Association between HLA-DQB1 alleles and HAM/TSP patients in Khorasan Province.

abstract：Objectives:Prompt detection of extended-spectrum β-lactamases (ESBL) and carbapenemase-producing enterobacteriaceae is crucial for infection prevention and control strategies. The present study aimed to characterize the ESBL and carbapenemase genes among Enterobacter isolates from an Iranian inpatient population. Mate...

journal_title：Iranian journal of basic medical sciences

authors： Khashei R,Edalati Sarvestani F,Malekzadegan Y,Motamedifar M

更新日期：2020-09-01 00:00:00

abstract：Objectives:Periodontal diseases are among prevalent oral health problems which may ultimately lead to severe complications in oral cavity. Herbal products can be designed as single or multicomponent preparations for better oral health. This study aims to review current clinical trials on the effectiveness of herbal pro...

journal_title：Iranian journal of basic medical sciences

authors： Safiaghdam H,Oveissi V,Bahramsoltani R,Farzaei MH,Rahimi R

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVES:To optimize the extraction method using response surface methodology, extract the phenolic compounds, and identify the antioxidant and biological properties of Stachys parviflora L. extracts. MATERIALS AND METHODS:Maceration and ultrasound-assisted extraction (UAE) (4, 7, 10 min treatment time, 40, 70, 100 ...

journal_title：Iranian journal of basic medical sciences

authors： Bashi DS,Dowom SA,Bazzaz BS,Khanzadeh F,Soheili V,Mohammadpour A

更新日期：2016-05-01 00:00:00

abstract：Objectives:The aim of the present research is to investigate the efficacy of L-carnitine (LC) as a complementary therapy to diclofenac sodium (Dic) treatment in a mono-iodoacetate (MIA) induced knee osteoarthritis (OA) rat model, with respect to pain relief and the underlying pathology. Materials and Methods:Fifty adu...

journal_title：Iranian journal of basic medical sciences

authors： Khodir SA,Al-Gholam MA,Salem HR

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE(S):The effect of prolonged overtraining on cytokine kinetics was compared with moderate exercise in the present study. MATERIALS AND METHODS:Male Wistar rats were randomly divided into control sedentary (C), moderate trained (MT), (V=20 m/min, 30 min/day for 6 days a week, 8 weeks), overtrained (OT) (V=25 m/...

journal_title：Iranian journal of basic medical sciences

authors： Gholamnezhad Z,Boskabady MH,Hosseini M,Sankian M,Khajavi Rad A

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:Hepatitis C is a major cause of liver failure worldwide. Current therapies applied for this disease are not fully effective and produce side effects in most cases. Non-structural protein 3 helicase (NS3) of HCV is one of the key enzymes in viral replication and infection. Therefore, this region is a promisin...

journal_title：Iranian journal of basic medical sciences

authors： Sadri M,Farajollahi MM,Sharifi Z

更新日期：2015-02-01 00:00:00

abstract：Objectives:Several lines of evidence showed that minocycline possesses antioxidant and anti-inflammatory properties. This study aimed to demonstrate the effects of minocycline in rats subjected to chronic constriction injury (CCI). Materials and Methods:In this study four groups (n = 6-8) of rats were used as follows:...

journal_title：Iranian journal of basic medical sciences

authors： Abbaszadeh A,Darabi S,Hasanvand A,Amini-Khoei H,Abbasnezhad A,Choghakhori R,Aaliehpour A

更新日期：2018-02-01 00:00:00

abstract：Objectives:Ferula ovina is an Iranian medicinal plant. Tschimgine and stylosin are two of its major monoterpene derivatives. In this study, we proceeded to investigate some fungal endophytes from F. ovina that can produce plant secondary metabolites. Materials and Methods:The isolated endophytic fungi were fermented i...

journal_title：Iranian journal of basic medical sciences

authors： Tazik Z,Rahnama K,White JF,Soltanloo H,Hasanpour M,Iranshahi M

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVES:Many cancer cells show significant resistance to drugs that kill drug sensitive cancer cells and non-tumor cells and such resistance might be a consequence of the difference in metabolism. Therefore, studying the metabolism of drug resistant cancer cells and comparison with drug sensitive and normal cell lin...

journal_title：Iranian journal of basic medical sciences

authors： Motamedian E,Ghavami G,Sardari S

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVES:In previous studies, researchers observed that doxepin could improve cognitive processes and has protective effects on the central nervous system. Thus, this study was designed to analyze the effects of doxepin on β-amyloid (Aβ)-induced memory impairment and neuronal toxicity in rat and to explore the underl...

journal_title：Iranian journal of basic medical sciences

authors： Bu J,Zu H

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVES:Seed of Cucumis sativus Linn. is one of the herbal remedies has been traditionally used for diabetes mellitus treatment. We studied the effect of hydroalcoholic and buthanolic extract obtained from C. sativus seeds in a model of streptozotocin (STZ)-induced diabetic (type I) rats. MATERIALS AND METHODS:Norm...

