Abstract：
OBJECTIVES:To clarify the protective effects of Cichorium glandulosum (CG) extracts on thioacetamide (TAA)-induced rat hepatic fibrosis. MATERIALS AND METHODS:The dry roots of CG were smashed and percolated with 95% ethanol, and the residual was prepared into petroleum ether extract (CG-V), ethyl acetate extract (CG-VI) and n-butyl alcohol extract (CG-VII). Thirty-six Wistar rats were randomly divided into a normal group, a model group, a CG-V group (15 mg/kg), a CG-VI group (3 mg/kg), a CG-VII group (6 mg/kg) and a positive drug group (silibinin capsule, 8 mg/kg). Organ indices and serum levels of glutamic-oxaloacetic and glutamic-pyruvic transaminases of intragastrically administered rats were obtained. Expressions of FN, Smad3, IGFBPrP1 and TGF-β1 genes were detected by Western Blot and immunohistochemical assays. Apoptosis was examined by TUNEL assay. RESULTS:Hepatic fibrosis of treatment groups was evidently mitigated. Expressions of FN, Smad3 and TGF-β1 in administration groups were higher than those in normal group, and moreover were significantly higher in CG-V and CG-VII groups than those of model group. Apoptotic index of model group was significantly higher than that of normal group, but indices of CG-V and CG-VII groups were significantly lower than that of model group. Significantly more FN, Smad3 and IGFBPrP1 were expressed in treatment groups than those in normal group. CONCLUSION:CG extracts may function by altering TGF-β/Smads signal transduction pathway.
journal_name
Iran J Basic Med Scijournal_title
Iranian journal of basic medical sciencesauthors
Qin D,Nie Y,Wen Zsubject
Has Abstractpub_date
2014-11-01 00:00:00pages
879-85issue
11eissn
2008-3866issn
2008-3874journal_volume
17pub_type
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：
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journal_title：Iranian journal of basic medical sciences
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abstract：OBJECTIVES:Many cancer cells show significant resistance to drugs that kill drug sensitive cancer cells and non-tumor cells and such resistance might be a consequence of the difference in metabolism. Therefore, studying the metabolism of drug resistant cancer cells and comparison with drug sensitive and normal cell lin...
journal_title：Iranian journal of basic medical sciences
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journal_title：Iranian journal of basic medical sciences
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更新日期：2016-11-01 00:00:00
abstract：Objectives:Ferula ovina is an Iranian medicinal plant. Tschimgine and stylosin are two of its major monoterpene derivatives. In this study, we proceeded to investigate some fungal endophytes from F. ovina that can produce plant secondary metabolites. Materials and Methods:The isolated endophytic fungi were fermented i...
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更新日期：2020-12-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
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journal_title：Iranian journal of basic medical sciences
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更新日期：2013-09-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
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更新日期：2014-01-01 00:00:00
abstract：Objectives:Neurodegeneration is an outcome of Methamphetamine (METH) abuse. Studies have emphasized on the neuroprotective properties of lithium. The current study is designed towards evaluating the role of Akt-1/GSK3 and CREB-BDNF signaling pathways in mediating lithium neuroprotection against METH-induced neurodegene...
journal_title：Iranian journal of basic medical sciences
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journal_title：Iranian journal of basic medical sciences
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doi：
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journal_title：Iranian journal of basic medical sciences
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doi：
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doi：
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：
更新日期：2011-07-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
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更新日期：2014-07-01 00:00:00
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doi：10.22038/ijbms.2017.8237
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更新日期：2017-10-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
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doi：
更新日期：2015-01-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：10.22038/IJBMS.2018.29639.7165
更新日期：2018-10-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章,评审
doi：
更新日期：2013-10-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVE(S):Gingivitis is an inflammatory disease that affects tooth-supporting tissues and is caused by a microbe-immune response. The aim of this study was to evaluate the effects of omega-3 fatty acids on immune system regulation and the prevention and treatment of gingivitis using an animal model. MATERIALS AND M...
journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：
更新日期：2014-02-01 00:00:00
