Estrogen agonist genistein differentially influences the cognitive and motor disorders in an ovariectomized animal model of Parkinsonism.

abstract：Objectives:Alginates play a key role in mucoid Pseudomonas aeruginosa colonization, biofilm formation, and driving out of cationic antibiotics. P. aeruginosa alginate lyase (AlgL) is a periplasmic enzyme that is necessary for alginate synthesis and secretion. It also has a role in depolymerization of alginates. Using A...

journal_title：Iranian journal of basic medical sciences

authors： Piroozmand F,Ghadam P,Zarrabi M,Abdi-Ali A

更新日期：2020-04-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disease and the leading cause of dementia worldwide. Epidemiological studies support the important role of diet in prevention and improvement of AD. In Traditional Persian Medicine (TPM), there is multiple dietary guidelines to prevent and alleviate dementia and memory i...

journal_title：Iranian journal of basic medical sciences

authors： Iranshahy M,Javadi B

更新日期：2019-10-01 00:00:00

abstract：Objectives:The monitoring of cancer treatment response to chemotherapy is considered an essential strategy for follow-up of patients. The aim of this study was to evaluate the use of 99mTc-glucarate as a radiotracer for in vivo quantification and visualization of necrotic area and therapeutic effect of paclitaxel in ov...

journal_title：Iranian journal of basic medical sciences

authors： Sadeghi H,Rahmanian N,Amiri FT,Amirfakhrian H,Abedi SM,Hosseinimehr SJ

更新日期：2018-01-01 00:00:00

abstract：Objectives:The preclinical reports have shown that specific probiotics like Bifidobacterium bifidum (B. bifidum) and Lactobacillus acidophilus (L. acidophilus) can be applied as the biotherapeutic agents in the inhibition or therapy of colorectal cancer via the modification of gut bacteria. In the previous studies, we ...

journal_title：Iranian journal of basic medical sciences

authors： Ranji P,Agah S,Heydari Z,Rahmati-Yamchi M,Mohammad Alizadeh A

更新日期：2019-06-01 00:00:00

abstract：Objectives:Cord blood (CB) is known as a valuable source of hematopoietic stem cells (HSC). Identifying strategies that enhance expansion and maintain engraftment and homing capacity of HSCs can improve transplant efficiency. In this study, we examined different culture conditions on ex vivo expansion and homing capaci...

journal_title：Iranian journal of basic medical sciences

authors： Mohammadali F,Abroun S,Atashi A

更新日期：2018-07-01 00:00:00

abstract：Objectives:Precision-cut tissue slices are considered an organotypic 3D model widely used in biomedical research. The comet assay is an important screening test for early genotoxicity risk assessment that is mainly applied on in vitro models. The aim of the present study was to provide a 3D organ system for determinati...

journal_title：Iranian journal of basic medical sciences

authors： Carranza-Torres IE,Viveros-Valdez E,Guzmán-Delgado NE,García-Davis S,Morán-Martínez J,Betancourt-Martínez ND,Balderas-Rentería I,Carranza-Rosales P

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVES:Valproic acid (VPA) has proven to be as one of the most promising useful drug with anticancer properties. In this study, we investigate the VPA effects on E-cadherin expression in HeLa, TC1, MKN45, and HCT116 cell lines. This study assesses the effects of VPA on human papillomavirus E7 expression in HPV posi...

journal_title：Iranian journal of basic medical sciences

authors： Faghihloo E,Akbari A,Adjaminezhad-Fard F,Mokhtari-Azad T

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the methylation status and mRNA expression levels of P15, death-associated protein kinase (DAPK), and suppressor of cytokine signaling-1 (SOCS1) genes in multiple myeloma (MM). MATERIALS AND METHODS:The bone marrow samples of 54 MM patients were collected and the met...

journal_title：Iranian journal of basic medical sciences

authors： Liu L,Tan L,He Z

更新日期：2016-07-01 00:00:00

abstract：:Cancer testis antigens (CTAs), a large family of tumor-associated and immunogenic antigens expressed in human tumors of various histological origins, are highly restricted to the testis and trophoblast. CTAs have been identified as potent targets for tumor-specific immunotherapeutic advances and have immensely lead to...

journal_title：Iranian journal of basic medical sciences

authors： Babatunde KA,Najafi A,Salehipour P,Modarressi MH,Mobasheri MB

更新日期：2017-09-01 00:00:00

abstract：Objectives:This study aimed to investigate the glucose and lipid metabolism improving effect of the total flavonoids from Selaginella tamariscina (Beauv.) Spring (TFST) on db/db mice, and to study its mechanism of action. Materials and Methods:The db/db mice were divided into 5 groups: the normal group (NC), the diabe...

