Evaluation of HTLV-I and HCV Prevalence in Non-Hodgkin's Lymphoma.

abstract：OBJECTIVES:Nitric oxide (NO), a product of inducible nitric oxide synthase (iNOS), contributes in germ cell apoptosis. This study was aimed to evaluate the effects of Aloe vera gel (AVG) on male Wistar rat reproductive organ, serum NO level, and expression of iNOS gene in leydig cells. MATERIALS AND METHODS:Adult male...

journal_title：Iranian journal of basic medical sciences

authors： Asgharzade S,Rafieian-Kopaei M,Mirzaeian A,Reiisi S,Salimzadeh L

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVES:To optimize the extraction method using response surface methodology, extract the phenolic compounds, and identify the antioxidant and biological properties of Stachys parviflora L. extracts. MATERIALS AND METHODS:Maceration and ultrasound-assisted extraction (UAE) (4, 7, 10 min treatment time, 40, 70, 100 ...

journal_title：Iranian journal of basic medical sciences

authors： Bashi DS,Dowom SA,Bazzaz BS,Khanzadeh F,Soheili V,Mohammadpour A

更新日期：2016-05-01 00:00:00

abstract：Objectives:The aim of the present research is to investigate the efficacy of L-carnitine (LC) as a complementary therapy to diclofenac sodium (Dic) treatment in a mono-iodoacetate (MIA) induced knee osteoarthritis (OA) rat model, with respect to pain relief and the underlying pathology. Materials and Methods:Fifty adu...

journal_title：Iranian journal of basic medical sciences

authors： Khodir SA,Al-Gholam MA,Salem HR

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVES:Valproic acid (VPA) has proven to be as one of the most promising useful drug with anticancer properties. In this study, we investigate the VPA effects on E-cadherin expression in HeLa, TC1, MKN45, and HCT116 cell lines. This study assesses the effects of VPA on human papillomavirus E7 expression in HPV posi...

journal_title：Iranian journal of basic medical sciences

authors： Faghihloo E,Akbari A,Adjaminezhad-Fard F,Mokhtari-Azad T

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVES:Both caloric restriction (CR) and resveratrol (RSV) have been shown to improve learning and memory, but their potential effects in juvenile animals were unknown. Here, we evaluated the effects of RSV and CR on learning and memory function in juvenile mice and investigated potential molecular mechanisms. MET...

journal_title：Iranian journal of basic medical sciences

authors： Xu BL,Wang R,Ma LN,Dong W,Zhao ZW,Zhang JS,Wang YL,Zhang X

更新日期：2015-11-01 00:00:00

abstract：Objectives:Association of adolescent emotional stress (ES) with the incidence of cardiovascular disease (CVD) at older age was investigated. Materials and Methods:21 female rats were divided into three groups of 7 each; ES, foot-shock, and control. Chronic ES was induced by exposing the rats to witness foot-shock of t...

journal_title：Iranian journal of basic medical sciences

authors： Mousavi MS,Imani A,Meknatkhah S,Riazi G

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVES:Obesity considered being a low-grade inflammatory disease. The objective of this study was to examine the association between inflammatory markers (IM) including C-reactive protein (hs-CRP), Interleukin-6 (IL-6), and homocystein (Hcy) and obesity-related factors (e.g. BMI, waist, hip) in adult participants o...

journal_title：Iranian journal of basic medical sciences

authors： Faam B,Zarkesh M,Daneshpour MS,Azizi F,Hedayati M

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE(S):The effect of the extract of Crocus sativus and its constituent, safranal on inflammatory markers in sensitized guinea pigs was examined. MATERIALS AND METHODS:Ovalbumin (OA) sensitized guinea pigs were given drinking water alone (group S), or drinking water containing three concentrations of safranal, th...

journal_title：Iranian journal of basic medical sciences

authors： Gholamnezhad Z,Koushyar H,Byrami G,Boskabady MH

更新日期：2013-09-01 00:00:00

abstract：Objectives:Recent evidence has shown underlying roles of gut dysbiosis and metabolic endotoxemia in obesity and its complications. Despite the large number of experimental and clinical researches performed on gut microbiota and obesity, no bibliometrics' study has been conducted so far. We aimed to assess the trend of ...

journal_title：Iranian journal of basic medical sciences

authors： Ejtahed HS,Tabatabaei-Malazy O,Soroush AR,Hasani-Ranjbar S,Siadat SD,Raes J,Larijani B

更新日期：2019-01-01 00:00:00

abstract：Objectives:Hyperuricemia is a risk for cardiovascular and metabolic diseases, but the mechanism is ambiguous. Increased intestinal permeability is correlated with metabolic syndrome risk factors. Intestinal epithelial cells play a pivotal role in maintaining intestinal permeability. Uric acid is directly eliminated int...