journal_title：Iranian journal of basic medical sciences

authors： Minaiyan M,Zolfaghari B,Kamal A

更新日期：2011-09-01 00:00:00

abstract：Objectives:Adipose-derived stem cells (ADSCs), with suitable and easy access, are multipotential cells that have the ability for differentiation into other mesodermal and transdifferentiate into neural phenotype cells. In this study, Lithium chloride (LiCl) was used for in vitro transdifferentiation of rat ADSCs into n...

journal_title：Iranian journal of basic medical sciences

authors： Farrokhfar S,Tiraihi T,Movahedin M,Azizi H

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVES:Amyotrophic lateral sclerosis (ALS), a fatal progressive neurodegenerative disorder, is the most common motor neuron disease in European populations. Approximately 10% of ALS cases are familial (FALS) and the other patients are considered as sporadic ALS (SALS). Among many ALS causing genes that have been id...

journal_title：Iranian journal of basic medical sciences

authors： Alavi A,Khani M,Nafissi S,Shamshiri H,Elahi E

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVES:Primary or adult type hypolactasia, the most common enzyme deficiency in the world, is due to reduced lactase activity in the intestinal cell after weaning. Lactase non-persistence is inherited as an autosomal recessive trait. A DNA variant, single nucleotide polymorphism C/T-13910 which is located on 13910 ...

journal_title：Iranian journal of basic medical sciences

authors： Alizadeh M,Sadr-Nabavi A

更新日期：2012-11-01 00:00:00

abstract：:The study of tumor viruses paves the way for understanding the mechanisms of virus pathogenesis, including those involved in establishing infection and dissemination in the host tumor affecting immune-compromised patients. The processes ranging from viral infection to progressing malignancy are slow and usually insuff...

journal_title：Iranian journal of basic medical sciences

authors： Ahmadi Ghezeldasht S,Shirdel A,Assarehzadegan MA,Hassannia T,Rahimi H,Miri R,Rezaee SA

更新日期：2013-03-01 00:00:00

abstract：Objectives:A growing body of evidence indicates that rhomboid domain containing 1 (RHBDD1) plays an important role in a variety of physiological and pathological processes, including tumorigenesis. We aimed to determine the function of RHBDD1 in breast cancer cells. Materials and Methods:In this study, we used the Onc...

journal_title：Iranian journal of basic medical sciences

authors： Huang C,Ji X,Peng Y,Wu M,Wu W,Luo Y,Cheng G,Zhu Y

更新日期：2018-11-01 00:00:00

abstract：Objectives:The present study investigated the prevalence of genes encoding for exotoxins, adhesion and biofilm factors in Staphylococcus aureus isolates obtained from samples in a referral burn hospital in Tehran, Iran. Materials and Methods:S. aureus isolates obtained from patients, personnel and surfaces in the ward...

journal_title：Iranian journal of basic medical sciences

authors： Mir Z,Nodeh Farahani N,Abbasian S,Alinejad F,Sattarzadeh M,Pouriran R,Dahmardehei M,Mirzaii M,Khoramrooz SS,Darban-Sarokhalil D

更新日期：2019-11-01 00:00:00

abstract：:Thromboangiitis obliterans (TAO) is a thrombotic-occlusive as well as an inflammatory peripheral vascular disease with unknown etiology. Recent evidence has supported the immunopathogenesis of the disease, however, the factors contributing to the altered immune function and vascular tissue inflammation are still uncle...

journal_title：Iranian journal of basic medical sciences

authors： Shapouri-Moghaddam A,Saeed Modaghegh MH,Rahimi HR,Ehteshamfar SM,Tavakol Afshari J

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:Systemic lupus erythematosus (SLE) is a multi-factorial autoimmune disease which may be characterized by T lymphocytes dysfunctions. Th17 cells have been identified as new effector cells, which play an important role in the pathogenesis. In recent years, immunomodulatory effect of vitamin D3 has been noticed...

journal_title：Iranian journal of basic medical sciences

authors： Faraji F,Rastin M,Arab FL,Kalantari MR,Rabe SZ,Tabasi N,Mahmoudi M

更新日期：2016-04-01 00:00:00

abstract：Objectives:Heparin-binding hemagglutinin (HBHA), a mycobacterial cell surface protein, mediates adhesion to nonphagocytic cells and the dissemination of Mycobacterium tuberculosis (M. tuberculosis) from the site of primary infection. Superior expression systems are required to obtain abundant M. tuberculosis proteins f...

