Abstract：
:Milk represents a unique resource for translational medicine: It contains a rich pool of biologically active molecules with demonstrated clinical benefits. The ongoing characterization of the mechanistic process through which milk components promote development and immunity has revealed numerous milk-derived compounds with potential applications as clinical therapies in infectious and inflammatory disease, cancer, and other conditions. Lactoferrin is an effective antimicrobial and antiviral agent in high-risk patient populations and a potentially potent adjuvant to chemotherapy in lung cancer. Enteric nutrition formulas supplemented with transforming growth factor β, a milk cytokine, have been shown to promote remission in pediatric Crohn's disease. A number of milk glycans, including human milk oligosaccharides, show promise in preclinical studies as antimicrobial and anti-inflammatory agents. While active preclinical investigations of human milk may soon result in large-scale production of human milk molecules, bovine milk components in many instances represent a practical source of bioactive milk compounds for use in clinical trials. This review summarizes current efforts to translate the compounds derived from human and bovine milk into effective clinical therapies. These efforts suggest a common pathway for the translation of milk-derived compounds into clinical applications.
journal_name
Nutr Revjournal_title
Nutrition reviewsauthors
Hill DR,Newburg DSdoi
10.1093/nutrit/nuv009subject
Has Abstractpub_date
2015-07-01 00:00:00pages
463-76issue
7eissn
0029-6643issn
1753-4887pii
nuv009journal_volume
73pub_type
杂志文章,评审abstract：:Milk intake is considered an important determinant of peak bone mass; consequently, its intake early in life may decrease risk of osteoporotic fractures later. Using the milk history questionnaire, many investigators have conducted retrospective cross-sectional studies and have determined a positive effect of milk int...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1301/nr2004.jun256-260
更新日期：2004-06-01 00:00:00
abstract：CONTEXT:The presence of retail food establishments around schools can be a potentiating or protective factor for overweight in students, depending on access to these places as well as types of foods available therein. The hypothesis for this study was that a greater density and proximity of retail food establishments a...
journal_title：Nutrition reviews
pub_type： 杂志文章
doi：10.1093/nutrit/nuz110
更新日期：2020-10-01 00:00:00
abstract：:The sequence of repair of fat deficiency symptoms depends on whether linoleate or arachidonate is used in treatment, although both methods lead to an increase in arachidonate. Arachidonate is less rapidly oxidized and more rapidly incorporated into phospholipid. ...
journal_title：Nutrition reviews
pub_type： 杂志文章
doi：10.1111/j.1753-4887.1966.tb08384.x
更新日期：1966-04-01 00:00:00
abstract：:Obesity is an established risk factor for postmenopausal, but not premenopausal, development of breast cancer. Evidence for a positive association between obesity and breast cancer mortality is mounting. Avoiding adult weight gain and maintaining a healthy body weight may contribute importantly to decreasing breast ca...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1301/nr.2003.febr.73-76
更新日期：2003-02-01 00:00:00
abstract：:Plant-based diets, and more specifically plant-based proteins, have been the subject of growing interest from researchers and consumers because of their potential health benefits as well as their positive environmental impact. Of course, plant proteins are found in plant foods, and positive health benefits of plant fo...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1093/nutrit/nuz028
更新日期：2019-11-01 00:00:00
abstract：:Intrinsic aging of the brain and its relationship to age-related neurodegenerative diseases need to be understood as part of global aging, which results from gradual accumulation of a variety of kinds of cellular and molecular damage. While certain kinds of molecular lesions are particularly associated with specific d...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2010.00343.x
更新日期：2010-12-01 00:00:00
abstract：:We present a case of the eosinophilia-myalgia syndrome in a patient taking large doses of L-tryptophan for sedation. He developed the now-classic findings of myalgias, skin changes, and marked eosinophilia. This syndrome was first recognized in late 1989, and epidemiologic studies have demonstrated an association of t...
