Abstract:
:Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a multisystem disease, the pathogenesis of which remains undetermined. Following two microarray studies, we reported the differential expression of 88 human genes in patients with CFS; 85 of these genes were upregulated and 3 were downregulated. The top functional categories of these 88 genes were hematologic disease and function, immunologic disease and function, cancer, cell death, immune response, and infection. Clustering of quantitative polymerase chain reaction data from CFS/ME patients revealed seven subtypes with distinct differences in Short Form (SF)-36 scores, clinical phenotypes, and severity. Gene signatures in each subtype implicate five human genes as possible targets for specific therapy. Development of a diagnostic test for subtype status is now a priority. The possibility that these subtypes represent individual host responses to particular microbial infections is being investigated and may provide another route to specific therapies for CFS patients.
journal_name
Curr Rheumatol Repjournal_title
Current rheumatology reportsauthors
Kerr JRdoi
10.1007/s11926-008-0079-5subject
Has Abstractpub_date
2008-12-01 00:00:00pages
482-91issue
6eissn
1523-3774issn
1534-6307journal_volume
10pub_type
杂志文章abstract:PURPOSE OF REVIEW:Childhood arthritis is in need of a new system of classification, owing to deficiencies in the International League of Associations for Rheumatology (ILAR) criteria. We briefly review the history of classification of childhood arthritis, discuss the major criticisms of the current system, and highligh...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-020-0880-3
更新日期:2020-01-11 00:00:00
abstract::The classification of Spondyloarthritis (SpA) has been revised with the introduction of the ASAS classification criteria. Although this has best been described in ankylosing spondylitis and psoriatic arthritis, there are population studies evaluating the epidemiology of the different subgroups of SpA. In this paper, w...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-013-0351-1
更新日期:2013-09-01 00:00:00
abstract::Antiphospholipid syndrome (APS) is characterized by antiphospholipid antibodies (aPL) associated with thrombosis and/or pregnancy morbidity. However, there is a range of other manifestations associated with APS, called non-criteria manifestations that add significant morbidity to this syndrome and, some of them, repre...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-015-0502-7
更新日期:2015-04-01 00:00:00
abstract::Spondyloarthritis (SpA) is a group of inflammatory rheumatic diseases whose main clinical feature is inflammation of the axial spine. Articular, periarticular, and extra-articular manifestations can also occur, depending on the type of spondyloarthritis. The most common clinical subsets of SpA are ankylosing spondylit...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-013-0347-x
更新日期:2013-08-01 00:00:00
abstract::While the most obvious manifestations of rheumatoid arthritis (RA) involve inflammation and damage in the synovial joints, the systemic effects of the condition are widespread and life-threatening. Of particular interest is the 'lipid paradox' of RA, where patients with a numerically equivocal starting lipid profile h...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-015-0534-z
更新日期:2015-09-01 00:00:00
abstract::Health outcomes and their measures used as end points in systemic lupus erythematosus (SLE) patient care and clinical trials have been varied and are still evolving. Although significant reductions in morbidity and mortality in SLE have been achieved, the medications approved for SLE have remained the same during the ...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-010-0105-2
更新日期:2010-08-01 00:00:00
abstract::Vasculitis is defined as inflammation of blood vessels and can affect multiple organs. Several classification systems exist to categorize vasculitis such as vessel size, presence of anti-neutrophil cytoplasmic antibody, pathogenesis of the inflammation, and type of inflammatory cell infiltrate. Cutaneous vasculitis oc...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-005-0037-4
更新日期:2005-08-01 00:00:00
abstract::Behçet's syndrome is a systemic vasculitis with an unknown etiology affecting the small and large vessels of the venous and arterial systems. At least two clusters of disease expression have been described. The first includes superficial vein thrombosis, deep vein thrombosis, and dural sinus thrombi. The second includ...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-010-0132-z
更新日期:2010-12-01 00:00:00