journal_title：Iranian journal of basic medical sciences

authors： Wang X,Feng A,Yuan P,Fu Y,Bai Z,Zhou N,Zheng X

更新日期：2020-10-01 00:00:00

abstract：Objectives:Several lines of evidence showed that minocycline possesses antioxidant and anti-inflammatory properties. This study aimed to demonstrate the effects of minocycline in rats subjected to chronic constriction injury (CCI). Materials and Methods:In this study four groups (n = 6-8) of rats were used as follows:...

journal_title：Iranian journal of basic medical sciences

authors： Abbaszadeh A,Darabi S,Hasanvand A,Amini-Khoei H,Abbasnezhad A,Choghakhori R,Aaliehpour A

更新日期：2018-02-01 00:00:00

abstract：Objectives:Interleukin-36 receptor antagonist (IL-36Ra) is a new member of the IL-1 family that exhibits anti-inflammatory activity in a variety of inflammatory and immune diseases. Our purpose was to determine the effect of IL-36Ra on liver injury in a mouse hepatitis model induced by concanavalin A (ConA). Materials...

journal_title：Iranian journal of basic medical sciences

authors： Peng X,Pan X,Tan J,Li Y,Li M

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVE(S):Carotenoids which are naturally synthesized by fungi such as yeasts can act as an antioxidant which is closely related to their ability to decrease the risk of a variety of degenerative diseases. In recent years, the increase of demand for carotenoids obtained from natural sources has promoted major effort...

journal_title：Iranian journal of basic medical sciences

authors： Sadat Naghavi F,Hanachi P,Soudi MR,Saboora A,Ghorbani A

更新日期：2013-10-01 00:00:00

abstract：Objectives:A growing body of evidence indicates that rhomboid domain containing 1 (RHBDD1) plays an important role in a variety of physiological and pathological processes, including tumorigenesis. We aimed to determine the function of RHBDD1 in breast cancer cells. Materials and Methods:In this study, we used the Onc...

journal_title：Iranian journal of basic medical sciences

authors： Huang C,Ji X,Peng Y,Wu M,Wu W,Luo Y,Cheng G,Zhu Y

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:In the present study, we evaluated immunological and immunomodulatory properties of royal jelly (RJ) in 2,4,6 trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats. MATERIALS AND METHODS:Eighteen adult female Wistar albino rats were divided into three groups of six animals each: a control group that ...

journal_title：Iranian journal of basic medical sciences

authors： Karaca T,Uz YH,Demirtas S,Karaboga I,Can G

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVES:Prostate cancer is the world's leading cause of cancer and the second cause of cancer-related death in men after lung cancer. Differentiation of prostate adenocarcinoma from benign prostate lesions and hyperplasia sometimes cannot be done on the basis of morphologic findings. Considering the fact that in the...

journal_title：Iranian journal of basic medical sciences

authors： Kalantari MR,Anvari K,Jabbari H,Tabrizi FV

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVES:Due to unsatisfactory response or intolerable side effects of current drugs, treatment of essential tremor remains inadequate. Thus, we aimed to investigate the protective and therapeutic effects of aqueous and ethanolic extracts of Crocus sativus (saffron), and its active consistent, safranal, on the harmal...

journal_title：Iranian journal of basic medical sciences

authors： Amin B,Malekzadeh M,Heidari MR,Hosseinzadeh H

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVES:Fumonisins are a group of toxic and carcinogenic mycotoxins, which contaminate the grains and their products. The aim of this study was to examine the apoptotic and proliferative activity of mouse gastric mucosa following administration of fumonisin B1 (FB1). MATERIALS AND METHODS:Twenty-nine female mice di...

journal_title：Iranian journal of basic medical sciences

authors： Alizadeh AM,Mohammadghasemi F,Zendehdel K,Kamyabi-Moghaddam Z,Tavassoli A,Amini-Najafi F,Khosravi A

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVES:Astrodaucus persicus, Apiaceae, is used as vegetable or food additive in some parts of Iran. The essential oils of different parts of Astrodaucus persicus from Kordestan province were analyzed for the first time and compared with other regions. In this study, antioxidant activities and total phenols determin...

journal_title：Iranian journal of basic medical sciences

authors： Goodarzi S,Hadjiakhoondi A,Yassa N,Khanavi M,Tofighi Z

更新日期：2016-02-01 00:00:00

abstract：Objectives:Prenatal stresses increase incidence of neurodevelopmental disorders and influence cognitive abilities. Glucocorticoids are released in stress condition as endpoint activation of hypothalamus-pituitary-adrenal (HPA) axis. Evidence indicates a cross-talk between gut microbiota and brain function. This study a...

