure to resolve macrophage activation can lead to chronic inflammation and fibrosis, and ultimately...

journal_title：Current rheumatology reports

authors： Toledo DM,Pioli PA

更新日期：2019-05-23 00:00:00

abstract：:TNF-blocking biologics have revolutionized the care of patients with spondyloarthritis, a group of clinically overlapping conditions that includes ankylosing spondylitis and psoriatic arthritis. However, incomplete response rates speak to the need for alternative therapeutic approaches. Over the last decade, animal mo...

journal_title：Current rheumatology reports

authors： Smith JA

更新日期：2016-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Childhood arthritis is in need of a new system of classification, owing to deficiencies in the International League of Associations for Rheumatology (ILAR) criteria. We briefly review the history of classification of childhood arthritis, discuss the major criticisms of the current system, and highligh...

journal_title：Current rheumatology reports

authors： Rumsey DG,Laxer RM

更新日期：2020-01-11 00:00:00