Protective effects of erythropoietin against cuprizone-induced oxidative stress and demyelination in the mouse corpus callosum.

abstract：OBJECTIVE(S):Gastric cancer is the first and second leading cause of cancer related death in Iranian men and women, respectively. Gastric cancer management is based on the surgery, radiotherapy and chemotherapy. In the present study, for the first time, the beneficial effect of saffron (Crocus sativus L.) aqueous extra...

journal_title：Iranian journal of basic medical sciences

authors： Bathaie SZ,Miri H,Mohagheghi MA,Mokhtari-Dizaji M,Shahbazfar AA,Hasanzadeh H

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES:Astrodaucus persicus, Apiaceae, is used as vegetable or food additive in some parts of Iran. The essential oils of different parts of Astrodaucus persicus from Kordestan province were analyzed for the first time and compared with other regions. In this study, antioxidant activities and total phenols determin...

journal_title：Iranian journal of basic medical sciences

authors： Goodarzi S,Hadjiakhoondi A,Yassa N,Khanavi M,Tofighi Z

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVES:Nitric oxide (NO), a product of inducible nitric oxide synthase (iNOS), contributes in germ cell apoptosis. This study was aimed to evaluate the effects of Aloe vera gel (AVG) on male Wistar rat reproductive organ, serum NO level, and expression of iNOS gene in leydig cells. MATERIALS AND METHODS:Adult male...

journal_title：Iranian journal of basic medical sciences

authors： Asgharzade S,Rafieian-Kopaei M,Mirzaeian A,Reiisi S,Salimzadeh L

更新日期：2015-10-01 00:00:00

abstract：Objectives:Panax ginseng (PG) widely used for its various pharmacological activities, including effects on diabetes and its complications. This study aims to investigate the effect of PG on mortality-related hypomagnesemia, hyperlactatemia, metabolic acidosis, and other diabetes-induced abnormalities. Materials and Me...

journal_title：Iranian journal of basic medical sciences

authors： Adam GO,Kim GB,Lee SJ,Lee HR,Kim SJ,Kang HS,Kim JS

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVES:Valproic acid (VPA) has proven to be as one of the most promising useful drug with anticancer properties. In this study, we investigate the VPA effects on E-cadherin expression in HeLa, TC1, MKN45, and HCT116 cell lines. This study assesses the effects of VPA on human papillomavirus E7 expression in HPV posi...

journal_title：Iranian journal of basic medical sciences

authors： Faghihloo E,Akbari A,Adjaminezhad-Fard F,Mokhtari-Azad T

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVES:The Muller cell is the principal glial cell of the vertebrate retina. The expression of Glial fibrillary acidic protein (GFAP) in the Muller cells was used as a cellular marker for retinal damage. This study was done to evaluate the effect of gestational diabetes on retinal Muller cells in rat's offspring. ...

journal_title：Iranian journal of basic medical sciences

authors： Tabasi A,Ghafari S,Mehdizadeh M,Shekari MA,Golalipour MJ

更新日期：2017-02-01 00:00:00

abstract：Objectives:Ferula ovina is an Iranian medicinal plant. Tschimgine and stylosin are two of its major monoterpene derivatives. In this study, we proceeded to investigate some fungal endophytes from F. ovina that can produce plant secondary metabolites. Materials and Methods:The isolated endophytic fungi were fermented i...

journal_title：Iranian journal of basic medical sciences

authors： Tazik Z,Rahnama K,White JF,Soltanloo H,Hasanpour M,Iranshahi M

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE(S):Carotenoids which are naturally synthesized by fungi such as yeasts can act as an antioxidant which is closely related to their ability to decrease the risk of a variety of degenerative diseases. In recent years, the increase of demand for carotenoids obtained from natural sources has promoted major effort...

journal_title：Iranian journal of basic medical sciences

authors： Sadat Naghavi F,Hanachi P,Soudi MR,Saboora A,Ghorbani A

更新日期：2013-10-01 00:00:00

abstract：Objectives:Charcot-Marie Tooth disease (CMT) is one of the main inherited causes of motor and sensory neuropathies with variable expressivity and age-of onset. Although more than 70 genes have been identified for CMT, more studies are needed to discover other genes involved in CMT. Introduction of whole exome sequencin...

journal_title：Iranian journal of basic medical sciences

authors： Tahmasebi-Birgani M,Hajjari M,Golchin N,Shalbafan B,Mohammadi-Asl J,Sadeghian F

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVES:Many cancer cells show significant resistance to drugs that kill drug sensitive cancer cells and non-tumor cells and such resistance might be a consequence of the difference in metabolism. Therefore, studying the metabolism of drug resistant cancer cells and comparison with drug sensitive and normal cell lin...