journal_title：Iranian journal of basic medical sciences

authors： Hadizadeh M,Hamidi GA,Salami M

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVES:Many cancer cells show significant resistance to drugs that kill drug sensitive cancer cells and non-tumor cells and such resistance might be a consequence of the difference in metabolism. Therefore, studying the metabolism of drug resistant cancer cells and comparison with drug sensitive and normal cell lin...

journal_title：Iranian journal of basic medical sciences

authors： Motamedian E,Ghavami G,Sardari S

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVES:Previous studies showed that skeletal muscle microcirculation was reduced in chronic heart failure. The aim of this study was to investigate the effects of endurance training on capillary and arteriolar density of fast and slow twitch muscles in rats with chronic heart failure. MATERIALS AND METHODS:Four we...

journal_title：Iranian journal of basic medical sciences

authors： Ranjbar K,Ardakanizade M,Nazem F

更新日期：2017-01-01 00:00:00

abstract：Objectives:Resveratrol (RSV) is a naturally occurring plant polyphenol with cardioprotective, neuroprotective, immunoregulatory, and anticancer properties and is biologically effective against various diseases. This study aimed to investigate the chemopreventive effect of different doses of RSV against hepatocellular c...

journal_title：Iranian journal of basic medical sciences

authors： Karabekir SC,Özgörgülü A

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE(S):Based on knowledge from traditional herbal medicine, Ferula assa-foetida (asafoetida) has several therapeutic applications but there is less knowledge about its effect on neurons. MATERIALS AND METHODS:In order to evaluate neuronal differentiation, neuronal like cells were stained against neuronal specifi...

journal_title：Iranian journal of basic medical sciences

authors： Homayouni Moghadam F,Vakili Zarch B,Shafiei M

更新日期：2013-04-01 00:00:00

abstract：:Metastasis is the primary cause of mortality and morbidity among cancer patients and accounts for about 90% of cancer deaths. The most common types of treatment for cancer metastasis are chemotherapy and radiotherapy. However, such therapy has many serious side effects that could diminish the quality of life in patien...

journal_title：Iranian journal of basic medical sciences

authors： Ahmadiankia N

更新日期：2019-09-01 00:00:00

abstract：Objectives:Inflammation is involved in various forms of pulmonary arterial hypertension (PAH). Although the pathophysiology of PAH remains uncertain, NF-κB and p38 mitogen-activated protein kinase (p38 MAPK) has been reported to be associated with many inflammatory mediators of PAH. This study aimed to evaluate the eff...

journal_title：Iranian journal of basic medical sciences

authors： Gao L,Liu J,Hao Y,Zhao Z,Tan H,Zhang J,Meng N,Zheng Q,Wang Z,Zhang Y

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVES:Morphine is widely used to treat chronic pain. However, its utility is hindered by the development of tolerance to its analgesic effects. Despite the renowned beneficial effects of physical exercise on cognitive functions and signs of morphine withdrawal in morphine-dependent rats, little is known about the ...

journal_title：Iranian journal of basic medical sciences

authors： Shokraviyan M,Miladi-Gorji H,Vaezi GH

更新日期：2014-01-01 00:00:00

abstract：Objectives:The present study investigated the prevalence of genes encoding for exotoxins, adhesion and biofilm factors in Staphylococcus aureus isolates obtained from samples in a referral burn hospital in Tehran, Iran. Materials and Methods:S. aureus isolates obtained from patients, personnel and surfaces in the ward...

journal_title：Iranian journal of basic medical sciences

authors： Mir Z,Nodeh Farahani N,Abbasian S,Alinejad F,Sattarzadeh M,Pouriran R,Dahmardehei M,Mirzaii M,Khoramrooz SS,Darban-Sarokhalil D

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE(S):The effect of prolonged overtraining on cytokine kinetics was compared with moderate exercise in the present study. MATERIALS AND METHODS:Male Wistar rats were randomly divided into control sedentary (C), moderate trained (MT), (V=20 m/min, 30 min/day for 6 days a week, 8 weeks), overtrained (OT) (V=25 m/...

journal_title：Iranian journal of basic medical sciences

authors： Gholamnezhad Z,Boskabady MH,Hosseini M,Sankian M,Khajavi Rad A

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:Production of extended-spectrum beta-lactamases (ESBLs) by enteric bacteria continues to be a major problem in hospitals and community. ESBLs producing bacteria cause many serious infections including urinary tract infections, peritonitis, cholangitis and intra-abdominal abscess. The aim of this study was to...

journal_title：Iranian journal of basic medical sciences

authors： Zaniani FR,Meshkat Z,Naderi Nasab M,Khaje-Karamadini M,Ghazvini K,Rezaee A,Esmaily H,Nabavinia MS,Darban Hoseini M

更新日期：2012-01-01 00:00:00