Abstract：
:Excitation-contraction coupling describes the series of events that beginning with propagated action potential on the muscle fiber surface membrane, leads to the twitch contraction of the fiber. Myotonic disorders are inherited diseases whose clinical manifestations include electrophysiological signs such as increased excitability and delayed relaxation of the muscles after voluntary contraction. All these disorders appear to be due to an abnormality of the muscle itself, since they persist after section or blocking of the motor nerve and after curarization. Most experimental and clinical data suggest that human myotonia arises from genetically-induced structural and functional alterations of the muscle cell membrane. The purpose of this review is to summarize the more recent developments in the molecular and pharmacological analysis of cation transporting systems such as ionic channels and (Na+,K+)-ATPase in myotonic disorders.
journal_name
Biochimiejournal_title
Biochimieauthors
Renaud JFdoi
10.1016/0300-9084(87)90032-0subject
Has Abstractpub_date
1987-04-01 00:00:00pages
407-10issue
4eissn
0300-9084issn
1638-6183pii
0300-9084(87)90032-0journal_volume
69pub_type
杂志文章,评审相关文献
BIOCHIMIE文献大全abstract：:The widespread nature of protein phosphorylation/dephosphorylation underscores its key role in cell signaling metabolism, growth and differentiation. Tyrosine phosphorylation of cytoplasmic proteins is a critical event in the regulation of intracellular signaling pathways activated by external stimuli. An adequate bal...
journal_title：Biochimie
pub_type： 杂志文章,评审
doi：10.1016/j.biochi.2010.01.002
更新日期：2010-04-01 00:00:00
abstract：:The proteasome activators known as 11S REG or PA28 were discovered about 10 years ago. They are homo- or heteroheptameric rings that bind to the ends of 20S proteasomes and activate cleavage of peptides but not folded proteins. In this article, we focus on structural features of three homologous REG subunits (termed a...
journal_title：Biochimie
pub_type： 杂志文章,评审
doi：10.1016/s0300-9084(01)01236-6
更新日期：2001-03-01 00:00:00
abstract：:The present study was conducted on CD4(+) T cells, isolated from wild type (WT) and PPARalpha(null) mice, in order to assess the mechanism of action of docosahexaenoic acid (DHA), an n-3 fatty acid, in the modulation of two transcription factors, i.e., T-bet and GATA-3, implicated in T-cell differentiation towards, re...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2009.09.012
更新日期：2009-11-01 00:00:00
abstract：:The present review deals with the place of single chain oligonucleotide ligands (aptamers) in affinity chromatography applied to proteins. Aptamers are not the only affinity ligands available but they represent an emerging and highly promising route that advantageously competes with antibodies in immunopurification pr...
journal_title：Biochimie
pub_type： 杂志文章,评审
doi：10.1016/j.biochi.2017.10.008
更新日期：2018-02-01 00:00:00
abstract：:Organisms exposed to ionizing radiation (IR) undergo increases in the production of reactive oxygen species (ROS), which are determinant components in the induction of apoptosis. Sensitive to apoptosis gene (SAG) encodes a redox-inducible and apoptosis-protective antioxidant protein. This report demonstrates that the ...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2010.09.020
更新日期：2011-02-01 00:00:00
abstract：:Phospholipases A2 (PLA2) are a family of enzymes that catalyze the hydrolysis of the sn-2 ester bond of glycerophospholipids liberating lysophospholipids and free fatty acids; important second messengers involved in atherogenesis. Plasma PAF-acetylhydrolase (PAF-AH) or Lp-PLA2 is a Ca(2+)-independent PLA2 which is pro...
journal_title：Biochimie
pub_type： 杂志文章,评审
doi：10.1016/j.biochi.2010.02.002
更新日期：2010-06-01 00:00:00
abstract：:The lysosomal aspartic protease cathepsin D (cath-D) is overexpressed and hyper-secreted by epithelial breast cancer cells. This protease is an independent marker of poor prognosis in breast cancer as it is correlated with the incidence of clinical metastasis. In normal cells, cath-D is localized in intracellular vesi...
journal_title：Biochimie
pub_type： 杂志文章,评审
doi：10.1016/j.biochi.2010.05.009
更新日期：2010-11-01 00:00:00
abstract：:The number of proteins known to contain collagen-like triple helical domains is rapidly increasing. The functions of these domains are to provide molecular rods that separate spatially non-triple helical domains with varied properties and structures and to permit lateral interactions between molecules. Two-thirds of t...
