Abstract：
Objectives:The aim of the present research is to investigate the efficacy of L-carnitine (LC) as a complementary therapy to diclofenac sodium (Dic) treatment in a mono-iodoacetate (MIA) induced knee osteoarthritis (OA) rat model, with respect to pain relief and the underlying pathology. Materials and Methods:Fifty adult male albino rats were randomly divided into five groups (n=10): Control, OA, OA/Dic, OA/LC, and OA/Dic+LC. Knee diameter and pain assessment tests were done weekly. After four weeks, serum malondialdehyde, reduced glutathione, interleukin 1-β, tumor necrosis factor-alpha, prostaglandin E2, and bone-specific alkaline phosphatase were measured. The injected knees were removed and processed for the histological and immunohistological study of matrix metalloproteinase-13 (MMP-13) and cyclooxygenase 2 (COX-2). Also, histological examination of dorsal root ganglia and calcitonin gene-related peptide (CGRP) expression in the spinal cord were assessed. Results:Treatment with Dic and/or LC significantly reduced knee swelling, improved pain-related behaviors, inflammatory and oxidative stress markers, attenuated the MIA-mediated histopathological alteration in the knee joint, and down-regulated expression of MMP-13 and COX-2 in the knee joint. It, also, significantly reduced CGRP expression, compared with the OA group. Dic+LC showed a better effect in improving some parameters than each treatment alone. Conclusion:LC plus Dic is a more effective therapy than Dic alone for OA treatment.
journal_name
Iran J Basic Med Scijournal_title
Iranian journal of basic medical sciencesauthors
Khodir SA,Al-Gholam MA,Salem HRdoi
10.22038/ijbms.2020.43136.10138subject
Has Abstractpub_date
2020-08-01 00:00:00pages
1035-1044issue
8eissn
2008-3866issn
2008-3874journal_volume
23pub_type
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journal_title：Iranian journal of basic medical sciences
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journal_title：Iranian journal of basic medical sciences
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