AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION): 5-Year Update.

Abstract:

:Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) is the first-ever international network created to design and conduct large-scale, multicenter clinical trials and research in persistently antiphospholipid antibody (aPL)-positive patients. Since its inception in 2010, the APS ACTION has made important strides toward our goal of international research collaboration and data sharing. Through the dedication and hard work of 50 APS ACTION members, collaborative international projects are currently underway including a multicenter web-based registry and repository of aPL-positive patients, a randomized controlled clinical trial assessing the efficacy of hydroxychloroquine for primary thrombosis prevention in persistently aPL-positive but thrombosis-free patients, standardization of aPL testing through the use of core laboratories worldwide, identification of the limitations in the existing aPL/APS literature, and conducting observational research studies to further our understanding of the disease. Thus far, APS ACTION has held annual workshops and summits with the aim of facilitating international collaboration and developing initiatives to recruit young scholars to APS research. This paper describes updates related to the organization's structure, ongoing research efforts, and recent accomplishments and discusses future directions.

journal_name

Curr Rheumatol Rep

authors

Barbhaiya M,Andrade D,Erkan D,APS ACTION.

doi

10.1007/s11926-016-0611-y

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

64

issue

10

eissn

1523-3774

issn

1534-6307

pii

10.1007/s11926-016-0611-y

journal_volume

18

pub_type

杂志文章,评审
  • Exercise: an important component of treatment in the idiopathic inflammatory myopathies.

    abstract::Resistive exercise is controversial for patients with idiopathic inflammatory myopathies. This paper provides an update on exercise and clinical assessment in these patients. The few published studies on this topic report unchanged disease activity from a variety of exercise regimens in patients in all stages of disea...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-005-0063-2

    authors: Alexanderson H

    更新日期:2005-04-01 00:00:00

  • Takayasu's arteritis.

    abstract::The frequency of Takayasu's arteritis (TA) has been estimated to be 2.9 cases per 1 million people, with a female preponderance, although female-to-male ratio varies from different geographic areas. A high frequency of haplotype A24-B52-DR2 has been found in Japanese patients, without this association in other populat...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-002-0021-1

    authors: Fraga A,Medina F

    更新日期:2002-02-01 00:00:00

  • Disentangling the emerging evidence around atypical fractures.

    abstract::Atypical femur fractures are rare but a growing concern, as they are more common in patients who use bisphosphonates. The best radiology-based studies have had access to only short-term exposure data, while the studies using prescription databases with substantial long-term data did not have access to radiology report...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-012-0241-y

    authors: Abrahamsen B,Clark EM

    更新日期:2012-06-01 00:00:00

  • Systemic manifestations in localized scleroderma.

    abstract::In this paper, the various systemic manifestations reported in localized scleroderma, their incidence, their relationship with systemic sclerosis, and their relationship with other autoimmune or connective tissue diseases will be analyzed. ...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-004-0020-5

    authors: Zulian F

    更新日期:2004-12-01 00:00:00

  • Chikungunya Virus-Associated Disease.

    abstract:PURPOSE OF REVIEW:Chikungunya virus (CHIKV) infection has become increasingly prevalent in the last decade not only across the southern hemisphere but also, because of a recently documented viral mutation, in southern Europe and the USA. With the global spread of CHIKV infection, practitioners should know its epidemiol...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-017-0694-0

    authors: Hua C,Combe B

    更新日期:2017-10-05 00:00:00

  • The microbiome and psoriatic arthritis.

    abstract::Psoriatic arthritis is a chronic inflammatory joint disease, seen in combination with the chronic inflammatory skin disease psoriasis and belonging to the family of spondylarthritides (SpA). A link is recognized between psoriatic arthritis and inflammatory bowel disease (IBD). Environmental factors seem to induce infl...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-013-0407-2

    authors: Eppinga H,Konstantinov SR,Peppelenbosch MP,Thio HB

    更新日期:2014-03-01 00:00:00

  • Ocular vasculitis.

