Immunogenicity of heparin-binding hemagglutinin expressed by Pichia pastoris GS115 strain.

abstract：OBJECTIVES:Opioids and cannabinoids are two important compounds that have been shown to influence the activity of magnocellular neurons (MCNs) of supraoptic nucleus (SON). The interaction between opioidergic and cannabinoidergic systems in various structures of the brain and spinal cord is now well established, but not...

journal_title：Iranian journal of basic medical sciences

authors： Yousefpour M,Naderi N,Motamedi F

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVES:Prostate cancer is the world's leading cause of cancer and the second cause of cancer-related death in men after lung cancer. Differentiation of prostate adenocarcinoma from benign prostate lesions and hyperplasia sometimes cannot be done on the basis of morphologic findings. Considering the fact that in the...

journal_title：Iranian journal of basic medical sciences

authors： Kalantari MR,Anvari K,Jabbari H,Tabrizi FV

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE(S):Gingivitis is an inflammatory disease that affects tooth-supporting tissues and is caused by a microbe-immune response. The aim of this study was to evaluate the effects of omega-3 fatty acids on immune system regulation and the prevention and treatment of gingivitis using an animal model. MATERIALS AND M...

journal_title：Iranian journal of basic medical sciences

authors： Araghizadeh N,Paknejad M,Alaeddini M,Minaii B,Abdollahi M,Khorasanie R

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVES:Various studies have shown that the diabetes is associated with liver failure. The objective of this study was determining the effects of Berberis vulgaris fruit on histopathological and biochemical markers of liver in diabetic rats. MATERIALS AND METHODS:In this experimental study, 60 male Wistar rats weig...

journal_title：Iranian journal of basic medical sciences

authors： Rahimi-Madiseh M,Karimian P,Kafeshani M,Rafieian-Kopaei M

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVES:To clarify the protective effects of Cichorium glandulosum (CG) extracts on thioacetamide (TAA)-induced rat hepatic fibrosis. MATERIALS AND METHODS:The dry roots of CG were smashed and percolated with 95% ethanol, and the residual was prepared into petroleum ether extract (CG-V), ethyl acetate extract (CG-V...

journal_title：Iranian journal of basic medical sciences

authors： Qin D,Nie Y,Wen Z

更新日期：2014-11-01 00:00:00

abstract：Objectives:Eupafolin, a major active component of Eupatorium perfoliatum L., has anti-inflammatory and anti-oxidant properties. Lipopolysaccharide (LPS) is responsible for myocardial depression. A line of evidences revealed that LPS induces autophagy in cardiomyocytes injury. This study aims to evaluate the effects of ...

journal_title：Iranian journal of basic medical sciences

authors： Gao Y,Zhang Y,Fan Y

更新日期：2019-11-01 00:00:00

abstract：Objectives:Bacteriophages are infectious replicating entities that are under consideration as antimicrobial bioagents to control bacterial infections. As an alternative or supplement to antibiotics, bacteriophages can be used to circumvent the resistance to existing antibiotics. The aim of this study was to assess the ...

journal_title：Iranian journal of basic medical sciences

authors： Moradpour Z,Yousefi N,Sadeghi D,Ghasemian A

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVES:This study aimed to examine the hypothesis that an antiarrhythmic effect might be obtained by ischemic preconditioning of the liver, and also to characterize the potential underlying mechanisms. MATERIALS AND METHODS:Male Wistar rats were anesthetized by thiopental sodium (50 mg/kg, IP) followed by IV injec...

journal_title：Iranian journal of basic medical sciences

authors： Noorbakhsh MF,Arab HA,Kazerani HR

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE(S):Garlic (Allium sativum L. family Liliaceae) is well known in Iran and its leaves, flowers, and cloves have been used in traditional medicine for a long time. Research in recent decades has shown widespread pharmacological effects of A. sativum and its organosulfur compounds especially Allicin. Studies carr...

journal_title：Iranian journal of basic medical sciences

authors： Mikaili P,Maadirad S,Moloudizargari M,Aghajanshakeri S,Sarahroodi S

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVES:Similar characteristics of molecular pathways between cellular reprogramming events and tumorigenesis have been accentuated in recent years. Reprogramming-related transcription factors, also known as Yamanaka factors (OCT4, SOX2, KLF4, and c-MYC), are also well-known oncogenes promoting cancer initiation, pr...

journal_title：Iranian journal of basic medical sciences

authors： Sahebi R,Malakootian M,Balalaee B,Shahryari A,Khoshnia M,Abbaszadegan MR,Moradi A,Javad Mowla S

