Abstract:
UNLABELLED:Objective(s) : Although bacteria and molds are the pioneering microorganisms for production of many enzymes, yet yeasts provide safe and reliable sources of enzymes with applications in food and feed. MATERIALS AND METHODS:Single xylanase producer yeast was isolated from plant residues based on formation of transparent halo zones on xylan agar plates. The isolate showed much greater endo-1, 4-β-xylanase activity of 2.73 IU/ml after optimization of the initial extrinsic conditions. It was shown that the strain was also able to produce β-xylosidase (0.179 IU/ml) and α-arabinofuranosidase (0.063 IU/ml). Identification of the isolate was carried out and the endo-1, 4-β-xylanaseproduction by feeding the yeast cells on agro-industrial residues was optimized using one factor at a time approach. RESULTS:The enzyme producer strain was identified as Aureobasidiumpullulans. Based on the optimization approach, an incubation time of 48 hr at 27°C, inoculum size of 2% (v/v), initial pH value of 4 and agitation rate of 90 rpm were found to be the optimal conditions for achieving maximum yield of the enzyme. Xylan, containing agricultural residues, was evaluated as low-cost alternative carbon source for production of xylanolytic enzymes. The production of xylanase enzyme in media containing wheat bran as the sole carbon source was very similar to that of the medium containing pure beechwoodxylan. CONCLUSION:This finding indicates the feasibility of growing of A. pullulans strain SN090 on wheat bran as an alternate economical substrate in order for reducing the costs of enzyme production and using this fortified agro-industrial byproduct in formulation of animal feed.
journal_name
Iran J Basic Med Scijournal_title
Iranian journal of basic medical sciencesauthors
Nasr S,Soudi MR,Hatef Salmanian A,Ghadam Psubject
Has Abstractpub_date
2013-12-01 00:00:00pages
1245-53issue
12eissn
2008-3866issn
2008-3874journal_volume
16pub_type
杂志文章abstract:Objectives:Renal ischemia-reperfusion injury (IRI) as a severe condition of acute kidney injury (AKI) is the most common clinical problem with high mortality rates of 35-60% deaths in hospital. Mesenchymal stem cells (MSC) due to unique regenerative characteristics are ideal candidates for the treatment of the ischemic...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/IJBMS.2018.26829.6566
更新日期:2018-08-01 00:00:00
abstract:Objectives:The present paper aims to review the studies describing the interactions between HopQ and CEACAMs along with possible mechanisms responsible for pathogenicity of Helicobacter pylori. Materials and Methods:The literature was searched on "PubMed" using different key words including Helicobacter pylori, CEACAM...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章,评审
doi:10.22038/ijbms.2019.34237.81
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVES:Many cancer cells show significant resistance to drugs that kill drug sensitive cancer cells and non-tumor cells and such resistance might be a consequence of the difference in metabolism. Therefore, studying the metabolism of drug resistant cancer cells and comparison with drug sensitive and normal cell lin...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVES:Tadalafil can restore endothelial function and treat atherosclerosis. However, the effect of tadalafil on transplant arteriosclerosis remains unclear. In this study, we explore the effects of tadalafil on allograft vasculopathy. MATERIALS AND METHODS:Male Brow-Norway rats supplied aorta grafts for Male Lewi...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2015-09-01 00:00:00
abstract:Objectives:Periodontal diseases are among prevalent oral health problems which may ultimately lead to severe complications in oral cavity. Herbal products can be designed as single or multicomponent preparations for better oral health. This study aims to review current clinical trials on the effectiveness of herbal pro...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章,评审
doi:10.22038/IJBMS.2018.31997.7690
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to investigate the relationship between insulin resistance (IR) and leptin (LEP) gene polymorphisms in peritoneal dialysis (PD) patients. MATERIALS AND METHODS:From July 1, 2011 to August 1, 2011, patients who received chronic PD were chosen and divided into three groups (DM, high H...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVES:Lupus nephritis (LN) is frequently associated with a poor long-term prognosis. Renal biopsy is the diagnostic method of choice in this condition. Urine biomarkers have been mentioned in the diagnosis of LN. The study(,)s purpose was to evaluate the performance of urinary monocyte chemoattractant protein 1(UM...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2012-11-01 00:00:00
