当前位置： SCI文献检索 > Iranian Journal of Basic Medical Sciences期刊下所有文献 > Naringin enhances osteogenic differentiation through the activation of ERK signaling in human bone marrow mesenchymal stem cells.

Naringin enhances osteogenic differentiation through the activation of ERK signaling in human bone marrow mesenchymal stem cells.

Abstract：

OBJECTIVES:Naringin has been reported to regulate bone metabolism. However, its effect on osteogenesis remains unclear. The aim was to investigate the effect of naringin on osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs) through the activation of the ERK signaling pathway in osteogenic differentiation. MATERIALS AND METHODS:Annexin V-FITC assay and MTT assay were used to measure the effect of naringin on cytotoxicity and proliferation of hBMSCs, respectively. Alkaline phosphatase activity analysis, Alizarin Red S staining, Western blotting, and real-time PCR assay were used to evaluate both the potential effect of naringin on osteogenic differentiation and the role of ERK signaling pathway in osteogenic differentiation. RESULTS:Our results showed that naringin had no obvious toxicity on hBMSCs, and could significantly promote the proliferation of hBMSCs. Naringin also enhanced the osteogenic differentiation of hBMSCs and increased the protein and mRNA expression levels of osteogenic markers such as Runx-2, OXS, OCN, and Col1 in a dose-dependent manner. In addition, we found that the enhancing effect of naringin on osteogenic differentiation was related to the activation of phosphor-ERK, with an increase in duration of activity from 30 min to 120 min. More importantly, both the enhancing effect of naringin on osteogenic differentiation and the activity effect of naringin on ERK signaling pathway were reversed by U0126 addition. CONCLUSION:Our findings demonstrated that naringin promoted proliferation and osteogenesis of hBMSCs by activating the ERK signaling pathway and it might be a potential therapeutic agent for treating or preventing osteoporosis.

journal_name

Iran J Basic Med Sci

journal_title

Iranian journal of basic medical sciences

authors

Wang H,Li C,Li J,Zhu Y,Jia Y,Zhang Y,Zhang X,Li W,Cui L,Li W,Liu Y

doi

10.22038/IJBMS.2017.8582

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

408-414

issue

4

eissn

2008-3866

issn

2008-3874

pii

IJBMS-20-408

journal_volume

20

pub_type

杂志文章

相关文献

Iranian Journal of Basic Medical Sciences文献大全
  • The effects of ethanol extract of Berberis vulgaris fruit on histopathological changes and biochemical markers of the liver damage in diabetic rats.

    abstract：OBJECTIVES:Various studies have shown that the diabetes is associated with liver failure. The objective of this study was determining the effects of Berberis vulgaris fruit on histopathological and biochemical markers of liver in diabetic rats. MATERIALS AND METHODS:In this experimental study, 60 male Wistar rats weig...

    journal_title：Iranian journal of basic medical sciences

    pub_type： 杂志文章

    doi：10.22038/IJBMS.2017.8681

    authors： Rahimi-Madiseh M,Karimian P,Kafeshani M,Rafieian-Kopaei M

    更新日期：2017-05-01 00:00:00

  • Effects of nano-copper on maize yield and inflammatory response in mice.

    abstract：Objectives:Copper (Cu) is an essential dietary supplement in animal feeds, which plays an important role in maintaining the balance of all living organisms. Copper nanoparticles (nCu) participate in catalysing activities of multiple antioxidant/defensive enzymes and exerts pro-inflammatory and pro-apoptotic effects on ...

    journal_title：Iranian journal of basic medical sciences

    pub_type： 杂志文章

    doi：10.22038/ijbms.2019.35787.8526

    authors： Hien LTT,Trang PTT,Phuong PC,Tam PT,Xuan NT

    更新日期：2019-07-01 00:00:00

  • The effects of whole green tea infusion on mouse urinary bladder chemical carcinogenesis.