journal_title：Iranian journal of basic medical sciences

authors： Teng X,Chen X,Zhu K,Xu H

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVES:Tadalafil can restore endothelial function and treat atherosclerosis. However, the effect of tadalafil on transplant arteriosclerosis remains unclear. In this study, we explore the effects of tadalafil on allograft vasculopathy. MATERIALS AND METHODS:Male Brow-Norway rats supplied aorta grafts for Male Lewi...

journal_title：Iranian journal of basic medical sciences

authors： Ziqiang X,Jingjun W,Jianjian Z,Yong L,Peng X

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVES:Acquisition of TNF-α resistance plays role in the onset and growth of malignant tumors. Previous studies have demonstrated that MCF-7 cell line and its doxorubicin resistant variant MCF-7/Adr are resistant against the cytotoxic effects of TNF-α. In this study, we investigated the role of Akt activation in re...

journal_title：Iranian journal of basic medical sciences

authors： Ghandadi M,Mohammadi A,Behravan J,Abnous K,Haj-Ali N,Gharaee ME,Mosaffa F

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVES:Herbal waters are extensively used in most parts of including . Visiting a patient with total blindness due to daily ingestion of around 200 ml of herbal water (Plant forty water) per day for six months was the rational for methanol determination in all herbal waters available in markets. MATERIALS AND METH...

journal_title：Iranian journal of basic medical sciences

authors： Mousavi SR,Namaei-Ghassemi M,Layegh M,Afzalaghaee M,Vafaee M,Zare G,Moghiman T,Mood MB

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVES:This study aimed to examine the hypothesis that an antiarrhythmic effect might be obtained by ischemic preconditioning of the liver, and also to characterize the potential underlying mechanisms. MATERIALS AND METHODS:Male Wistar rats were anesthetized by thiopental sodium (50 mg/kg, IP) followed by IV injec...

journal_title：Iranian journal of basic medical sciences

authors： Noorbakhsh MF,Arab HA,Kazerani HR

更新日期：2015-01-01 00:00:00

abstract：Objectives:Renal ischemia-reperfusion injury (IRI) as a severe condition of acute kidney injury (AKI) is the most common clinical problem with high mortality rates of 35-60% deaths in hospital. Mesenchymal stem cells (MSC) due to unique regenerative characteristics are ideal candidates for the treatment of the ischemic...

journal_title：Iranian journal of basic medical sciences

authors： Havakhah S,Sankian M,Kazemzadeh GH,Sadri K,Bidkhori HR,Naderi-Meshkin H,Ebrahimzadeh Bideskan A,Niazmand S,Bahrami AR,Khajavi Rad A

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE(S):PDE3 has a functional role in insulin secretion and action. We investigated the metabolic effects of new synthetic PDE3 inhibitors (mc1, mc2, mc5 and mc6), on mice and hyperglycemic rat. MATERIALS AND METHODS:The test compound or solvent was injected subcutaneously to mice, for 7 days. On day 8, blood and...

journal_title：Iranian journal of basic medical sciences

authors： Hosseini A,Shafiee-Nick R,Pour Ali Behzad N,Sadeghian H

更新日期：2012-07-01 00:00:00

abstract：Objectives:Osteonecrosis of the jaw, as an exposed necrotic bone in the oral cavity, is one of the adverse effects of bisphosphonates, which have an affinity for bone minerals. This study investigates the cytotoxic effects of alendronate (ALN) as a nitrogen-containing bisphosphonate, on human dental pulp stem cells (hD...

journal_title：Iranian journal of basic medical sciences

authors： Pourgonabadi S,Ghorbani A,Tayarani Najarn Z,Mousavi SH

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVES:Crocin bleaching assay (CBA) is a new method for determination of antioxidant capacity. In CBA, addition of hydrogen to the conjugated double bonds of crocin results in reduction of crocin and increase in the absorbance at 440 nm, which is considered as a measure of antioxidant potential. Here CBA method was...

journal_title：Iranian journal of basic medical sciences

authors： Bathaie SZ,Shams A,Moghadas Zadeh Kermani F

更新日期：2011-09-01 00:00:00

abstract：Objectives:Bacteriophages are infectious replicating entities that are under consideration as antimicrobial bioagents to control bacterial infections. As an alternative or supplement to antibiotics, bacteriophages can be used to circumvent the resistance to existing antibiotics. The aim of this study was to assess the ...

journal_title：Iranian journal of basic medical sciences

authors： Moradpour Z,Yousefi N,Sadeghi D,Ghasemian A

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVES:One strategy for the treatment of diabetes is inhibition of pancreatic α- amylase. Plants contains different chemical constituents with potential for inhibition of α-amylase and hence maybe used as therapeutic. MATERIALS AND METHODS:Urtica dioica and Juglans regia Linn were tested for α-amylase inhibition. ...

journal_title：Iranian journal of basic medical sciences

authors： Rahimzadeh M,Jahanshahi S,Moein S,Moein MR

更新日期：2014-06-01 00:00:00