abstract:Objectives:Cholinergic neurons are important neurons in the Pedunculopontine tegmental nucleus (PPT). In this study, nicotinic receptor of the PPT in central cardiovascular regulation in the anesthetized rat was evaluated. Materials and Methods:Saline, acetylcholine (Ach; doses: 90 and 150 nmol), hexamethonium (Hexa; ...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/IJBMS.2018.25616.6319
更新日期:2018-04-01 00:00:00
abstract:Objectives:The present study evaluates the protective effects of myricitrin and its solid lipid nanoparticle (SLN) on diabetic nephropathy (DN) induced by streptozotocin-nicotinamide (STZ-NA) in mice. Materials and Methods:In this experimental study, 108 adult male NMRI mice were divided into 9 groups: control, vehicl...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/IJBMS.2019.13989
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVES:Bone marrow mesenchymal stem cells (MSCs) play an important role in bone health. Cadmium causes osteoporosis, but the exact mechanisms of its effect on MSCs are not known. MATERIALS AND METHODS:Rats were treated with cadmium chloride (40 mg/l) in drinking water for six weeks, and then the biochemical and mo...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/IJBMS.2017.8356
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVES:In food industry, the inhibition of tyrosinase is very important, because this enzyme catalyzes the oxidation of phenolic compounds found in fruits and vegetables into quinones, which contribute in undesirable color and taste of fruits and vegetables. Teucrium polium L. var. gnaphalodes (Lamiaceae), a wild-g...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2016-08-01 00:00:00
abstract:Objectives:Ferula ovina is an Iranian medicinal plant. Tschimgine and stylosin are two of its major monoterpene derivatives. In this study, we proceeded to investigate some fungal endophytes from F. ovina that can produce plant secondary metabolites. Materials and Methods:The isolated endophytic fungi were fermented i...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/ijbms.2020.46334.10703
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE(S):Because of the high total phenolic contents of Feijoa sellowiana, its nephroprotective effect was determined in 3,4-methylene dioxymethamphetamine (MDMA) treated mice. MATERIALS AND METHODS:Animals received 10, 20 and 40 mg/kg doses of aqueous or methanol extract of F. sellowiana leaves, intra-peritoneall...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2014-01-01 00:00:00
abstract:Objectives:Hyperuricemia is a risk for cardiovascular and metabolic diseases, but the mechanism is ambiguous. Increased intestinal permeability is correlated with metabolic syndrome risk factors. Intestinal epithelial cells play a pivotal role in maintaining intestinal permeability. Uric acid is directly eliminated int...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/ijbms.2020.44948.10482
更新日期:2020-06-01 00:00:00
abstract:Objectives:Morbidity and mortality due to diabetes mellitus (DM) result in exorbitant psycho-economical costs, so there is a strong need to create new strategies and drugs for controlling DM. The aim of the current study was to investigate the anti-diabetic effect of the aqueous extract of Pterocarpus santalinus on str...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/ijbms.2019.34998.8325
更新日期:2019-08-01 00:00:00
abstract::Metastasis is the primary cause of mortality and morbidity among cancer patients and accounts for about 90% of cancer deaths. The most common types of treatment for cancer metastasis are chemotherapy and radiotherapy. However, such therapy has many serious side effects that could diminish the quality of life in patien...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章,评审
doi:10.22038/ijbms.2019.34653.8217
更新日期:2019-09-01 00:00:00
abstract:Objectives:Chemotherapies used to treat colon cancer might often fail due to the emergence of chemoresistance and side effects. Escherichia coli Nissle 1917 (EcN) is a beneficial probiotic, whose molecular mechanisms in the prevention of colon cancer are yet to be fully understood. The present study assessed the anti-c...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/ijbms.2020.43016.10115
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVE(S):Gastric cancer is the first and second leading cause of cancer related death in Iranian men and women, respectively. Gastric cancer management is based on the surgery, radiotherapy and chemotherapy. In the present study, for the first time, the beneficial effect of saffron (Crocus sativus L.) aqueous extra...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2013-01-01 00:00:00