    abstract::Systemic vasculitis can affect practically any structure in or around the eye. Although the ocular presentations of vasculitic disease are highly variable and may be quite subtle, it is important for physicians to understand some of the basic concepts, critical findings, and potential significance of ocular signs and ...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-003-0037-1

    authors: Shepherd JB 3rd

    更新日期:2003-04-01 00:00:00

  • Idiopathic Pericarditis-an Autoinflammatory Disease?

    abstract:PURPOSE OF THE REVIEW:Idiopathic acute and recurrent pericarditis are rare diseases of unknown origin. Here, we review trigger factors, pathomechanism, and treatment options for acute and recurrent pericarditis. RECENT FINDINGS:Acute pericarditis can be triggered by viral infections, myocardial ischemia, heart cathete...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-019-0820-2

    authors: Blank N,Lorenz HM

    更新日期:2019-03-09 00:00:00

  • Clinical update on teriparatide.

    abstract::Teriparatide (recombinant human parathyroid hormone ) is an anabolic agent approved for the treatment of patients at high risk for fracture. The Fracture Prevention Trial administered teriparatide to treatment-naïve patients, leading to its US Food and Drug Administration approval in 2002. Clinical trial data using an...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-009-0023-3

    authors: File E,Deal C

    更新日期:2009-07-01 00:00:00

  • The clinical laboratory evaluation of the patient with noninflammatory myopathy.

    abstract::The investigations used to diagnose an inflammatory muscle disease include history and physical examination, evaluation of serum levels of enzymes derived from skeletal muscle, electromyography, magnetic resonance imaging, and muscle histology. The evaluation of patients who may have noninflammatory myopathy includes,...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-001-0035-0

    authors: Wortmann RL,Vladutiu GD

    更新日期:2001-08-01 00:00:00

  • Control of connective tissue gene expression by TGF beta: role of Smad proteins in fibrosis.

    abstract::Transforming growth factor-beta (TGF beta) plays a critical role in the development of tissue fibrosis. Its expression is consistently elevated in affected organs and correlates with increased extracellular matrix deposition. During the last few years, tremendous progress has been made in understanding the molecular a...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-002-0010-4

    authors: Verrecchia F,Mauviel A

    更新日期:2002-04-01 00:00:00

  • Cardiovascular and Metabolic Comorbidities in Rheumatoid Arthritis.

    abstract:PURPOSE OF THE REVIEW:An increased prevalence of cardiovascular risk factors in rheumatoid arthritis (RA) is reported. The absolute cardiovascular risk in RA patients is higher than in the general population, and although the RA prognosis has gradually improved, premature cardiovascular (CV) mortality remains a matter ...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-018-0790-9

    authors: Romano S,Salustri E,Ruscitti P,Carubbi F,Penco M,Giacomelli R

    更新日期:2018-11-05 00:00:00

  • Consensus procedures and their role in pediatric rheumatology.

    abstract::The Delphi Technique and Nominal Group Technique are two well-recognized consensus-formation methodologies specifically designed to combine judgments from a group of experts. The Delphi Technique utilizes a series of well-defined questionnaire-based surveys, whereas Nominal Group Technique is a structured face-to-face...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-008-0025-6

    authors: Ruperto N,Meiorin S,Iusan SM,Ravelli A,Pistorio A,Martini A

    更新日期:2008-04-01 00:00:00

  • Current Perspectives on Arthroplasty in Systemic Lupus Erythematosus: Rates, Outcomes, and Adverse Events.

    abstract::Systemic lupus erythematosus (SLE) is a chronic debilitating condition with significant impact on the musculoskeletal system. Arthroplasty may be indicated for damage related to active lupus or its treatment. As therapies for SLE have advanced, morbidity and mortality have declined, while the rate of joint replacement...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-016-0608-6

    authors: Kasturi S,Goodman S

    更新日期:2016-09-01 00:00:00

  • Aspirin and acetaminophen: should they be available over the counter?

