Effect of interaction between acute administration of morphine and cannabinoid compounds on spontaneous excitatory and inhibitory postsynaptic currents of magnocellular neurons of supraoptic nucleus.

abstract：OBJECTIVES:Amyotrophic lateral sclerosis (ALS), a fatal progressive neurodegenerative disorder, is the most common motor neuron disease in European populations. Approximately 10% of ALS cases are familial (FALS) and the other patients are considered as sporadic ALS (SALS). Among many ALS causing genes that have been id...

journal_title：Iranian journal of basic medical sciences

authors： Alavi A,Khani M,Nafissi S,Shamshiri H,Elahi E

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVES:Chemoresistance remains the main causes of treatment failure and mortality in cancer patients. There is an urgent need to investigate novel approaches to improve current therapeutic modalities and increase cancer patients' survival. Induction of drug efflux due to overexpression of P-glycoproteins is conside...

journal_title：Iranian journal of basic medical sciences

authors： Mohseni M,Samadi N,Ghanbari P,Yousefi B,Tabasinezhad M,Sharifi S,Nazemiyeh H

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE(S):Pre-eclampsia is characterized by hypertension, dyslipidemia, and increased systemic inflammatory response and has been associated with an increased maternal risk of cardiovascular disease later in life. Endothelial dysfunction is thought to be a central pathogenic feature in pre-eclampsia on the basis of ...

journal_title：Iranian journal of basic medical sciences

authors： Farzadnia M,Ayatollahi H,Hasan-Zade M,Rahimi HR

更新日期：2013-05-01 00:00:00

abstract：Objectives:Morbidity and mortality due to diabetes mellitus (DM) result in exorbitant psycho-economical costs, so there is a strong need to create new strategies and drugs for controlling DM. The aim of the current study was to investigate the anti-diabetic effect of the aqueous extract of Pterocarpus santalinus on str...

journal_title：Iranian journal of basic medical sciences

authors： El-Badawy RE,Ibrahim KA,Hassan NS,El-Sayed WM

更新日期：2019-08-01 00:00:00

abstract：:The study of tumor viruses paves the way for understanding the mechanisms of virus pathogenesis, including those involved in establishing infection and dissemination in the host tumor affecting immune-compromised patients. The processes ranging from viral infection to progressing malignancy are slow and usually insuff...

journal_title：Iranian journal of basic medical sciences

authors： Ahmadi Ghezeldasht S,Shirdel A,Assarehzadegan MA,Hassannia T,Rahimi H,Miri R,Rezaee SA

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE(S):The effect of the extract of Crocus sativus and its constituent, safranal on inflammatory markers in sensitized guinea pigs was examined. MATERIALS AND METHODS:Ovalbumin (OA) sensitized guinea pigs were given drinking water alone (group S), or drinking water containing three concentrations of safranal, th...

journal_title：Iranian journal of basic medical sciences

authors： Gholamnezhad Z,Koushyar H,Byrami G,Boskabady MH

更新日期：2013-09-01 00:00:00

abstract：:Nigella sativa is the miraculous plant having a lot of nutritional and medicinal benefits, and attracts large number of nutrition and pharmacological researchers. N. sativa seed composition shows that it is the blessing of nature and it contains and many bioactive compounds like thymoquinone, α-hederin, alkaloids, fla...

journal_title：Iranian journal of basic medical sciences

authors： Shafiq H,Ahmad A,Masud T,Kaleem M

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVES:Eukaryotic translation initiation factor 4E (eIF4E) is overexpressed in cervical cancer (CC). However, the molecular mechanisms are unclear. This study aimed to investigate the molecular mechanism of eIF4E gene overexpression in CC. MATERIALS AND METHODS:The human papillomavirus (HPV) type 18 E7 and eIF4E m...

journal_title：Iranian journal of basic medical sciences

authors： Pang T,Wang S,Gao M,Kang H,Zhao Y,Yao Y,Hu X

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVES:In previous studies, researchers observed that doxepin could improve cognitive processes and has protective effects on the central nervous system. Thus, this study was designed to analyze the effects of doxepin on β-amyloid (Aβ)-induced memory impairment and neuronal toxicity in rat and to explore the underl...

journal_title：Iranian journal of basic medical sciences

authors： Bu J,Zu H

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVES:Previous studies showed that skeletal muscle microcirculation was reduced in chronic heart failure. The aim of this study was to investigate the effects of endurance training on capillary and arteriolar density of fast and slow twitch muscles in rats with chronic heart failure. MATERIALS AND METHODS:Four we...

