Tadalafil attenuates graft arteriosclerosis of aortic transplant in a rat model.

abstract：OBJECTIVES:HTLVI-1 is the first human retrovirus with limited endemic regions in the world. The epidemiological studies have shown that the genetic background and immune response to the virus have a significant role in HTLV-I-associated diseases. Among the genes are involved in HTLV-I infection, the role of human leuko...

journal_title：Iranian journal of basic medical sciences

authors： Tafreshian AR,Etemadi M,Farid-Hosseini R,Salhi M,Afshari JT

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE(S):Green tea (GT) is one of the most popular beverages worldwide whose beneficial effects on health have been demonstrated. Recent studies suggest that GT may contribute to reduction of cancer risk and progression. The aim of this study was to evaluate the effects of whole GT on urinary bladder chemical carci...

journal_title：Iranian journal of basic medical sciences

authors： Henriques A,Arantes-Rodrigues R,I Faustino-Rocha A,I Teixeira-Guedes C,Pinho-Oliveira J,Talhada D,H Teixeira J,Andrade A,Colaço B,N Paiva-Cardoso M,J Pires M,Mvd Ferreira A,M Nunes F,A Oliveira P

更新日期：2014-02-01 00:00:00

abstract：:Klotho (KL) encodes a single-pass transmembrane protein and is predominantly expressed in the kidney, parathyroid glands, and choroid plexus. Genetic studies on the KL gene have revealed that DNA hypermethylation is one of the major risk factors for aging, diseases, and cancer. Besides, KL exerts anti-inflammatory and...

journal_title：Iranian journal of basic medical sciences

authors： Xuan NT,Hai NV

更新日期：2018-01-01 00:00:00

abstract：Objectives:Heparin-binding hemagglutinin (HBHA), a mycobacterial cell surface protein, mediates adhesion to nonphagocytic cells and the dissemination of Mycobacterium tuberculosis (M. tuberculosis) from the site of primary infection. Superior expression systems are required to obtain abundant M. tuberculosis proteins f...

journal_title：Iranian journal of basic medical sciences

authors： Teng X,Chen X,Zhu K,Xu H

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVES:Fumonisins are a group of toxic and carcinogenic mycotoxins, which contaminate the grains and their products. The aim of this study was to examine the apoptotic and proliferative activity of mouse gastric mucosa following administration of fumonisin B1 (FB1). MATERIALS AND METHODS:Twenty-nine female mice di...

journal_title：Iranian journal of basic medical sciences

authors： Alizadeh AM,Mohammadghasemi F,Zendehdel K,Kamyabi-Moghaddam Z,Tavassoli A,Amini-Najafi F,Khosravi A

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVES:One strategy for the treatment of diabetes is inhibition of pancreatic α- amylase. Plants contains different chemical constituents with potential for inhibition of α-amylase and hence maybe used as therapeutic. MATERIALS AND METHODS:Urtica dioica and Juglans regia Linn were tested for α-amylase inhibition. ...

journal_title：Iranian journal of basic medical sciences

authors： Rahimzadeh M,Jahanshahi S,Moein S,Moein MR

更新日期：2014-06-01 00:00:00

abstract：Objectives:A growing body of evidence indicates that rhomboid domain containing 1 (RHBDD1) plays an important role in a variety of physiological and pathological processes, including tumorigenesis. We aimed to determine the function of RHBDD1 in breast cancer cells. Materials and Methods:In this study, we used the Onc...

journal_title：Iranian journal of basic medical sciences

authors： Huang C,Ji X,Peng Y,Wu M,Wu W,Luo Y,Cheng G,Zhu Y

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:Prostaglandins have been shown to mediate the gastro-protective effect of sodium hydrosulfide (NaHS) but effect of NaHS on mRNA expression of prostaglandin E2 receptors (EP1, 3-4; EPs) has not been investigated. Therefore, this study designed to evaluate the effect of NaHS on mRNA expression of EPs receptors...

journal_title：Iranian journal of basic medical sciences

authors： Mard SA,Mahini S,Dianat M,Farbood Y

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE(S):Staphylococcus aureus is both a successful human commensal and a major pathogen. In this study we investigated the genetic diversity of 26 S. aureus isolates recovered from human skin and urinary tract infections. MATERIALS AND METHODS:Typing procedure for the studied S. aureus isolates was performed base...

journal_title：Iranian journal of basic medical sciences

authors： Talebi-Satlou R,Ahmadi M,Ghavam F,Saei HD

更新日期：2012-07-01 00:00:00

abstract：Objectives:Periodontal diseases are among prevalent oral health problems which may ultimately lead to severe complications in oral cavity. Herbal products can be designed as single or multicomponent preparations for better oral health. This study aims to review current clinical trials on the effectiveness of herbal pro...

