Abstract：
Objectives:Ferula ovina is an Iranian medicinal plant. Tschimgine and stylosin are two of its major monoterpene derivatives. In this study, we proceeded to investigate some fungal endophytes from F. ovina that can produce plant secondary metabolites. Materials and Methods:The isolated endophytic fungi were fermented in potato dextrose broth (PDB) medium and their extracts were screened for the presence of the plant compounds by liquid chromatography-tandem mass spectrometry (LC-MS). Endophytes identification was performed by morphological and molecular methods. Three markers (ITS, LSU, and TEF1) were used for accurate molecular identification. Results:Forty isolates from 9 different genera of endophytic fungi were identified, of which two recently reported species of O. ferulica and Pithoascus persicus were able to produce tschimgine and stylosin. Conclusion:These fungi can be used as a substitute for the production of plant's medicinal compounds independent of wild populations of the source plant.
journal_name
Iran J Basic Med Scijournal_title
Iranian journal of basic medical sciencesauthors
Tazik Z,Rahnama K,White JF,Soltanloo H,Hasanpour M,Iranshahi Mdoi
10.22038/ijbms.2020.46334.10703subject
Has Abstractpub_date
2020-12-01 00:00:00pages
1565-1570issue
12eissn
2008-3866issn
2008-3874journal_volume
23pub_type
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