Molecular mechanisms regulating immune responses in thromboangiitis obliterans: A comprehensive review.

abstract：Objectives:Traumatic brain injury (TBI) is one of the main causes of intellectual and cognitive disabilities. Clinically, it is essential to limit the development of cognitive impairment after TBI. In the present study, the neuroprotective effects of gallic acid (GA) on neurological score, memory, long-term potentiatio...

journal_title：Iranian journal of basic medical sciences

authors： Mirshekar MA,Sarkaki A,Farbood Y,Gharib Naseri MK,Badavi M,Mansouri MT,Haghparast A

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVES:Cyclooxygenases (COXs) are known to play some roles in physiological mechanisms related to learning and memory. Since sodium salicylate is an inhibitor of COX, we have evaluated the effect of peripheral and intra-hippocampal administration of sodium salicylate on spatial learning and memory in male rats. MA...

journal_title：Iranian journal of basic medical sciences

authors： Azimi L,Pourmotabbed A,Ghadami MR,Nedaei SE,Pourmotabbed T

更新日期：2012-03-01 00:00:00

abstract：OBJECTIVES:Primary or adult type hypolactasia, the most common enzyme deficiency in the world, is due to reduced lactase activity in the intestinal cell after weaning. Lactase non-persistence is inherited as an autosomal recessive trait. A DNA variant, single nucleotide polymorphism C/T-13910 which is located on 13910 ...

journal_title：Iranian journal of basic medical sciences

authors： Alizadeh M,Sadr-Nabavi A

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVES:Asthma results from the interaction between genetic and environmental factors. ADAM33 gene on chromosome 20p13 is associated with asthma and airway hyperresponsiveness. MATERIALS AND METHODS:This is a case-control study, where four SNPs S1 (rs3918396), T1 (rs2280091), T2 (rs2280090), V4 (rs2787094) of ADAM3...

journal_title：Iranian journal of basic medical sciences

authors： Karimi MR,Faridhosseini R,Abbaszadegan MR,Azad FJ,Shirkani A,Riyahi A,Montazar M,Gholamin M

更新日期：2014-09-01 00:00:00

abstract：Objectives:During the last years with increasing resistant bacteria to the most antibiotics bacteriophages are suggested as appropriate treatment option. To investigate lytic activity of bacteriophages there are indirect microbial procedures and direct methods. The present study to complement microbial procedures and i...

journal_title：Iranian journal of basic medical sciences

authors： Rahimzadeh G,Gill P,Rezai MS

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:Determination of stages of colon cancer is done by biopsy usually after surgery. Metabolomics is the study of all the metabolites using LC-MS and 1HNMR spectroscopy with chemometric techniques. The stages of colon cancer were detected from patients' sera using 1HNMR. MATERIALS AND METHODS:Five ml blood was ...

journal_title：Iranian journal of basic medical sciences

authors： Vahabi F,Sadeghi S,Arjmand M,Mirkhani F,Hosseini E,Mehrabanfar M,Hajhosseini R,Iravani A,Bayat P,Zamani Z

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVES:Endometriosis is a complex gynecologic disease with unknown etiology. Noscapine has been introduced as a cancer cell suppressor. Endometriosis was considered as a cancer like disorder, The aim of present study was to investigate noscapine apoptotic effect on human endometriotic epithelial and stromal cells i...

journal_title：Iranian journal of basic medical sciences

authors： Khazaei MR,Rashidi Z,Chobsaz F,Khazaei M

更新日期：2016-09-01 00:00:00

abstract：Objectives:Charcot-Marie Tooth disease (CMT) is one of the main inherited causes of motor and sensory neuropathies with variable expressivity and age-of onset. Although more than 70 genes have been identified for CMT, more studies are needed to discover other genes involved in CMT. Introduction of whole exome sequencin...

journal_title：Iranian journal of basic medical sciences

authors： Tahmasebi-Birgani M,Hajjari M,Golchin N,Shalbafan B,Mohammadi-Asl J,Sadeghian F

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to investigate the relationship between insulin resistance (IR) and leptin (LEP) gene polymorphisms in peritoneal dialysis (PD) patients. MATERIALS AND METHODS:From July 1, 2011 to August 1, 2011, patients who received chronic PD were chosen and divided into three groups (DM, high H...

journal_title：Iranian journal of basic medical sciences

authors： Cao L,Mou S,Fang W,Qi C,Chang X,Gu L,Qian J,Ni Z

更新日期：2015-09-01 00:00:00

abstract：Objectives:Methamphetamine (METH) is a powerful stimulant drug that directly affects the brain and induces neurological deficits. B12 is a water-soluble vitamin (vit) that is reported to attenuate neuronal degeneration. The goal of the present study is to investigate the effect of vitamin B12 on METH's neurodegenerativ...

