Abstract：
Objectives:This study was to investigate the antihyperlipidemic and antioxidant effect of total flavonoid extract from Actinidiakolomikta (TFAK) in hyperlipidemia induced by a high-fat diet. Materials and Methods:Male SD rats were randomly divided into 6 groups: normal group, model (hyperlipidemic diet) group, hyperlipedemic diet supplemented with TFAK (50, 100 and 200 mg/kg) and simvastatin (30 mg/kg) groups. The rats were administrated TFAK by oral for 28 days. Body weight, total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), superoxide dismutase (SOD), catalase(CAT), glutathione peroxidase(GSH-Px) and malondialdehyde (MDA) were measured. The atherogenic index (AI) and coronary risk index (CRI) were calculated. The activity of hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase in hepatic tissue was examined. Histopathologic changes were also checked. Results:The levels of TC, TG and LDL-c were increased in model group. Compared to the model group, TFAK reduced significantly the body weight, TC, TG, LDL-c, AI, CRI and elevated the level of HDL-c. Moreover, the activity of SOD was elevated significantly, whereas the content of MDA decreased. The activity of HMG-CoA reductase was also decreased. Morphological evaluation found that rats in model group developed a severe steatosis, but the severity of liver steatosis was ameliorated in TFAK treated groups. The possible mechanism may be associated with decrease HMG-CoA reductase activity. Conclusion:Our results suggest that TFAK exerts strong antioxidant and lipid-lowering effects, prevents hepatic fatty deposition and regulates the HMG-CoA reductase.
journal_name
Iran J Basic Med Scijournal_title
Iranian journal of basic medical sciencesauthors
Yu Z,Xu H,Yu X,Sui D,Lin Gdoi
10.22038/IJBMS.2017.9365subject
Has Abstractpub_date
2017-10-01 00:00:00pages
1141-1148issue
10eissn
2008-3866issn
2008-3874pii
IJBMS-20-1141journal_volume
20pub_type
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journal_title：Iranian journal of basic medical sciences
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journal_title：Iranian journal of basic medical sciences
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journal_title：Iranian journal of basic medical sciences
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journal_title：Iranian journal of basic medical sciences
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：
更新日期：2016-08-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
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doi：10.22038/ijbms.2019.30056.7242
更新日期：2019-04-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：
更新日期：2016-01-01 00:00:00
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更新日期：2019-10-01 00:00:00
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更新日期：2014-02-01 00:00:00
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更新日期：2019-06-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
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doi：10.22038/IJBMS.2018.25616.6319
更新日期：2018-04-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
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doi：
更新日期：2016-04-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：
更新日期：2014-11-01 00:00:00
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更新日期：2015-08-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2017-09-01 00:00:00
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更新日期：2019-05-01 00:00:00
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更新日期：2019-07-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：
更新日期：2011-07-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：
更新日期：2014-03-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：
更新日期：2012-11-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
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更新日期：2014-01-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：
更新日期：2012-07-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：10.22038/ijbms.2018.30149.7268
更新日期：2018-12-01 00:00:00
