p63 is more sensitive and specific than 34βE12 to differentiate adenocarcinoma of prostate from cancer mimickers.

abstract：OBJECTIVE(S):Based on knowledge from traditional herbal medicine, Ferula assa-foetida (asafoetida) has several therapeutic applications but there is less knowledge about its effect on neurons. MATERIALS AND METHODS:In order to evaluate neuronal differentiation, neuronal like cells were stained against neuronal specifi...

journal_title：Iranian journal of basic medical sciences

authors： Homayouni Moghadam F,Vakili Zarch B,Shafiei M

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVES:Hyperthermia is one of the most common environmental stressors that affect multi-biological systems in the body including the central nervous system as well as the hematopoietic organs. The objective of the present study was to investigate the protective role of ethanolic extract of propolis (EEP) on some se...

journal_title：Iranian journal of basic medical sciences

authors： Mohamed WA,Ismail T,Farouk S

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVES:Morphine is widely used to treat chronic pain. However, its utility is hindered by the development of tolerance to its analgesic effects. Despite the renowned beneficial effects of physical exercise on cognitive functions and signs of morphine withdrawal in morphine-dependent rats, little is known about the ...

journal_title：Iranian journal of basic medical sciences

authors： Shokraviyan M,Miladi-Gorji H,Vaezi GH

更新日期：2014-01-01 00:00:00

abstract：Objectives:The present paper aims to review the studies describing the interactions between HopQ and CEACAMs along with possible mechanisms responsible for pathogenicity of Helicobacter pylori. Materials and Methods:The literature was searched on "PubMed" using different key words including Helicobacter pylori, CEACAM...

journal_title：Iranian journal of basic medical sciences

authors： Xia R,Zhang B,Wang X,Jia Q

更新日期：2019-07-01 00:00:00

abstract：Objectives:Mycobacterium tuberculosis (M. tuberculosis), an intracellular pathogen, causes 1.5 million deaths globally. Bacilli Calmette-Guérin (BCG) is commonly administered to protect people against M. tuberculosis infection; however, there are some obstacles with this first-generation vaccine. DNA vaccines, the thir...

journal_title：Iranian journal of basic medical sciences

authors： Dalirfardouei R,Tafaghodi M,Meshkat Z,Najafi A,Gholoobi A,Nabavinia MS,Sajedifar S,Meshkat M,Badiee A,Ramezani M,Varasteh AR,Naderinasab M

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVES:The purpose of the current study was to assess the feasibility of microspheres from biocompatible polymer for oral bioavailability (BA) enhancement of potent sulfonamide- type loop diuretic- Furosemide - which used in the treatment of congestive heart failure, caused edema, cirrhosis, renal disease and as an...

journal_title：Iranian journal of basic medical sciences

authors： Derakhshandeh K,Karimi M,Azandaryani AH,Bahrami G,Ghanbari K

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVES:This study examined whether conjugated linoleic acid (CLA) supplementation affects insulin sensitivity and peroxisome proliferator-activated receptor gamma (PPAR-γ) and glucose transporter type 4 (GLUT-4) protein expressions in the skeletal muscles of rats during endurance exercise. MATERIALS AND METHODS:Sp...

journal_title：Iranian journal of basic medical sciences

authors： Cho K,Song Y,Kwon D

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE(S):Gingivitis is an inflammatory disease that affects tooth-supporting tissues and is caused by a microbe-immune response. The aim of this study was to evaluate the effects of omega-3 fatty acids on immune system regulation and the prevention and treatment of gingivitis using an animal model. MATERIALS AND M...

journal_title：Iranian journal of basic medical sciences

authors： Araghizadeh N,Paknejad M,Alaeddini M,Minaii B,Abdollahi M,Khorasanie R

更新日期：2014-02-01 00:00:00

abstract：Objectives:Panax ginseng (PG) widely used for its various pharmacological activities, including effects on diabetes and its complications. This study aims to investigate the effect of PG on mortality-related hypomagnesemia, hyperlactatemia, metabolic acidosis, and other diabetes-induced abnormalities. Materials and Me...

journal_title：Iranian journal of basic medical sciences

authors： Adam GO,Kim GB,Lee SJ,Lee HR,Kim SJ,Kang HS,Kim JS

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVES:Obesity considered being a low-grade inflammatory disease. The objective of this study was to examine the association between inflammatory markers (IM) including C-reactive protein (hs-CRP), Interleukin-6 (IL-6), and homocystein (Hcy) and obesity-related factors (e.g. BMI, waist, hip) in adult participants o...

