Microbiome alterations are related to an imbalance of immune response and bacterial translocation in BDL-rats.

Abstract:

Objectives:Bacterial translocation in patients with cirrhosis is an important triggering factor for infections and mortality. In the bile duct ligation (BDL) model, crucial players of bacterial translocation are still unknown. This study aims to determine the interrelation between microbiome composition in the colon, mesenteric lymph nodes, and liver, as well as the local inflammatory microenvironment in the BDL model. Materials and Methods:Liver damage was assayed by Masson trichrome staining, and hepatic enzymes. The diversity of microbiota in colon stools, mesenteric lymph nodes, and liver was determined by 16S rRNA pyrosequencing. Cytokine expression in mesenteric lymph nodes was analyzed by qRT-PCR. Results:Our results show that Proteobacteria was the predominant phylum found to translocate to mesenteric lymph nodes and liver in cirrhotic rats. Bile duct ligation induces a drastic intestinal dysbiosis, revealed by an increased relative abundance of Sarcina, Clostridium, Helicobacter, Turicibacter, and Streptococcus genera. However, beneficial bacteria, such as Lactobacillus, Prevotella and Ruminococcus were found to be notably decreased in BDL groups. Mesenteric pro-inflammatory (TNF-α, IL-1β, IL-6, TLR-4) and regulatory (TGF-β, Foxp3, and IL-10) molecules at 30 days post-BDL were significantly increased. Conversely, TGF-β and Foxp3 were significantly augmented at 8 days post-BDL. Conclusion:Dysbiosis in the colon and mesenteric lymph nodes is linked to an imbalance in the immune response; therefore, this may be an important trigger for bacterial translocation in the BDL model.

journal_name

Iran J Basic Med Sci

authors

Vega-Magaña N,Galiana A,Jave-Suárez LF,Garcia-Benavides L,Del Toro-Arreola S,Andrade-Villanueva JF,González-Hernández LA,Cremades R,Aguilar-Lemarroy A,Flores-Miramontes MG,Haramati J,Meza-Arroyo J,Bueno-Topete MR

doi

10.22038/IJBMS.2019.36487.8753

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

178-185

issue

2

eissn

2008-3866

issn

2008-3874

journal_volume

23

pub_type

杂志文章
  • An Iranian familial amyotrophic lateral sclerosis pedigree with p.Val48Phe causing mutation in SOD1: a genetic and clinical report.

    abstract:OBJECTIVES:Amyotrophic lateral sclerosis (ALS), a fatal progressive neurodegenerative disorder, is the most common motor neuron disease in European populations. Approximately 10% of ALS cases are familial (FALS) and the other patients are considered as sporadic ALS (SALS). Among many ALS causing genes that have been id...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Alavi A,Khani M,Nafissi S,Shamshiri H,Elahi E

    更新日期:2014-10-01 00:00:00

  • Therapeutic uses and pharmacological properties of garlic, shallot, and their biologically active compounds.

    abstract:OBJECTIVE(S):Garlic (Allium sativum L. family Liliaceae) is well known in Iran and its leaves, flowers, and cloves have been used in traditional medicine for a long time. Research in recent decades has shown widespread pharmacological effects of A. sativum and its organosulfur compounds especially Allicin. Studies carr...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章,评审

    doi:

    authors: Mikaili P,Maadirad S,Moloudizargari M,Aghajanshakeri S,Sarahroodi S

    更新日期:2013-10-01 00:00:00

  • Worldwide trends in scientific publications on association of gut microbiota with obesity.

    abstract:Objectives:Recent evidence has shown underlying roles of gut dysbiosis and metabolic endotoxemia in obesity and its complications. Despite the large number of experimental and clinical researches performed on gut microbiota and obesity, no bibliometrics' study has been conducted so far. We aimed to assess the trend of ...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章,评审

    doi:10.22038/ijbms.2018.30203.7281

    authors: Ejtahed HS,Tabatabaei-Malazy O,Soroush AR,Hasani-Ranjbar S,Siadat SD,Raes J,Larijani B

