Abstract:
Objectives:Bacterial translocation in patients with cirrhosis is an important triggering factor for infections and mortality. In the bile duct ligation (BDL) model, crucial players of bacterial translocation are still unknown. This study aims to determine the interrelation between microbiome composition in the colon, mesenteric lymph nodes, and liver, as well as the local inflammatory microenvironment in the BDL model. Materials and Methods:Liver damage was assayed by Masson trichrome staining, and hepatic enzymes. The diversity of microbiota in colon stools, mesenteric lymph nodes, and liver was determined by 16S rRNA pyrosequencing. Cytokine expression in mesenteric lymph nodes was analyzed by qRT-PCR. Results:Our results show that Proteobacteria was the predominant phylum found to translocate to mesenteric lymph nodes and liver in cirrhotic rats. Bile duct ligation induces a drastic intestinal dysbiosis, revealed by an increased relative abundance of Sarcina, Clostridium, Helicobacter, Turicibacter, and Streptococcus genera. However, beneficial bacteria, such as Lactobacillus, Prevotella and Ruminococcus were found to be notably decreased in BDL groups. Mesenteric pro-inflammatory (TNF-α, IL-1β, IL-6, TLR-4) and regulatory (TGF-β, Foxp3, and IL-10) molecules at 30 days post-BDL were significantly increased. Conversely, TGF-β and Foxp3 were significantly augmented at 8 days post-BDL. Conclusion:Dysbiosis in the colon and mesenteric lymph nodes is linked to an imbalance in the immune response; therefore, this may be an important trigger for bacterial translocation in the BDL model.
journal_name
Iran J Basic Med Scijournal_title
Iranian journal of basic medical sciencesauthors
Vega-Magaña N,Galiana A,Jave-Suárez LF,Garcia-Benavides L,Del Toro-Arreola S,Andrade-Villanueva JF,González-Hernández LA,Cremades R,Aguilar-Lemarroy A,Flores-Miramontes MG,Haramati J,Meza-Arroyo J,Bueno-Topete MRdoi
10.22038/IJBMS.2019.36487.8753subject
Has Abstractpub_date
2020-02-01 00:00:00pages
178-185issue
2eissn
2008-3866issn
2008-3874journal_volume
23pub_type
杂志文章abstract:OBJECTIVES:Amyotrophic lateral sclerosis (ALS), a fatal progressive neurodegenerative disorder, is the most common motor neuron disease in European populations. Approximately 10% of ALS cases are familial (FALS) and the other patients are considered as sporadic ALS (SALS). Among many ALS causing genes that have been id...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE(S):Garlic (Allium sativum L. family Liliaceae) is well known in Iran and its leaves, flowers, and cloves have been used in traditional medicine for a long time. Research in recent decades has shown widespread pharmacological effects of A. sativum and its organosulfur compounds especially Allicin. Studies carr...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章,评审
doi:
更新日期:2013-10-01 00:00:00
abstract:Objectives:Recent evidence has shown underlying roles of gut dysbiosis and metabolic endotoxemia in obesity and its complications. Despite the large number of experimental and clinical researches performed on gut microbiota and obesity, no bibliometrics' study has been conducted so far. We aimed to assess the trend of ...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章,评审
doi:10.22038/ijbms.2018.30203.7281
更新日期:2019-01-01 00:00:00
abstract:Objectives:The aim of the present research is to investigate the efficacy of L-carnitine (LC) as a complementary therapy to diclofenac sodium (Dic) treatment in a mono-iodoacetate (MIA) induced knee osteoarthritis (OA) rat model, with respect to pain relief and the underlying pathology. Materials and Methods:Fifty adu...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/ijbms.2020.43136.10138
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVES:The Muller cell is the principal glial cell of the vertebrate retina. The expression of Glial fibrillary acidic protein (GFAP) in the Muller cells was used as a cellular marker for retinal damage. This study was done to evaluate the effect of gestational diabetes on retinal Muller cells in rat's offspring. ...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/ijbms.2017.8251
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVES:Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of multiple sclerosis. The aim of the present work is to investigate the protective effects of erythropoietin against cuprizone-induced oxidative stress. MATERIALS AND METHODS:...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/IJBMS.2017.9110
更新日期:2017-08-01 00:00:00
abstract:Objectives:Morbidity and mortality due to diabetes mellitus (DM) result in exorbitant psycho-economical costs, so there is a strong need to create new strategies and drugs for controlling DM. The aim of the current study was to investigate the anti-diabetic effect of the aqueous extract of Pterocarpus santalinus on str...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/ijbms.2019.34998.8325