journal_title：Iranian journal of basic medical sciences

authors： Moshiri M,Hosseiniyan SM,Moallem SA,Hadizadeh F,Jafarian AH,Ghadiri A,Hoseini T,Seifi M,Etemad L

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVES:This study aimed to examine the hypothesis that an antiarrhythmic effect might be obtained by ischemic preconditioning of the liver, and also to characterize the potential underlying mechanisms. MATERIALS AND METHODS:Male Wistar rats were anesthetized by thiopental sodium (50 mg/kg, IP) followed by IV injec...

journal_title：Iranian journal of basic medical sciences

authors： Noorbakhsh MF,Arab HA,Kazerani HR

更新日期：2015-01-01 00:00:00

abstract：Objectives:Recent evidence has shown underlying roles of gut dysbiosis and metabolic endotoxemia in obesity and its complications. Despite the large number of experimental and clinical researches performed on gut microbiota and obesity, no bibliometrics' study has been conducted so far. We aimed to assess the trend of ...

journal_title：Iranian journal of basic medical sciences

authors： Ejtahed HS,Tabatabaei-Malazy O,Soroush AR,Hasani-Ranjbar S,Siadat SD,Raes J,Larijani B

更新日期：2019-01-01 00:00:00

abstract：Objectives:The aim of the present research is to investigate the efficacy of L-carnitine (LC) as a complementary therapy to diclofenac sodium (Dic) treatment in a mono-iodoacetate (MIA) induced knee osteoarthritis (OA) rat model, with respect to pain relief and the underlying pathology. Materials and Methods:Fifty adu...

journal_title：Iranian journal of basic medical sciences

authors： Khodir SA,Al-Gholam MA,Salem HR

更新日期：2020-08-01 00:00:00

abstract：Objectives:Renal ischemia-reperfusion injury (IRI) as a severe condition of acute kidney injury (AKI) is the most common clinical problem with high mortality rates of 35-60% deaths in hospital. Mesenchymal stem cells (MSC) due to unique regenerative characteristics are ideal candidates for the treatment of the ischemic...

journal_title：Iranian journal of basic medical sciences

authors： Havakhah S,Sankian M,Kazemzadeh GH,Sadri K,Bidkhori HR,Naderi-Meshkin H,Ebrahimzadeh Bideskan A,Niazmand S,Bahrami AR,Khajavi Rad A

更新日期：2018-08-01 00:00:00

abstract：:Metastasis is the primary cause of mortality and morbidity among cancer patients and accounts for about 90% of cancer deaths. The most common types of treatment for cancer metastasis are chemotherapy and radiotherapy. However, such therapy has many serious side effects that could diminish the quality of life in patien...

journal_title：Iranian journal of basic medical sciences

authors： Ahmadiankia N

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVES:Parkinson's disease (PD) is a progressive neurological disorder associated with motor disabilities and cognitive dysfunction as well. Evidence indicates that PD occurs less frequently in women than men, confirming a role for steroid hormones in protection of dopaminergic nigrostriatal neurons. It is reported...

journal_title：Iranian journal of basic medical sciences

authors： Arbabi E,Hamidi G,Talaei SA,Salami M

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVES:Crocin bleaching assay (CBA) is a new method for determination of antioxidant capacity. In CBA, addition of hydrogen to the conjugated double bonds of crocin results in reduction of crocin and increase in the absorbance at 440 nm, which is considered as a measure of antioxidant potential. Here CBA method was...

journal_title：Iranian journal of basic medical sciences

authors： Bathaie SZ,Shams A,Moghadas Zadeh Kermani F

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE(S):Carotenoids which are naturally synthesized by fungi such as yeasts can act as an antioxidant which is closely related to their ability to decrease the risk of a variety of degenerative diseases. In recent years, the increase of demand for carotenoids obtained from natural sources has promoted major effort...

journal_title：Iranian journal of basic medical sciences

authors： Sadat Naghavi F,Hanachi P,Soudi MR,Saboora A,Ghorbani A

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVES:Eukaryotic translation initiation factor 4E (eIF4E) is overexpressed in cervical cancer (CC). However, the molecular mechanisms are unclear. This study aimed to investigate the molecular mechanism of eIF4E gene overexpression in CC. MATERIALS AND METHODS:The human papillomavirus (HPV) type 18 E7 and eIF4E m...

journal_title：Iranian journal of basic medical sciences

authors： Pang T,Wang S,Gao M,Kang H,Zhao Y,Yao Y,Hu X

更新日期：2015-07-01 00:00:00

abstract：Objectives:The aims of the present study were to investigate the expression of calcium sensing receptor (CaSR) at different times in acute myocardial infarction (AMI) rat myocardial tissue after mouse embryonic stem cells (mESCs) transplantation treatment and to assess its effects on apoptosis and oxidative stress of c...

