Protective effects of phenolic acids on mercury-induced DNA damage in precision-cut kidney slices.

abstract：OBJECTIVES:Cyclooxygenases (COXs) are known to play some roles in physiological mechanisms related to learning and memory. Since sodium salicylate is an inhibitor of COX, we have evaluated the effect of peripheral and intra-hippocampal administration of sodium salicylate on spatial learning and memory in male rats. MA...

journal_title：Iranian journal of basic medical sciences

authors： Azimi L,Pourmotabbed A,Ghadami MR,Nedaei SE,Pourmotabbed T

更新日期：2012-03-01 00:00:00

abstract：OBJECTIVES:To study the effect of low-frequency vibration on bone marrow stromal cell differentiation and potential bone repair in vivo. MATERIALS AND METHODS:Forty New Zealand rabbits were randomly divided into five groups with eight rabbits in each group. For each group, bone defects were generated in the left humer...

journal_title：Iranian journal of basic medical sciences

authors： He S,Zhao W,Zhang L,Mi L,Du G,Sun C,Sun X

更新日期：2017-01-01 00:00:00

abstract：Objectives:The monitoring of cancer treatment response to chemotherapy is considered an essential strategy for follow-up of patients. The aim of this study was to evaluate the use of 99mTc-glucarate as a radiotracer for in vivo quantification and visualization of necrotic area and therapeutic effect of paclitaxel in ov...

journal_title：Iranian journal of basic medical sciences

authors： Sadeghi H,Rahmanian N,Amiri FT,Amirfakhrian H,Abedi SM,Hosseinimehr SJ

更新日期：2018-01-01 00:00:00

abstract：Objectives:Panax ginseng (PG) widely used for its various pharmacological activities, including effects on diabetes and its complications. This study aims to investigate the effect of PG on mortality-related hypomagnesemia, hyperlactatemia, metabolic acidosis, and other diabetes-induced abnormalities. Materials and Me...

journal_title：Iranian journal of basic medical sciences

authors： Adam GO,Kim GB,Lee SJ,Lee HR,Kim SJ,Kang HS,Kim JS

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE(S):Atherosclerosis is a chronic immune-inflammatory disease that generally leads to ischemic heart disease. Ghrelin has several modulatory effects on cardiovascular system. In this study, we investigated the effect of ghrelin on aortic intima-media thickness, size and the number of adipocyte cells in obese an...

journal_title：Iranian journal of basic medical sciences

authors： Tahergorabi Z,Rashidi B,Khazaei M

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVE(S):Pre-eclampsia is characterized by hypertension, dyslipidemia, and increased systemic inflammatory response and has been associated with an increased maternal risk of cardiovascular disease later in life. Endothelial dysfunction is thought to be a central pathogenic feature in pre-eclampsia on the basis of ...

journal_title：Iranian journal of basic medical sciences

authors： Farzadnia M,Ayatollahi H,Hasan-Zade M,Rahimi HR

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVES:The utilization of molecular techniques in the epidemiology of tuberculosis have provided an opportunity for using effective markers to trace the transmission of the disease. The purpose of this study was to compare the genetic patterns of Mycobacterium tuberculosis by three methods of RFLP technique. MATER...

journal_title：Iranian journal of basic medical sciences

authors： Farazi A,Jabbariasl M,Tadayon K,Mossavar N,Keshavarz R,Hoseini SD

更新日期：2014-06-01 00:00:00

abstract：Objectives:In addition to genetic factors, environmental phenomena during postnatal age highly affect development and, in turn, function of the brain. The present work evaluates if morphine consumption during lactation period influences the spatial performances and synaptic plasticity in rats at neonatal period of age....

journal_title：Iranian journal of basic medical sciences

authors： Aghighi F,Mohammadifar M,Banafsheh H,Salami M,Talaei SA

更新日期：2019-09-01 00:00:00

abstract：:Nigella sativa is the miraculous plant having a lot of nutritional and medicinal benefits, and attracts large number of nutrition and pharmacological researchers. N. sativa seed composition shows that it is the blessing of nature and it contains and many bioactive compounds like thymoquinone, α-hederin, alkaloids, fla...

journal_title：Iranian journal of basic medical sciences

authors： Shafiq H,Ahmad A,Masud T,Kaleem M

更新日期：2014-12-01 00:00:00

abstract：Objectives:Alginates play a key role in mucoid Pseudomonas aeruginosa colonization, biofilm formation, and driving out of cationic antibiotics. P. aeruginosa alginate lyase (AlgL) is a periplasmic enzyme that is necessary for alginate synthesis and secretion. It also has a role in depolymerization of alginates. Using A...