    abstract：OBJECTIVE(S):Green tea (GT) is one of the most popular beverages worldwide whose beneficial effects on health have been demonstrated. Recent studies suggest that GT may contribute to reduction of cancer risk and progression. The aim of this study was to evaluate the effects of whole GT on urinary bladder chemical carci...

    journal_title：Iranian journal of basic medical sciences

    pub_type： 杂志文章

    doi：

    authors： Henriques A,Arantes-Rodrigues R,I Faustino-Rocha A,I Teixeira-Guedes C,Pinho-Oliveira J,Talhada D,H Teixeira J,Andrade A,Colaço B,N Paiva-Cardoso M,J Pires M,Mvd Ferreira A,M Nunes F,A Oliveira P

    更新日期：2014-02-01 00:00:00

  • Epigenetic: A missing paradigm in cellular and molecular pathways of sulfur mustard lung: a prospective and comparative study.

    abstract：:Sulfur mustard (SM, bis- (2-chloroethyl) sulphide) is a chemical warfare agent that causes DNA alkylation, protein modification and membrane damage. SM can trigger several molecular pathways involved in inflammation and oxidative stress, which cause cell necrosis and apoptosis, and loss of cells integrity and function...

    journal_title：Iranian journal of basic medical sciences

    pub_type： 杂志文章,评审

    doi：

    authors： Imani S,Panahi Y,Salimian J,Fu J,Ghanei M

    更新日期：2015-08-01 00:00:00

  • Use of 5-Enolpyruvylshikmate-3-Phosphate Synthase Encoding Gene for Typing of Staphylococcus aureus Isolated from Skin and Urinary Tract Infections of Human.

    abstract：OBJECTIVE(S):Staphylococcus aureus is both a successful human commensal and a major pathogen. In this study we investigated the genetic diversity of 26 S. aureus isolates recovered from human skin and urinary tract infections. MATERIALS AND METHODS:Typing procedure for the studied S. aureus isolates was performed base...

    journal_title：Iranian journal of basic medical sciences

    pub_type： 杂志文章

    doi：

    authors： Talebi-Satlou R,Ahmadi M,Ghavam F,Saei HD

    更新日期：2012-07-01 00:00:00

  • Changes in expression of klotho affect physiological processes, diseases, and cancer.

    abstract：:Klotho (KL) encodes a single-pass transmembrane protein and is predominantly expressed in the kidney, parathyroid glands, and choroid plexus. Genetic studies on the KL gene have revealed that DNA hypermethylation is one of the major risk factors for aging, diseases, and cancer. Besides, KL exerts anti-inflammatory and...

    journal_title：Iranian journal of basic medical sciences

    pub_type： 杂志文章,评审

    doi：

    authors： Xuan NT,Hai NV

    更新日期：2018-01-01 00:00:00

  • Anticonvulsant Activity of Hydroalcoholic Extract and Aqueous Fraction of Ebenus stellata in Mice.

    abstract：OBJECTIVES:Fabaceae is the third largest family of flowering plants. Lack of essential oils in the plants of this family can be considered as an advantage and can favor them in search for safe and antiepileptic medicines. The effects of Fabacea family plants including Ebenus stellata (E. stellata), Sophora alopecuroide...

    journal_title：Iranian journal of basic medical sciences

    pub_type： 杂志文章

    doi：

    authors： Khodaparast A,Sayyah M,Sardari S

    更新日期：2012-05-01 00:00:00

  • Isolation, Cloning and High- Level Expression of Neutrophil Gelatinase-Associated Lipocalin Lipocalin2 by Baculovirus Expression System through Gateway Technology.

    abstract：OBJECTIVES:Lipocalin 2 (Lcn2) is a 25-kDa glycoprotein that has initially been extracted from neutrophil granules. Expression of Lcn2 is induced under various pathophysiological conditions. It is also known as an early marker of kidney and heart injury. High-level expression of recombinant Lcn2 neutrophil gelatinase-as...

    journal_title：Iranian journal of basic medical sciences

    pub_type： 杂志文章

    doi：

    authors： Rouhbakhsh M,Halabian R,Masroori N,Mohammadi Pour M,Bahmani P,Mohammadi Roush A,Jahanian-Najafabadi A,Habibi Roudkenar M

