Correlational studies on insulin resistance and leptin gene polymorphisms in peritoneal dialysis patients.

Abstract:

OBJECTIVES:The aim of the study was to investigate the relationship between insulin resistance (IR) and leptin (LEP) gene polymorphisms in peritoneal dialysis (PD) patients. MATERIALS AND METHODS:From July 1, 2011 to August 1, 2011, patients who received chronic PD were chosen and divided into three groups (DM, high HOMR-IR, and low HOMR-IR). Two PCR products of LEP were sequenced and aligned and the distribution of polymorphisms was analyzed using χ(2) analysis. In addition, serum leptin level, PD conditions, and biochemical parameters according to different genotype of G-2548A and A19G were statistically analyzed (P-value<0.05). The relationship between LEP gene polymorphisms and prognosis was explored. RESULTS:Totally 157 patients with average age of 55±15 years old were chosen. Distribution of genotype frequencies was complied with Hardy-Weinberg equilibrium. Leptin level and BMI (body mass index) of the GG genotype of G-2548A were higher than that of GA or AA. The fasting glucose, cholesterol, etc. of AA genotype were lower, and the nPCR was higher than the two other genotypes. Serum leptin level and BMI of AA genotype of A19G was higher than GA and GG genotypes; meanwhile, fasting blood glucose of that genotypes was the highest. In addition, survival rate of AA group of A19G was very low. CONCLUSION:The G-2548A and A19G polymorphisms were correlated with serum leptin level and IR. Leptin A19G polymorphism may be prognostic for PD patients. This study may facilitate early intervention for IR in PD patients.

journal_name

Iran J Basic Med Sci

authors

Cao L,Mou S,Fang W,Qi C,Chang X,Gu L,Qian J,Ni Z

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

878-86

issue

9

eissn

2008-3866

issn

2008-3874

journal_volume

18

pub_type

杂志文章
  • Biochemical and computational study of an alginate lyase produced by Pseudomonas aeruginosa strain S21.

    abstract:Objectives:Alginates play a key role in mucoid Pseudomonas aeruginosa colonization, biofilm formation, and driving out of cationic antibiotics. P. aeruginosa alginate lyase (AlgL) is a periplasmic enzyme that is necessary for alginate synthesis and secretion. It also has a role in depolymerization of alginates. Using A...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/ijbms.2020.37277.8874

    authors: Piroozmand F,Ghadam P,Zarrabi M,Abdi-Ali A

    更新日期:2020-04-01 00:00:00

  • Use of 5-Enolpyruvylshikmate-3-Phosphate Synthase Encoding Gene for Typing of Staphylococcus aureus Isolated from Skin and Urinary Tract Infections of Human.

    abstract:OBJECTIVE(S):Staphylococcus aureus is both a successful human commensal and a major pathogen. In this study we investigated the genetic diversity of 26 S. aureus isolates recovered from human skin and urinary tract infections. MATERIALS AND METHODS:Typing procedure for the studied S. aureus isolates was performed base...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Talebi-Satlou R,Ahmadi M,Ghavam F,Saei HD

    更新日期:2012-07-01 00:00:00

  • Evaluation of nicotinic receptor of pedunculopontine tegmental nucleus in central cardiovascular regulation in anesthetized rat.

    abstract:Objectives:Cholinergic neurons are important neurons in the Pedunculopontine tegmental nucleus (PPT). In this study, nicotinic receptor of the PPT in central cardiovascular regulation in the anesthetized rat was evaluated. Materials and Methods:Saline, acetylcholine (Ach; doses: 90 and 150 nmol), hexamethonium (Hexa; ...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/IJBMS.2018.25616.6319

    authors: Nikyar T,Hosseini M,Niazmand S,Shafei MN

    更新日期:2018-04-01 00:00:00

  • Staging of colorectal cancer using serum metabolomics with 1HNMR Spectroscopy.

