Renal urate handling: clinical relevance of recent advances.

abstract：:Dendritic cells are professional antigen-presenting cells that are most studied for their function in mediating T-cell tolerance and T-cell activation. In addition, recent evidence indicates that dendritic cells can regulate the vasculature and function of fibroblast-type cells. The potential contribution of dendritic...

journal_title：Current rheumatology reports

authors： Lu TT

更新日期：2012-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Positron emission tomography (PET) combined with computed tomography (CT) has proven useful as a cancer screening technique in patients with inflammatory myopathy, mainly dermatomyositis. In this review, we focus on advances in this direction and other potential applications of PET/CT in patients with...

journal_title：Current rheumatology reports

authors： Selva-O'Callaghan A,Gil-Vila A,Simó-Perdigó M,Trallero-Araguás E,Alvarado-Cárdenas M,Pinal-Fernandez I

更新日期：2019-11-21 00:00:00

abstract：:There is a wide variation in the prevalence, incidence, and clinical manifestation of psoriatic arthritis (PsA) across countries due to genetic and environmental factors. Data on PsA in Asia are limited and come from small cross-sectional studies. The burden of PsA in Asia is high, including poor physical functioning,...

journal_title：Current rheumatology reports

authors： Leung YY,Tam LS,Li EK

更新日期：2011-08-01 00:00:00

abstract：:Although the pathogenesis of SLE remains poorly understood, there is consensus that it involves a combination of genetic, hormonal, and environmental factors. New technologies applied to genomic and gene expression studies have revealed novel gene mutations and cytokine alterations in this disease. Recently, advances ...

journal_title：Current rheumatology reports

authors： Stichweh D,Pascual V

更新日期：2005-12-01 00:00:00

abstract：:Behçet's syndrome is a systemic vasculitis with an unknown etiology affecting the small and large vessels of the venous and arterial systems. At least two clusters of disease expression have been described. The first includes superficial vein thrombosis, deep vein thrombosis, and dural sinus thrombi. The second includ...

journal_title：Current rheumatology reports

authors： Yazici Y,Yurdakul S,Yazici H

更新日期：2010-12-01 00:00:00

abstract：:Health outcomes and their measures used as end points in systemic lupus erythematosus (SLE) patient care and clinical trials have been varied and are still evolving. Although significant reductions in morbidity and mortality in SLE have been achieved, the medications approved for SLE have remained the same during the ...

journal_title：Current rheumatology reports

authors： Jolly M

更新日期：2010-08-01 00:00:00

abstract：:The Delphi Technique and Nominal Group Technique are two well-recognized consensus-formation methodologies specifically designed to combine judgments from a group of experts. The Delphi Technique utilizes a series of well-defined questionnaire-based surveys, whereas Nominal Group Technique is a structured face-to-face...

journal_title：Current rheumatology reports

authors： Ruperto N,Meiorin S,Iusan SM,Ravelli A,Pistorio A,Martini A

更新日期：2008-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Antiphospholipid syndrome (APS) is a chronic autoimmune disease that can be seen as a burden, with consequences on patients' daily life. Health has traditionally been measured using measures of morbidity or mortality. Health-related quality of life (HRQoL) is a concept that includes quality of life th...

journal_title：Current rheumatology reports

authors： Desnoyers M,Dufrost V,Wahl D,Zuily S

更新日期：2020-05-13 00:00:00

abstract：PURPOSE OF REVIEW:Several biologic drugs are available for treatment of immune-mediated diseases, and the number of children treated with biologics is increasing. This review summarises current knowledge about the safety and immunogenicity of vaccines in children treated with biologic therapy. RECENT FINDINGS:A recent...

journal_title：Current rheumatology reports

authors： Toplak N,Uziel Y

更新日期：2020-05-20 00:00:00

abstract：:Antiphospholipid syndrome (APS) is characterized by antiphospholipid antibodies (aPL) associated with thrombosis and/or pregnancy morbidity. However, there is a range of other manifestations associated with APS, called non-criteria manifestations that add significant morbidity to this syndrome and, some of them, repre...