journal_title：Iranian journal of basic medical sciences

authors： Motamedian E,Ghavami G,Sardari S

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVES:This study aimed to evaluate the protective effects of total flavonoid extract from Coreopsis tinctoria Nutt. (CTF) against myocardial ischemia/reperfusion injury (MIRI) using an isolated Langendorff rat heart model. MATERIALS AND METHODS:Left ventricular developed pressure (LVDP) and the maximum rate of ri...

journal_title：Iranian journal of basic medical sciences

authors： Zhang Y,Yuan C,Fang H,Li J,Su S,Chen W

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVES:Lipocalin 2 (Lcn2) is a 25-kDa glycoprotein that has initially been extracted from neutrophil granules. Expression of Lcn2 is induced under various pathophysiological conditions. It is also known as an early marker of kidney and heart injury. High-level expression of recombinant Lcn2 neutrophil gelatinase-as...

journal_title：Iranian journal of basic medical sciences

authors： Rouhbakhsh M,Halabian R,Masroori N,Mohammadi Pour M,Bahmani P,Mohammadi Roush A,Jahanian-Najafabadi A,Habibi Roudkenar M

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE(S):In the current study, the effects of selected folk medicinal herbs were evaluated in D-galactose-induced aging in male mice. MATERIALS AND METHODS:Male BALB/c mice were randomly divided into 12 groups composing sham, control, and treated groups. Aging was induced by administration of D-galactose (500 mg/k...

journal_title：Iranian journal of basic medical sciences

authors： Mohammadirad A,Aghamohammadali-Sarraf F,Badiei S,Faraji Z,Hajiaghaee R,Baeeri M,Gholami M,Abdollahi M

更新日期：2013-11-01 00:00:00

abstract：Objectives:The present study aimed to determine and compare moisturizing and occlusion effects of different solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) using magnetized water and deionized water. Materials and Methods:SLN formulations were prepared using various lipids, including Tripalmiti...

journal_title：Iranian journal of basic medical sciences

authors： Sarhadi S,Gholizadeh M,Moghadasian T,Golmohammadzadeh S

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVES:Both caloric restriction (CR) and resveratrol (RSV) have been shown to improve learning and memory, but their potential effects in juvenile animals were unknown. Here, we evaluated the effects of RSV and CR on learning and memory function in juvenile mice and investigated potential molecular mechanisms. MET...

journal_title：Iranian journal of basic medical sciences

authors： Xu BL,Wang R,Ma LN,Dong W,Zhao ZW,Zhang JS,Wang YL,Zhang X

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVES:Obesity considered being a low-grade inflammatory disease. The objective of this study was to examine the association between inflammatory markers (IM) including C-reactive protein (hs-CRP), Interleukin-6 (IL-6), and homocystein (Hcy) and obesity-related factors (e.g. BMI, waist, hip) in adult participants o...

journal_title：Iranian journal of basic medical sciences

authors： Faam B,Zarkesh M,Daneshpour MS,Azizi F,Hedayati M

更新日期：2014-08-01 00:00:00

abstract：:Sulfur mustard (SM, bis- (2-chloroethyl) sulphide) is a chemical warfare agent that causes DNA alkylation, protein modification and membrane damage. SM can trigger several molecular pathways involved in inflammation and oxidative stress, which cause cell necrosis and apoptosis, and loss of cells integrity and function...

journal_title：Iranian journal of basic medical sciences

authors： Imani S,Panahi Y,Salimian J,Fu J,Ghanei M

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVES:Cyclooxygenases (COXs) are known to play some roles in physiological mechanisms related to learning and memory. Since sodium salicylate is an inhibitor of COX, we have evaluated the effect of peripheral and intra-hippocampal administration of sodium salicylate on spatial learning and memory in male rats. MA...

journal_title：Iranian journal of basic medical sciences

authors： Azimi L,Pourmotabbed A,Ghadami MR,Nedaei SE,Pourmotabbed T

更新日期：2012-03-01 00:00:00

abstract：OBJECTIVES:Asthma results from the interaction between genetic and environmental factors. ADAM33 gene on chromosome 20p13 is associated with asthma and airway hyperresponsiveness. MATERIALS AND METHODS:This is a case-control study, where four SNPs S1 (rs3918396), T1 (rs2280091), T2 (rs2280090), V4 (rs2787094) of ADAM3...

journal_title：Iranian journal of basic medical sciences

authors： Karimi MR,Faridhosseini R,Abbaszadegan MR,Azad FJ,Shirkani A,Riyahi A,Montazar M,Gholamin M

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVES:The purpose of the current study was to assess the feasibility of microspheres from biocompatible polymer for oral bioavailability (BA) enhancement of potent sulfonamide- type loop diuretic- Furosemide - which used in the treatment of congestive heart failure, caused edema, cirrhosis, renal disease and as an...