abstract::Rheumatoid arthritis (RA) is associated with a heightened risk of cardiovascular disease (CVD) events, presumably related to a greater burden of atherosclerosis, as well as atherosclerotic plaques that tend to be inflamed and rupture prone. Many of the inflammatory pathways underlying the pathobiology of RA are also r...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-016-0578-8
更新日期:2016-05-01 00:00:00
abstract::Osteoporosis is a potentially preventable condition frequently encountered in patients with systemic lupus erythematosus (SLE). Bone loss in SLE is likely a multi- factorial process involving traditional osteoporosis risk factors along with lupus-related factors. Recognizing potential contributors to bone loss in pati...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-005-0056-1
更新日期:2005-12-01 00:00:00
abstract::Sjögren's syndrome is a chronic inflammatory process involving primarily the exocrine glands. Its association with lymphoma is well documented. A low-grade marginal-zone lymphoma related to mucosa-associated lymphoid tissue is the most common lymphoid neoplasia in Sjögren's syndrome. Among all autoimmune diseases, Sjö...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-003-0011-y
更新日期:2003-08-01 00:00:00
abstract::The recent increase in the number of patients taking opioids chronically for pain has not yielded the expected benefits in reduction of symptoms and improved function. Chronic pain patients typically respond well initially to opioid medications, but regular use is associated with adverse psychological and physical eff...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-012-0311-1
更新日期:2013-03-01 00:00:00
abstract:PURPOSE OF THE REVIEW:Osteoarthritis (OA) is a chronic, painful joint disease that affects approximately 40% of adults over 70 year. Age is the strongest predictor of OA, while obesity is considered the primary preventable risk factor for OA. Both conditions are associated with abnormal innate immune inflammatory respo...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-017-0672-6
更新日期:2017-08-01 00:00:00
abstract::Management of the pregnant patient with antiphospholipid antibody (aPL) is reviewed, with emphasis on recent randomized controlled clinical trials. These support the use of subcutaneous heparin and low dose aspirin, current standard therapy for women with aPL and a history of fetal loss. Prednisone is rarely used due ...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-001-0021-6
更新日期:2001-06-01 00:00:00
abstract::Upregulated adhesion molecule and cytokine expression on endothelial cells and infiltrating inflammatory cells occur in most vasculitis syndromes. These observations suggest that vasculitis is associated with pathologic activation of normal immune cell cytokine cascades. Abnormal expression of adhesion molecules and c...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-000-0040-8
更新日期:2000-10-01 00:00:00
abstract::Childhood systemic lupus erythematosus (SLE) is known to have a worse prognosis than adult-onset disease, and monitoring and treatment of the disease are still a challenge. Thus, there is an urgent need for highly reliable, non-invasive biomarkers for early detection of relapses, to avoid long-term complications and t...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-012-0312-0
更新日期:2013-03-01 00:00:00
abstract::The vasculitides are a group of protean diseases, some of which are caused by conditions including infections, other autoimmune diseases, or neoplasias. They are a challenge to the clinician, in terms of both diagnosis and therapy. No diagnostic criteria exist, although a multinational effort to develop them is in pro...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-014-0422-y
更新日期:2014-06-01 00:00:00
abstract::The investigations used to diagnose an inflammatory muscle disease include history and physical examination, evaluation of serum levels of enzymes derived from skeletal muscle, electromyography, magnetic resonance imaging, and muscle histology. The evaluation of patients who may have noninflammatory myopathy includes,...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-001-0035-0
更新日期:2001-08-01 00:00:00
abstract::This article attempts to evaluate the results of several recently published clinical trials of drugs used in the treatment and prevention of glucocorticoid-induced osteoporosis. Despite our lack of understanding regarding the biological mechanisms that lead to glucocorticoid-induced bone loss, effective therapy has be...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-996-0069-4
更新日期:2000-02-01 00:00:00
