Abstract:
:Mesenchymal stem cell (MSC) transplantation is used for treatment of many diseases. The paracrine role of MSCs in tissue regeneration is attracting particular attention. We investigate the role of MSC exosomes in skeletal muscle regeneration. MSC exosomes promote myogenesis and angiogenesis in vitro, and muscle regeneration in an in vivo model of muscle injury. Although MSC exosomes had low concentrations of muscle-repair-related cytokines, a number of repair-related miRNAs were identified. This study suggests that the MSC-derived exosomes promote muscle regeneration by enhancing myogenesis and angiogenesis, which is at least in part mediated by miRNAs such as miR-494.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Nakamura Y,Miyaki S,Ishitobi H,Matsuyama S,Nakasa T,Kamei N,Akimoto T,Higashi Y,Ochi Mdoi
10.1016/j.febslet.2015.03.031subject
Has Abstractpub_date
2015-05-08 00:00:00pages
1257-65issue
11eissn
0014-5793issn
1873-3468pii
S0014-5793(15)00209-4journal_volume
589pub_type
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