journal_title：Iranian journal of basic medical sciences

authors： Ranjbar K,Ardakanizade M,Nazem F

更新日期：2017-01-01 00:00:00

abstract：UNLABELLED:Objective(s) : Although bacteria and molds are the pioneering microorganisms for production of many enzymes, yet yeasts provide safe and reliable sources of enzymes with applications in food and feed. MATERIALS AND METHODS:Single xylanase producer yeast was isolated from plant residues based on formation of...

journal_title：Iranian journal of basic medical sciences

authors： Nasr S,Soudi MR,Hatef Salmanian A,Ghadam P

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVES:Primary or adult type hypolactasia, the most common enzyme deficiency in the world, is due to reduced lactase activity in the intestinal cell after weaning. Lactase non-persistence is inherited as an autosomal recessive trait. A DNA variant, single nucleotide polymorphism C/T-13910 which is located on 13910 ...

journal_title：Iranian journal of basic medical sciences

authors： Alizadeh M,Sadr-Nabavi A

更新日期：2012-11-01 00:00:00

abstract：:Rosa damascena mill L., known as Gole Mohammadi in is one of the most important species of Rosaceae family flowers. R. damascena is an ornamental plant and beside perfuming effect, several pharmacological properties including anti-HIV, antibacterial, antioxidant, antitussive, hypnotic, antidiabetic, and relaxant effec...

journal_title：Iranian journal of basic medical sciences

authors： Boskabady MH,Shafei MN,Saberi Z,Amini S

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVES:Human Cytomegalovirus (HCMV) remains a major morbidity and mortality cause in immuno suppressed patients. Therefore, significant effort has been made towards the development of a vaccine. In this study, the expression of the pp65 and gB fusion peptides and Fc domain of mouse IgG2a as a novel delivery system ...

journal_title：Iranian journal of basic medical sciences

authors： Tabaei S,Mashkani B,Esmaili A,Karimi R,Jamehdar SA

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVES:Bone marrow mesenchymal stem cells (MSCs) play an important role in bone health. Cadmium causes osteoporosis, but the exact mechanisms of its effect on MSCs are not known. MATERIALS AND METHODS:Rats were treated with cadmium chloride (40 mg/l) in drinking water for six weeks, and then the biochemical and mo...

journal_title：Iranian journal of basic medical sciences

authors： Abnosi MH,Golami S

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVE(S):Non-Hodgkin's lymphoma (NHL) is a lymphoproliferative malignancy in which cells undergo microscopic changes with unknown etiology, and risk factors such as age, sex, genetic and environmental factors are involved. The relationship between the presence of infectious agents and the development of lymphoproli...

journal_title：Iranian journal of basic medical sciences

authors： Rastin M,Khoee AR,Tabasi N,Sheikh A,Ziaolhagh S,Esmaeeli E,Zamani S,Khazaee M,Mahmoudi M

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE(S):Because of the high total phenolic contents of Feijoa sellowiana, its nephroprotective effect was determined in 3,4-methylene dioxymethamphetamine (MDMA) treated mice. MATERIALS AND METHODS:Animals received 10, 20 and 40 mg/kg doses of aqueous or methanol extract of F. sellowiana leaves, intra-peritoneall...

journal_title：Iranian journal of basic medical sciences

authors： Karami M,Karimian Nokabadi F,Ebrahimzadeh MA,Naghshvar F

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:Determination of stages of colon cancer is done by biopsy usually after surgery. Metabolomics is the study of all the metabolites using LC-MS and 1HNMR spectroscopy with chemometric techniques. The stages of colon cancer were detected from patients' sera using 1HNMR. MATERIALS AND METHODS:Five ml blood was ...

journal_title：Iranian journal of basic medical sciences

authors： Vahabi F,Sadeghi S,Arjmand M,Mirkhani F,Hosseini E,Mehrabanfar M,Hajhosseini R,Iravani A,Bayat P,Zamani Z

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVE(S):Atherosclerosis is a chronic immune-inflammatory disease that generally leads to ischemic heart disease. Ghrelin has several modulatory effects on cardiovascular system. In this study, we investigated the effect of ghrelin on aortic intima-media thickness, size and the number of adipocyte cells in obese an...

journal_title：Iranian journal of basic medical sciences

authors： Tahergorabi Z,Rashidi B,Khazaei M

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVES:Solid dispersion formulation is the most promising strategy to improve oral bioavailability of poorly water soluble drugs. The aim of this study was to compare the effect of polyvinylpyrrolidone K30 (PVP) and poloxamer-188 (PLX) as carrier in solid dispersion formulations of celecoxib (CLX). MATERIALS AND M...

journal_title：Iranian journal of basic medical sciences

authors： Homayouni A,Sadeghi F,Nokhodchi A,Varshosaz J,Garekani HA

更新日期：2014-05-01 00:00:00

abstract：:Cancer testis antigens (CTAs), a large family of tumor-associated and immunogenic antigens expressed in human tumors of various histological origins, are highly restricted to the testis and trophoblast. CTAs have been identified as potent targets for tumor-specific immunotherapeutic advances and have immensely lead to...

