Staging of colorectal cancer using serum metabolomics with 1HNMR Spectroscopy.

abstract：OBJECTIVES:Astrodaucus persicus, Apiaceae, is used as vegetable or food additive in some parts of Iran. The essential oils of different parts of Astrodaucus persicus from Kordestan province were analyzed for the first time and compared with other regions. In this study, antioxidant activities and total phenols determin...

journal_title：Iranian journal of basic medical sciences

authors： Goodarzi S,Hadjiakhoondi A,Yassa N,Khanavi M,Tofighi Z

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVES:In the present study, we evaluated immunological and immunomodulatory properties of royal jelly (RJ) in 2,4,6 trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats. MATERIALS AND METHODS:Eighteen adult female Wistar albino rats were divided into three groups of six animals each: a control group that ...

journal_title：Iranian journal of basic medical sciences

authors： Karaca T,Uz YH,Demirtas S,Karaboga I,Can G

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVES:Acquisition of TNF-α resistance plays role in the onset and growth of malignant tumors. Previous studies have demonstrated that MCF-7 cell line and its doxorubicin resistant variant MCF-7/Adr are resistant against the cytotoxic effects of TNF-α. In this study, we investigated the role of Akt activation in re...

journal_title：Iranian journal of basic medical sciences

authors： Ghandadi M,Mohammadi A,Behravan J,Abnous K,Haj-Ali N,Gharaee ME,Mosaffa F

更新日期：2016-12-01 00:00:00

abstract：Objectives:This study aimed to investigate the glucose and lipid metabolism improving effect of the total flavonoids from Selaginella tamariscina (Beauv.) Spring (TFST) on db/db mice, and to study its mechanism of action. Materials and Methods:The db/db mice were divided into 5 groups: the normal group (NC), the diabe...

journal_title：Iranian journal of basic medical sciences

authors： Wang X,Feng A,Yuan P,Fu Y,Bai Z,Zhou N,Zheng X

更新日期：2020-10-01 00:00:00

abstract：Objectives:The aim of this study is to determine the therapeutic effects of pomegranate seed oil, which is a powerful antioxidant and anti-inflammatory agent, on ovarian-ischemia and reperfusion injury in rats. Materials and Methods:Fifty-six female albino Wistar rats were divided into 7 equal groups. Group 1; Sham Op...

journal_title：Iranian journal of basic medical sciences

authors： Yayla M,Cetin D,Adali Y,Kilicle PA,Toktay E

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE(S):Spermatogonial Stem Cells (SSCs) maintain spermatogenesis throughout the life of the male. Because of the small number of SSCs in adult, enriching and culturing them is a crucial step prior to differentiation or transplantation. Maintenance of SSCs and transplantation or induction of in vitro spermio-genes...

journal_title：Iranian journal of basic medical sciences

authors： Rastegar T,Minaee MB,Habibi Roudkenar M,Raghardi Kashani I,Amidi F,Abolhasani F,Barbarestani M

更新日期：2013-02-01 00:00:00

abstract：Objectives:During the last years with increasing resistant bacteria to the most antibiotics bacteriophages are suggested as appropriate treatment option. To investigate lytic activity of bacteriophages there are indirect microbial procedures and direct methods. The present study to complement microbial procedures and i...

journal_title：Iranian journal of basic medical sciences

authors： Rahimzadeh G,Gill P,Rezai MS

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:To clarify the protective effects of Cichorium glandulosum (CG) extracts on thioacetamide (TAA)-induced rat hepatic fibrosis. MATERIALS AND METHODS:The dry roots of CG were smashed and percolated with 95% ethanol, and the residual was prepared into petroleum ether extract (CG-V), ethyl acetate extract (CG-V...

journal_title：Iranian journal of basic medical sciences

authors： Qin D,Nie Y,Wen Z

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVES:Due to unsatisfactory response or intolerable side effects of current drugs, treatment of essential tremor remains inadequate. Thus, we aimed to investigate the protective and therapeutic effects of aqueous and ethanolic extracts of Crocus sativus (saffron), and its active consistent, safranal, on the harmal...

journal_title：Iranian journal of basic medical sciences

authors： Amin B,Malekzadeh M,Heidari MR,Hosseinzadeh H

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE(S):The ongoing increasing antibiotic resistance is one of the biggest challenges faced by global public health. The perennial need for new antimicrobials against a background of increasing antibiotic resistance in pathogenic and opportunistic microorganisms obliges the scientific community to constantly devel...

journal_title：Iranian journal of basic medical sciences

authors： Chauhan R,Abraham J

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE(S):PDE3 has a functional role in insulin secretion and action. We investigated the metabolic effects of new synthetic PDE3 inhibitors (mc1, mc2, mc5 and mc6), on mice and hyperglycemic rat. MATERIALS AND METHODS:The test compound or solvent was injected subcutaneously to mice, for 7 days. On day 8, blood and...