    abstract:OBJECTIVES:Determination of stages of colon cancer is done by biopsy usually after surgery. Metabolomics is the study of all the metabolites using LC-MS and 1HNMR spectroscopy with chemometric techniques. The stages of colon cancer were detected from patients' sera using 1HNMR. MATERIALS AND METHODS:Five ml blood was ...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/IJBMS.2017.9022

    authors: Vahabi F,Sadeghi S,Arjmand M,Mirkhani F,Hosseini E,Mehrabanfar M,Hajhosseini R,Iravani A,Bayat P,Zamani Z

    更新日期:2017-07-01 00:00:00

  • Evaluation of immune response after moderate and overtraining exercise in wistar rat.

    abstract:OBJECTIVE(S):The effect of prolonged overtraining on cytokine kinetics was compared with moderate exercise in the present study. MATERIALS AND METHODS:Male Wistar rats were randomly divided into control sedentary (C), moderate trained (MT), (V=20 m/min, 30 min/day for 6 days a week, 8 weeks), overtrained (OT) (V=25 m/...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Gholamnezhad Z,Boskabady MH,Hosseini M,Sankian M,Khajavi Rad A

    更新日期:2014-01-01 00:00:00

  • Potential therapeutic effect of pomegranate seed oil on ovarian ischemia/reperfusion injury in rats.

    abstract:Objectives:The aim of this study is to determine the therapeutic effects of pomegranate seed oil, which is a powerful antioxidant and anti-inflammatory agent, on ovarian-ischemia and reperfusion injury in rats. Materials and Methods:Fifty-six female albino Wistar rats were divided into 7 equal groups. Group 1; Sham Op...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/ijbms.2018.30149.7268

    authors: Yayla M,Cetin D,Adali Y,Kilicle PA,Toktay E

    更新日期:2018-12-01 00:00:00

  • The Extract of Crocus sativus and Its Constituent Safranal, Affect Serum Levels of Endothelin and Total Protein in Sensitized Guinea Pigs.

    abstract:OBJECTIVE(S):The effect of the extract of Crocus sativus and its constituent, safranal on inflammatory markers in sensitized guinea pigs was examined. MATERIALS AND METHODS:Ovalbumin (OA) sensitized guinea pigs were given drinking water alone (group S), or drinking water containing three concentrations of safranal, th...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Gholamnezhad Z,Koushyar H,Byrami G,Boskabady MH

    更新日期:2013-09-01 00:00:00

  • Cadmium chloride treatment of rats significantly impairs membrane integrity of mesenchymal stem cells via electrolyte imbalance and lipid peroxidation, a possible explanation of Cd related osteoporosis.

    abstract:OBJECTIVES:Bone marrow mesenchymal stem cells (MSCs) play an important role in bone health. Cadmium causes osteoporosis, but the exact mechanisms of its effect on MSCs are not known. MATERIALS AND METHODS:Rats were treated with cadmium chloride (40 mg/l) in drinking water for six weeks, and then the biochemical and mo...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/IJBMS.2017.8356

    authors: Abnosi MH,Golami S

    更新日期:2017-03-01 00:00:00

  • Deregulation of miR-21 and miR-155 and their putative targets after silibinin treatment in T47D breast cancer cells.

    abstract:OBJECTIVES:MicroRNAs (miRNAs) are a class of short RNAs that control the biological processes including cell proliferation, apoptosis and development. Aberrant expression of miRNAs was determined in the different stages of tumor development and metastasis. To study the effect of silibinin on miRNAs expression, we evalu...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Zadeh MM,Ranji N,Motamed N

    更新日期:2015-12-01 00:00:00

  • Oxidative stress, biochemical alterations, and hyperlipidemia in female rats induced by lead chronic toxicity during puberty and post puberty periods.

    abstract:OBJECTIVES:Lead (Pb) is a toxic metal inducing many destructive effects leading to a broad range of physiological, biochemical, and neurological dysfunctions in humans and laboratory animals. MATERIALS AND METHODS:Here, we investigated the effect of chronic exposure to Pb (50 mg/l) on oxidative stress, hepatotoxicity,...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Alya A,Ines DB,Montassar L,Najoua G,Saloua el F