journal_title：Biochimie
pub_type： 杂志文章,评审
doi：10.1016/0300-9084(90)90071-n
更新日期：1990-06-01 00:00:00
abstract：:An efficient phosphotriester methodology based on the use of condensing agents in the presence of several O-nucleophilic catalysts has been developed. ...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/s0300-9084(85)80169-3
更新日期：1985-07-01 00:00:00
abstract：:Many human conditions, including neurological diseases, atherosclerosis, cancer, diabetic complications and aging, are thought to be associated with oxidative stress (OS). The development of reliable and informative markers for the characterization of OS in humans is thus highly important. Various endogenous markers a...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2012.03.005
更新日期：2013-03-01 00:00:00
abstract：:Mitochondria are essential organelles and consequently proper expression and maintenance of the mitochondrial genome are indispensable for proper cell function. The mitochondrial Suv3 (SUPV3L1) helicase is known to have a central role in mitochondrial RNA metabolism and to be essential for maintenance of mitochondrial...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2014.11.003
更新日期：2015-01-01 00:00:00
abstract：:Tri(n-butyl)phosphate (TNBP) and sodium cholate (SC) mixtures have been used to inactivate lipid-enveloped viruses like HIV and hepatitis B. We exploited the use of this combination to purify fibroblast growth factor-2 (FGF-2) from human placenta. Human placentas were extracted in the presence of 0.3% TNBP/0.2% SC and...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/0300-9084(96)89504-6
更新日期：1996-01-01 00:00:00
abstract：:The periplasmic histidine permease of Salmonella typhimurium is composed of a soluble histidine-binding protein and three membrane-bound components. These latter are produced in very small amounts and only two, the Q and the P protein, have been previously identified. This paper describes the construction of a plasmid...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/s0300-9084(85)80242-x
更新日期：1985-01-01 00:00:00
abstract：:NDPK-A, NDPK-B and NDPK-D are three enzymes which belong to the NDPK group I isoforms and are not only involved in metabolism process but also in transcriptional regulation, DNA cleavage, histidine protein kinase activity and metastasis development. Those enzymes were reported to bind to membranes either in mitochondr...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2014.06.025
更新日期：2014-10-01 00:00:00
abstract：:The antiviral activity of L-nucleoside analogs depends in part on the enantioselectivity of nucleoside kinases which catalyse their monophosphorylation. The substrate properties of human recombinant deoxycytidine kinase (dCK) and human recombinant deoxyguanosine kinase (dGK) with respect to L-adenosine and L-guanosine...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/s0300-9084(99)00331-4
更新日期：1999-11-01 00:00:00
abstract：:Laccases, blue copper-containing oxidases, ≿ an play an important role in a variety of natural processes. The majority of fungal laccases are encoded by multigene families that express closely related proteins with distinct functions. Currently, only the properties of major gene products of the fungal laccase families...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2015.07.015
更新日期：2015-09-01 00:00:00
abstract：:Herein, we report the purification and biochemical characterization of a novel bi-functional protein proteinase/amylase inhibitor from the dietary leguminous pulse Phaseolus aureus Roxb. (Vigna radiata L.) by means of acetic acid precipitation, salt fractionation, ion-exchange chromatography (DEAE-cellulose) and affin...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2005.05.007
更新日期：2005-12-01 00:00:00
abstract：:Obesity prevalence continues to rise throughout the developed world, as a result of positive energy balance and reduced physical activity. At present, there is still a perception within the general community, and amongst some nutritionists, that eating multiple small meals spaced throughout the day is beneficial for w...