journal_title：Iranian journal of basic medical sciences

authors： Derakhshandeh K,Karimi M,Azandaryani AH,Bahrami G,Ghanbari K

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVES:Production of extended-spectrum beta-lactamases (ESBLs) by enteric bacteria continues to be a major problem in hospitals and community. ESBLs producing bacteria cause many serious infections including urinary tract infections, peritonitis, cholangitis and intra-abdominal abscess. The aim of this study was to...

journal_title：Iranian journal of basic medical sciences

authors： Zaniani FR,Meshkat Z,Naderi Nasab M,Khaje-Karamadini M,Ghazvini K,Rezaee A,Esmaily H,Nabavinia MS,Darban Hoseini M

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE(S):The effect of prolonged overtraining on cytokine kinetics was compared with moderate exercise in the present study. MATERIALS AND METHODS:Male Wistar rats were randomly divided into control sedentary (C), moderate trained (MT), (V=20 m/min, 30 min/day for 6 days a week, 8 weeks), overtrained (OT) (V=25 m/...

journal_title：Iranian journal of basic medical sciences

authors： Gholamnezhad Z,Boskabady MH,Hosseini M,Sankian M,Khajavi Rad A

更新日期：2014-01-01 00:00:00

abstract：Objectives:Prompt detection of extended-spectrum β-lactamases (ESBL) and carbapenemase-producing enterobacteriaceae is crucial for infection prevention and control strategies. The present study aimed to characterize the ESBL and carbapenemase genes among Enterobacter isolates from an Iranian inpatient population. Mate...

journal_title：Iranian journal of basic medical sciences

authors： Khashei R,Edalati Sarvestani F,Malekzadegan Y,Motamedifar M

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE(S):Pre-eclampsia is characterized by hypertension, dyslipidemia, and increased systemic inflammatory response and has been associated with an increased maternal risk of cardiovascular disease later in life. Endothelial dysfunction is thought to be a central pathogenic feature in pre-eclampsia on the basis of ...

journal_title：Iranian journal of basic medical sciences

authors： Farzadnia M,Ayatollahi H,Hasan-Zade M,Rahimi HR

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVES:Prostaglandins have been shown to mediate the gastro-protective effect of sodium hydrosulfide (NaHS) but effect of NaHS on mRNA expression of prostaglandin E2 receptors (EP1, 3-4; EPs) has not been investigated. Therefore, this study designed to evaluate the effect of NaHS on mRNA expression of EPs receptors...

journal_title：Iranian journal of basic medical sciences

authors： Mard SA,Mahini S,Dianat M,Farbood Y

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the methylation status and mRNA expression levels of P15, death-associated protein kinase (DAPK), and suppressor of cytokine signaling-1 (SOCS1) genes in multiple myeloma (MM). MATERIALS AND METHODS:The bone marrow samples of 54 MM patients were collected and the met...

journal_title：Iranian journal of basic medical sciences

authors： Liu L,Tan L,He Z

更新日期：2016-07-01 00:00:00

abstract：Objectives:Renal ischemia-reperfusion injury (IRI) as a severe condition of acute kidney injury (AKI) is the most common clinical problem with high mortality rates of 35-60% deaths in hospital. Mesenchymal stem cells (MSC) due to unique regenerative characteristics are ideal candidates for the treatment of the ischemic...

journal_title：Iranian journal of basic medical sciences

authors： Havakhah S,Sankian M,Kazemzadeh GH,Sadri K,Bidkhori HR,Naderi-Meshkin H,Ebrahimzadeh Bideskan A,Niazmand S,Bahrami AR,Khajavi Rad A

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE(S):Drug resistant Acinetobacter baumannii have emerged as a major problem in many hospitals and intensive care units. Various types of extended spectrum beta-lactamases (ESBLs) are responsible for resistance to beta-lactam antibiotics in different parts of the world. The objective of this study was to determi...

journal_title：Iranian journal of basic medical sciences

authors： Farajnia S,Azhari F,Alikhani MY,Hosseini MK,Peymani A,Sohrabi N

更新日期：2013-06-01 00:00:00

abstract：Objectives:The present paper aims to review the studies describing the interactions between HopQ and CEACAMs along with possible mechanisms responsible for pathogenicity of Helicobacter pylori. Materials and Methods:The literature was searched on "PubMed" using different key words including Helicobacter pylori, CEACAM...

journal_title：Iranian journal of basic medical sciences

authors： Xia R,Zhang B,Wang X,Jia Q

更新日期：2019-07-01 00:00:00

abstract：Objectives:Alginates play a key role in mucoid Pseudomonas aeruginosa colonization, biofilm formation, and driving out of cationic antibiotics. P. aeruginosa alginate lyase (AlgL) is a periplasmic enzyme that is necessary for alginate synthesis and secretion. It also has a role in depolymerization of alginates. Using A...

journal_title：Iranian journal of basic medical sciences

authors： Piroozmand F,Ghadam P,Zarrabi M,Abdi-Ali A

更新日期：2020-04-01 00:00:00