    更新日期:2015-10-01 00:00:00

  • Effect of Crocus sativus extracts and its active constituent safranal on the harmaline-induced tremor in mice.

    abstract:OBJECTIVES:Due to unsatisfactory response or intolerable side effects of current drugs, treatment of essential tremor remains inadequate. Thus, we aimed to investigate the protective and therapeutic effects of aqueous and ethanolic extracts of Crocus sativus (saffron), and its active consistent, safranal, on the harmal...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Amin B,Malekzadeh M,Heidari MR,Hosseinzadeh H

    更新日期:2015-05-01 00:00:00

  • Protective effects of piperine on lead acetate induced-nephrotoxicity in rats.

    abstract:Objectives:In this study, we investigated the protective effects of piperine on lead acetate-induced renal damage in rat kidney tissue. Materials and Methods:Forty male rats were divided into 5 groups: negative control (rats were given aquadest daily), positive control (rats were given lead acetate 30 mg/kg BW orally ...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/IJBMS.2017.9487

    authors: Sudjarwo SA,Eraiko K,Sudjarwo GW,Koerniasari

    更新日期:2017-11-01 00:00:00

  • Aloe vera toxic effects: expression of inducible nitric oxide synthase (iNOS) in testis of Wistar rat.

    abstract:OBJECTIVES:Nitric oxide (NO), a product of inducible nitric oxide synthase (iNOS), contributes in germ cell apoptosis. This study was aimed to evaluate the effects of Aloe vera gel (AVG) on male Wistar rat reproductive organ, serum NO level, and expression of iNOS gene in leydig cells. MATERIALS AND METHODS:Adult male...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Asgharzade S,Rafieian-Kopaei M,Mirzaeian A,Reiisi S,Salimzadeh L

    更新日期:2015-10-01 00:00:00

  • Naringin enhances osteogenic differentiation through the activation of ERK signaling in human bone marrow mesenchymal stem cells.

    abstract:OBJECTIVES:Naringin has been reported to regulate bone metabolism. However, its effect on osteogenesis remains unclear. The aim was to investigate the effect of naringin on osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs) through the activation of the ERK signaling pathway in osteogenic d...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/IJBMS.2017.8582

    authors: Wang H,Li C,Li J,Zhu Y,Jia Y,Zhang Y,Zhang X,Li W,Cui L,Li W,Liu Y

    更新日期:2017-04-01 00:00:00

  • Moisturizing effects of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) using deionized and magnetized water by in vivo and in vitro methods.

    abstract:Objectives:The present study aimed to determine and compare moisturizing and occlusion effects of different solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) using magnetized water and deionized water. Materials and Methods:SLN formulations were prepared using various lipids, including Tripalmiti...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/IJBMS.2020.39587.9397

    authors: Sarhadi S,Gholizadeh M,Moghadasian T,Golmohammadzadeh S

    更新日期:2020-03-01 00:00:00

  • Calcium sensing receptor involving in therapy of embryonic stem cell transplantation alleviates acute myocardial infarction by inhibiting apoptosis and oxidative stress in rats.

    abstract:Objectives:The aims of the present study were to investigate the expression of calcium sensing receptor (CaSR) at different times in acute myocardial infarction (AMI) rat myocardial tissue after mouse embryonic stem cells (mESCs) transplantation treatment and to assess its effects on apoptosis and oxidative stress of c...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/ijbms.2020.47436.10916

    authors: Yuan H,Yang G,Li S,Li L,Wei T,Song G,Luan H,Meng J,Wang Q,Yu Y,Sun J

    更新日期:2020-10-01 00:00:00

  • Medicinal plants for gingivitis: a review of clinical trials.