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVES:Pharmacological studies showed that the extracts of Jin Yin Hua and its active constituents have lipid lowering, antipyretic, hepatoprotective, cytoprotective, antimicrobial, antibiotic, antioxidative, antiviral, and anti-inflammatory effects. The purpose of the present study was to investigate the protectiv...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2016-01-01 00:00:00
abstract:Objectives:Alginates play a key role in mucoid Pseudomonas aeruginosa colonization, biofilm formation, and driving out of cationic antibiotics. P. aeruginosa alginate lyase (AlgL) is a periplasmic enzyme that is necessary for alginate synthesis and secretion. It also has a role in depolymerization of alginates. Using A...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/ijbms.2020.37277.8874
更新日期:2020-04-01 00:00:00
abstract:Objectives:Copper (Cu) is an essential dietary supplement in animal feeds, which plays an important role in maintaining the balance of all living organisms. Copper nanoparticles (nCu) participate in catalysing activities of multiple antioxidant/defensive enzymes and exerts pro-inflammatory and pro-apoptotic effects on ...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/ijbms.2019.35787.8526
更新日期:2019-07-01 00:00:00
abstract::Metastasis is the primary cause of mortality and morbidity among cancer patients and accounts for about 90% of cancer deaths. The most common types of treatment for cancer metastasis are chemotherapy and radiotherapy. However, such therapy has many serious side effects that could diminish the quality of life in patien...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章,评审
doi:10.22038/ijbms.2019.34653.8217
更新日期:2019-09-01 00:00:00
abstract:Objectives:A growing body of evidence indicates that rhomboid domain containing 1 (RHBDD1) plays an important role in a variety of physiological and pathological processes, including tumorigenesis. We aimed to determine the function of RHBDD1 in breast cancer cells. Materials and Methods:In this study, we used the Onc...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/IJBMS.2018.29788.7191
更新日期:2018-11-01 00:00:00
abstract:Objectives:Periodontal diseases are among prevalent oral health problems which may ultimately lead to severe complications in oral cavity. Herbal products can be designed as single or multicomponent preparations for better oral health. This study aims to review current clinical trials on the effectiveness of herbal pro...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章,评审
doi:10.22038/IJBMS.2018.31997.7690
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVES:Hyperthermia is one of the most common environmental stressors that affect multi-biological systems in the body including the central nervous system as well as the hematopoietic organs. The objective of the present study was to investigate the protective role of ethanolic extract of propolis (EEP) on some se...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVES:Clinical studies of treating traumatic brain injury (TBI) with autologous adult stem cells led us to examine the impression of a combination therapy. This was performed by intravenous injection of human umbilical cord matrix stem cell (hUCMSC-Wharton(,)s jelly stem cell) with bone marrow cell mobilized by gr...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVES:Due to unsatisfactory response or intolerable side effects of current drugs, treatment of essential tremor remains inadequate. Thus, we aimed to investigate the protective and therapeutic effects of aqueous and ethanolic extracts of Crocus sativus (saffron), and its active consistent, safranal, on the harmal...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2015-05-01 00:00:00
abstract:Objectives:Eupafolin, a major active component of Eupatorium perfoliatum L., has anti-inflammatory and anti-oxidant properties. Lipopolysaccharide (LPS) is responsible for myocardial depression. A line of evidences revealed that LPS induces autophagy in cardiomyocytes injury. This study aims to evaluate the effects of ...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/ijbms.2019.37748.8977
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVES:Previous studies showed that skeletal muscle microcirculation was reduced in chronic heart failure. The aim of this study was to investigate the effects of endurance training on capillary and arteriolar density of fast and slow twitch muscles in rats with chronic heart failure. MATERIALS AND METHODS:Four we...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/ijbms.2017.8101
更新日期:2017-01-01 00:00:00
