Abstract：
:Gout is the most common inflammatory arthropathy and occurs in the setting of elevated serum urate levels. Gout is also known to be associated with multiple comorbidities including cardiovascular disease and the metabolic syndrome. Recent advances in research have increased our understanding and improved our knowledge of the pathophysiology of gout. Genome-wide association studies have permitted the identification of several new and common genetic factors that contribute to hyperuricemia and gout. Most of these are involved with the renal urate transport system (the uric acid transportasome), generally considered the most influential regulator of serum urate homeostasis. Thus far, SCL22A12, SCL2A9, and GLUT9 have been found to have the greatest variation and most influence on serum urate levels. However, genetics are only a part of the explanation in the development of hyperuricemia and gout. As results have been mixed, the role of known urate influential genes in gout's associated comorbidities remains unclear. Regardless, GWAS findings have expanded our understanding of the pathophysiology of hyperuricemia and gout, and will likely play a role in the development of future therapies and treatment of this ancient disease.
journal_name
Curr Rheumatol Repjournal_title
Current rheumatology reportsauthors
George RL,Keenan RTdoi
10.1007/s11926-012-0309-8subject
Has Abstractpub_date
2013-02-01 00:00:00pages
309issue
2eissn
1523-3774issn
1534-6307journal_volume
15pub_type
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journal_title：Current rheumatology reports
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journal_title：Current rheumatology reports
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journal_title：Current rheumatology reports
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journal_title：Current rheumatology reports
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journal_title：Current rheumatology reports
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journal_title：Current rheumatology reports
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journal_title：Current rheumatology reports
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journal_title：Current rheumatology reports
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journal_title：Current rheumatology reports
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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更新日期：2019-12-07 00:00:00
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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journal_title：Current rheumatology reports
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pub_type： 杂志文章,评审
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更新日期：2003-08-01 00:00:00
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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更新日期：2019-05-23 00:00:00
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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journal_title：Current rheumatology reports
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pub_type： 杂志文章,评审
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更新日期：2005-03-01 00:00:00
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journal_title：Current rheumatology reports
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更新日期：2014-08-01 00:00:00
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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更新日期：2005-10-01 00:00:00
abstract：:Psoriatic arthritis (PsA) is a chronic inflammatory joint disease associated with psoriasis that can lead to joint deformity and disability. PsA has a low likelihood of clinical remission and cure. For a long time, therapeutic options for PsA patients have been unsatisfactory, but the introduction of anti-tumor necros...
journal_title：Current rheumatology reports
pub_type： 杂志文章
doi：10.1007/s11926-008-0048-z
更新日期：2008-08-01 00:00:00
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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更新日期：2006-02-01 00:00:00
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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更新日期：2003-02-01 00:00:00
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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更新日期：2003-06-01 00:00:00
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更新日期：2000-10-01 00:00:00
