Oxidative stress, biochemical alterations, and hyperlipidemia in female rats induced by lead chronic toxicity during puberty and post puberty periods.

abstract：Objectives:Traumatic brain injury (TBI) is one of the main causes of intellectual and cognitive disabilities. Clinically, it is essential to limit the development of cognitive impairment after TBI. In the present study, the neuroprotective effects of gallic acid (GA) on neurological score, memory, long-term potentiatio...

journal_title：Iranian journal of basic medical sciences

authors： Mirshekar MA,Sarkaki A,Farbood Y,Gharib Naseri MK,Badavi M,Mansouri MT,Haghparast A

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVES:Chemoresistance remains the main causes of treatment failure and mortality in cancer patients. There is an urgent need to investigate novel approaches to improve current therapeutic modalities and increase cancer patients' survival. Induction of drug efflux due to overexpression of P-glycoproteins is conside...

journal_title：Iranian journal of basic medical sciences

authors： Mohseni M,Samadi N,Ghanbari P,Yousefi B,Tabasinezhad M,Sharifi S,Nazemiyeh H

更新日期：2016-03-01 00:00:00

abstract：Objectives:Weight gain and metabolic disturbances such as dyslipidemia, are frequent side effects of second-generation antipsychotics, including olanzapine. This study examined the metabolic effects of chronic olanzapine exposure. In addition, we investigated the hepatic fatty acid effects of olanzapine in female C57BL...

journal_title：Iranian journal of basic medical sciences

authors： Hou PH,Chang GR,Chen CP,Lin YL,Chao IS,Shen TT,Mao FC

更新日期：2018-05-01 00:00:00

abstract：Objectives:During the last years with increasing resistant bacteria to the most antibiotics bacteriophages are suggested as appropriate treatment option. To investigate lytic activity of bacteriophages there are indirect microbial procedures and direct methods. The present study to complement microbial procedures and i...

journal_title：Iranian journal of basic medical sciences

authors： Rahimzadeh G,Gill P,Rezai MS

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:To study the effect of low-frequency vibration on bone marrow stromal cell differentiation and potential bone repair in vivo. MATERIALS AND METHODS:Forty New Zealand rabbits were randomly divided into five groups with eight rabbits in each group. For each group, bone defects were generated in the left humer...

journal_title：Iranian journal of basic medical sciences

authors： He S,Zhao W,Zhang L,Mi L,Du G,Sun C,Sun X

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVES:Clinical studies of treating traumatic brain injury (TBI) with autologous adult stem cells led us to examine the impression of a combination therapy. This was performed by intravenous injection of human umbilical cord matrix stem cell (hUCMSC-Wharton(,)s jelly stem cell) with bone marrow cell mobilized by gr...

journal_title：Iranian journal of basic medical sciences

authors： Bakhtiary M,Marzban M,Mehdizadeh M,Joghataei MT,Khoei S,Tondar M,Mahabadi VP,Laribi B,Ebrahimi A,Hashemian SJ,Modiry N,Mehrabi S

更新日期：2011-07-01 00:00:00

abstract：:Cancer testis antigens (CTAs), a large family of tumor-associated and immunogenic antigens expressed in human tumors of various histological origins, are highly restricted to the testis and trophoblast. CTAs have been identified as potent targets for tumor-specific immunotherapeutic advances and have immensely lead to...

journal_title：Iranian journal of basic medical sciences

authors： Babatunde KA,Najafi A,Salehipour P,Modarressi MH,Mobasheri MB

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVES:Eukaryotic translation initiation factor 4E (eIF4E) is overexpressed in cervical cancer (CC). However, the molecular mechanisms are unclear. This study aimed to investigate the molecular mechanism of eIF4E gene overexpression in CC. MATERIALS AND METHODS:The human papillomavirus (HPV) type 18 E7 and eIF4E m...

journal_title：Iranian journal of basic medical sciences

authors： Pang T,Wang S,Gao M,Kang H,Zhao Y,Yao Y,Hu X

更新日期：2015-07-01 00:00:00

abstract：Objectives:The main goal of the current research was to examine the effects of Berberine (BBR) on apoptotic signaling and hippocampal oxidative stress induced by common carotid artery occlusion. Materials and Methods:Chronic cerebral hypoperfusion (CCH) model was created by occluding the two common carotid arteries (t...

journal_title：Iranian journal of basic medical sciences

authors： Pirmoradi Z,Yadegari M,Moradi A,Khojasteh F,Zare Mehrjerdi F

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVES:Neuroprotective effect of creatine (Cr) against β-amyloid (Aβ) is reported in an in vitro study. This study investigated the effect of Cr supplementation on β-amyloid toxicity in vivo. MATERIALS AND METHODS:Thirty two, male Wistar rats were divided into 4 groups. During ten weeks of study, control group wen...

