Abstract：
:Health outcomes and their measures used as end points in systemic lupus erythematosus (SLE) patient care and clinical trials have been varied and are still evolving. Although significant reductions in morbidity and mortality in SLE have been achieved, the medications approved for SLE have remained the same during the past 50 years. Despite the pressing need, aggressive advocacy in the community, and advances in drug development and testing in SLE, no medications have met US Food and Drug Administration guidelines for a new indication claim approval for SLE. This may be attributable to its multisystemic, remitting, and relapsing nature, and difficulty in identifying useful end points and appropriate tools to measure them. Thus, it is pivotal to identify and validate appropriate global, disease-specific, and perhaps organ-specific health outcomes for clinical research. This article reviews recent physician- and patient-generated health outcomes in SLE.
journal_name
Curr Rheumatol Repjournal_title
Current rheumatology reportsauthors
Jolly Mdoi
10.1007/s11926-010-0105-2subject
Has Abstractpub_date
2010-08-01 00:00:00pages
229-36issue
4eissn
1523-3774issn
1534-6307journal_volume
12pub_type
杂志文章,评审abstract：:Focal chondral or osteochondral lesions can be painful and disabling because they have insufficient intrinsic repair potential, and constitute one of the major extrinsic risk factors for osteoarthritis (OA). Attention has, therefore, been paid to regenerative therapeutic procedures for the early treatment of cartilagi...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-014-0452-5
更新日期：2014-10-01 00:00:00
abstract：:The distribution of the anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitides (AAV) is not uniform across geographical regions and ethnic and racial groups, suggesting that genetic and environmental factors affect the pathogenesis of these diseases. In addition, genetic factors affect not only the clin...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-014-0428-5
更新日期：2014-07-01 00:00:00
abstract：:Management of the pregnant patient with antiphospholipid antibody (aPL) is reviewed, with emphasis on recent randomized controlled clinical trials. These support the use of subcutaneous heparin and low dose aspirin, current standard therapy for women with aPL and a history of fetal loss. Prednisone is rarely used due ...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-001-0021-6
更新日期：2001-06-01 00:00:00
abstract：:The inflammatory myopathies are a heterogeneous group of diseases including dermatomyositis, polymyositis, and inclusion body myositis. Few clinical trials have been conducted in myositis, making it difficult to provide clear recommendations on the treatment of these rare disorders. Although corticosteroids have not b...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-011-0172-z
更新日期：2011-06-01 00:00:00
abstract：:Although exercise in the form of stretching, strength maintenance, and aerobic conditioning is generally considered beneficial to patients with fibromyalgia (FM), there is no reliable evidence to explain why exercise should help alleviate the primary symptom of FM, namely pain. Study results are varied and do not prov...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-001-0009-2
更新日期：2001-04-01 00:00:00
abstract：:Widespread muscle pain, fatigue, and weakness are defining characteristics of patients with fibromyalgia (FM). The aim of this review is to summarize recent investigations of muscle abnormalities in FM, which can be classified as structural, metabolic, or functional in nature. Histologic muscle abnormalities of membra...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-000-0053-3
更新日期：2000-04-01 00:00:00
abstract：:Seronegative spondyloarthropathies comprise a group of inflammatory arthritides, which consists of ankylosing spondylitis, psoriatic arthritis, reactive arthritis (Reiter's syndrome), enteropathic arthritis, and undifferentiated spondyloarthropathy. All of them share common laboratory, clinical, and imaging findings, ...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-004-0054-8
更新日期：2004-04-01 00:00:00
abstract：PURPOSE OF REVIEW:Macrophages play key roles in tissue homeostasis and immune surveillance, mobilizing immune activation in response to microbial invasion and promoting wound healing to repair damaged tissue. However, failure to resolve macrophage activation can lead to chronic inflammation and fibrosis, and ultimately...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-019-0831-z
更新日期：2019-05-23 00:00:00
abstract：:Although the pathogenesis of SLE remains poorly understood, there is consensus that it involves a combination of genetic, hormonal, and environmental factors. New technologies applied to genomic and gene expression studies have revealed novel gene mutations and cytokine alterations in this disease. Recently, advances ...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-005-0045-4
更新日期：2005-12-01 00:00:00
abstract：:Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) is the first-ever international network created to design and conduct large-scale, multicenter clinical trials and research in persistently antiphospholipid antibody (aPL)-positive patients. Since its inception in 2010, th...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-016-0611-y
更新日期：2016-10-01 00:00:00
abstract：:Rheumatoid arthritis (RA) is associated with a heightened risk of cardiovascular disease (CVD) events, presumably related to a greater burden of atherosclerosis, as well as atherosclerotic plaques that tend to be inflamed and rupture prone. Many of the inflammatory pathways underlying the pathobiology of RA are also r...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-016-0578-8
更新日期：2016-05-01 00:00:00
abstract：:Spondyloarthritis (SpA) is characterized by inflammation and new bone formation in the spine and entheses. The disease is the result of a complex interplay among susceptibility genes, microbial triggers, inflammation of bone marrow, and the enthesial structures and new bone formation. This article gives a conceptual o...