journal_title：Iranian journal of basic medical sciences

authors： Ma C,Yang X,Lv Q,Yan Z,Chen Z,Xu D,Liu X,Yang W,Xing S

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVES:Lupus nephritis (LN) is frequently associated with a poor long-term prognosis. Renal biopsy is the diagnostic method of choice in this condition. Urine biomarkers have been mentioned in the diagnosis of LN. The study(,)s purpose was to evaluate the performance of urinary monocyte chemoattractant protein 1(UM...

journal_title：Iranian journal of basic medical sciences

authors： Mirfeizi Z,Mahmoudi M,Naghibi M,Hatef M,Sharifipour F,Jokar M,Zeraati A,Shariati Sarabi Z,Azarian A

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVES:Astrodaucus persicus, Apiaceae, is used as vegetable or food additive in some parts of Iran. The essential oils of different parts of Astrodaucus persicus from Kordestan province were analyzed for the first time and compared with other regions. In this study, antioxidant activities and total phenols determin...

journal_title：Iranian journal of basic medical sciences

authors： Goodarzi S,Hadjiakhoondi A,Yassa N,Khanavi M,Tofighi Z

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVES:Opioids and cannabinoids are two important compounds that have been shown to influence the activity of magnocellular neurons (MCNs) of supraoptic nucleus (SON). The interaction between opioidergic and cannabinoidergic systems in various structures of the brain and spinal cord is now well established, but not...

journal_title：Iranian journal of basic medical sciences

authors： Yousefpour M,Naderi N,Motamedi F

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVES:Morphine is widely used to treat chronic pain. However, its utility is hindered by the development of tolerance to its analgesic effects. Despite the renowned beneficial effects of physical exercise on cognitive functions and signs of morphine withdrawal in morphine-dependent rats, little is known about the ...

journal_title：Iranian journal of basic medical sciences

authors： Shokraviyan M,Miladi-Gorji H,Vaezi GH

更新日期：2014-01-01 00:00:00

abstract：:Nigella sativa is the miraculous plant having a lot of nutritional and medicinal benefits, and attracts large number of nutrition and pharmacological researchers. N. sativa seed composition shows that it is the blessing of nature and it contains and many bioactive compounds like thymoquinone, α-hederin, alkaloids, fla...

journal_title：Iranian journal of basic medical sciences

authors： Shafiq H,Ahmad A,Masud T,Kaleem M

更新日期：2014-12-01 00:00:00

abstract：Objectives:Eupafolin, a major active component of Eupatorium perfoliatum L., has anti-inflammatory and anti-oxidant properties. Lipopolysaccharide (LPS) is responsible for myocardial depression. A line of evidences revealed that LPS induces autophagy in cardiomyocytes injury. This study aims to evaluate the effects of ...

journal_title：Iranian journal of basic medical sciences

authors： Gao Y,Zhang Y,Fan Y

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE(S):In the current study, the effects of selected folk medicinal herbs were evaluated in D-galactose-induced aging in male mice. MATERIALS AND METHODS:Male BALB/c mice were randomly divided into 12 groups composing sham, control, and treated groups. Aging was induced by administration of D-galactose (500 mg/k...

journal_title：Iranian journal of basic medical sciences

authors： Mohammadirad A,Aghamohammadali-Sarraf F,Badiei S,Faraji Z,Hajiaghaee R,Baeeri M,Gholami M,Abdollahi M

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE(S):Atherosclerosis is a chronic immune-inflammatory disease that generally leads to ischemic heart disease. Ghrelin has several modulatory effects on cardiovascular system. In this study, we investigated the effect of ghrelin on aortic intima-media thickness, size and the number of adipocyte cells in obese an...

journal_title：Iranian journal of basic medical sciences

authors： Tahergorabi Z,Rashidi B,Khazaei M

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVES:Systemic lupus erythematosus (SLE) is a multi-factorial autoimmune disease which may be characterized by T lymphocytes dysfunctions. Th17 cells have been identified as new effector cells, which play an important role in the pathogenesis. In recent years, immunomodulatory effect of vitamin D3 has been noticed...

journal_title：Iranian journal of basic medical sciences

authors： Faraji F,Rastin M,Arab FL,Kalantari MR,Rabe SZ,Tabasi N,Mahmoudi M

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE(S):Garlic (Allium sativum L. family Liliaceae) is well known in Iran and its leaves, flowers, and cloves have been used in traditional medicine for a long time. Research in recent decades has shown widespread pharmacological effects of A. sativum and its organosulfur compounds especially Allicin. Studies carr...

journal_title：Iranian journal of basic medical sciences

authors： Mikaili P,Maadirad S,Moloudizargari M,Aghajanshakeri S,Sarahroodi S

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVES:Endometriosis is a complex gynecologic disease with unknown etiology. Noscapine has been introduced as a cancer cell suppressor. Endometriosis was considered as a cancer like disorder, The aim of present study was to investigate noscapine apoptotic effect on human endometriotic epithelial and stromal cells i...