    更新日期:2019-01-01 00:00:00

  • L-Carnitine potentiates the anti-inflammatory and antinociceptive effects of diclofenac sodium in an experimentally-induced knee osteoarthritis rat model.

    abstract:Objectives:The aim of the present research is to investigate the efficacy of L-carnitine (LC) as a complementary therapy to diclofenac sodium (Dic) treatment in a mono-iodoacetate (MIA) induced knee osteoarthritis (OA) rat model, with respect to pain relief and the underlying pathology. Materials and Methods:Fifty adu...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/ijbms.2020.43136.10138

    authors: Khodir SA,Al-Gholam MA,Salem HR

    更新日期:2020-08-01 00:00:00

  • Gestational diabetes influences retinal Muller cells in rat's offspring.

    abstract:OBJECTIVES:The Muller cell is the principal glial cell of the vertebrate retina. The expression of Glial fibrillary acidic protein (GFAP) in the Muller cells was used as a cellular marker for retinal damage. This study was done to evaluate the effect of gestational diabetes on retinal Muller cells in rat's offspring. ...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/ijbms.2017.8251

    authors: Tabasi A,Ghafari S,Mehdizadeh M,Shekari MA,Golalipour MJ

    更新日期:2017-02-01 00:00:00

  • Protective effects of erythropoietin against cuprizone-induced oxidative stress and demyelination in the mouse corpus callosum.

    abstract:OBJECTIVES:Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of multiple sclerosis. The aim of the present work is to investigate the protective effects of erythropoietin against cuprizone-induced oxidative stress. MATERIALS AND METHODS:...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/IJBMS.2017.9110

    authors: Kashani IR,Chavoshi H,Pasbakhsh P,Hassani M,Omidi A,Mahmoudi R,Beyer C,Zendedel A

    更新日期:2017-08-01 00:00:00

  • Pterocarpus santalinus ameliorates streptozotocin-induced diabetes mellitus via anti-inflammatory pathways and enhancement of insulin function.

    abstract:Objectives:Morbidity and mortality due to diabetes mellitus (DM) result in exorbitant psycho-economical costs, so there is a strong need to create new strategies and drugs for controlling DM. The aim of the current study was to investigate the anti-diabetic effect of the aqueous extract of Pterocarpus santalinus on str...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/ijbms.2019.34998.8325

    authors: El-Badawy RE,Ibrahim KA,Hassan NS,El-Sayed WM

    更新日期:2019-08-01 00:00:00

  • Protective effect of bioactive compounds from Lonicera japonica Thunb. against H2O2-induced cytotoxicity using neonatal rat cardiomyocytes.

    abstract:OBJECTIVES:Pharmacological studies showed that the extracts of Jin Yin Hua and its active constituents have lipid lowering, antipyretic, hepatoprotective, cytoprotective, antimicrobial, antibiotic, antioxidative, antiviral, and anti-inflammatory effects. The purpose of the present study was to investigate the protectiv...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Wang C,Wang G,Liu H,Hou YL

    更新日期:2016-01-01 00:00:00

  • Biochemical and computational study of an alginate lyase produced by Pseudomonas aeruginosa strain S21.

    abstract:Objectives:Alginates play a key role in mucoid Pseudomonas aeruginosa colonization, biofilm formation, and driving out of cationic antibiotics. P. aeruginosa alginate lyase (AlgL) is a periplasmic enzyme that is necessary for alginate synthesis and secretion. It also has a role in depolymerization of alginates. Using A...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/ijbms.2020.37277.8874

    authors: Piroozmand F,Ghadam P,Zarrabi M,Abdi-Ali A

    更新日期:2020-04-01 00:00:00

  • Effects of nano-copper on maize yield and inflammatory response in mice.