    abstract:Objectives:Periodontal diseases are among prevalent oral health problems which may ultimately lead to severe complications in oral cavity. Herbal products can be designed as single or multicomponent preparations for better oral health. This study aims to review current clinical trials on the effectiveness of herbal pro...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章,评审

    doi:10.22038/IJBMS.2018.31997.7690

    authors: Safiaghdam H,Oveissi V,Bahramsoltani R,Farzaei MH,Rahimi R

    更新日期:2018-10-01 00:00:00

  • Comparison of the effects of resveratrol and caloric restriction on learning and memory in juvenile C57BL/6J mice.

    abstract:OBJECTIVES:Both caloric restriction (CR) and resveratrol (RSV) have been shown to improve learning and memory, but their potential effects in juvenile animals were unknown. Here, we evaluated the effects of RSV and CR on learning and memory function in juvenile mice and investigated potential molecular mechanisms. MET...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Xu BL,Wang R,Ma LN,Dong W,Zhao ZW,Zhang JS,Wang YL,Zhang X

    更新日期:2015-11-01 00:00:00

  • Chronic effects of aerobic exercise on gene expression of LOX-1 receptor in the heart of rats fed with high fat diet.

    abstract:OBJECTIVES:Lectin-like low density lipoprotein receptor (LOX-1) has pivot role in vascular complications, which is upregulated in numerous pathological conditions. Since exercise has beneficial effects in prevention of hyperlipidemic complications, present study examined protective effects of aerobic exercise through r...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Riahi S,Mohammadi MT,Sobhani V,Soleimany M

    更新日期:2015-08-01 00:00:00

  • Soluble uric acid induces inflammation via TLR4/NLRP3 pathway in intestinal epithelial cells.

    abstract:Objectives:Hyperuricemia is a risk for cardiovascular and metabolic diseases, but the mechanism is ambiguous. Increased intestinal permeability is correlated with metabolic syndrome risk factors. Intestinal epithelial cells play a pivotal role in maintaining intestinal permeability. Uric acid is directly eliminated int...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/ijbms.2020.44948.10482

    authors: Ma C,Yang X,Lv Q,Yan Z,Chen Z,Xu D,Liu X,Yang W,Xing S

    更新日期:2020-06-01 00:00:00

  • Probiotic supplementation improves the cognitive function and the anxiety-like behaviors in the stressed rats.

    abstract:Objectives:Prenatal stresses increase incidence of neurodevelopmental disorders and influence cognitive abilities. Glucocorticoids are released in stress condition as endpoint activation of hypothalamus-pituitary-adrenal (HPA) axis. Evidence indicates a cross-talk between gut microbiota and brain function. This study a...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/ijbms.2019.33956.8078

    authors: Hadizadeh M,Hamidi GA,Salami M

    更新日期:2019-05-01 00:00:00

  • Worldwide trends in scientific publications on association of gut microbiota with obesity.

    abstract:Objectives:Recent evidence has shown underlying roles of gut dysbiosis and metabolic endotoxemia in obesity and its complications. Despite the large number of experimental and clinical researches performed on gut microbiota and obesity, no bibliometrics' study has been conducted so far. We aimed to assess the trend of ...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章,评审

    doi:10.22038/ijbms.2018.30203.7281

    authors: Ejtahed HS,Tabatabaei-Malazy O,Soroush AR,Hasani-Ranjbar S,Siadat SD,Raes J,Larijani B

    更新日期:2019-01-01 00:00:00

  • Correlation between adolescent chronic emotional stress and incidence of adult cardiovascular disease in female rats.

    abstract:Objectives:Association of adolescent emotional stress (ES) with the incidence of cardiovascular disease (CVD) at older age was investigated. Materials and Methods:21 female rats were divided into three groups of 7 each; ES, foot-shock, and control. Chronic ES was induced by exposing the rats to witness foot-shock of t...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/ijbms.2019.32888.7857

    authors: Mousavi MS,Imani A,Meknatkhah S,Riazi G

    更新日期:2019-10-01 00:00:00

  • Voluntary and forced exercises prevent the development of tolerance to analgesic effects of morphine in rats.