journal_title：Iranian journal of basic medical sciences

authors： Khazaei MR,Rashidi Z,Chobsaz F,Khazaei M

更新日期：2016-09-01 00:00:00

abstract：Objectives:Mycobacterium tuberculosis (M. tuberculosis), an intracellular pathogen, causes 1.5 million deaths globally. Bacilli Calmette-Guérin (BCG) is commonly administered to protect people against M. tuberculosis infection; however, there are some obstacles with this first-generation vaccine. DNA vaccines, the thir...

journal_title：Iranian journal of basic medical sciences

authors： Dalirfardouei R,Tafaghodi M,Meshkat Z,Najafi A,Gholoobi A,Nabavinia MS,Sajedifar S,Meshkat M,Badiee A,Ramezani M,Varasteh AR,Naderinasab M

更新日期：2020-06-01 00:00:00

abstract：Objectives:Several lines of evidence showed that minocycline possesses antioxidant and anti-inflammatory properties. This study aimed to demonstrate the effects of minocycline in rats subjected to chronic constriction injury (CCI). Materials and Methods:In this study four groups (n = 6-8) of rats were used as follows:...

journal_title：Iranian journal of basic medical sciences

authors： Abbaszadeh A,Darabi S,Hasanvand A,Amini-Khoei H,Abbasnezhad A,Choghakhori R,Aaliehpour A

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVES:Pseudomonas aeruginosa is a Gram-negative and aerobic rod bacterium that displays mucoid and non-mucoid phenotype. Mucoid strains secrete alginate, which is the main agent of biofilms in chronic P. aeruginosa infections, show high resistance to antibiotics; consequently, the biological disruption of mucoid P...

journal_title：Iranian journal of basic medical sciences

authors： Ghadam P,Akhlaghi F,Ali AA

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVES:Bone marrow mesenchymal stem cells (MSCs) play an important role in bone health. Cadmium causes osteoporosis, but the exact mechanisms of its effect on MSCs are not known. MATERIALS AND METHODS:Rats were treated with cadmium chloride (40 mg/l) in drinking water for six weeks, and then the biochemical and mo...

journal_title：Iranian journal of basic medical sciences

authors： Abnosi MH,Golami S

更新日期：2017-03-01 00:00:00

abstract：Objectives:Resveratrol (RSV) is a naturally occurring plant polyphenol with cardioprotective, neuroprotective, immunoregulatory, and anticancer properties and is biologically effective against various diseases. This study aimed to investigate the chemopreventive effect of different doses of RSV against hepatocellular c...

journal_title：Iranian journal of basic medical sciences

authors： Karabekir SC,Özgörgülü A

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE(S):Gastric cancer is the first and second leading cause of cancer related death in Iranian men and women, respectively. Gastric cancer management is based on the surgery, radiotherapy and chemotherapy. In the present study, for the first time, the beneficial effect of saffron (Crocus sativus L.) aqueous extra...

journal_title：Iranian journal of basic medical sciences

authors： Bathaie SZ,Miri H,Mohagheghi MA,Mokhtari-Dizaji M,Shahbazfar AA,Hasanzadeh H

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES:Amyotrophic lateral sclerosis (ALS), a fatal progressive neurodegenerative disorder, is the most common motor neuron disease in European populations. Approximately 10% of ALS cases are familial (FALS) and the other patients are considered as sporadic ALS (SALS). Among many ALS causing genes that have been id...

journal_title：Iranian journal of basic medical sciences

authors： Alavi A,Khani M,Nafissi S,Shamshiri H,Elahi E

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVES:Neuroprotective effect of creatine (Cr) against β-amyloid (Aβ) is reported in an in vitro study. This study investigated the effect of Cr supplementation on β-amyloid toxicity in vivo. MATERIALS AND METHODS:Thirty two, male Wistar rats were divided into 4 groups. During ten weeks of study, control group wen...

journal_title：Iranian journal of basic medical sciences

authors： Alimohammadi-Kamalabadi M,Eshraghian M,Zarindast MR,Aliaghaei A,Pishva H

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:Acquisition of TNF-α resistance plays role in the onset and growth of malignant tumors. Previous studies have demonstrated that MCF-7 cell line and its doxorubicin resistant variant MCF-7/Adr are resistant against the cytotoxic effects of TNF-α. In this study, we investigated the role of Akt activation in re...

journal_title：Iranian journal of basic medical sciences

authors： Ghandadi M,Mohammadi A,Behravan J,Abnous K,Haj-Ali N,Gharaee ME,Mosaffa F

更新日期：2016-12-01 00:00:00