journal_title：Nutrition reviews
pub_type： 杂志文章
doi：10.1111/j.1753-4887.1990.tb02969.x
更新日期：1990-08-01 00:00:00
abstract：:Functional genomics, commonly applied to the genes and enzymes involved in metabolism of chemicals, can also be applied to enzymes involved in the metabolism of nutrients. Although in its infancy, genomics can be used to determine relationships between nutrition and toxicology, drug metabolism, and cancer. ...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2001.tb05510.x
更新日期：2001-08-01 00:00:00
abstract：:The impact of the obesity epidemic on women of childbearing age has been of particular concern in recent years as a result of studies linking maternal weight status to long-term adverse outcomes for obese mothers and their offspring. The US Institute of Medicine developed new gestational weight gain guidelines based o...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/nure.12074
更新日期：2013-10-01 00:00:00
abstract：:The American public consumes a wide array of caffeinated products as coffee, tea, chocolate, cola beverages, and caffeine-containing medication. Therefore, it seems of value to inform both the scientific community and the consumer about the potential effects of excessive caffeine consumption, particularly by pregnant ...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1996.tb03933.x
更新日期：1996-07-01 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is an age-dependent degeneration of motor neurons in the central nervous system. ALS is not caused by faulty nutrition. Recent data suggest that ALS could be an oxidative neurotoxicity induced by a mutation in the SOD1 protein. This finding extends beyond the simple loss of an antio...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1998.tb01698.x
更新日期：1998-03-01 00:00:00
abstract：:Intestinal adaptation, in terms of increasing intestinal length and weight, usually occurs rapidly after small-bowel resection. However, this response depends on provision of enteral nutrients. If total parenteral nutrition without enteral feeding is prolonged, hypoplasia of the intestinal mucosa results. Adaptation i...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1989.tb02837.x
更新日期：1989-07-01 00:00:00
abstract：:Despite forty years of research on the potential role of chromium in carbohydrate and lipid metabolism, significant progress has only recently been made regarding the mode of action of chromium at a molecular level. The oligopeptide low-molecular-weight chromium-binding substance (LMWCr) may function as part of a nove...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2000.tb01841.x
更新日期：2000-03-01 00:00:00
abstract：CONTEXT:Fish oil and omega-3 polyunsaturated fatty acids (ω-3 PUFAs) have anti-inflammatory properties, but their effect on psoriasis and its comorbidities remains inconclusive. OBJECTIVE:The aim of this quantitative systematic review was to evaluate the efficacy and safety of fish oil and its components in the treatm...
journal_title：Nutrition reviews
pub_type： 杂志文章
doi：10.1093/nutrit/nuz098
更新日期：2020-10-01 00:00:00
abstract：:From late 1991 to mid-1993, cases of optic neuropathy of unknown etiology, which first appeared in unusual numbers in a western province of Cuba, spread and multiplied throughout the island. The dominant symptoms changed, becoming increasingly those of peripheral neuropathy. Incidence rates peaked in April 1993. An es...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1993.tb03766.x
更新日期：1993-12-01 00:00:00
abstract：:Olive tree (Olea europaea L.) leaves have been widely used in traditional remedies in European and Mediterranean countries such as Greece, Spain, Italy, France, Turkey, Israel, Morocco, and Tunisia. They have been used in the human diet as an extract, an herbal tea, and a powder, and they contain many potentially bioa...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2009.00248.x
更新日期：2009-11-01 00:00:00
abstract：:The popularity of energy drinks has increased rapidly in the past decade. One of the main reasons people use energy drinks is to counteract effects of insufficient sleep or sleepiness. Risks associated with energy drink use, including those related to sleep loss, may be disproportionately borne by racial minorities an...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/nure.12137
更新日期：2014-10-01 00:00:00
abstract：:Provision of nourishment to terminally ill patients has been a controversial topic in clinical medicine. Determination of the limits of palliative care requires an understanding of the disease process, as well as the boundaries of patient self-determination. With the advent of living wills, the determination of the pa...