journal_title：Iranian journal of basic medical sciences

authors： Faam B,Zarkesh M,Daneshpour MS,Azizi F,Hedayati M

更新日期：2014-08-01 00:00:00

abstract：Objectives:Interleukin-36 receptor antagonist (IL-36Ra) is a new member of the IL-1 family that exhibits anti-inflammatory activity in a variety of inflammatory and immune diseases. Our purpose was to determine the effect of IL-36Ra on liver injury in a mouse hepatitis model induced by concanavalin A (ConA). Materials...

journal_title：Iranian journal of basic medical sciences

authors： Peng X,Pan X,Tan J,Li Y,Li M

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVES:Hepatitis C is a major cause of liver failure worldwide. Current therapies applied for this disease are not fully effective and produce side effects in most cases. Non-structural protein 3 helicase (NS3) of HCV is one of the key enzymes in viral replication and infection. Therefore, this region is a promisin...

journal_title：Iranian journal of basic medical sciences

authors： Sadri M,Farajollahi MM,Sharifi Z

更新日期：2015-02-01 00:00:00

abstract：Objectives:A growing body of evidence indicates that rhomboid domain containing 1 (RHBDD1) plays an important role in a variety of physiological and pathological processes, including tumorigenesis. We aimed to determine the function of RHBDD1 in breast cancer cells. Materials and Methods:In this study, we used the Onc...

journal_title：Iranian journal of basic medical sciences

authors： Huang C,Ji X,Peng Y,Wu M,Wu W,Luo Y,Cheng G,Zhu Y

更新日期：2018-11-01 00:00:00

abstract：Objectives:Gallic acid (GA) is a highly effective antioxidant, which its beneficial effects are well known, but its impact on expression of microRNAs (miRs) following hepatic ischemia-reperfusion (I/R) is not well recognized. Therefore, the current research was designed to specify the beneficial effect of GA on miRs (1...

journal_title：Iranian journal of basic medical sciences

authors： Akbari G,Savari F,Mard SA,Rezaie A,Moradi M

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVES:In the present study, we evaluated immunological and immunomodulatory properties of royal jelly (RJ) in 2,4,6 trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats. MATERIALS AND METHODS:Eighteen adult female Wistar albino rats were divided into three groups of six animals each: a control group that ...

journal_title：Iranian journal of basic medical sciences

authors： Karaca T,Uz YH,Demirtas S,Karaboga I,Can G

更新日期：2015-04-01 00:00:00

abstract：Objectives:The preclinical reports have shown that specific probiotics like Bifidobacterium bifidum (B. bifidum) and Lactobacillus acidophilus (L. acidophilus) can be applied as the biotherapeutic agents in the inhibition or therapy of colorectal cancer via the modification of gut bacteria. In the previous studies, we ...

journal_title：Iranian journal of basic medical sciences

authors： Ranji P,Agah S,Heydari Z,Rahmati-Yamchi M,Mohammad Alizadeh A

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVES:To study the effect of low-frequency vibration on bone marrow stromal cell differentiation and potential bone repair in vivo. MATERIALS AND METHODS:Forty New Zealand rabbits were randomly divided into five groups with eight rabbits in each group. For each group, bone defects were generated in the left humer...

journal_title：Iranian journal of basic medical sciences

authors： He S,Zhao W,Zhang L,Mi L,Du G,Sun C,Sun X

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE(S):Garlic (Allium sativum L. family Liliaceae) is well known in Iran and its leaves, flowers, and cloves have been used in traditional medicine for a long time. Research in recent decades has shown widespread pharmacological effects of A. sativum and its organosulfur compounds especially Allicin. Studies carr...

journal_title：Iranian journal of basic medical sciences

authors： Mikaili P,Maadirad S,Moloudizargari M,Aghajanshakeri S,Sarahroodi S

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVES:Recently, we showed that some new synthetic compounds structurally related to cilostamide (4-(1,2-dihydro-2-oxoquinolin-6-hydroxy)- N-cyclohexyl-N-methylbutanamide), a selective phosphodiesterase 3 (PDE3) inhibitor, produce inotropic effect comparable to that of IBMX (3-isobutyl-1-methylxanthine), a non-sele...

journal_title：Iranian journal of basic medical sciences

authors： Hosseini A,Shafiee-Nick R,Sadeghian H,Parsaee H

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE(S):Drug resistant Acinetobacter baumannii have emerged as a major problem in many hospitals and intensive care units. Various types of extended spectrum beta-lactamases (ESBLs) are responsible for resistance to beta-lactam antibiotics in different parts of the world. The objective of this study was to determi...

