The Prevalence of TEM and SHV Genes among Extended-Spectrum Beta-Lactamases Producing Escherichia Coli and Klebsiella Pneumoniae.

abstract：OBJECTIVES:Pseudomonas aeruginosa is a Gram-negative and aerobic rod bacterium that displays mucoid and non-mucoid phenotype. Mucoid strains secrete alginate, which is the main agent of biofilms in chronic P. aeruginosa infections, show high resistance to antibiotics; consequently, the biological disruption of mucoid P...

journal_title：Iranian journal of basic medical sciences

authors： Ghadam P,Akhlaghi F,Ali AA

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVES:HTLVI-1 is the first human retrovirus with limited endemic regions in the world. The epidemiological studies have shown that the genetic background and immune response to the virus have a significant role in HTLV-I-associated diseases. Among the genes are involved in HTLV-I infection, the role of human leuko...

journal_title：Iranian journal of basic medical sciences

authors： Tafreshian AR,Etemadi M,Farid-Hosseini R,Salhi M,Afshari JT

更新日期：2014-10-01 00:00:00

abstract：Objectives:We investigated the role of nitric oxide (NO) in the protective effects of remote ischemic per-conditioning (rIPerC) on renal ischemia/reperfusion (I/R) injury in male rats. Materials and Methods:I/R treatment consisted of 45 min bilateral renal artery ischemia and 24 hr reperfusion interval. rIPerC was per...

journal_title：Iranian journal of basic medical sciences

authors： Gholampour F,Khangah L,Vatanparast J,Karbalaei-Heidari HR,Owji SM,Bahaoddini A

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVES:Eukaryotic translation initiation factor 4E (eIF4E) is overexpressed in cervical cancer (CC). However, the molecular mechanisms are unclear. This study aimed to investigate the molecular mechanism of eIF4E gene overexpression in CC. MATERIALS AND METHODS:The human papillomavirus (HPV) type 18 E7 and eIF4E m...

journal_title：Iranian journal of basic medical sciences

authors： Pang T,Wang S,Gao M,Kang H,Zhao Y,Yao Y,Hu X

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE(S):Non-Hodgkin's lymphoma (NHL) is a lymphoproliferative malignancy in which cells undergo microscopic changes with unknown etiology, and risk factors such as age, sex, genetic and environmental factors are involved. The relationship between the presence of infectious agents and the development of lymphoproli...

journal_title：Iranian journal of basic medical sciences

authors： Rastin M,Khoee AR,Tabasi N,Sheikh A,Ziaolhagh S,Esmaeeli E,Zamani S,Khazaee M,Mahmoudi M

更新日期：2013-03-01 00:00:00

abstract：Objectives:Eupafolin, a major active component of Eupatorium perfoliatum L., has anti-inflammatory and anti-oxidant properties. Lipopolysaccharide (LPS) is responsible for myocardial depression. A line of evidences revealed that LPS induces autophagy in cardiomyocytes injury. This study aims to evaluate the effects of ...

journal_title：Iranian journal of basic medical sciences

authors： Gao Y,Zhang Y,Fan Y

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVES:Intracerebral injection of bone marrow stromal cells (BMSCs) is being investigated as a therapeutic tool to prevent Alzheimer's disease (AD). Our aim was to investigate the effects of BMSCs by intrathecal injection in AD rat model. MATERIALS AND METHODS:BMSCs were obtained from the bone marrow of Wistar rat...

journal_title：Iranian journal of basic medical sciences

authors： Eftekharzadeh M,Nobakht M,Alizadeh A,Soleimani M,Hajghasem M,Kordestani Shargh B,Karkuki Osguei N,Behnam B,Samadikuchaksaraei A

更新日期：2015-05-01 00:00:00

abstract：:Thromboangiitis obliterans (TAO) is a thrombotic-occlusive as well as an inflammatory peripheral vascular disease with unknown etiology. Recent evidence has supported the immunopathogenesis of the disease, however, the factors contributing to the altered immune function and vascular tissue inflammation are still uncle...

journal_title：Iranian journal of basic medical sciences

authors： Shapouri-Moghaddam A,Saeed Modaghegh MH,Rahimi HR,Ehteshamfar SM,Tavakol Afshari J

更新日期：2019-03-01 00:00:00

abstract：:Metastasis is the primary cause of mortality and morbidity among cancer patients and accounts for about 90% of cancer deaths. The most common types of treatment for cancer metastasis are chemotherapy and radiotherapy. However, such therapy has many serious side effects that could diminish the quality of life in patien...

journal_title：Iranian journal of basic medical sciences

authors： Ahmadiankia N

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE(S):Based on knowledge from traditional herbal medicine, Ferula assa-foetida (asafoetida) has several therapeutic applications but there is less knowledge about its effect on neurons. MATERIALS AND METHODS:In order to evaluate neuronal differentiation, neuronal like cells were stained against neuronal specifi...