journal_title：Iranian journal of basic medical sciences

authors： Hosseini A,Shafiee-Nick R,Pour Ali Behzad N,Sadeghian H

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the methylation status and mRNA expression levels of P15, death-associated protein kinase (DAPK), and suppressor of cytokine signaling-1 (SOCS1) genes in multiple myeloma (MM). MATERIALS AND METHODS:The bone marrow samples of 54 MM patients were collected and the met...

journal_title：Iranian journal of basic medical sciences

authors： Liu L,Tan L,He Z

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVES:In previous studies, researchers observed that doxepin could improve cognitive processes and has protective effects on the central nervous system. Thus, this study was designed to analyze the effects of doxepin on β-amyloid (Aβ)-induced memory impairment and neuronal toxicity in rat and to explore the underl...

journal_title：Iranian journal of basic medical sciences

authors： Bu J,Zu H

更新日期：2017-09-01 00:00:00

abstract：Objectives:Prenatal stresses increase incidence of neurodevelopmental disorders and influence cognitive abilities. Glucocorticoids are released in stress condition as endpoint activation of hypothalamus-pituitary-adrenal (HPA) axis. Evidence indicates a cross-talk between gut microbiota and brain function. This study a...

journal_title：Iranian journal of basic medical sciences

authors： Hadizadeh M,Hamidi GA,Salami M

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVES:Lead (Pb) is a toxic metal inducing many destructive effects leading to a broad range of physiological, biochemical, and neurological dysfunctions in humans and laboratory animals. MATERIALS AND METHODS:Here, we investigated the effect of chronic exposure to Pb (50 mg/l) on oxidative stress, hepatotoxicity,...

journal_title：Iranian journal of basic medical sciences

authors： Alya A,Ines DB,Montassar L,Najoua G,Saloua el F

更新日期：2015-10-01 00:00:00

abstract：Objectives:Inflammation is involved in various forms of pulmonary arterial hypertension (PAH). Although the pathophysiology of PAH remains uncertain, NF-κB and p38 mitogen-activated protein kinase (p38 MAPK) has been reported to be associated with many inflammatory mediators of PAH. This study aimed to evaluate the eff...

journal_title：Iranian journal of basic medical sciences

authors： Gao L,Liu J,Hao Y,Zhao Z,Tan H,Zhang J,Meng N,Zheng Q,Wang Z,Zhang Y

更新日期：2018-03-01 00:00:00

abstract：Objectives:We investigated the role of various biomaterials on cell viability and in healing of an experimentally induced femoral bone hole model in rats. Materials and Methods:Cell viability and cytotoxicity of gelatin (Gel; 50 µg/µl), chitosan (Chi; 20 µg/µl), hydroxyapatite (HA; 50 µg/µl), nanohydroxyapatite (nHA; ...

journal_title：Iranian journal of basic medical sciences

authors： Moshiri A,Tekyieh Maroof N,Mohammad Sharifi A

更新日期：2020-11-01 00:00:00

abstract：Objectives:In addition to genetic factors, environmental phenomena during postnatal age highly affect development and, in turn, function of the brain. The present work evaluates if morphine consumption during lactation period influences the spatial performances and synaptic plasticity in rats at neonatal period of age....

journal_title：Iranian journal of basic medical sciences

authors： Aghighi F,Mohammadifar M,Banafsheh H,Salami M,Talaei SA

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE(S):Drug resistant Acinetobacter baumannii have emerged as a major problem in many hospitals and intensive care units. Various types of extended spectrum beta-lactamases (ESBLs) are responsible for resistance to beta-lactam antibiotics in different parts of the world. The objective of this study was to determi...

journal_title：Iranian journal of basic medical sciences

authors： Farajnia S,Azhari F,Alikhani MY,Hosseini MK,Peymani A,Sohrabi N

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE(S):Gingivitis is an inflammatory disease that affects tooth-supporting tissues and is caused by a microbe-immune response. The aim of this study was to evaluate the effects of omega-3 fatty acids on immune system regulation and the prevention and treatment of gingivitis using an animal model. MATERIALS AND M...

journal_title：Iranian journal of basic medical sciences

authors： Araghizadeh N,Paknejad M,Alaeddini M,Minaii B,Abdollahi M,Khorasanie R

更新日期：2014-02-01 00:00:00

abstract：Objectives:Bacterial translocation in patients with cirrhosis is an important triggering factor for infections and mortality. In the bile duct ligation (BDL) model, crucial players of bacterial translocation are still unknown. This study aims to determine the interrelation between microbiome composition in the colon, m...