journal_title：Nutrition reviews
pub_type： 杂志文章
doi：
更新日期：1994-08-01 00:00:00
abstract：:In cell cultures of carcinogen-initiated fibroblasts, a number of retinoids and carotenoids can reversibly inhibit progression to the transformed state. The anticarcinogenic action of retinoids and carotenoids is closely correlated with enhanced gap-junction cell-to-cell communication and with increased synthesis of t...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1992.tb01345.x
更新日期：1992-09-01 00:00:00
abstract：:Restriction of copper intake during lactation and postlactation periods reduced T cells and increased interleukin-2 receptors in isolated splenocytes from male, but not female, rats. However, a reduced in vitro proliferative response to phytohemagglutin (PHA) was seen in both male and female Cu-deficient rats. These f...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1992.tb01300.x
更新日期：1992-04-01 00:00:00
abstract：:A relationship between folate and neuropsychiatric disorders has been inferred from clinical observation and from the enhanced understanding of the role of folate in critical brain metabolic pathways. Depressive symptoms are the most common neuropsychiatric manifestation of folate deficiency. Conversely, borderline lo...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1997.tb06468.x
更新日期：1997-05-01 00:00:00
abstract：CONTEXT:The impact of various dietary interventions on rheumatoid arthritis (RA), characterized by immune-inflammatory response, has been subject to increased attention. OBJECTIVE:A systematic review was conducted to update the current knowledge on the effects of nutritional, dietary supplement, and fasting interventi...
journal_title：Nutrition reviews
pub_type： 杂志文章
doi：10.1093/nutrit/nuaa033
更新日期：2020-06-25 00:00:00
abstract：:We present a case of an African-American child with vitamin D-deficient rickets. In addition to being solely breast-fed for the period of 1 year, he resided in New England, where exposure to ultraviolet light is limited owing to its northern latitude and long cold winters. He presented with classical signs of nutritio...
journal_title：Nutrition reviews
pub_type： 杂志文章
doi：10.1111/j.1753-4887.2000.tb01867.x
更新日期：2000-07-01 00:00:00
abstract：:All-trans and 13-cis-retinoic acids are normal constituents of human blood. Blood levels of both compounds increase upon oral ingestion of all-trans-retinyl palmitate, to a greater extent with higher amounts of ingested retinyl palmitate. These data suggest a mechanism whereby levels of dietary vitamin A could influen...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1991.tb07423.x
更新日期：1991-09-01 00:00:00
abstract：:Proanthocyanidins are a major group of flavonoids in the human diet, known for their strong antioxidant properties. Emerging evidence from clinical studies indicates a role of proanthocyanidins in modulating glucose homeostasis, and higher proanthocyanidin intake has been associated with reduced risk of diabetes. On t...
journal_title：Nutrition reviews
pub_type： 杂志文章
doi：10.1093/nutrit/nux028
更新日期：2017-08-01 00:00:00
abstract：:The energy cost of daily physical activity was derived for 30 Pima Indians ages 19-71 using simultaneous measurements of total daily expenditure and basal metabolic rate in the free-living situation. The body fat of the subjects ranged from 10 to 45%. Weight-adjusted indexes of physical activity correlated negatively ...
journal_title：Nutrition reviews
pub_type： 杂志文章
doi：10.1111/j.1753-4887.1995.tb01470.x
更新日期：1995-01-01 00:00:00
abstract：:Sarcopenia is the degenerative loss of skeletal muscle that occurs naturally in individuals as they age. Although many factors underlie sarcopenia, epidemiological and experimental evidence suggests that low-grade chronic inflammation is an important contributor to its progression. Still, few healthcare professionals ...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2007.tb00364.x
更新日期：2007-12-01 00:00:00
abstract：:Choline is involved in methyl group metabolism and lipid transport and is a component of a number of important biological compounds including the membrane phospholipids lecithin, sphingomyelin, and plasmalogen; the neurotransmitter acetylcholine; and platelet activating factor. Although a required nutrient for several...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1994.tb01357.x
更新日期：1994-10-01 00:00:00
abstract：:A food intake pattern specifying amounts and types of food was created for Canada's revised food guide, Eating Well with Canada's Food Guide (2007), using a two-step modeling process. In step one, food composites were manipulated to develop a food intake pattern. The second step used the step one food intake pattern t...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2007.tb00295.x
更新日期：2007-04-01 00:00:00
abstract：:Glucokinase plays a major role in the control of hepatic glucose uptake and storage as glycogen. Small amounts of fructose-1-phosphate, in the presence of relatively high glucose levels, markedly stimulate glucokinase through a novel mechanism of regulation involving dissociation from a regulatory protein and transloc...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1301/002966402320289377
更新日期：2002-08-01 00:00:00