journal_title：Iranian journal of basic medical sciences

authors： Alimohammadi-Kamalabadi M,Eshraghian M,Zarindast MR,Aliaghaei A,Pishva H

更新日期：2016-11-01 00:00:00

abstract：Objectives:The aims of the present study were to investigate the expression of calcium sensing receptor (CaSR) at different times in acute myocardial infarction (AMI) rat myocardial tissue after mouse embryonic stem cells (mESCs) transplantation treatment and to assess its effects on apoptosis and oxidative stress of c...

journal_title：Iranian journal of basic medical sciences

authors： Yuan H,Yang G,Li S,Li L,Wei T,Song G,Luan H,Meng J,Wang Q,Yu Y,Sun J

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVES:Various studies have shown that the diabetes is associated with liver failure. The objective of this study was determining the effects of Berberis vulgaris fruit on histopathological and biochemical markers of liver in diabetic rats. MATERIALS AND METHODS:In this experimental study, 60 male Wistar rats weig...

journal_title：Iranian journal of basic medical sciences

authors： Rahimi-Madiseh M,Karimian P,Kafeshani M,Rafieian-Kopaei M

更新日期：2017-05-01 00:00:00

abstract：Objectives:Chemotherapies used to treat colon cancer might often fail due to the emergence of chemoresistance and side effects. Escherichia coli Nissle 1917 (EcN) is a beneficial probiotic, whose molecular mechanisms in the prevention of colon cancer are yet to be fully understood. The present study assessed the anti-c...

journal_title：Iranian journal of basic medical sciences

authors： Alizadeh S,Esmaeili A,Omidi Y

更新日期：2020-07-01 00:00:00

abstract：:The study of tumor viruses paves the way for understanding the mechanisms of virus pathogenesis, including those involved in establishing infection and dissemination in the host tumor affecting immune-compromised patients. The processes ranging from viral infection to progressing malignancy are slow and usually insuff...

journal_title：Iranian journal of basic medical sciences

authors： Ahmadi Ghezeldasht S,Shirdel A,Assarehzadegan MA,Hassannia T,Rahimi H,Miri R,Rezaee SA

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVES:Tadalafil can restore endothelial function and treat atherosclerosis. However, the effect of tadalafil on transplant arteriosclerosis remains unclear. In this study, we explore the effects of tadalafil on allograft vasculopathy. MATERIALS AND METHODS:Male Brow-Norway rats supplied aorta grafts for Male Lewi...

journal_title：Iranian journal of basic medical sciences

authors： Ziqiang X,Jingjun W,Jianjian Z,Yong L,Peng X

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE(S):The effect of the extract of Crocus sativus and its constituent, safranal on inflammatory markers in sensitized guinea pigs was examined. MATERIALS AND METHODS:Ovalbumin (OA) sensitized guinea pigs were given drinking water alone (group S), or drinking water containing three concentrations of safranal, th...

journal_title：Iranian journal of basic medical sciences

authors： Gholamnezhad Z,Koushyar H,Byrami G,Boskabady MH

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVES:Particulate matter (PM) exposure can promote cardiac ischemia and myocardial damage. The effects of PM10 on hemodynamic parameters, lipid peroxidation, and infarct size induced by ischemia-reperfusion injury and the protective effects of vanillic acid (VA) in isolated rat heart were investigated. MATERIALS ...

journal_title：Iranian journal of basic medical sciences

authors： Radmanesh E,Dianat M,Badavi M,Goudarzi G,Mard SA

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVES:Although previous studies have confirmed the beneficial effects of human umbilical cord matrix stem cell (hUCM) transplantation post myocardial infarction (MI), but this stem cell resource has no potential to induce angiogenesis. In order to achieve the process of angiogenesis and cardiomyocyte regeneration,...

journal_title：Iranian journal of basic medical sciences

authors： Moradi K,Abbasi M,Aboulhasani F,Abbasi N,Babatunde KA,Sargolzaeiaval F,Dehpour AR

更新日期：2015-06-01 00:00:00

abstract：Objectives:Hyperuricemia is a risk for cardiovascular and metabolic diseases, but the mechanism is ambiguous. Increased intestinal permeability is correlated with metabolic syndrome risk factors. Intestinal epithelial cells play a pivotal role in maintaining intestinal permeability. Uric acid is directly eliminated int...

journal_title：Iranian journal of basic medical sciences

authors： Ma C,Yang X,Lv Q,Yan Z,Chen Z,Xu D,Liu X,Yang W,Xing S

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVE(S):Gingivitis is an inflammatory disease that affects tooth-supporting tissues and is caused by a microbe-immune response. The aim of this study was to evaluate the effects of omega-3 fatty acids on immune system regulation and the prevention and treatment of gingivitis using an animal model. MATERIALS AND M...