journal_title：Iranian journal of basic medical sciences

authors： Vega-Magaña N,Galiana A,Jave-Suárez LF,Garcia-Benavides L,Del Toro-Arreola S,Andrade-Villanueva JF,González-Hernández LA,Cremades R,Aguilar-Lemarroy A,Flores-Miramontes MG,Haramati J,Meza-Arroyo J,Bueno-Topete MR

更新日期：2020-02-01 00:00:00

abstract：Objectives:Traumatic brain injury (TBI) is one of the main causes of intellectual and cognitive disabilities. Clinically, it is essential to limit the development of cognitive impairment after TBI. In the present study, the neuroprotective effects of gallic acid (GA) on neurological score, memory, long-term potentiatio...

journal_title：Iranian journal of basic medical sciences

authors： Mirshekar MA,Sarkaki A,Farbood Y,Gharib Naseri MK,Badavi M,Mansouri MT,Haghparast A

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to investigate the relationship between insulin resistance (IR) and leptin (LEP) gene polymorphisms in peritoneal dialysis (PD) patients. MATERIALS AND METHODS:From July 1, 2011 to August 1, 2011, patients who received chronic PD were chosen and divided into three groups (DM, high H...

journal_title：Iranian journal of basic medical sciences

authors： Cao L,Mou S,Fang W,Qi C,Chang X,Gu L,Qian J,Ni Z

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVES:Herbal waters are extensively used in most parts of including . Visiting a patient with total blindness due to daily ingestion of around 200 ml of herbal water (Plant forty water) per day for six months was the rational for methanol determination in all herbal waters available in markets. MATERIALS AND METH...

journal_title：Iranian journal of basic medical sciences

authors： Mousavi SR,Namaei-Ghassemi M,Layegh M,Afzalaghaee M,Vafaee M,Zare G,Moghiman T,Mood MB

更新日期：2011-07-01 00:00:00

abstract：:Cancer testis antigens (CTAs), a large family of tumor-associated and immunogenic antigens expressed in human tumors of various histological origins, are highly restricted to the testis and trophoblast. CTAs have been identified as potent targets for tumor-specific immunotherapeutic advances and have immensely lead to...

journal_title：Iranian journal of basic medical sciences

authors： Babatunde KA,Najafi A,Salehipour P,Modarressi MH,Mobasheri MB

更新日期：2017-09-01 00:00:00

abstract：Objectives:Panax ginseng (PG) widely used for its various pharmacological activities, including effects on diabetes and its complications. This study aims to investigate the effect of PG on mortality-related hypomagnesemia, hyperlactatemia, metabolic acidosis, and other diabetes-induced abnormalities. Materials and Me...

journal_title：Iranian journal of basic medical sciences

authors： Adam GO,Kim GB,Lee SJ,Lee HR,Kim SJ,Kang HS,Kim JS

更新日期：2019-06-01 00:00:00

abstract：:The study of tumor viruses paves the way for understanding the mechanisms of virus pathogenesis, including those involved in establishing infection and dissemination in the host tumor affecting immune-compromised patients. The processes ranging from viral infection to progressing malignancy are slow and usually insuff...

journal_title：Iranian journal of basic medical sciences

authors： Ahmadi Ghezeldasht S,Shirdel A,Assarehzadegan MA,Hassannia T,Rahimi H,Miri R,Rezaee SA

更新日期：2013-03-01 00:00:00

abstract：Objectives:Radiotherapy is one of the most effective modalities of cancer therapy, but clinical responses of individual patients varies considerably. To enhance treatment efficiency it is essential to implement an individual-based treatment. The aim of present study was to identify the mechanism of intrinsic apoptosis ...

journal_title：Iranian journal of basic medical sciences

authors： Azimian H,Dayyani M,Toossi MTB,Mahmoudi M

更新日期：2018-03-01 00:00:00

abstract：:Nigella sativa is the miraculous plant having a lot of nutritional and medicinal benefits, and attracts large number of nutrition and pharmacological researchers. N. sativa seed composition shows that it is the blessing of nature and it contains and many bioactive compounds like thymoquinone, α-hederin, alkaloids, fla...

journal_title：Iranian journal of basic medical sciences

authors： Shafiq H,Ahmad A,Masud T,Kaleem M

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVES:Pharmacological studies showed that the extracts of Jin Yin Hua and its active constituents have lipid lowering, antipyretic, hepatoprotective, cytoprotective, antimicrobial, antibiotic, antioxidative, antiviral, and anti-inflammatory effects. The purpose of the present study was to investigate the protectiv...

journal_title：Iranian journal of basic medical sciences

authors： Wang C,Wang G,Liu H,Hou YL

更新日期：2016-01-01 00:00:00