更新日期：2016-10-01 00:00:00

abstract：:Cancer testis antigens (CTAs), a large family of tumor-associated and immunogenic antigens expressed in human tumors of various histological origins, are highly restricted to the testis and trophoblast. CTAs have been identified as potent targets for tumor-specific immunotherapeutic advances and have immensely lead to...

journal_title：Iranian journal of basic medical sciences

authors： Babatunde KA,Najafi A,Salehipour P,Modarressi MH,Mobasheri MB

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVE(S):Pre-eclampsia is characterized by hypertension, dyslipidemia, and increased systemic inflammatory response and has been associated with an increased maternal risk of cardiovascular disease later in life. Endothelial dysfunction is thought to be a central pathogenic feature in pre-eclampsia on the basis of ...

journal_title：Iranian journal of basic medical sciences

authors： Farzadnia M,Ayatollahi H,Hasan-Zade M,Rahimi HR

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVES:The Muller cell is the principal glial cell of the vertebrate retina. The expression of Glial fibrillary acidic protein (GFAP) in the Muller cells was used as a cellular marker for retinal damage. This study was done to evaluate the effect of gestational diabetes on retinal Muller cells in rat's offspring. ...

journal_title：Iranian journal of basic medical sciences

authors： Tabasi A,Ghafari S,Mehdizadeh M,Shekari MA,Golalipour MJ

更新日期：2017-02-01 00:00:00

abstract：Objectives:Charcot-Marie Tooth disease (CMT) is one of the main inherited causes of motor and sensory neuropathies with variable expressivity and age-of onset. Although more than 70 genes have been identified for CMT, more studies are needed to discover other genes involved in CMT. Introduction of whole exome sequencin...

journal_title：Iranian journal of basic medical sciences

authors： Tahmasebi-Birgani M,Hajjari M,Golchin N,Shalbafan B,Mohammadi-Asl J,Sadeghian F

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the methylation status and mRNA expression levels of P15, death-associated protein kinase (DAPK), and suppressor of cytokine signaling-1 (SOCS1) genes in multiple myeloma (MM). MATERIALS AND METHODS:The bone marrow samples of 54 MM patients were collected and the met...

journal_title：Iranian journal of basic medical sciences

authors： Liu L,Tan L,He Z

更新日期：2016-07-01 00:00:00

abstract：Objectives:Cord blood (CB) is known as a valuable source of hematopoietic stem cells (HSC). Identifying strategies that enhance expansion and maintain engraftment and homing capacity of HSCs can improve transplant efficiency. In this study, we examined different culture conditions on ex vivo expansion and homing capaci...

journal_title：Iranian journal of basic medical sciences

authors： Mohammadali F,Abroun S,Atashi A

更新日期：2018-07-01 00:00:00

abstract：Objectives:Adipose-derived stem cells (ADSCs), with suitable and easy access, are multipotential cells that have the ability for differentiation into other mesodermal and transdifferentiate into neural phenotype cells. In this study, Lithium chloride (LiCl) was used for in vitro transdifferentiation of rat ADSCs into n...

journal_title：Iranian journal of basic medical sciences

authors： Farrokhfar S,Tiraihi T,Movahedin M,Azizi H

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVES:One strategy for the treatment of diabetes is inhibition of pancreatic α- amylase. Plants contains different chemical constituents with potential for inhibition of α-amylase and hence maybe used as therapeutic. MATERIALS AND METHODS:Urtica dioica and Juglans regia Linn were tested for α-amylase inhibition. ...

journal_title：Iranian journal of basic medical sciences

authors： Rahimzadeh M,Jahanshahi S,Moein S,Moein MR

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVES:Psoriasis is an autoimmune disease that appears on the skin. Although psoriasis is clinically and histologically well characterized, its pathogenesis is unknown in detail. The aims of this study were to evaluate the proteome of psoriatic patients' sera and to compare them with those of normal healthy human t...

journal_title：Iranian journal of basic medical sciences

authors： Fattahi S,Kazemipour N,Hashemi M,Sepehrimanesh M

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVES:Lupus nephritis (LN) is frequently associated with a poor long-term prognosis. Renal biopsy is the diagnostic method of choice in this condition. Urine biomarkers have been mentioned in the diagnosis of LN. The study(,)s purpose was to evaluate the performance of urinary monocyte chemoattractant protein 1(UM...

journal_title：Iranian journal of basic medical sciences

authors： Mirfeizi Z,Mahmoudi M,Naghibi M,Hatef M,Sharifipour F,Jokar M,Zeraati A,Shariati Sarabi Z,Azarian A

更新日期：2012-11-01 00:00:00

abstract：Objectives:The present study evaluates the protective effects of myricitrin and its solid lipid nanoparticle (SLN) on diabetic nephropathy (DN) induced by streptozotocin-nicotinamide (STZ-NA) in mice. Materials and Methods:In this experimental study, 108 adult male NMRI mice were divided into 9 groups: control, vehicl...

