Abstract:
OBJECTIVES:One strategy for the treatment of diabetes is inhibition of pancreatic α- amylase. Plants contains different chemical constituents with potential for inhibition of α-amylase and hence maybe used as therapeutic. MATERIALS AND METHODS:Urtica dioica and Juglans regia Linn were tested for α-amylase inhibition. Different concentrations of leaf aqueous extracts were incubated with enzyme substrate solution and the activity of enzyme was measured. For determination of the type of inhibition, Dixon plot was depicted. Acarbose was used as the standard inhibitor. RESULTS:Both plant extracts showed time and concentration dependent inhibition of α-amylase. 60% inhibition was seen with 2 mg/ml of U. dioica and 0.4 mg/ml of J. regia aqueous extract. Dixon plots revealed the type of α-amylase inhibition by these two extracts as competitive inhibition. CONCLUSION:Determination of the type of α-amylase inhibition by these plant extracts could provide by successful use of plant chemicals as drug targets.
journal_name
Iran J Basic Med Scijournal_title
Iranian journal of basic medical sciencesauthors
Rahimzadeh M,Jahanshahi S,Moein S,Moein MRsubject
Has Abstractpub_date
2014-06-01 00:00:00pages
465-9issue
6eissn
2008-3866issn
2008-3874journal_volume
17pub_type
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
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journal_title:Iranian journal of basic medical sciences
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journal_title:Iranian journal of basic medical sciences
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更新日期:2016-01-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
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更新日期:2016-09-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
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更新日期:2014-08-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
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journal_title:Iranian journal of basic medical sciences
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更新日期:2012-11-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
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doi:10.22038/IJBMS.2019.36821.8774
更新日期:2020-01-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章,评审
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更新日期:2019-03-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2014-11-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2014-05-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2016-06-01 00:00:00
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doi:10.22038/ijbms.2019.31226.7521
更新日期:2019-03-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2016-05-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2015-10-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/IJBMS.2018.26179.6429
更新日期:2018-03-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
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更新日期:2020-06-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
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更新日期:2012-07-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/IJBMS.2017.9007
更新日期:2017-07-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
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doi:
更新日期:2016-06-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
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更新日期:2018-10-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/IJBMS.2017.8582
更新日期:2017-04-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2013-09-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/IJBMS.2017.9487
更新日期:2017-11-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章,评审
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更新日期:2017-09-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2013-07-01 00:00:00