journal_title：Iranian journal of basic medical sciences

authors： Piroozmand F,Ghadam P,Zarrabi M,Abdi-Ali A

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVES:Naringin has been reported to regulate bone metabolism. However, its effect on osteogenesis remains unclear. The aim was to investigate the effect of naringin on osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs) through the activation of the ERK signaling pathway in osteogenic d...

journal_title：Iranian journal of basic medical sciences

authors： Wang H,Li C,Li J,Zhu Y,Jia Y,Zhang Y,Zhang X,Li W,Cui L,Li W,Liu Y

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE(S):In the current study, the effects of selected folk medicinal herbs were evaluated in D-galactose-induced aging in male mice. MATERIALS AND METHODS:Male BALB/c mice were randomly divided into 12 groups composing sham, control, and treated groups. Aging was induced by administration of D-galactose (500 mg/k...

journal_title：Iranian journal of basic medical sciences

authors： Mohammadirad A,Aghamohammadali-Sarraf F,Badiei S,Faraji Z,Hajiaghaee R,Baeeri M,Gholami M,Abdollahi M

更新日期：2013-11-01 00:00:00

abstract：Objectives:Osteonecrosis of the jaw, as an exposed necrotic bone in the oral cavity, is one of the adverse effects of bisphosphonates, which have an affinity for bone minerals. This study investigates the cytotoxic effects of alendronate (ALN) as a nitrogen-containing bisphosphonate, on human dental pulp stem cells (hD...

journal_title：Iranian journal of basic medical sciences

authors： Pourgonabadi S,Ghorbani A,Tayarani Najarn Z,Mousavi SH

更新日期：2018-09-01 00:00:00

abstract：:Sulfur mustard (SM, bis- (2-chloroethyl) sulphide) is a chemical warfare agent that causes DNA alkylation, protein modification and membrane damage. SM can trigger several molecular pathways involved in inflammation and oxidative stress, which cause cell necrosis and apoptosis, and loss of cells integrity and function...

journal_title：Iranian journal of basic medical sciences

authors： Imani S,Panahi Y,Salimian J,Fu J,Ghanei M

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVES:Opioids and cannabinoids are two important compounds that have been shown to influence the activity of magnocellular neurons (MCNs) of supraoptic nucleus (SON). The interaction between opioidergic and cannabinoidergic systems in various structures of the brain and spinal cord is now well established, but not...

journal_title：Iranian journal of basic medical sciences

authors： Yousefpour M,Naderi N,Motamedi F

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE(S):Based on knowledge from traditional herbal medicine, Ferula assa-foetida (asafoetida) has several therapeutic applications but there is less knowledge about its effect on neurons. MATERIALS AND METHODS:In order to evaluate neuronal differentiation, neuronal like cells were stained against neuronal specifi...

journal_title：Iranian journal of basic medical sciences

authors： Homayouni Moghadam F,Vakili Zarch B,Shafiei M

更新日期：2013-04-01 00:00:00

abstract：Objectives:The present paper aims to review the studies describing the interactions between HopQ and CEACAMs along with possible mechanisms responsible for pathogenicity of Helicobacter pylori. Materials and Methods:The literature was searched on "PubMed" using different key words including Helicobacter pylori, CEACAM...

journal_title：Iranian journal of basic medical sciences

authors： Xia R,Zhang B,Wang X,Jia Q

更新日期：2019-07-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disease and the leading cause of dementia worldwide. Epidemiological studies support the important role of diet in prevention and improvement of AD. In Traditional Persian Medicine (TPM), there is multiple dietary guidelines to prevent and alleviate dementia and memory i...

journal_title：Iranian journal of basic medical sciences

authors： Iranshahy M,Javadi B

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVES:Prostaglandins have been shown to mediate the gastro-protective effect of sodium hydrosulfide (NaHS) but effect of NaHS on mRNA expression of prostaglandin E2 receptors (EP1, 3-4; EPs) has not been investigated. Therefore, this study designed to evaluate the effect of NaHS on mRNA expression of EPs receptors...

journal_title：Iranian journal of basic medical sciences

authors： Mard SA,Mahini S,Dianat M,Farbood Y

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVES:Lipocalin 2 (Lcn2) is a 25-kDa glycoprotein that has initially been extracted from neutrophil granules. Expression of Lcn2 is induced under various pathophysiological conditions. It is also known as an early marker of kidney and heart injury. High-level expression of recombinant Lcn2 neutrophil gelatinase-as...

journal_title：Iranian journal of basic medical sciences

authors： Rouhbakhsh M,Halabian R,Masroori N,Mohammadi Pour M,Bahmani P,Mohammadi Roush A,Jahanian-Najafabadi A,Habibi Roudkenar M