journal_title：Iranian journal of basic medical sciences

authors： Ahangarpour A,Oroojan AA,Khorsandi L,Kouchak M,Badavi M

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVES:The purpose of the current study was to assess the feasibility of microspheres from biocompatible polymer for oral bioavailability (BA) enhancement of potent sulfonamide- type loop diuretic- Furosemide - which used in the treatment of congestive heart failure, caused edema, cirrhosis, renal disease and as an...

journal_title：Iranian journal of basic medical sciences

authors： Derakhshandeh K,Karimi M,Azandaryani AH,Bahrami G,Ghanbari K

更新日期：2016-10-01 00:00:00

abstract：Objectives:A growing body of evidence indicates that rhomboid domain containing 1 (RHBDD1) plays an important role in a variety of physiological and pathological processes, including tumorigenesis. We aimed to determine the function of RHBDD1 in breast cancer cells. Materials and Methods:In this study, we used the Onc...

journal_title：Iranian journal of basic medical sciences

authors： Huang C,Ji X,Peng Y,Wu M,Wu W,Luo Y,Cheng G,Zhu Y

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE(S):Because of the high total phenolic contents of Feijoa sellowiana, its nephroprotective effect was determined in 3,4-methylene dioxymethamphetamine (MDMA) treated mice. MATERIALS AND METHODS:Animals received 10, 20 and 40 mg/kg doses of aqueous or methanol extract of F. sellowiana leaves, intra-peritoneall...

journal_title：Iranian journal of basic medical sciences

authors： Karami M,Karimian Nokabadi F,Ebrahimzadeh MA,Naghshvar F

更新日期：2014-01-01 00:00:00

abstract：Objectives:Panax ginseng (PG) widely used for its various pharmacological activities, including effects on diabetes and its complications. This study aims to investigate the effect of PG on mortality-related hypomagnesemia, hyperlactatemia, metabolic acidosis, and other diabetes-induced abnormalities. Materials and Me...

journal_title：Iranian journal of basic medical sciences

authors： Adam GO,Kim GB,Lee SJ,Lee HR,Kim SJ,Kang HS,Kim JS

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVES:Particulate matter (PM) exposure can promote cardiac ischemia and myocardial damage. The effects of PM10 on hemodynamic parameters, lipid peroxidation, and infarct size induced by ischemia-reperfusion injury and the protective effects of vanillic acid (VA) in isolated rat heart were investigated. MATERIALS ...

journal_title：Iranian journal of basic medical sciences

authors： Radmanesh E,Dianat M,Badavi M,Goudarzi G,Mard SA

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVES:Amyotrophic lateral sclerosis (ALS), a fatal progressive neurodegenerative disorder, is the most common motor neuron disease in European populations. Approximately 10% of ALS cases are familial (FALS) and the other patients are considered as sporadic ALS (SALS). Among many ALS causing genes that have been id...

journal_title：Iranian journal of basic medical sciences

authors： Alavi A,Khani M,Nafissi S,Shamshiri H,Elahi E

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE(S):Cerebral hypoperfusion/ischemia (CHI) is a neurological disease where impaired hippocampus electrical activity and cognition caused by a serial pathophysiological events. This study aimed to evaluate the effects of chronic oral administration of grape seed extract (GSE) on passive avoidance memory and long...

journal_title：Iranian journal of basic medical sciences

authors： Sarkaki A,Rafieirad M,Hossini SE,Farbood Y,Motamedi F,Mansouri SM,Naghizadeh B

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVES:Herbal waters are extensively used in most parts of including . Visiting a patient with total blindness due to daily ingestion of around 200 ml of herbal water (Plant forty water) per day for six months was the rational for methanol determination in all herbal waters available in markets. MATERIALS AND METH...

journal_title：Iranian journal of basic medical sciences

authors： Mousavi SR,Namaei-Ghassemi M,Layegh M,Afzalaghaee M,Vafaee M,Zare G,Moghiman T,Mood MB

更新日期：2011-07-01 00:00:00

abstract：Objectives:The monitoring of cancer treatment response to chemotherapy is considered an essential strategy for follow-up of patients. The aim of this study was to evaluate the use of 99mTc-glucarate as a radiotracer for in vivo quantification and visualization of necrotic area and therapeutic effect of paclitaxel in ov...

journal_title：Iranian journal of basic medical sciences

authors： Sadeghi H,Rahmanian N,Amiri FT,Amirfakhrian H,Abedi SM,Hosseinimehr SJ

更新日期：2018-01-01 00:00:00