journal_title：Iranian journal of basic medical sciences

authors： Araghizadeh N,Paknejad M,Alaeddini M,Minaii B,Abdollahi M,Khorasanie R

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVES:MicroRNAs (miRNAs) are a class of short RNAs that control the biological processes including cell proliferation, apoptosis and development. Aberrant expression of miRNAs was determined in the different stages of tumor development and metastasis. To study the effect of silibinin on miRNAs expression, we evalu...

journal_title：Iranian journal of basic medical sciences

authors： Zadeh MM,Ranji N,Motamed N

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVES:Asthma results from the interaction between genetic and environmental factors. ADAM33 gene on chromosome 20p13 is associated with asthma and airway hyperresponsiveness. MATERIALS AND METHODS:This is a case-control study, where four SNPs S1 (rs3918396), T1 (rs2280091), T2 (rs2280090), V4 (rs2787094) of ADAM3...

journal_title：Iranian journal of basic medical sciences

authors： Karimi MR,Faridhosseini R,Abbaszadegan MR,Azad FJ,Shirkani A,Riyahi A,Montazar M,Gholamin M

更新日期：2014-09-01 00:00:00

abstract：Objectives:Renal ischemia-reperfusion injury (IRI) as a severe condition of acute kidney injury (AKI) is the most common clinical problem with high mortality rates of 35-60% deaths in hospital. Mesenchymal stem cells (MSC) due to unique regenerative characteristics are ideal candidates for the treatment of the ischemic...

journal_title：Iranian journal of basic medical sciences

authors： Havakhah S,Sankian M,Kazemzadeh GH,Sadri K,Bidkhori HR,Naderi-Meshkin H,Ebrahimzadeh Bideskan A,Niazmand S,Bahrami AR,Khajavi Rad A

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVES:Morphine is widely used to treat chronic pain. However, its utility is hindered by the development of tolerance to its analgesic effects. Despite the renowned beneficial effects of physical exercise on cognitive functions and signs of morphine withdrawal in morphine-dependent rats, little is known about the ...

journal_title：Iranian journal of basic medical sciences

authors： Shokraviyan M,Miladi-Gorji H,Vaezi GH

更新日期：2014-01-01 00:00:00

abstract：Objectives:In addition to genetic factors, environmental phenomena during postnatal age highly affect development and, in turn, function of the brain. The present work evaluates if morphine consumption during lactation period influences the spatial performances and synaptic plasticity in rats at neonatal period of age....

journal_title：Iranian journal of basic medical sciences

authors： Aghighi F,Mohammadifar M,Banafsheh H,Salami M,Talaei SA

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVES:Lupus nephritis (LN) is frequently associated with a poor long-term prognosis. Renal biopsy is the diagnostic method of choice in this condition. Urine biomarkers have been mentioned in the diagnosis of LN. The study(,)s purpose was to evaluate the performance of urinary monocyte chemoattractant protein 1(UM...

journal_title：Iranian journal of basic medical sciences

authors： Mirfeizi Z,Mahmoudi M,Naghibi M,Hatef M,Sharifipour F,Jokar M,Zeraati A,Shariati Sarabi Z,Azarian A

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVES:Many cancer cells show significant resistance to drugs that kill drug sensitive cancer cells and non-tumor cells and such resistance might be a consequence of the difference in metabolism. Therefore, studying the metabolism of drug resistant cancer cells and comparison with drug sensitive and normal cell lin...

journal_title：Iranian journal of basic medical sciences

authors： Motamedian E,Ghavami G,Sardari S

更新日期：2015-03-01 00:00:00

abstract：Objectives:Copper (Cu) is an essential dietary supplement in animal feeds, which plays an important role in maintaining the balance of all living organisms. Copper nanoparticles (nCu) participate in catalysing activities of multiple antioxidant/defensive enzymes and exerts pro-inflammatory and pro-apoptotic effects on ...

journal_title：Iranian journal of basic medical sciences

authors： Hien LTT,Trang PTT,Phuong PC,Tam PT,Xuan NT

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVES:HTLVI-1 is the first human retrovirus with limited endemic regions in the world. The epidemiological studies have shown that the genetic background and immune response to the virus have a significant role in HTLV-I-associated diseases. Among the genes are involved in HTLV-I infection, the role of human leuko...

journal_title：Iranian journal of basic medical sciences

authors： Tafreshian AR,Etemadi M,Farid-Hosseini R,Salhi M,Afshari JT

更新日期：2014-10-01 00:00:00

abstract：:Thromboangiitis obliterans (TAO) is a thrombotic-occlusive as well as an inflammatory peripheral vascular disease with unknown etiology. Recent evidence has supported the immunopathogenesis of the disease, however, the factors contributing to the altered immune function and vascular tissue inflammation are still uncle...

journal_title：Iranian journal of basic medical sciences

authors： Shapouri-Moghaddam A,Saeed Modaghegh MH,Rahimi HR,Ehteshamfar SM,Tavakol Afshari J

更新日期：2019-03-01 00:00:00