    abstract::Traditional nonsteroidal anti-inflammatory drugs block cyclooxygenase (COX). They are the most widely used drugs for pain relief. They are indispensable for their effects but are condemned for their adverse drug reactions. Two COX inhibitors, acetaminophen and aspirin, are the most widely used over-the-counter drugs. ...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章

    doi:10.1007/s11926-009-0006-4

    authors: Brune K,Hinz B,Otterness I

    更新日期:2009-02-01 00:00:00

  • Pathophysiology of spondyloarthritis.

    abstract::Spondyloarthritis (SpA) is characterized by inflammation and new bone formation in the spine and entheses. The disease is the result of a complex interplay among susceptibility genes, microbial triggers, inflammation of bone marrow, and the enthesial structures and new bone formation. This article gives a conceptual o...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章

    doi:10.1007/s11926-011-0202-x

    authors: Ronneberger M,Schett G

    更新日期:2011-10-01 00:00:00

  • B Cell Therapies, Approved and Emerging: a Review of Infectious Risk and Prevention During Use.

    abstract::The development of B cell-targeted biologics represents a major advance in the treatment of autoimmune rheumatic diseases. As with other immunosuppressive agents, risk of infection is a key clinical concern. This review summarises safety data from 15 years of experience of rituximab in autoimmune diseases with a parti...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-015-0539-7

    authors: Md Yusof MY,Vital EM,Buch MH

    更新日期:2015-10-01 00:00:00

  • Myelodysplasia and malignancy-associated vasculitis.

    abstract::While the link between malignancy and vasculitis has been known for some time, the association of vasculitis and myelodysplastic syndrome (MDS) has only recently been reported. This article reviews the most current and landmark publications regarding MDS, as well as malignancy-associated vasculitis. We include theorie...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-012-0281-3

    authors: Agha A,Bateman H,Sterrett A,Valeriano-Marcet J

    更新日期:2012-12-01 00:00:00

  • Behçet's syndrome.

    abstract::Behçet's syndrome is a systemic vasculitis with an unknown etiology affecting the small and large vessels of the venous and arterial systems. At least two clusters of disease expression have been described. The first includes superficial vein thrombosis, deep vein thrombosis, and dural sinus thrombi. The second includ...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-010-0132-z

    authors: Yazici Y,Yurdakul S,Yazici H

    更新日期:2010-12-01 00:00:00

  • Beyond Medical Treatment: Surgical Treatment of Gout.

    abstract:PURPOSE OF REVIEW:Medical treatment with urate-lowering therapy (ULT) is efficacious. A recent publication suggested that surgery in gout is more prevalent than previously reported. This revelation led us to review what is known about surgical treatment of gout. RECENT FINDINGS:The Google Scholar database (January 1, ...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-020-00969-6

    authors: Carcione J,Bodofsky S,LaMoreaux B,Schlesinger N

    更新日期:2020-11-24 00:00:00

  • Economic Theory and Self-Reported Measures of Presenteeism in Musculoskeletal Disease.

    abstract::This study had two objectives: to describe the historical development of self-reported presenteeism instruments that can be used to identify and measure presenteeism as a result of musculoskeletal disease (MSD) and to identify if, and how many of these, presenteeism instruments are underpinned by economic theory. Syst...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-016-0600-1

    authors: Jones C,Payne K,Gannon B,Verstappen S

    更新日期:2016-08-01 00:00:00

  • Takayasu Arteritis: Recent Developments.

    abstract:PURPOSE OF REVIEW:Takayasu arteritis (TA) is a granulomatous inflammatory disorder that affects large vessels, especially aorta and its proximal branches. Its diagnosis can be extremely challenging due to the non-specificity of the systemic inflammatory manifestations during the early phase of the disease and usually f...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-019-0848-3

    authors: Zaldivar Villon MLF,de la Rocha JAL,Espinoza LR

    更新日期:2019-07-18 00:00:00

  • Acupuncture in the treatment of rheumatic diseases.