    abstract:Objectives:Copper (Cu) is an essential dietary supplement in animal feeds, which plays an important role in maintaining the balance of all living organisms. Copper nanoparticles (nCu) participate in catalysing activities of multiple antioxidant/defensive enzymes and exerts pro-inflammatory and pro-apoptotic effects on ...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/ijbms.2019.35787.8526

    authors: Hien LTT,Trang PTT,Phuong PC,Tam PT,Xuan NT

    更新日期:2019-07-01 00:00:00

  • Molecular targets of pomegranate (Punica granatum) in preventing cancer metastasis.

    abstract::Metastasis is the primary cause of mortality and morbidity among cancer patients and accounts for about 90% of cancer deaths. The most common types of treatment for cancer metastasis are chemotherapy and radiotherapy. However, such therapy has many serious side effects that could diminish the quality of life in patien...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章,评审

    doi:10.22038/ijbms.2019.34653.8217

    authors: Ahmadiankia N

    更新日期:2019-09-01 00:00:00

  • Silencing of rhomboid domain containing 1 to inhibit the metastasis of human breast cancer cells in vitro.

    abstract:Objectives:A growing body of evidence indicates that rhomboid domain containing 1 (RHBDD1) plays an important role in a variety of physiological and pathological processes, including tumorigenesis. We aimed to determine the function of RHBDD1 in breast cancer cells. Materials and Methods:In this study, we used the Onc...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/IJBMS.2018.29788.7191

    authors: Huang C,Ji X,Peng Y,Wu M,Wu W,Luo Y,Cheng G,Zhu Y

    更新日期:2018-11-01 00:00:00

  • Medicinal plants for gingivitis: a review of clinical trials.

    abstract:Objectives:Periodontal diseases are among prevalent oral health problems which may ultimately lead to severe complications in oral cavity. Herbal products can be designed as single or multicomponent preparations for better oral health. This study aims to review current clinical trials on the effectiveness of herbal pro...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章,评审

    doi:10.22038/IJBMS.2018.31997.7690

    authors: Safiaghdam H,Oveissi V,Bahramsoltani R,Farzaei MH,Rahimi R

    更新日期:2018-10-01 00:00:00

  • The ameliorative potential of ethanolic extract of propolis on hematotoxicity and structural neuronal damage in hyperthermia-exposed rats.

    abstract:OBJECTIVES:Hyperthermia is one of the most common environmental stressors that affect multi-biological systems in the body including the central nervous system as well as the hematopoietic organs. The objective of the present study was to investigate the protective role of ethanolic extract of propolis (EEP) on some se...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Mohamed WA,Ismail T,Farouk S

    更新日期:2016-08-01 00:00:00

  • Combination of stem cell mobilized by granulocyte-colony stimulating factor and human umbilical cord matrix stem cell: therapy of traumatic brain injury in rats.

    abstract:OBJECTIVES:Clinical studies of treating traumatic brain injury (TBI) with autologous adult stem cells led us to examine the impression of a combination therapy. This was performed by intravenous injection of human umbilical cord matrix stem cell (hUCMSC-Wharton(,)s jelly stem cell) with bone marrow cell mobilized by gr...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Bakhtiary M,Marzban M,Mehdizadeh M,Joghataei MT,Khoei S,Tondar M,Mahabadi VP,Laribi B,Ebrahimi A,Hashemian SJ,Modiry N,Mehrabi S

    更新日期:2011-07-01 00:00:00

  • Effect of Crocus sativus extracts and its active constituent safranal on the harmaline-induced tremor in mice.

    abstract:OBJECTIVES:Due to unsatisfactory response or intolerable side effects of current drugs, treatment of essential tremor remains inadequate. Thus, we aimed to investigate the protective and therapeutic effects of aqueous and ethanolic extracts of Crocus sativus (saffron), and its active consistent, safranal, on the harmal...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Amin B,Malekzadeh M,Heidari MR,Hosseinzadeh H

    更新日期:2015-05-01 00:00:00

  • Eupafolin ameliorates lipopolysaccharide-induced cardiomyocyte autophagy via PI3K/AKT/mTOR signaling pathway.