abstract::Wegener's granulomatosis (WG) is a complex autoimmune disorder that has been transformed from a uniformly lethal process to a chronic disease with a relapsing-remitting course. In the setting of frequent relapses, the need to manage cumulative disease damage and drug toxicities has spurred the identification and devel...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-006-0014-6
更新日期:2006-08-01 00:00:00
abstract::There have been few studies examining whether persons with chronic widespread pain or fibromyalgia are at increased risk for dying prematurely. Among the studies conducted there is little consistency in results. If there is an increased mortality risk, it is of the order of a 30% excess and it may be related to the li...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-005-0017-8
更新日期:2005-10-01 00:00:00
abstract::Our growing understanding of the immune response mechanism has created a wave of novel biologic agents for the treatment of rheumatoid arthritis. The domain of biologic agents includes: 1) Recombinant regulatory cytokines; 2) engineered molecules and monoclonal antibodies that target proinflammatory cytokines; 3) mono...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-999-0013-5
更新日期:1999-12-01 00:00:00
abstract::Osteoarthritis (OA), the most common type of arthritis worldwide, is a degenerative disease of diarthrodial joints resulting in pain, reduced quality of life, and socioeconomic burden. Gout, the most common form of inflammatory arthritis, is a consequence of persistently elevated levels of urate and the formation of p...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-016-0613-9
更新日期:2016-10-01 00:00:00
abstract::Osteoporosis and related fractures represent a major, and growing, public health concern for the United States and worldwide. The pathogenesis of osteoporosis is complex, requiring attention to the different life phases involved in growth, maintenance, and loss of bone, in addition to non-skeletal factors associated w...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-006-0030-6
更新日期:2006-02-01 00:00:00
abstract:PURPOSE OF THE REVIEW:Polymyalgia rheumatica (PMR) is one of the most common inflammatory rheumatologic condition occurring in older adults. It is characterized by proximal pain and stiffness in the shoulders, neck, and/or pelvic girdle in individuals over 50 years of age along with evidence of an intense systemic infl...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-020-00919-2
更新日期:2020-06-19 00:00:00
abstract::The World Health Organization criteria for classification of bone mineral density (BMD) cannot be applied to premenopausal women because the relationship between BMD and fracture risk is not the same as in postmenopausal women. Approximately 2.5% of premenopausal women have BMD that is more than 2.0 standard deviation...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-005-0008-9
更新日期:2005-03-01 00:00:00
abstract::Gout is the most common inflammatory arthropathy and occurs in the setting of elevated serum urate levels. Gout is also known to be associated with multiple comorbidities including cardiovascular disease and the metabolic syndrome. Recent advances in research have increased our understanding and improved our knowledge...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-012-0309-8
更新日期:2013-02-01 00:00:00
abstract::Traditional nonsteroidal anti-inflammatory drugs block cyclooxygenase (COX). They are the most widely used drugs for pain relief. They are indispensable for their effects but are condemned for their adverse drug reactions. Two COX inhibitors, acetaminophen and aspirin, are the most widely used over-the-counter drugs. ...
journal_title:Current rheumatology reports
pub_type: 杂志文章
doi:10.1007/s11926-009-0006-4
更新日期:2009-02-01 00:00:00
abstract::Widespread muscle pain, fatigue, and weakness are defining characteristics of patients with fibromyalgia (FM). The aim of this review is to summarize recent investigations of muscle abnormalities in FM, which can be classified as structural, metabolic, or functional in nature. Histologic muscle abnormalities of membra...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-000-0053-3
更新日期:2000-04-01 00:00:00
abstract::Hypocomplementemic urticarial vasculitis syndrome (HUVS) is an uncommon immune complex-mediated entity characterized by urticaria with persistent acquired hypocomplementemia. First described in 1973, HUVS is associated with several systemic findings including leukocytoclastic vasculitis, severe angioedema, laryngeal e...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-009-0060-y
更新日期:2009-12-01 00:00:00