更新日期：2012-05-01 00:00:00

abstract：:Klotho (KL) encodes a single-pass transmembrane protein and is predominantly expressed in the kidney, parathyroid glands, and choroid plexus. Genetic studies on the KL gene have revealed that DNA hypermethylation is one of the major risk factors for aging, diseases, and cancer. Besides, KL exerts anti-inflammatory and...

journal_title：Iranian journal of basic medical sciences

authors： Xuan NT,Hai NV

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVES:HTLVI-1 is the first human retrovirus with limited endemic regions in the world. The epidemiological studies have shown that the genetic background and immune response to the virus have a significant role in HTLV-I-associated diseases. Among the genes are involved in HTLV-I infection, the role of human leuko...

journal_title：Iranian journal of basic medical sciences

authors： Tafreshian AR,Etemadi M,Farid-Hosseini R,Salhi M,Afshari JT

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVES:Crocin bleaching assay (CBA) is a new method for determination of antioxidant capacity. In CBA, addition of hydrogen to the conjugated double bonds of crocin results in reduction of crocin and increase in the absorbance at 440 nm, which is considered as a measure of antioxidant potential. Here CBA method was...

journal_title：Iranian journal of basic medical sciences

authors： Bathaie SZ,Shams A,Moghadas Zadeh Kermani F

更新日期：2011-09-01 00:00:00

abstract：Objectives:Hyperuricemia is a risk for cardiovascular and metabolic diseases, but the mechanism is ambiguous. Increased intestinal permeability is correlated with metabolic syndrome risk factors. Intestinal epithelial cells play a pivotal role in maintaining intestinal permeability. Uric acid is directly eliminated int...

journal_title：Iranian journal of basic medical sciences

authors： Ma C,Yang X,Lv Q,Yan Z,Chen Z,Xu D,Liu X,Yang W,Xing S

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVES:Clinical studies of treating traumatic brain injury (TBI) with autologous adult stem cells led us to examine the impression of a combination therapy. This was performed by intravenous injection of human umbilical cord matrix stem cell (hUCMSC-Wharton(,)s jelly stem cell) with bone marrow cell mobilized by gr...

journal_title：Iranian journal of basic medical sciences

authors： Bakhtiary M,Marzban M,Mehdizadeh M,Joghataei MT,Khoei S,Tondar M,Mahabadi VP,Laribi B,Ebrahimi A,Hashemian SJ,Modiry N,Mehrabi S

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVES:Psoriasis is an autoimmune disease that appears on the skin. Although psoriasis is clinically and histologically well characterized, its pathogenesis is unknown in detail. The aims of this study were to evaluate the proteome of psoriatic patients' sera and to compare them with those of normal healthy human t...

journal_title：Iranian journal of basic medical sciences

authors： Fattahi S,Kazemipour N,Hashemi M,Sepehrimanesh M

更新日期：2014-09-01 00:00:00

abstract：Objectives:Weight gain and metabolic disturbances such as dyslipidemia, are frequent side effects of second-generation antipsychotics, including olanzapine. This study examined the metabolic effects of chronic olanzapine exposure. In addition, we investigated the hepatic fatty acid effects of olanzapine in female C57BL...

journal_title：Iranian journal of basic medical sciences

authors： Hou PH,Chang GR,Chen CP,Lin YL,Chao IS,Shen TT,Mao FC

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:Although previous studies have confirmed the beneficial effects of human umbilical cord matrix stem cell (hUCM) transplantation post myocardial infarction (MI), but this stem cell resource has no potential to induce angiogenesis. In order to achieve the process of angiogenesis and cardiomyocyte regeneration,...

journal_title：Iranian journal of basic medical sciences

authors： Moradi K,Abbasi M,Aboulhasani F,Abbasi N,Babatunde KA,Sargolzaeiaval F,Dehpour AR

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVES:To clarify the protective effects of Cichorium glandulosum (CG) extracts on thioacetamide (TAA)-induced rat hepatic fibrosis. MATERIALS AND METHODS:The dry roots of CG were smashed and percolated with 95% ethanol, and the residual was prepared into petroleum ether extract (CG-V), ethyl acetate extract (CG-V...

journal_title：Iranian journal of basic medical sciences

authors： Qin D,Nie Y,Wen Z

更新日期：2014-11-01 00:00:00

abstract：Objectives:Traumatic brain injury (TBI) is one of the main causes of intellectual and cognitive disabilities. Clinically, it is essential to limit the development of cognitive impairment after TBI. In the present study, the neuroprotective effects of gallic acid (GA) on neurological score, memory, long-term potentiatio...

journal_title：Iranian journal of basic medical sciences

authors： Mirshekar MA,Sarkaki A,Farbood Y,Gharib Naseri MK,Badavi M,Mansouri MT,Haghparast A

更新日期：2018-10-01 00:00:00