    abstract:Objectives:Eupafolin, a major active component of Eupatorium perfoliatum L., has anti-inflammatory and anti-oxidant properties. Lipopolysaccharide (LPS) is responsible for myocardial depression. A line of evidences revealed that LPS induces autophagy in cardiomyocytes injury. This study aims to evaluate the effects of ...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/ijbms.2019.37748.8977

    authors: Gao Y,Zhang Y,Fan Y

    更新日期:2019-11-01 00:00:00

  • Endurance training induces fiber type-specific revascularization in hindlimb skeletal muscles of rats with chronic heart failure.

    abstract:OBJECTIVES:Previous studies showed that skeletal muscle microcirculation was reduced in chronic heart failure. The aim of this study was to investigate the effects of endurance training on capillary and arteriolar density of fast and slow twitch muscles in rats with chronic heart failure. MATERIALS AND METHODS:Four we...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/ijbms.2017.8101

    authors: Ranjbar K,Ardakanizade M,Nazem F

    更新日期:2017-01-01 00:00:00

  • CB1 cannabinoid receptors are involved in neuroleptic-induced enhancement of brain neurotensin.

    abstract:UNLABELLED:Objective(s ): Targeting the neuropeptide systems has been shown to be useful for the development of more effective antipsychotic drugs. Neurotensin, an endogenous neuropeptide, appears to be involved in the mechanism of action of antipsychotics. However, the available data provide conflicting results and th...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Hassanzadeh P,Rostami F

    更新日期:2014-03-01 00:00:00

  • Effects of Lactobacillus acidophilus and Bifidobacterium bifidum probiotics on the serum biochemical parameters, and the vitamin D and leptin receptor genes on mice colon cancer.

    abstract:Objectives:The preclinical reports have shown that specific probiotics like Bifidobacterium bifidum (B. bifidum) and Lactobacillus acidophilus (L. acidophilus) can be applied as the biotherapeutic agents in the inhibition or therapy of colorectal cancer via the modification of gut bacteria. In the previous studies, we ...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/ijbms.2019.32624.7806

    authors: Ranji P,Agah S,Heydari Z,Rahmati-Yamchi M,Mohammad Alizadeh A

    更新日期:2019-06-01 00:00:00

  • Protective effect of interleukin-36 receptor antagonist on liver injury induced by concanavalin A in mice.

    abstract:Objectives:Interleukin-36 receptor antagonist (IL-36Ra) is a new member of the IL-1 family that exhibits anti-inflammatory activity in a variety of inflammatory and immune diseases. Our purpose was to determine the effect of IL-36Ra on liver injury in a mouse hepatitis model induced by concanavalin A (ConA). Materials...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/ijbms.2020.35614.8492

    authors: Peng X,Pan X,Tan J,Li Y,Li M

    更新日期:2020-05-01 00:00:00

  • Partial Optimization of Endo-1, 4-Β-Xylanase Production by Aureobasidium pullulans Using Agro-Industrial Residues.

    abstract:UNLABELLED:Objective(s) : Although bacteria and molds are the pioneering microorganisms for production of many enzymes, yet yeasts provide safe and reliable sources of enzymes with applications in food and feed. MATERIALS AND METHODS:Single xylanase producer yeast was isolated from plant residues based on formation of...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Nasr S,Soudi MR,Hatef Salmanian A,Ghadam P

    更新日期:2013-12-01 00:00:00

  • Association between HLA-DQB1 alleles and HAM/TSP patients in Khorasan Province.

    abstract:OBJECTIVES:HTLVI-1 is the first human retrovirus with limited endemic regions in the world. The epidemiological studies have shown that the genetic background and immune response to the virus have a significant role in HTLV-I-associated diseases. Among the genes are involved in HTLV-I infection, the role of human leuko...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Tafreshian AR,Etemadi M,Farid-Hosseini R,Salhi M,Afshari JT

    更新日期:2014-10-01 00:00:00

  • Liver ischemia preconditions the heart against ischemia-reperfusion arrhythmias.