abstract:Objectives:Neurodegeneration is an outcome of Methamphetamine (METH) abuse. Studies have emphasized on the neuroprotective properties of lithium. The current study is designed towards evaluating the role of Akt-1/GSK3 and CREB-BDNF signaling pathways in mediating lithium neuroprotection against METH-induced neurodegene...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/ijbms.2019.30855.7442
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVE(S):Green tea (GT) is one of the most popular beverages worldwide whose beneficial effects on health have been demonstrated. Recent studies suggest that GT may contribute to reduction of cancer risk and progression. The aim of this study was to evaluate the effects of whole GT on urinary bladder chemical carci...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVES:Endometriosis is a complex gynecologic disease with unknown etiology. Noscapine has been introduced as a cancer cell suppressor. Endometriosis was considered as a cancer like disorder, The aim of present study was to investigate noscapine apoptotic effect on human endometriotic epithelial and stromal cells i...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2016-09-01 00:00:00
abstract:Objectives:Several lines of evidence showed that minocycline possesses antioxidant and anti-inflammatory properties. This study aimed to demonstrate the effects of minocycline in rats subjected to chronic constriction injury (CCI). Materials and Methods:In this study four groups (n = 6-8) of rats were used as follows:...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/IJBMS.2017.24248.6053
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVES:Chemoresistance remains the main causes of treatment failure and mortality in cancer patients. There is an urgent need to investigate novel approaches to improve current therapeutic modalities and increase cancer patients' survival. Induction of drug efflux due to overexpression of P-glycoproteins is conside...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2016-03-01 00:00:00
abstract:Objectives:In this study, we investigated the protective effects of piperine on lead acetate-induced renal damage in rat kidney tissue. Materials and Methods:Forty male rats were divided into 5 groups: negative control (rats were given aquadest daily), positive control (rats were given lead acetate 30 mg/kg BW orally ...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/IJBMS.2017.9487
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE(S):Atherosclerosis is a chronic immune-inflammatory disease that generally leads to ischemic heart disease. Ghrelin has several modulatory effects on cardiovascular system. In this study, we investigated the effect of ghrelin on aortic intima-media thickness, size and the number of adipocyte cells in obese an...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2013-08-01 00:00:00
abstract:UNLABELLED:Objective(s ): Targeting the neuropeptide systems has been shown to be useful for the development of more effective antipsychotic drugs. Neurotensin, an endogenous neuropeptide, appears to be involved in the mechanism of action of antipsychotics. However, the available data provide conflicting results and th...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVES:Cyclooxygenases (COXs) are known to play some roles in physiological mechanisms related to learning and memory. Since sodium salicylate is an inhibitor of COX, we have evaluated the effect of peripheral and intra-hippocampal administration of sodium salicylate on spatial learning and memory in male rats. MA...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2012-03-01 00:00:00
abstract:Objectives:In addition to genetic factors, environmental phenomena during postnatal age highly affect development and, in turn, function of the brain. The present work evaluates if morphine consumption during lactation period influences the spatial performances and synaptic plasticity in rats at neonatal period of age....
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/ijbms.2019.36892.8789
更新日期:2019-09-01 00:00:00
abstract:Objectives:The present study aimed to determine and compare moisturizing and occlusion effects of different solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) using magnetized water and deionized water. Materials and Methods:SLN formulations were prepared using various lipids, including Tripalmiti...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/IJBMS.2020.39587.9397
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVES:This study examined whether conjugated linoleic acid (CLA) supplementation affects insulin sensitivity and peroxisome proliferator-activated receptor gamma (PPAR-γ) and glucose transporter type 4 (GLUT-4) protein expressions in the skeletal muscles of rats during endurance exercise. MATERIALS AND METHODS:Sp...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2016-01-01 00:00:00