journal_title：Iranian journal of basic medical sciences

authors： Homayouni Moghadam F,Vakili Zarch B,Shafiei M

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVES:Fumonisins are a group of toxic and carcinogenic mycotoxins, which contaminate the grains and their products. The aim of this study was to examine the apoptotic and proliferative activity of mouse gastric mucosa following administration of fumonisin B1 (FB1). MATERIALS AND METHODS:Twenty-nine female mice di...

journal_title：Iranian journal of basic medical sciences

authors： Alizadeh AM,Mohammadghasemi F,Zendehdel K,Kamyabi-Moghaddam Z,Tavassoli A,Amini-Najafi F,Khosravi A

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVES:Cyclooxygenases (COXs) are known to play some roles in physiological mechanisms related to learning and memory. Since sodium salicylate is an inhibitor of COX, we have evaluated the effect of peripheral and intra-hippocampal administration of sodium salicylate on spatial learning and memory in male rats. MA...

journal_title：Iranian journal of basic medical sciences

authors： Azimi L,Pourmotabbed A,Ghadami MR,Nedaei SE,Pourmotabbed T

更新日期：2012-03-01 00:00:00

abstract：Objectives:Chemotherapies used to treat colon cancer might often fail due to the emergence of chemoresistance and side effects. Escherichia coli Nissle 1917 (EcN) is a beneficial probiotic, whose molecular mechanisms in the prevention of colon cancer are yet to be fully understood. The present study assessed the anti-c...

journal_title：Iranian journal of basic medical sciences

authors： Alizadeh S,Esmaeili A,Omidi Y

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVES:The utilization of molecular techniques in the epidemiology of tuberculosis have provided an opportunity for using effective markers to trace the transmission of the disease. The purpose of this study was to compare the genetic patterns of Mycobacterium tuberculosis by three methods of RFLP technique. MATER...

journal_title：Iranian journal of basic medical sciences

authors： Farazi A,Jabbariasl M,Tadayon K,Mossavar N,Keshavarz R,Hoseini SD

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVES:Hepatitis C is a major cause of liver failure worldwide. Current therapies applied for this disease are not fully effective and produce side effects in most cases. Non-structural protein 3 helicase (NS3) of HCV is one of the key enzymes in viral replication and infection. Therefore, this region is a promisin...

journal_title：Iranian journal of basic medical sciences

authors： Sadri M,Farajollahi MM,Sharifi Z

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVES:Astrodaucus persicus, Apiaceae, is used as vegetable or food additive in some parts of Iran. The essential oils of different parts of Astrodaucus persicus from Kordestan province were analyzed for the first time and compared with other regions. In this study, antioxidant activities and total phenols determin...

journal_title：Iranian journal of basic medical sciences

authors： Goodarzi S,Hadjiakhoondi A,Yassa N,Khanavi M,Tofighi Z

更新日期：2016-02-01 00:00:00

abstract：Objectives:Cholinergic neurons are important neurons in the Pedunculopontine tegmental nucleus (PPT). In this study, nicotinic receptor of the PPT in central cardiovascular regulation in the anesthetized rat was evaluated. Materials and Methods:Saline, acetylcholine (Ach; doses: 90 and 150 nmol), hexamethonium (Hexa; ...

journal_title：Iranian journal of basic medical sciences

authors： Nikyar T,Hosseini M,Niazmand S,Shafei MN

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE(S):Cerebral hypoperfusion/ischemia (CHI) is a neurological disease where impaired hippocampus electrical activity and cognition caused by a serial pathophysiological events. This study aimed to evaluate the effects of chronic oral administration of grape seed extract (GSE) on passive avoidance memory and long...

journal_title：Iranian journal of basic medical sciences

authors： Sarkaki A,Rafieirad M,Hossini SE,Farbood Y,Motamedi F,Mansouri SM,Naghizadeh B

更新日期：2013-09-01 00:00:00

abstract：Objectives:Resveratrol (RSV) is a naturally occurring plant polyphenol with cardioprotective, neuroprotective, immunoregulatory, and anticancer properties and is biologically effective against various diseases. This study aimed to investigate the chemopreventive effect of different doses of RSV against hepatocellular c...

journal_title：Iranian journal of basic medical sciences

authors： Karabekir SC,Özgörgülü A

更新日期：2020-01-01 00:00:00

abstract：Objectives:The main goal of the current research was to examine the effects of Berberine (BBR) on apoptotic signaling and hippocampal oxidative stress induced by common carotid artery occlusion. Materials and Methods:Chronic cerebral hypoperfusion (CCH) model was created by occluding the two common carotid arteries (t...

journal_title：Iranian journal of basic medical sciences

authors： Pirmoradi Z,Yadegari M,Moradi A,Khojasteh F,Zare Mehrjerdi F

更新日期：2019-02-01 00:00:00

abstract：Objectives:Neurodegeneration is an outcome of Methamphetamine (METH) abuse. Studies have emphasized on the neuroprotective properties of lithium. The current study is designed towards evaluating the role of Akt-1/GSK3 and CREB-BDNF signaling pathways in mediating lithium neuroprotection against METH-induced neurodegene...