    更新日期：2012-05-01 00:00:00

  • Chronic intermittent hypobaric hypoxia attenuates monocrotaline-induced pulmonary arterial hypertension via modulating inflammation and suppressing NF-κB/p38 pathway.

    abstract：Objectives:Inflammation is involved in various forms of pulmonary arterial hypertension (PAH). Although the pathophysiology of PAH remains uncertain, NF-κB and p38 mitogen-activated protein kinase (p38 MAPK) has been reported to be associated with many inflammatory mediators of PAH. This study aimed to evaluate the eff...

    journal_title：Iranian journal of basic medical sciences

    pub_type： 杂志文章

    doi：10.22038/ijbms.2018.25399.6280

    authors： Gao L,Liu J,Hao Y,Zhao Z,Tan H,Zhang J,Meng N,Zheng Q,Wang Z,Zhang Y

    更新日期：2018-03-01 00:00:00

  • Evaluation of a genetic test for diagnose of primary hypolactasia in northeast of iran (khorasan).

    abstract：OBJECTIVES:Primary or adult type hypolactasia, the most common enzyme deficiency in the world, is due to reduced lactase activity in the intestinal cell after weaning. Lactase non-persistence is inherited as an autosomal recessive trait. A DNA variant, single nucleotide polymorphism C/T-13910 which is located on 13910 ...

    journal_title：Iranian journal of basic medical sciences

    pub_type： 杂志文章

    doi：

    authors： Alizadeh M,Sadr-Nabavi A

    更新日期：2012-11-01 00:00:00

  • Evaluation of immune response after moderate and overtraining exercise in wistar rat.

    abstract：OBJECTIVE(S):The effect of prolonged overtraining on cytokine kinetics was compared with moderate exercise in the present study. MATERIALS AND METHODS:Male Wistar rats were randomly divided into control sedentary (C), moderate trained (MT), (V=20 m/min, 30 min/day for 6 days a week, 8 weeks), overtrained (OT) (V=25 m/...

    journal_title：Iranian journal of basic medical sciences

    pub_type： 杂志文章

    doi：

    authors： Gholamnezhad Z,Boskabady MH,Hosseini M,Sankian M,Khajavi Rad A

    更新日期：2014-01-01 00:00:00

  • Moisturizing effects of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) using deionized and magnetized water by in vivo and in vitro methods.

    abstract：Objectives:The present study aimed to determine and compare moisturizing and occlusion effects of different solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) using magnetized water and deionized water. Materials and Methods:SLN formulations were prepared using various lipids, including Tripalmiti...

    journal_title：Iranian journal of basic medical sciences

    pub_type： 杂志文章

    doi：10.22038/IJBMS.2020.39587.9397

    authors： Sarhadi S,Gholizadeh M,Moghadasian T,Golmohammadzadeh S

    更新日期：2020-03-01 00:00:00

  • Hypolipidemic effects of total flavonoide extracted from the leaves of Actinidiakolomikta in rats fed a high-fat diet.

    abstract：Objectives:This study was to investigate the antihyperlipidemic and antioxidant effect of total flavonoid extract from Actinidiakolomikta (TFAK) in hyperlipidemia induced by a high-fat diet. Materials and Methods:Male SD rats were randomly divided into 6 groups: normal group, model (hyperlipidemic diet) group, hyperli...

    journal_title：Iranian journal of basic medical sciences

    pub_type： 杂志文章

    doi：10.22038/IJBMS.2017.9365

    authors： Yu Z,Xu H,Yu X,Sui D,Lin G

    更新日期：2017-10-01 00:00:00

  • Novel cilostamide analogs, phosphodiesterase 3 inhibitors, produce positive inotropic but differential lusitropic and chronotropic effects on isolated rat atria.