abstract:UNLABELLED:Objective(s ): Targeting the neuropeptide systems has been shown to be useful for the development of more effective antipsychotic drugs. Neurotensin, an endogenous neuropeptide, appears to be involved in the mechanism of action of antipsychotics. However, the available data provide conflicting results and th...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2014-03-01 00:00:00
abstract:Objectives:The preclinical reports have shown that specific probiotics like Bifidobacterium bifidum (B. bifidum) and Lactobacillus acidophilus (L. acidophilus) can be applied as the biotherapeutic agents in the inhibition or therapy of colorectal cancer via the modification of gut bacteria. In the previous studies, we ...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/ijbms.2019.32624.7806
更新日期:2019-06-01 00:00:00
abstract:Objectives:Interleukin-36 receptor antagonist (IL-36Ra) is a new member of the IL-1 family that exhibits anti-inflammatory activity in a variety of inflammatory and immune diseases. Our purpose was to determine the effect of IL-36Ra on liver injury in a mouse hepatitis model induced by concanavalin A (ConA). Materials...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/ijbms.2020.35614.8492
更新日期:2020-05-01 00:00:00
abstract:UNLABELLED:Objective(s) : Although bacteria and molds are the pioneering microorganisms for production of many enzymes, yet yeasts provide safe and reliable sources of enzymes with applications in food and feed. MATERIALS AND METHODS:Single xylanase producer yeast was isolated from plant residues based on formation of...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVES:HTLVI-1 is the first human retrovirus with limited endemic regions in the world. The epidemiological studies have shown that the genetic background and immune response to the virus have a significant role in HTLV-I-associated diseases. Among the genes are involved in HTLV-I infection, the role of human leuko...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVES:This study aimed to examine the hypothesis that an antiarrhythmic effect might be obtained by ischemic preconditioning of the liver, and also to characterize the potential underlying mechanisms. MATERIALS AND METHODS:Male Wistar rats were anesthetized by thiopental sodium (50 mg/kg, IP) followed by IV injec...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:Psoriasis is an autoimmune disease that appears on the skin. Although psoriasis is clinically and histologically well characterized, its pathogenesis is unknown in detail. The aims of this study were to evaluate the proteome of psoriatic patients' sera and to compare them with those of normal healthy human t...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2014-09-01 00:00:00
abstract:Objectives:In addition to genetic factors, environmental phenomena during postnatal age highly affect development and, in turn, function of the brain. The present work evaluates if morphine consumption during lactation period influences the spatial performances and synaptic plasticity in rats at neonatal period of age....
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/ijbms.2019.36892.8789
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVES:This study aimed to evaluate the protective effects of total flavonoid extract from Coreopsis tinctoria Nutt. (CTF) against myocardial ischemia/reperfusion injury (MIRI) using an isolated Langendorff rat heart model. MATERIALS AND METHODS:Left ventricular developed pressure (LVDP) and the maximum rate of ri...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVE(S):The effect of the extract of Crocus sativus and its constituent, safranal on inflammatory markers in sensitized guinea pigs was examined. MATERIALS AND METHODS:Ovalbumin (OA) sensitized guinea pigs were given drinking water alone (group S), or drinking water containing three concentrations of safranal, th...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2013-09-01 00:00:00
abstract:Objectives:This study was to investigate the antihyperlipidemic and antioxidant effect of total flavonoid extract from Actinidiakolomikta (TFAK) in hyperlipidemia induced by a high-fat diet. Materials and Methods:Male SD rats were randomly divided into 6 groups: normal group, model (hyperlipidemic diet) group, hyperli...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/IJBMS.2017.9365
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVES:This study examined whether conjugated linoleic acid (CLA) supplementation affects insulin sensitivity and peroxisome proliferator-activated receptor gamma (PPAR-γ) and glucose transporter type 4 (GLUT-4) protein expressions in the skeletal muscles of rats during endurance exercise. MATERIALS AND METHODS:Sp...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2016-01-01 00:00:00