journal_title：Iranian journal of basic medical sciences

authors： Mehrafza S,Kermanshahi S,Mostafidi S,Motaghinejad M,Motevalian M,Fatima S

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVES:Lipocalin 2 (Lcn2) is a 25-kDa glycoprotein that has initially been extracted from neutrophil granules. Expression of Lcn2 is induced under various pathophysiological conditions. It is also known as an early marker of kidney and heart injury. High-level expression of recombinant Lcn2 neutrophil gelatinase-as...

journal_title：Iranian journal of basic medical sciences

authors： Rouhbakhsh M,Halabian R,Masroori N,Mohammadi Pour M,Bahmani P,Mohammadi Roush A,Jahanian-Najafabadi A,Habibi Roudkenar M

更新日期：2012-05-01 00:00:00

abstract：Objectives:Prompt detection of extended-spectrum β-lactamases (ESBL) and carbapenemase-producing enterobacteriaceae is crucial for infection prevention and control strategies. The present study aimed to characterize the ESBL and carbapenemase genes among Enterobacter isolates from an Iranian inpatient population. Mate...

journal_title：Iranian journal of basic medical sciences

authors： Khashei R,Edalati Sarvestani F,Malekzadegan Y,Motamedifar M

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE(S):Spermatogonial Stem Cells (SSCs) maintain spermatogenesis throughout the life of the male. Because of the small number of SSCs in adult, enriching and culturing them is a crucial step prior to differentiation or transplantation. Maintenance of SSCs and transplantation or induction of in vitro spermio-genes...

journal_title：Iranian journal of basic medical sciences

authors： Rastegar T,Minaee MB,Habibi Roudkenar M,Raghardi Kashani I,Amidi F,Abolhasani F,Barbarestani M

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVES:Tadalafil can restore endothelial function and treat atherosclerosis. However, the effect of tadalafil on transplant arteriosclerosis remains unclear. In this study, we explore the effects of tadalafil on allograft vasculopathy. MATERIALS AND METHODS:Male Brow-Norway rats supplied aorta grafts for Male Lewi...

journal_title：Iranian journal of basic medical sciences

authors： Ziqiang X,Jingjun W,Jianjian Z,Yong L,Peng X

更新日期：2015-09-01 00:00:00

abstract：Objectives:Gallic acid (GA) is a highly effective antioxidant, which its beneficial effects are well known, but its impact on expression of microRNAs (miRs) following hepatic ischemia-reperfusion (I/R) is not well recognized. Therefore, the current research was designed to specify the beneficial effect of GA on miRs (1...

journal_title：Iranian journal of basic medical sciences

authors： Akbari G,Savari F,Mard SA,Rezaie A,Moradi M

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVES:Although previous studies have confirmed the beneficial effects of human umbilical cord matrix stem cell (hUCM) transplantation post myocardial infarction (MI), but this stem cell resource has no potential to induce angiogenesis. In order to achieve the process of angiogenesis and cardiomyocyte regeneration,...

journal_title：Iranian journal of basic medical sciences

authors： Moradi K,Abbasi M,Aboulhasani F,Abbasi N,Babatunde KA,Sargolzaeiaval F,Dehpour AR

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVES:Obesity considered being a low-grade inflammatory disease. The objective of this study was to examine the association between inflammatory markers (IM) including C-reactive protein (hs-CRP), Interleukin-6 (IL-6), and homocystein (Hcy) and obesity-related factors (e.g. BMI, waist, hip) in adult participants o...

journal_title：Iranian journal of basic medical sciences

authors： Faam B,Zarkesh M,Daneshpour MS,Azizi F,Hedayati M

更新日期：2014-08-01 00:00:00

abstract：Objectives:Several lines of evidence showed that minocycline possesses antioxidant and anti-inflammatory properties. This study aimed to demonstrate the effects of minocycline in rats subjected to chronic constriction injury (CCI). Materials and Methods:In this study four groups (n = 6-8) of rats were used as follows:...

journal_title：Iranian journal of basic medical sciences

authors： Abbaszadeh A,Darabi S,Hasanvand A,Amini-Khoei H,Abbasnezhad A,Choghakhori R,Aaliehpour A

更新日期：2018-02-01 00:00:00

abstract：Objectives:Heparin-binding hemagglutinin (HBHA), a mycobacterial cell surface protein, mediates adhesion to nonphagocytic cells and the dissemination of Mycobacterium tuberculosis (M. tuberculosis) from the site of primary infection. Superior expression systems are required to obtain abundant M. tuberculosis proteins f...

journal_title：Iranian journal of basic medical sciences

authors： Teng X,Chen X,Zhu K,Xu H

更新日期：2018-02-01 00:00:00