    abstract：OBJECTIVES:Recently, we showed that some new synthetic compounds structurally related to cilostamide (4-(1,2-dihydro-2-oxoquinolin-6-hydroxy)- N-cyclohexyl-N-methylbutanamide), a selective phosphodiesterase 3 (PDE3) inhibitor, produce inotropic effect comparable to that of IBMX (3-isobutyl-1-methylxanthine), a non-sele...

    journal_title：Iranian journal of basic medical sciences

    pub_type： 杂志文章

    doi：10.22038/IJBMS.2017.8831

    authors： Hosseini A,Shafiee-Nick R,Sadeghian H,Parsaee H

    更新日期：2017-06-01 00:00:00

  • Whole exome sequencing revealed a novel dystrophin-related protein-2 (DRP2) deletion in an Iranian family with symptoms of polyneuropathy.

    abstract：Objectives:Charcot-Marie Tooth disease (CMT) is one of the main inherited causes of motor and sensory neuropathies with variable expressivity and age-of onset. Although more than 70 genes have been identified for CMT, more studies are needed to discover other genes involved in CMT. Introduction of whole exome sequencin...

    journal_title：Iranian journal of basic medical sciences

    pub_type： 杂志文章

    doi：10.22038/ijbms.2019.30754.7414

    authors： Tahmasebi-Birgani M,Hajjari M,Golchin N,Shalbafan B,Mohammadi-Asl J,Sadeghian F

    更新日期：2019-05-01 00:00:00

  • The effects of vitamin B12 on the brain damages caused by methamphetamine in mice.

    abstract：Objectives:Methamphetamine (METH) is a powerful stimulant drug that directly affects the brain and induces neurological deficits. B12 is a water-soluble vitamin (vit) that is reported to attenuate neuronal degeneration. The goal of the present study is to investigate the effect of vitamin B12 on METH's neurodegenerativ...

    journal_title：Iranian journal of basic medical sciences

    pub_type： 杂志文章

    doi：10.22038/IJBMS.2018.23362.5897

    authors： Moshiri M,Hosseiniyan SM,Moallem SA,Hadizadeh F,Jafarian AH,Ghadiri A,Hoseini T,Seifi M,Etemad L

    更新日期：2018-04-01 00:00:00

  • Differential metabolic effects of novel cilostamide analogs, methyl carbostiryl derivatives, on mouse and hyperglycemic rat.

    abstract：OBJECTIVE(S):PDE3 has a functional role in insulin secretion and action. We investigated the metabolic effects of new synthetic PDE3 inhibitors (mc1, mc2, mc5 and mc6), on mice and hyperglycemic rat. MATERIALS AND METHODS:The test compound or solvent was injected subcutaneously to mice, for 7 days. On day 8, blood and...

    journal_title：Iranian journal of basic medical sciences

    pub_type： 杂志文章

    doi：

    authors： Hosseini A,Shafiee-Nick R,Pour Ali Behzad N,Sadeghian H

    更新日期：2012-07-01 00:00:00

  • Pterocarpus santalinus ameliorates streptozotocin-induced diabetes mellitus via anti-inflammatory pathways and enhancement of insulin function.

    abstract：Objectives:Morbidity and mortality due to diabetes mellitus (DM) result in exorbitant psycho-economical costs, so there is a strong need to create new strategies and drugs for controlling DM. The aim of the current study was to investigate the anti-diabetic effect of the aqueous extract of Pterocarpus santalinus on str...

    journal_title：Iranian journal of basic medical sciences

    pub_type： 杂志文章

    doi：10.22038/ijbms.2019.34998.8325

    authors： El-Badawy RE,Ibrahim KA,Hassan NS,El-Sayed WM

    更新日期：2019-08-01 00:00:00

  • Essential oils chemical composition, antioxidant activities and total phenols of Astrodaucus persicus.

    abstract：OBJECTIVES:Astrodaucus persicus, Apiaceae, is used as vegetable or food additive in some parts of Iran. The essential oils of different parts of Astrodaucus persicus from Kordestan province were analyzed for the first time and compared with other regions. In this study, antioxidant activities and total phenols determin...