journal_title：Current rheumatology reports
pub_type： 杂志文章
doi：10.1007/s11926-011-0202-x
更新日期：2011-10-01 00:00:00
abstract：:Many lines of evidence suggest that autoimmune diseases result from chronic immune activation following environmental exposures in genetically susceptible individuals. A genetic basis for autoimmunity is supported by twin and family studies, candidate gene investigations, animal models, and whole genome microsatellite...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-000-0080-0
更新日期：2000-06-01 00:00:00
abstract：:Hereditary hemochromatosis is a frequent disease in Caucasian populations. It leads to progressive iron overload in a variety of organs. The most common cause is the C282Y homozygous mutation in the HFE gene. The classical triad of skin hyperpigmentation, diabetes, and liver cirrhosis is nowadays rare but musculoskele...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-013-0393-4
更新日期：2014-01-01 00:00:00
abstract：PURPOSE OF REVIEW:The myofibroblast is the culprit in the pathogenesis of fibrosis in systemic sclerosis (SSc). Activation of morphogen signaling pathways has been shown to be critically involved in organ fibrosis. Remarkably, the cellular receptors and key molecules from these signaling pathways are localized in the p...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-019-0822-0
更新日期：2019-05-21 00:00:00
abstract：:To date, most studies examining cell death during the development of osteoarthritis (OA) have focused on death of chondrocytes and have primarily examined advanced stages of the disease. Very good evidence suggests that chondrocyte death does occur at some point in the pathogenesis of OA and that it can be due to apop...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-008-0007-8
更新日期：2008-01-01 00:00:00
abstract：PURPOSE OF REVIEW:Several biologic drugs are available for treatment of immune-mediated diseases, and the number of children treated with biologics is increasing. This review summarises current knowledge about the safety and immunogenicity of vaccines in children treated with biologic therapy. RECENT FINDINGS:A recent...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-020-00905-8
更新日期：2020-05-20 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this review paper is to provide an overview of the relationship between obesity, osteoarthritis, arthroplasty outcomes, and the potential use of bariatric surgery to improve these outcomes. RECENT FINDINGS:Unfortunately, the findings in the currently available literature evaluating the...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-018-0717-5
更新日期：2018-02-21 00:00:00
abstract：:This study had two objectives: to describe the historical development of self-reported presenteeism instruments that can be used to identify and measure presenteeism as a result of musculoskeletal disease (MSD) and to identify if, and how many of these, presenteeism instruments are underpinned by economic theory. Syst...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-016-0600-1
更新日期：2016-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Gout management is currently suboptimal despite excellent available therapy. Gout patient education has been shown to enhance medication adherence and self-management, but needs improvement. We explored the literature on gout patient education including gaps in gout patient knowledge; use of written m...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-018-0720-x
更新日期：2018-03-08 00:00:00
abstract：:Small-vessel vasculitis is a convenient descriptor for a wide range of diseases characterized by vascular inflammation of the venules, capillaries, and/or arterioles with pleomorphic clinical manifestations. The classical clinical phenotype is leukocytoclastic vasculitis with palpable purpura, but manifestations vary ...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-007-0049-3
更新日期：2007-08-01 00:00:00
abstract：:Congenital heart block (CHB) can occur in association with structural heart disease, such as atrioventricular septal defects, left atrial isomerism, and abnormalities of the great arteries, with tumors, such as mesotheliomas, or as an isolated defect. In 1928, Aylward reported the occurrence of CHB in two children who...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-003-0024-6
更新日期：2003-10-01 00:00:00
abstract：:Upregulated adhesion molecule and cytokine expression on endothelial cells and infiltrating inflammatory cells occur in most vasculitis syndromes. These observations suggest that vasculitis is associated with pathologic activation of normal immune cell cytokine cascades. Abnormal expression of adhesion molecules and c...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-000-0040-8
更新日期：2000-10-01 00:00:00
abstract：PURPOSE OF REVIEW:Medical treatment with urate-lowering therapy (ULT) is efficacious. A recent publication suggested that surgery in gout is more prevalent than previously reported. This revelation led us to review what is known about surgical treatment of gout. RECENT FINDINGS:The Google Scholar database (January 1, ...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-020-00969-6
更新日期：2020-11-24 00:00:00
abstract：:Synovitis is the characteristic feature of inflammatory joint disease. If synovitis is localized to interphalangeal joints, rheumatoid arthritis, psoriatic arthritis, and juvenile idiopathic arthritis are among the most common differential diagnoses. The absence of pain, tenderness, and limitation of function despite ...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-014-0442-7
更新日期：2014-01-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of the study is to briefly review the molecular mechanisms that leads to structural damage in ankylosing spondylitis (AS), defined as new bone formation resulting in complete or incomplete ankylosis of the spine, and the impact of treatment with biologics to retard this process. RECENT FI...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-017-0644-x
更新日期：2017-04-01 00:00:00
abstract：:Systemic lupus erythematosus (SLE) is a chronic disease affecting the physical, social, and psychological well-being of patients. Different instruments have been developed to measure health-related quality of life, some of which are SLE-specific. Contributors to poor quality of life in patients with SLE include fatigu...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-010-0114-1
更新日期：2010-08-01 00:00:00
abstract：:Antiphospholipid syndrome is an important cause of neurologic morbidity. The clinical criteria for antiphospholipid syndrome include only cerebrovascular arterial and venous thrombosis, but many other neurologic manifestations have been associated with antiphospholipid antibodies (aPL). This review discusses the role ...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-007-0004-3
更新日期：2007-05-01 00:00:00
abstract：:Sleep disturbance is one of the most common comorbid problems for chronic pain patients. The association between the two phenomena has long been recognized, but the nature of the relationship is not well-understood. Many agree that the relationship is likely bidirectional. In this review, we focus on one side of the r...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-011-0204-8
更新日期：2011-12-01 00:00:00
abstract：:The recent increase in the number of patients taking opioids chronically for pain has not yielded the expected benefits in reduction of symptoms and improved function. Chronic pain patients typically respond well initially to opioid medications, but regular use is associated with adverse psychological and physical eff...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-012-0311-1
更新日期：2013-03-01 00:00:00
