Regulatory T Cells in SLE: Biology and Use in Treatment.

Abstract:

:T regulatory cells (Tregs) represent a phenotypically and functionally heterogeneous group of lymphocytes that exert immunosuppressive activities on effector immune responses. Tregs play a key role in maintaining immune tolerance and homeostasis through diverse mechanisms which involve interactions with components of both the innate and adaptive immune systems. As in many autoimmune diseases, Tregs have been proposed to play a relevant role in the pathogenesis of systemic lupus erythematosus (SLE), an autoimmune disease characterized by a progressive breakdown of tolerance to self-antigens and the presence of concomitant hyperactive immune responses. Here, we review how Tregs dysfunction in SLE has been manipulated experimentally and preclinically in the attempt to restore, at last in part, the immune disturbances in the disease.

journal_name

Curr Rheumatol Rep

authors

Giang S,La Cava A

doi

10.1007/s11926-016-0616-6

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

67

issue

11

eissn

1523-3774

issn

1534-6307

pii

10.1007/s11926-016-0616-6

journal_volume

18

pub_type

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