    journal_title：Iranian journal of basic medical sciences

    pub_type： 杂志文章

    doi：

    authors： Goodarzi S,Hadjiakhoondi A,Yassa N,Khanavi M,Tofighi Z

    更新日期：2016-02-01 00:00:00

  • Anti-aging effects of some selected Iranian folk medicinal herbs-biochemical evidences.

    abstract：OBJECTIVE(S):In the current study, the effects of selected folk medicinal herbs were evaluated in D-galactose-induced aging in male mice. MATERIALS AND METHODS:Male BALB/c mice were randomly divided into 12 groups composing sham, control, and treated groups. Aging was induced by administration of D-galactose (500 mg/k...

    journal_title：Iranian journal of basic medical sciences

    pub_type： 杂志文章

    doi：

    authors： Mohammadirad A,Aghamohammadali-Sarraf F,Badiei S,Faraji Z,Hajiaghaee R,Baeeri M,Gholami M,Abdollahi M

    更新日期：2013-11-01 00:00:00

  • Cloning and expression of NS3 helicase fragment of hepatitis C virus and the study of its immunoreactivity in HCV infected patients.

    abstract：OBJECTIVES:Hepatitis C is a major cause of liver failure worldwide. Current therapies applied for this disease are not fully effective and produce side effects in most cases. Non-structural protein 3 helicase (NS3) of HCV is one of the key enzymes in viral replication and infection. Therefore, this region is a promisin...

    journal_title：Iranian journal of basic medical sciences

    pub_type： 杂志文章

    doi：

    authors： Sadri M,Farajollahi MM,Sharifi Z

    更新日期：2015-02-01 00:00:00

  • Voluntary and forced exercises prevent the development of tolerance to analgesic effects of morphine in rats.

    abstract：OBJECTIVES:Morphine is widely used to treat chronic pain. However, its utility is hindered by the development of tolerance to its analgesic effects. Despite the renowned beneficial effects of physical exercise on cognitive functions and signs of morphine withdrawal in morphine-dependent rats, little is known about the ...

    journal_title：Iranian journal of basic medical sciences

    pub_type： 杂志文章

    doi：

    authors： Shokraviyan M,Miladi-Gorji H,Vaezi GH

    更新日期：2014-01-01 00:00:00

  • Diet therapy for the treatment of Alzheimer's disease in view of traditional Persian medicine: A review.

    abstract：:Alzheimer's disease (AD) is a neurodegenerative disease and the leading cause of dementia worldwide. Epidemiological studies support the important role of diet in prevention and improvement of AD. In Traditional Persian Medicine (TPM), there is multiple dietary guidelines to prevent and alleviate dementia and memory i...

    journal_title：Iranian journal of basic medical sciences

    pub_type： 杂志文章,评审

    doi：10.22038/ijbms.2019.36505.8694

    authors： Iranshahy M,Javadi B

    更新日期：2019-10-01 00:00:00

  • Correlational studies on insulin resistance and leptin gene polymorphisms in peritoneal dialysis patients.

    abstract：OBJECTIVES:The aim of the study was to investigate the relationship between insulin resistance (IR) and leptin (LEP) gene polymorphisms in peritoneal dialysis (PD) patients. MATERIALS AND METHODS:From July 1, 2011 to August 1, 2011, patients who received chronic PD were chosen and divided into three groups (DM, high H...

    journal_title：Iranian journal of basic medical sciences

    pub_type： 杂志文章

    doi：

    authors： Cao L,Mou S,Fang W,Qi C,Chang X,Gu L,Qian J,Ni Z

    更新日期：2015-09-01 00:00:00

  • Microbiome alterations are related to an imbalance of immune response and bacterial translocation in BDL-rats.

    abstract：Objectives:Bacterial translocation in patients with cirrhosis is an important triggering factor for infections and mortality. In the bile duct ligation (BDL) model, crucial players of bacterial translocation are still unknown. This study aims to determine the interrelation between microbiome composition in the colon, m...