journal_title：Iranian journal of basic medical sciences

authors： Yuan H,Yang G,Li S,Li L,Wei T,Song G,Luan H,Meng J,Wang Q,Yu Y,Sun J

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVES:To study the effect of low-frequency vibration on bone marrow stromal cell differentiation and potential bone repair in vivo. MATERIALS AND METHODS:Forty New Zealand rabbits were randomly divided into five groups with eight rabbits in each group. For each group, bone defects were generated in the left humer...

journal_title：Iranian journal of basic medical sciences

authors： He S,Zhao W,Zhang L,Mi L,Du G,Sun C,Sun X

更新日期：2017-01-01 00:00:00

abstract：Objectives:Inflammation is involved in various forms of pulmonary arterial hypertension (PAH). Although the pathophysiology of PAH remains uncertain, NF-κB and p38 mitogen-activated protein kinase (p38 MAPK) has been reported to be associated with many inflammatory mediators of PAH. This study aimed to evaluate the eff...

journal_title：Iranian journal of basic medical sciences

authors： Gao L,Liu J,Hao Y,Zhao Z,Tan H,Zhang J,Meng N,Zheng Q,Wang Z,Zhang Y

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE(S):Green tea (GT) is one of the most popular beverages worldwide whose beneficial effects on health have been demonstrated. Recent studies suggest that GT may contribute to reduction of cancer risk and progression. The aim of this study was to evaluate the effects of whole GT on urinary bladder chemical carci...

journal_title：Iranian journal of basic medical sciences

authors： Henriques A,Arantes-Rodrigues R,I Faustino-Rocha A,I Teixeira-Guedes C,Pinho-Oliveira J,Talhada D,H Teixeira J,Andrade A,Colaço B,N Paiva-Cardoso M,J Pires M,Mvd Ferreira A,M Nunes F,A Oliveira P

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE(S):The effect of prolonged overtraining on cytokine kinetics was compared with moderate exercise in the present study. MATERIALS AND METHODS:Male Wistar rats were randomly divided into control sedentary (C), moderate trained (MT), (V=20 m/min, 30 min/day for 6 days a week, 8 weeks), overtrained (OT) (V=25 m/...

journal_title：Iranian journal of basic medical sciences

authors： Gholamnezhad Z,Boskabady MH,Hosseini M,Sankian M,Khajavi Rad A

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:Lectin-like low density lipoprotein receptor (LOX-1) has pivot role in vascular complications, which is upregulated in numerous pathological conditions. Since exercise has beneficial effects in prevention of hyperlipidemic complications, present study examined protective effects of aerobic exercise through r...

journal_title：Iranian journal of basic medical sciences

authors： Riahi S,Mohammadi MT,Sobhani V,Soleimany M

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVES:Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of multiple sclerosis. The aim of the present work is to investigate the protective effects of erythropoietin against cuprizone-induced oxidative stress. MATERIALS AND METHODS:...

journal_title：Iranian journal of basic medical sciences

authors： Kashani IR,Chavoshi H,Pasbakhsh P,Hassani M,Omidi A,Mahmoudi R,Beyer C,Zendedel A

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVE(S):PDE3 has a functional role in insulin secretion and action. We investigated the metabolic effects of new synthetic PDE3 inhibitors (mc1, mc2, mc5 and mc6), on mice and hyperglycemic rat. MATERIALS AND METHODS:The test compound or solvent was injected subcutaneously to mice, for 7 days. On day 8, blood and...

journal_title：Iranian journal of basic medical sciences

authors： Hosseini A,Shafiee-Nick R,Pour Ali Behzad N,Sadeghian H

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVES:The utilization of molecular techniques in the epidemiology of tuberculosis have provided an opportunity for using effective markers to trace the transmission of the disease. The purpose of this study was to compare the genetic patterns of Mycobacterium tuberculosis by three methods of RFLP technique. MATER...

journal_title：Iranian journal of basic medical sciences

authors： Farazi A,Jabbariasl M,Tadayon K,Mossavar N,Keshavarz R,Hoseini SD

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the methylation status and mRNA expression levels of P15, death-associated protein kinase (DAPK), and suppressor of cytokine signaling-1 (SOCS1) genes in multiple myeloma (MM). MATERIALS AND METHODS:The bone marrow samples of 54 MM patients were collected and the met...

journal_title：Iranian journal of basic medical sciences

authors： Liu L,Tan L,He Z

更新日期：2016-07-01 00:00:00

abstract：Objectives:Radiotherapy is one of the most effective modalities of cancer therapy, but clinical responses of individual patients varies considerably. To enhance treatment efficiency it is essential to implement an individual-based treatment. The aim of present study was to identify the mechanism of intrinsic apoptosis ...

journal_title：Iranian journal of basic medical sciences

authors： Azimian H,Dayyani M,Toossi MTB,Mahmoudi M

更新日期：2018-03-01 00:00:00