journal_title：Iranian journal of basic medical sciences

authors： Babatunde KA,Najafi A,Salehipour P,Modarressi MH,Mobasheri MB

更新日期：2017-09-01 00:00:00

abstract：Objectives:The present study evaluates the protective effects of myricitrin and its solid lipid nanoparticle (SLN) on diabetic nephropathy (DN) induced by streptozotocin-nicotinamide (STZ-NA) in mice. Materials and Methods:In this experimental study, 108 adult male NMRI mice were divided into 9 groups: control, vehicl...

journal_title：Iranian journal of basic medical sciences

authors： Ahangarpour A,Oroojan AA,Khorsandi L,Kouchak M,Badavi M

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVES:Tadalafil can restore endothelial function and treat atherosclerosis. However, the effect of tadalafil on transplant arteriosclerosis remains unclear. In this study, we explore the effects of tadalafil on allograft vasculopathy. MATERIALS AND METHODS:Male Brow-Norway rats supplied aorta grafts for Male Lewi...

journal_title：Iranian journal of basic medical sciences

authors： Ziqiang X,Jingjun W,Jianjian Z,Yong L,Peng X

更新日期：2015-09-01 00:00:00

abstract：Objectives:Mycobacterium tuberculosis (M. tuberculosis), an intracellular pathogen, causes 1.5 million deaths globally. Bacilli Calmette-Guérin (BCG) is commonly administered to protect people against M. tuberculosis infection; however, there are some obstacles with this first-generation vaccine. DNA vaccines, the thir...

journal_title：Iranian journal of basic medical sciences

authors： Dalirfardouei R,Tafaghodi M,Meshkat Z,Najafi A,Gholoobi A,Nabavinia MS,Sajedifar S,Meshkat M,Badiee A,Ramezani M,Varasteh AR,Naderinasab M

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVES:The purpose of the current study was to assess the feasibility of microspheres from biocompatible polymer for oral bioavailability (BA) enhancement of potent sulfonamide- type loop diuretic- Furosemide - which used in the treatment of congestive heart failure, caused edema, cirrhosis, renal disease and as an...

journal_title：Iranian journal of basic medical sciences

authors： Derakhshandeh K,Karimi M,Azandaryani AH,Bahrami G,Ghanbari K

更新日期：2016-10-01 00:00:00

abstract：Objectives:Ferula ovina is an Iranian medicinal plant. Tschimgine and stylosin are two of its major monoterpene derivatives. In this study, we proceeded to investigate some fungal endophytes from F. ovina that can produce plant secondary metabolites. Materials and Methods:The isolated endophytic fungi were fermented i...

journal_title：Iranian journal of basic medical sciences

authors： Tazik Z,Rahnama K,White JF,Soltanloo H,Hasanpour M,Iranshahi M

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVES:Many cancer cells show significant resistance to drugs that kill drug sensitive cancer cells and non-tumor cells and such resistance might be a consequence of the difference in metabolism. Therefore, studying the metabolism of drug resistant cancer cells and comparison with drug sensitive and normal cell lin...

journal_title：Iranian journal of basic medical sciences

authors： Motamedian E,Ghavami G,Sardari S

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVES:Herbal waters are extensively used in most parts of including . Visiting a patient with total blindness due to daily ingestion of around 200 ml of herbal water (Plant forty water) per day for six months was the rational for methanol determination in all herbal waters available in markets. MATERIALS AND METH...

journal_title：Iranian journal of basic medical sciences

authors： Mousavi SR,Namaei-Ghassemi M,Layegh M,Afzalaghaee M,Vafaee M,Zare G,Moghiman T,Mood MB

更新日期：2011-07-01 00:00:00

abstract：Objectives:Inflammation is involved in various forms of pulmonary arterial hypertension (PAH). Although the pathophysiology of PAH remains uncertain, NF-κB and p38 mitogen-activated protein kinase (p38 MAPK) has been reported to be associated with many inflammatory mediators of PAH. This study aimed to evaluate the eff...

journal_title：Iranian journal of basic medical sciences

authors： Gao L,Liu J,Hao Y,Zhao Z,Tan H,Zhang J,Meng N,Zheng Q,Wang Z,Zhang Y

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE(S):As not only few evidences but also contradictory results exist with regard to the effects of resistance training (RT) and resistance plus endurance training (ERT) on respiratory system, so the purpose of this research was therefore to study single and concurrent effects of endurance and resistance training...

journal_title：Iranian journal of basic medical sciences

authors： Khosravi M,Tayebi SM,Safari H

更新日期：2013-04-01 00:00:00