journal_title：Current rheumatology reports

authors： Rosa RF,Ugolini-Lopes MR,Zeinad-Valim AK,D'Amico E,Andrade D

更新日期：2015-04-01 00:00:00

abstract：:Activation of the complement system plays a fundamental role in the pathogenesis of systemic lupus erythematosus (SLE). For the past several decades, quantifying this process has focused primarily on determination of serum C3 and C4, although the utility of these assays for diagnosis and monitoring disease activity is...

journal_title：Current rheumatology reports

authors： Liu CC,Manzi S,Danchenko N,Ahearn JM

更新日期：2004-10-01 00:00:00

abstract：:Epidemiologic studies of pediatric rheumatologic disease are becoming increasingly focused on subfields of epidemiology. Genetic epidemiology is assuming an ever-greater role in the understanding of disease risks and pathogenesis. Such studies involve major histocompatibility complex, cytokine gene polymorphisms, T ce...

journal_title：Current rheumatology reports

authors： Manners PJ

更新日期：2003-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Childhood arthritis is in need of a new system of classification, owing to deficiencies in the International League of Associations for Rheumatology (ILAR) criteria. We briefly review the history of classification of childhood arthritis, discuss the major criticisms of the current system, and highligh...

journal_title：Current rheumatology reports

authors： Rumsey DG,Laxer RM

更新日期：2020-01-11 00:00:00

abstract：PURPOSE OF THE REVIEW:Osteoarthritis (OA) is a chronic, painful joint disease that affects approximately 40% of adults over 70 year. Age is the strongest predictor of OA, while obesity is considered the primary preventable risk factor for OA. Both conditions are associated with abnormal innate immune inflammatory respo...

journal_title：Current rheumatology reports

authors： Kalaitzoglou E,Griffin TM,Humphrey MB

更新日期：2017-08-01 00:00:00

abstract：:Recent human genetic discoveries have increased our understanding of rheumatoid arthritis (RA) susceptibility. Genome-wide association studies have expanded the number of validated RA risk loci beyond HLA-DRB1 "shared epitope" alleles to include additional major histocompatibility complex (MHC) risk alleles and more t...

journal_title：Current rheumatology reports

authors： Plenge RM

更新日期：2009-10-01 00:00:00

abstract：:Small-vessel vasculitis is a convenient descriptor for a wide range of diseases characterized by vascular inflammation of the venules, capillaries, and/or arterioles with pleomorphic clinical manifestations. The classical clinical phenotype is leukocytoclastic vasculitis with palpable purpura, but manifestations vary ...

journal_title：Current rheumatology reports

authors： Iglesias-Gamarra A,Restrepo JF,Matteson EL

更新日期：2007-08-01 00:00:00

abstract：:Vasculitis is defined as inflammation of blood vessels and can affect multiple organs. Several classification systems exist to categorize vasculitis such as vessel size, presence of anti-neutrophil cytoplasmic antibody, pathogenesis of the inflammation, and type of inflammatory cell infiltrate. Cutaneous vasculitis oc...

journal_title：Current rheumatology reports

authors： Hayat S,Berney SM

更新日期：2005-08-01 00:00:00

abstract：:β2-glycoprotein I (β2GPI) is the major autoantigen in the antiphospholipid syndrome. The central importance of understanding β2GPI physiology from the perspective of the rheumatologist is that it forms the foundation for understanding the pathophysiology underlying autoantibody generation, and the diverse mechanisms b...

journal_title：Current rheumatology reports

authors： Giannakopoulos B,Mirarabshahi P,Krilis SA

更新日期：2011-02-01 00:00:00

abstract：PURPOSE OF THE REVIEW:Osteoarthritis (OA) is an aging-associated and injury-induced joint disease characterized by cartilage degradation, bone sclerosis, and persistent low-grade inflammation in the joint. Aging and injury are triggers of joint pathological changes mediated by pro-inflammatory factors, some of which ar...

journal_title：Current rheumatology reports

authors： Xie C,Chen Q

更新日期：2019-12-07 00:00:00

abstract：:It has been known for some time that central nervous system (CNS) pain amplification is present in some individuals with osteoarthritis; the implications of this involvement, however, are just starting to be realized. In the past year, several research reviews have focused on evidence supporting shared mechanisms acro...