journal_title：Biochimie
pub_type： 杂志文章,评审
doi：10.1016/j.biochi.2015.07.025
更新日期：2016-05-01 00:00:00
abstract：:Staphylococcus aureus is one of the most dreaded pathogens worldwide and emergence of notorious antibiotic resistant strains have further exacerbated the present scenario. The glycolytic enzyme, triosephosphate isomerase (TIM) is one of the cell envelope proteins of the coccus and is involved in biofilm formation. It ...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2012.07.001
更新日期：2012-12-01 00:00:00
abstract：:Unspliced human immunodeficiency virus-1 (HIV-1) mRNA is capped and therefore can be translated via conventional scanning mechanism. In addition, its 5' untranslated region (5'UTR) is thought to function as an internal ribosome entry site (IRES) during G2/M-phase of cell cycle or when cap-dependent translation is inhi...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2015.12.004
更新日期：2016-02-01 00:00:00
abstract：:Purified chromatin isolated from lymphocytic cells derived from patients with acute leukemia, or other lymphoproliferative disorders has been compared with chromatin isolated from normal human lymphocytic cells by gel electrophoresis and differential gradient ultracentrifugation. Thermal denaturation studies showed hi...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/s0300-9084(75)80307-5
更新日期：1975-01-01 00:00:00
abstract：:Experimental Lyme arthritis provides a mouse model for exploring the development of pathology following infection of C3H mice with Borrelia burgdorferi. Infected mice develop a reliable inflammatory arthritis of the ankle joint with severity that typically peaks around two to three weeks post-infection and then underg...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2017.06.010
更新日期：2017-10-01 00:00:00
abstract：:In vitro cycling rates of E. coli ribosomes and of elongation factors EF-Tu and EF-G have been obtained and these are compatible with translation rates in vivo. We show that the rate of translocation is faster than 50 s-1 and therefore that the EF-G function is not a rate limiting step in protein synthesis. The in viv...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/0300-9084(88)90244-1
更新日期：1988-05-01 00:00:00
abstract：:Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases that process growth factors, growth factor binding proteins, cell surface proteins, degrade extracellular matrix (ECM) components and thereby play a central role in tissue remodeling and tumor progression. Membrane-type matrix metalloproteinases (MT-...
journal_title：Biochimie
pub_type： 杂志文章,评审
doi：10.1016/j.biochi.2004.07.012
更新日期：2005-03-01 00:00:00
abstract：:The recent increase in the intake of folic acid by the general public through fortified foods and supplements, has raised safety concern based on early reports of adverse health outcome in elderly with low B12 status who took high doses of folic acid. These safety concerns are contrary to the 2015 WHO statement that "...
journal_title：Biochimie
pub_type： 杂志文章,评审
doi：10.1016/j.biochi.2016.04.010
更新日期：2016-07-01 00:00:00
abstract：:Sialate 9(4)-O-acetylesterases (EC 3.1.1.53) have been isolated from equine liver, bovine brain and influenza C virus. In this latter case, the esterase represents the receptor-destroying enzyme of the virus. The kinetic properties of these enzymes were determined with Neu5,9Ac2 and in part with 4-methylumbelliferyl a...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/0300-9084(88)90288-x
更新日期：1988-11-01 00:00:00
abstract：:A nuclear poly(ADP-ribose) polymerase (PARP) is activated by gamma-irradiation and consequently synthesizes poly(ADP-ribose) by binding to DNA strand-breaks. This property suggests that PARP is a DNA strand-break-signal generator. Meanwhile, the cell-cycle arrest occurs in G1 and G2 phases following gamma-irradiation....
journal_title：Biochimie
pub_type： 杂志文章,评审
doi：10.1016/0300-9084(96)88161-2
更新日期：1995-01-01 00:00:00
abstract：:Oxidative stress is the main mechanism behind efficient disinfectants, causing damage in bacterial macromolecules. Importantly, bacteria activate resistance mechanisms in response to damage generated by oxidative stress. Strategies allowing pathogens to survive oxidative stress are highly conserved among microorganism...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2020.11.009
更新日期：2021-01-01 00:00:00
abstract：:The effects on intra- and extracellular pH of two polyenic derivatives of amphotericin B, N-fructosyl amphotericin B and N-fructosyl amphotericin B methyl-ester, were tested on HL-60 promyelocytic leukemia cells. Both derivatives raised the internal pH and reduced the external pH in weakly buffered medium. These resul...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/0300-9084(89)90133-8
更新日期：1989-01-01 00:00:00
abstract：:Explants from 7, 8, 9, 11, 13-day chick embryonic skin incorporating (3H) Uridine for different periods 1 hr, 3 or 4 hr and a chase with actinomycin) are studied with respect to free (F) or membrane bound (B) cytoplasmic polysomes and to RNA extracted from them. Polysome specific activity decreases at older stages but...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/s0300-9084(76)80226-x
更新日期：1976-01-01 00:00:00
