Abstract:
:During clinical trials, a number of fully characterized molecules are dropped along the way because they do not provide enough benefit for the patient. Some of them show limited side effects and might be of great use for other applications. AS1411 is a nucleolin-targeting aptamer that underwent phase II clinical trials as anticancer agent. Here, we show that AS1411 exhibits extremely potent antiviral activity and is therefore an attractive new lead as anti-HIV agent.
journal_name
Biochimiejournal_title
Biochimieauthors
Métifiot M,Amrane S,Mergny JL,Andreola MLdoi
10.1016/j.biochi.2015.09.009subject
Has Abstractpub_date
2015-11-01 00:00:00pages
173-5eissn
0300-9084issn
1638-6183pii
S0300-9084(15)00284-9journal_volume
118pub_type
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