journal_title：Current rheumatology reports

authors： Murphy SL,Phillips K,Williams DA,Clauw DJ

更新日期：2012-12-01 00:00:00

abstract：:Resistive exercise is controversial for patients with idiopathic inflammatory myopathies. This paper provides an update on exercise and clinical assessment in these patients. The few published studies on this topic report unchanged disease activity from a variety of exercise regimens in patients in all stages of disea...

journal_title：Current rheumatology reports

authors： Alexanderson H

更新日期：2005-04-01 00:00:00

abstract：:Skin fibrosis occurs in a variety of human diseases, most notably systemic sclerosis (SSc). The end stage of scleroderma in human skin consists of excess collagen deposition in the dermis with loss of adnexal structures and associated adipose tissue. The initiating factors for this process and the early stages are bel...

journal_title：Current rheumatology reports

authors： Smith GP,Chan ES

更新日期：2010-02-01 00:00:00

abstract：:There have been few studies examining whether persons with chronic widespread pain or fibromyalgia are at increased risk for dying prematurely. Among the studies conducted there is little consistency in results. If there is an increased mortality risk, it is of the order of a 30% excess and it may be related to the li...

journal_title：Current rheumatology reports

authors： Macfarlane GJ

更新日期：2005-10-01 00:00:00

abstract：:Focal chondral or osteochondral lesions can be painful and disabling because they have insufficient intrinsic repair potential, and constitute one of the major extrinsic risk factors for osteoarthritis (OA). Attention has, therefore, been paid to regenerative therapeutic procedures for the early treatment of cartilagi...

journal_title：Current rheumatology reports

authors： Grässel S,Lorenz J

更新日期：2014-10-01 00:00:00

abstract：:Widespread muscle pain, fatigue, and weakness are defining characteristics of patients with fibromyalgia (FM). The aim of this review is to summarize recent investigations of muscle abnormalities in FM, which can be classified as structural, metabolic, or functional in nature. Histologic muscle abnormalities of membra...

journal_title：Current rheumatology reports

authors： Park JH,Niermann KJ,Olsen N

更新日期：2000-04-01 00:00:00

abstract：:Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a multisystem disease, the pathogenesis of which remains undetermined. Following two microarray studies, we reported the differential expression of 88 human genes in patients with CFS; 85 of these genes were upregulated and 3 were downregulated. The top fu...

journal_title：Current rheumatology reports

authors： Kerr JR

更新日期：2008-12-01 00:00:00

abstract：:Synovitis is the characteristic feature of inflammatory joint disease. If synovitis is localized to interphalangeal joints, rheumatoid arthritis, psoriatic arthritis, and juvenile idiopathic arthritis are among the most common differential diagnoses. The absence of pain, tenderness, and limitation of function despite ...

journal_title：Current rheumatology reports

authors： Dallos T,Oppl B,Kovács L,Zwerina J

更新日期：2014-01-01 00:00:00

abstract：PURPOSE OF THE REVIEW:Polymyalgia rheumatica (PMR) is one of the most common inflammatory rheumatologic condition occurring in older adults. It is characterized by proximal pain and stiffness in the shoulders, neck, and/or pelvic girdle in individuals over 50 years of age along with evidence of an intense systemic infl...

journal_title：Current rheumatology reports

authors： Gazitt T,Zisman D,Gardner G

更新日期：2020-06-19 00:00:00

abstract：:Wegener's granulomatosis (WG) is a complex autoimmune disorder that has been transformed from a uniformly lethal process to a chronic disease with a relapsing-remitting course. In the setting of frequent relapses, the need to manage cumulative disease damage and drug toxicities has spurred the identification and devel...

journal_title：Current rheumatology reports

authors： Sarraf P,Kay J,Friday RP,Reginato AM

更新日期：2006-08-01 00:00:00

abstract：:The development of B cell-targeted biologics represents a major advance in the treatment of autoimmune rheumatic diseases. As with other immunosuppressive agents, risk of infection is a key clinical concern. This review summarises safety data from 15 years of experience of rituximab in autoimmune diseases with a parti...

journal_title：Current rheumatology reports

authors： Md Yusof MY,Vital EM,Buch MH

更新日期：2015-10-01 00:00:00