    abstract:OBJECTIVES:Morphine is widely used to treat chronic pain. However, its utility is hindered by the development of tolerance to its analgesic effects. Despite the renowned beneficial effects of physical exercise on cognitive functions and signs of morphine withdrawal in morphine-dependent rats, little is known about the ...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Shokraviyan M,Miladi-Gorji H,Vaezi GH

    更新日期:2014-01-01 00:00:00

  • Synergistic bactericidal activity of a naturally isolated phage and ampicillin against urinary tract infecting Escherichia coli O157.

    abstract:Objectives:Bacteriophages are infectious replicating entities that are under consideration as antimicrobial bioagents to control bacterial infections. As an alternative or supplement to antibiotics, bacteriophages can be used to circumvent the resistance to existing antibiotics. The aim of this study was to assess the ...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/IJBMS.2019.37561.8989

    authors: Moradpour Z,Yousefi N,Sadeghi D,Ghasemian A

    更新日期:2020-02-01 00:00:00

  • Gestational diabetes influences retinal Muller cells in rat's offspring.

    abstract:OBJECTIVES:The Muller cell is the principal glial cell of the vertebrate retina. The expression of Glial fibrillary acidic protein (GFAP) in the Muller cells was used as a cellular marker for retinal damage. This study was done to evaluate the effect of gestational diabetes on retinal Muller cells in rat's offspring. ...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/ijbms.2017.8251

    authors: Tabasi A,Ghafari S,Mehdizadeh M,Shekari MA,Golalipour MJ

    更新日期:2017-02-01 00:00:00

  • Long-term administration of olanzapine induces adiposity and increases hepatic fatty acid desaturation protein in female C57BL/6J mice.

    abstract:Objectives:Weight gain and metabolic disturbances such as dyslipidemia, are frequent side effects of second-generation antipsychotics, including olanzapine. This study examined the metabolic effects of chronic olanzapine exposure. In addition, we investigated the hepatic fatty acid effects of olanzapine in female C57BL...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/IJBMS.2018.22759.5780

    authors: Hou PH,Chang GR,Chen CP,Lin YL,Chao IS,Shen TT,Mao FC

    更新日期:2018-05-01 00:00:00

  • Epigenetic: A missing paradigm in cellular and molecular pathways of sulfur mustard lung: a prospective and comparative study.

    abstract::Sulfur mustard (SM, bis- (2-chloroethyl) sulphide) is a chemical warfare agent that causes DNA alkylation, protein modification and membrane damage. SM can trigger several molecular pathways involved in inflammation and oxidative stress, which cause cell necrosis and apoptosis, and loss of cells integrity and function...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章,评审

    doi:

    authors: Imani S,Panahi Y,Salimian J,Fu J,Ghanei M

    更新日期:2015-08-01 00:00:00

  • Cancer/Testis genes in relation to sperm biology and function.

    abstract::Cancer testis antigens (CTAs), a large family of tumor-associated and immunogenic antigens expressed in human tumors of various histological origins, are highly restricted to the testis and trophoblast. CTAs have been identified as potent targets for tumor-specific immunotherapeutic advances and have immensely lead to...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章,评审

    doi:10.22038/IJBMS.2017.9259

    authors: Babatunde KA,Najafi A,Salehipour P,Modarressi MH,Mobasheri MB

    更新日期:2017-09-01 00:00:00

  • Urine Monocyte Chemoattractant Protein-1(UMCP-1) as a Biomarker of Renal Involvement in Systemic Lupus Erythematosus.

    abstract:OBJECTIVES:Lupus nephritis (LN) is frequently associated with a poor long-term prognosis. Renal biopsy is the diagnostic method of choice in this condition. Urine biomarkers have been mentioned in the diagnosis of LN. The study(,)s purpose was to evaluate the performance of urinary monocyte chemoattractant protein 1(UM...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Mirfeizi Z,Mahmoudi M,Naghibi M,Hatef M,Sharifipour F,Jokar M,Zeraati A,Shariati Sarabi Z,Azarian A

    更新日期:2012-11-01 00:00:00