    abstract:OBJECTIVES:This study aimed to examine the hypothesis that an antiarrhythmic effect might be obtained by ischemic preconditioning of the liver, and also to characterize the potential underlying mechanisms. MATERIALS AND METHODS:Male Wistar rats were anesthetized by thiopental sodium (50 mg/kg, IP) followed by IV injec...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Noorbakhsh MF,Arab HA,Kazerani HR

    更新日期:2015-01-01 00:00:00

  • Alpha-1 antitrypsin, retinol binding protein and keratin 10 alterations in patients with psoriasis vulgaris, a proteomic approach.

    abstract:OBJECTIVES:Psoriasis is an autoimmune disease that appears on the skin. Although psoriasis is clinically and histologically well characterized, its pathogenesis is unknown in detail. The aims of this study were to evaluate the proteome of psoriatic patients' sera and to compare them with those of normal healthy human t...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Fattahi S,Kazemipour N,Hashemi M,Sepehrimanesh M

    更新日期:2014-09-01 00:00:00

  • Behavioral and electrophysiological aspects of cognition in neonate rats lactated by morphine addicted mothers.

    abstract:Objectives:In addition to genetic factors, environmental phenomena during postnatal age highly affect development and, in turn, function of the brain. The present work evaluates if morphine consumption during lactation period influences the spatial performances and synaptic plasticity in rats at neonatal period of age....

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/ijbms.2019.36892.8789

    authors: Aghighi F,Mohammadifar M,Banafsheh H,Salami M,Talaei SA

    更新日期:2019-09-01 00:00:00

  • Total flavonoid extract from Coreopsis tinctoria Nutt. protects rats against myocardial ischemia/reperfusion injury.

    abstract:OBJECTIVES:This study aimed to evaluate the protective effects of total flavonoid extract from Coreopsis tinctoria Nutt. (CTF) against myocardial ischemia/reperfusion injury (MIRI) using an isolated Langendorff rat heart model. MATERIALS AND METHODS:Left ventricular developed pressure (LVDP) and the maximum rate of ri...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Zhang Y,Yuan C,Fang H,Li J,Su S,Chen W

    更新日期:2016-09-01 00:00:00

  • The Extract of Crocus sativus and Its Constituent Safranal, Affect Serum Levels of Endothelin and Total Protein in Sensitized Guinea Pigs.

    abstract:OBJECTIVE(S):The effect of the extract of Crocus sativus and its constituent, safranal on inflammatory markers in sensitized guinea pigs was examined. MATERIALS AND METHODS:Ovalbumin (OA) sensitized guinea pigs were given drinking water alone (group S), or drinking water containing three concentrations of safranal, th...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Gholamnezhad Z,Koushyar H,Byrami G,Boskabady MH

    更新日期:2013-09-01 00:00:00

  • Hypolipidemic effects of total flavonoide extracted from the leaves of Actinidiakolomikta in rats fed a high-fat diet.

    abstract:Objectives:This study was to investigate the antihyperlipidemic and antioxidant effect of total flavonoid extract from Actinidiakolomikta (TFAK) in hyperlipidemia induced by a high-fat diet. Materials and Methods:Male SD rats were randomly divided into 6 groups: normal group, model (hyperlipidemic diet) group, hyperli...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/IJBMS.2017.9365

    authors: Yu Z,Xu H,Yu X,Sui D,Lin G

    更新日期:2017-10-01 00:00:00

  • Conjugated linoleic acid supplementation enhances insulin sensitivity and peroxisome proliferator-activated receptor gamma and glucose transporter type 4 protein expression in the skeletal muscles of rats during endurance exercise.

    abstract:OBJECTIVES:This study examined whether conjugated linoleic acid (CLA) supplementation affects insulin sensitivity and peroxisome proliferator-activated receptor gamma (PPAR-γ) and glucose transporter type 4 (GLUT-4) protein expressions in the skeletal muscles of rats during endurance exercise. MATERIALS AND METHODS:Sp...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Cho K,Song Y,Kwon D

    更新日期:2016-01-01 00:00:00