journal_title：Iranian journal of basic medical sciences

authors： Farajnia S,Azhari F,Alikhani MY,Hosseini MK,Peymani A,Sohrabi N

更新日期：2013-06-01 00:00:00

abstract：Objectives:In this study, we investigated the protective effects of piperine on lead acetate-induced renal damage in rat kidney tissue. Materials and Methods:Forty male rats were divided into 5 groups: negative control (rats were given aquadest daily), positive control (rats were given lead acetate 30 mg/kg BW orally ...

journal_title：Iranian journal of basic medical sciences

authors： Sudjarwo SA,Eraiko K,Sudjarwo GW,Koerniasari

更新日期：2017-11-01 00:00:00

abstract：Objectives:Cord blood (CB) is known as a valuable source of hematopoietic stem cells (HSC). Identifying strategies that enhance expansion and maintain engraftment and homing capacity of HSCs can improve transplant efficiency. In this study, we examined different culture conditions on ex vivo expansion and homing capaci...

journal_title：Iranian journal of basic medical sciences

authors： Mohammadali F,Abroun S,Atashi A

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVES:The aim of the present study was to prepare, characterize, and evaluate solid lipid nanoparticles (SLNs) containing Zataria multiflora essential oil (ZEO). MATERIALS AND METHODS:In this study, Z. multiflora essential oil-loaded solid lipid nanoparticles (ZE-SLNs) were prepared to improve its efficiency in c...

journal_title：Iranian journal of basic medical sciences

authors： Nasseri M,Golmohammadzadeh S,Arouiee H,Jaafari MR,Neamati H

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:Amyotrophic lateral sclerosis (ALS), a fatal progressive neurodegenerative disorder, is the most common motor neuron disease in European populations. Approximately 10% of ALS cases are familial (FALS) and the other patients are considered as sporadic ALS (SALS). Among many ALS causing genes that have been id...

journal_title：Iranian journal of basic medical sciences

authors： Alavi A,Khani M,Nafissi S,Shamshiri H,Elahi E

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVES:This study aimed to examine the hypothesis that an antiarrhythmic effect might be obtained by ischemic preconditioning of the liver, and also to characterize the potential underlying mechanisms. MATERIALS AND METHODS:Male Wistar rats were anesthetized by thiopental sodium (50 mg/kg, IP) followed by IV injec...

journal_title：Iranian journal of basic medical sciences

authors： Noorbakhsh MF,Arab HA,Kazerani HR

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE(S):Staphylococcus aureus is both a successful human commensal and a major pathogen. In this study we investigated the genetic diversity of 26 S. aureus isolates recovered from human skin and urinary tract infections. MATERIALS AND METHODS:Typing procedure for the studied S. aureus isolates was performed base...

journal_title：Iranian journal of basic medical sciences

authors： Talebi-Satlou R,Ahmadi M,Ghavam F,Saei HD

更新日期：2012-07-01 00:00:00

abstract：Objectives:Adipose-derived stem cells (ADSCs), with suitable and easy access, are multipotential cells that have the ability for differentiation into other mesodermal and transdifferentiate into neural phenotype cells. In this study, Lithium chloride (LiCl) was used for in vitro transdifferentiation of rat ADSCs into n...

journal_title：Iranian journal of basic medical sciences

authors： Farrokhfar S,Tiraihi T,Movahedin M,Azizi H

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVES:Pharmacological studies showed that the extracts of Jin Yin Hua and its active constituents have lipid lowering, antipyretic, hepatoprotective, cytoprotective, antimicrobial, antibiotic, antioxidative, antiviral, and anti-inflammatory effects. The purpose of the present study was to investigate the protectiv...

journal_title：Iranian journal of basic medical sciences

authors： Wang C,Wang G,Liu H,Hou YL

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:To optimize the extraction method using response surface methodology, extract the phenolic compounds, and identify the antioxidant and biological properties of Stachys parviflora L. extracts. MATERIALS AND METHODS:Maceration and ultrasound-assisted extraction (UAE) (4, 7, 10 min treatment time, 40, 70, 100 ...

journal_title：Iranian journal of basic medical sciences

authors： Bashi DS,Dowom SA,Bazzaz BS,Khanzadeh F,Soheili V,Mohammadpour A

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVES:Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of multiple sclerosis. The aim of the present work is to investigate the protective effects of erythropoietin against cuprizone-induced oxidative stress. MATERIALS AND METHODS:...

journal_title：Iranian journal of basic medical sciences

authors： Kashani IR,Chavoshi H,Pasbakhsh P,Hassani M,Omidi A,Mahmoudi R,Beyer C,Zendedel A

更新日期：2017-08-01 00:00:00