    abstract::Acupuncture has been used for millennia in traditional Chinese medicine as a technique believed to restore the balance of energy in the body caused by disease through the use of needles inserted into specific points or energy channels. This energy is called the de qi. The use of acupuncture for the treatment of pain i...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-012-0295-x

    authors: Amezaga Urruela M,Suarez-Almazor ME

    更新日期:2012-12-01 00:00:00

  • Chronic widespread pain and fibromyalgia: Should reports of increased mortality influence management?

    abstract::There have been few studies examining whether persons with chronic widespread pain or fibromyalgia are at increased risk for dying prematurely. Among the studies conducted there is little consistency in results. If there is an increased mortality risk, it is of the order of a 30% excess and it may be related to the li...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-005-0017-8

    authors: Macfarlane GJ

    更新日期:2005-10-01 00:00:00

  • The collagenopathies: review of clinical phenotypes and molecular correlations.

    abstract::Genetic defects of collagen formation (the collagenopathies) affect almost every organ system and tissue in the body. They can be grouped by clinical phenotype, which usually correlates with the tissue distribution of the affected collagen subtype. Many of these conditions present in childhood; however, milder phenoty...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-013-0394-3

    authors: Jobling R,D'Souza R,Baker N,Lara-Corrales I,Mendoza-Londono R,Dupuis L,Savarirayan R,Ala-Kokko L,Kannu P

    更新日期:2014-01-01 00:00:00

  • Exercise for patients with fibromyalgia: risks versus benefits.

    abstract::Although exercise in the form of stretching, strength maintenance, and aerobic conditioning is generally considered beneficial to patients with fibromyalgia (FM), there is no reliable evidence to explain why exercise should help alleviate the primary symptom of FM, namely pain. Study results are varied and do not prov...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-001-0009-2

    authors: Clark SR,Jones KD,Burckhardt CS,Bennett R

    更新日期:2001-04-01 00:00:00

  • Peripheral Mechanisms Contributing to Osteoarthritis Pain.

    abstract:PURPOSE OF REVIEW:Osteoarthritis (OA) is the most common form of arthritis and a major source of pain and disability worldwide. OA-associated pain is usually refractory to classically used analgesics, and disease-modifying therapies are still lacking. Therefore, a better understanding of mechanisms and mediators contri...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-018-0716-6

    authors: Syx D,Tran PB,Miller RE,Malfait AM

    更新日期:2018-02-26 00:00:00

  • Heat shock proteins in juvenile idiopathic arthritis: keys for understanding remitting arthritis and candidate antigens for immune therapy.

    abstract::Juvenile idiopathic arthritis (JIA) is in a majority of the cases of self-limiting, and sometimes even a self-remitting, disease. A growing amount of data suggests that active T cell regulation determines, at least partly, the clinical outcome of JIA. In experimental models of arthritis, a group of highly conserved mi...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-002-0052-7

    authors: Prakken B,Kuis W,van Eden W,Albani S

    更新日期:2002-12-01 00:00:00

  • Neurologic manifestations of the antiphospholipid syndrome.

    abstract::Antiphospholipid syndrome is an important cause of neurologic morbidity. The clinical criteria for antiphospholipid syndrome include only cerebrovascular arterial and venous thrombosis, but many other neurologic manifestations have been associated with antiphospholipid antibodies (aPL). This review discusses the role ...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-007-0004-3

    authors: Roldan JF,Brey RL

    更新日期:2007-05-01 00:00:00

  • Glucocorticoid-induced osteoporosis.

    abstract::This article attempts to evaluate the results of several recently published clinical trials of drugs used in the treatment and prevention of glucocorticoid-induced osteoporosis. Despite our lack of understanding regarding the biological mechanisms that lead to glucocorticoid-induced bone loss, effective therapy has be...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-996-0069-4

    authors: Boulos P,Ioannidis G,Adachi JD

    更新日期:2000-02-01 00:00:00