    journal_title：Iranian journal of basic medical sciences

    pub_type： 杂志文章

    doi：10.22038/IJBMS.2019.36487.8753

    authors： Vega-Magaña N,Galiana A,Jave-Suárez LF,Garcia-Benavides L,Del Toro-Arreola S,Andrade-Villanueva JF,González-Hernández LA,Cremades R,Aguilar-Lemarroy A,Flores-Miramontes MG,Haramati J,Meza-Arroyo J,Bueno-Topete MR

    更新日期：2020-02-01 00:00:00

  • Generation of Helper Plasmids Encoding Mutant Adeno-associated Virus Type 2 Capsid Proteins with Increased Resistance against Proteasomal Degradation.

    abstract：OBJECTIVE(S):Adeno-associated virus type 2 (AAV2) vectors are widely used for both experimental and clinical gene therapy. A recent research has shown that the performance of these vectors can be greatly improved by substitution of specific surface-exposed tyrosine residues with phenylalanines. In this study, a fast an...

    journal_title：Iranian journal of basic medical sciences

    pub_type： 杂志文章

    doi：

    authors： Ahmadiankia N,Neshati V,Neshati Z,Swildens J,de Vries AA

    更新日期：2013-07-01 00:00:00

  • 99mTc-Glucarate for assessment of paclitaxel therapy in human ovarian cancer in mice.

    abstract：Objectives:The monitoring of cancer treatment response to chemotherapy is considered an essential strategy for follow-up of patients. The aim of this study was to evaluate the use of 99mTc-glucarate as a radiotracer for in vivo quantification and visualization of necrotic area and therapeutic effect of paclitaxel in ov...

    journal_title：Iranian journal of basic medical sciences

    pub_type： 杂志文章

    doi：10.22038/IJBMS.2017.24707.6138

    authors： Sadeghi H,Rahmanian N,Amiri FT,Amirfakhrian H,Abedi SM,Hosseinimehr SJ

    更新日期：2018-01-01 00:00:00

  • Eupafolin ameliorates lipopolysaccharide-induced cardiomyocyte autophagy via PI3K/AKT/mTOR signaling pathway.

    abstract：Objectives:Eupafolin, a major active component of Eupatorium perfoliatum L., has anti-inflammatory and anti-oxidant properties. Lipopolysaccharide (LPS) is responsible for myocardial depression. A line of evidences revealed that LPS induces autophagy in cardiomyocytes injury. This study aims to evaluate the effects of ...

    journal_title：Iranian journal of basic medical sciences

    pub_type： 杂志文章

    doi：10.22038/ijbms.2019.37748.8977

    authors： Gao Y,Zhang Y,Fan Y

    更新日期：2019-11-01 00:00:00

  • Staging of colorectal cancer using serum metabolomics with 1HNMR Spectroscopy.

    abstract：OBJECTIVES:Determination of stages of colon cancer is done by biopsy usually after surgery. Metabolomics is the study of all the metabolites using LC-MS and 1HNMR spectroscopy with chemometric techniques. The stages of colon cancer were detected from patients' sera using 1HNMR. MATERIALS AND METHODS:Five ml blood was ...

    journal_title：Iranian journal of basic medical sciences

    pub_type： 杂志文章

    doi：10.22038/IJBMS.2017.9022

    authors： Vahabi F,Sadeghi S,Arjmand M,Mirkhani F,Hosseini E,Mehrabanfar M,Hajhosseini R,Iravani A,Bayat P,Zamani Z

    更新日期：2017-07-01 00:00:00

  • Mechanism underlying the effects of doxepin on β-amyloid -induced memory impairment in rats.

    abstract：OBJECTIVES:In previous studies, researchers observed that doxepin could improve cognitive processes and has protective effects on the central nervous system. Thus, this study was designed to analyze the effects of doxepin on β-amyloid (Aβ)-induced memory impairment and neuronal toxicity in rat and to explore the underl...

    journal_title：Iranian journal of basic medical sciences

    pub_type： 杂志文章

    doi：10.22038/IJBMS.2017.9274

    authors： Bu J,Zu H

    更新日期：2017-09-01 00:00:00