journal_title：Iranian journal of basic medical sciences

authors： Safiaghdam H,Oveissi V,Bahramsoltani R,Farzaei MH,Rahimi R

更新日期：2018-10-01 00:00:00

abstract：Objectives:Copper (Cu) is an essential dietary supplement in animal feeds, which plays an important role in maintaining the balance of all living organisms. Copper nanoparticles (nCu) participate in catalysing activities of multiple antioxidant/defensive enzymes and exerts pro-inflammatory and pro-apoptotic effects on ...

journal_title：Iranian journal of basic medical sciences

authors： Hien LTT,Trang PTT,Phuong PC,Tam PT,Xuan NT

更新日期：2019-07-01 00:00:00

abstract：Objectives:Alginates play a key role in mucoid Pseudomonas aeruginosa colonization, biofilm formation, and driving out of cationic antibiotics. P. aeruginosa alginate lyase (AlgL) is a periplasmic enzyme that is necessary for alginate synthesis and secretion. It also has a role in depolymerization of alginates. Using A...

journal_title：Iranian journal of basic medical sciences

authors： Piroozmand F,Ghadam P,Zarrabi M,Abdi-Ali A

更新日期：2020-04-01 00:00:00

abstract：:Sulfur mustard (SM, bis- (2-chloroethyl) sulphide) is a chemical warfare agent that causes DNA alkylation, protein modification and membrane damage. SM can trigger several molecular pathways involved in inflammation and oxidative stress, which cause cell necrosis and apoptosis, and loss of cells integrity and function...

journal_title：Iranian journal of basic medical sciences

authors： Imani S,Panahi Y,Salimian J,Fu J,Ghanei M

更新日期：2015-08-01 00:00:00

abstract：Objectives:We investigated the role of various biomaterials on cell viability and in healing of an experimentally induced femoral bone hole model in rats. Materials and Methods:Cell viability and cytotoxicity of gelatin (Gel; 50 µg/µl), chitosan (Chi; 20 µg/µl), hydroxyapatite (HA; 50 µg/µl), nanohydroxyapatite (nHA; ...

journal_title：Iranian journal of basic medical sciences

authors： Moshiri A,Tekyieh Maroof N,Mohammad Sharifi A

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVES:The purpose of the current study was to assess the feasibility of microspheres from biocompatible polymer for oral bioavailability (BA) enhancement of potent sulfonamide- type loop diuretic- Furosemide - which used in the treatment of congestive heart failure, caused edema, cirrhosis, renal disease and as an...

journal_title：Iranian journal of basic medical sciences

authors： Derakhshandeh K,Karimi M,Azandaryani AH,Bahrami G,Ghanbari K

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVES:Valproic acid (VPA) has proven to be as one of the most promising useful drug with anticancer properties. In this study, we investigate the VPA effects on E-cadherin expression in HeLa, TC1, MKN45, and HCT116 cell lines. This study assesses the effects of VPA on human papillomavirus E7 expression in HPV posi...

journal_title：Iranian journal of basic medical sciences

authors： Faghihloo E,Akbari A,Adjaminezhad-Fard F,Mokhtari-Azad T

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVES:This study aimed to examine the hypothesis that an antiarrhythmic effect might be obtained by ischemic preconditioning of the liver, and also to characterize the potential underlying mechanisms. MATERIALS AND METHODS:Male Wistar rats were anesthetized by thiopental sodium (50 mg/kg, IP) followed by IV injec...

journal_title：Iranian journal of basic medical sciences

authors： Noorbakhsh MF,Arab HA,Kazerani HR

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE(S):Gastric cancer is the first and second leading cause of cancer related death in Iranian men and women, respectively. Gastric cancer management is based on the surgery, radiotherapy and chemotherapy. In the present study, for the first time, the beneficial effect of saffron (Crocus sativus L.) aqueous extra...

journal_title：Iranian journal of basic medical sciences

authors： Bathaie SZ,Miri H,Mohagheghi MA,Mokhtari-Dizaji M,Shahbazfar AA,Hasanzadeh H

更新日期：2013-01-01 00:00:00

abstract：:Cancer testis antigens (CTAs), a large family of tumor-associated and immunogenic antigens expressed in human tumors of various histological origins, are highly restricted to the testis and trophoblast. CTAs have been identified as potent targets for tumor-specific immunotherapeutic advances and have immensely lead to...

journal_title：Iranian journal of basic medical sciences

authors： Babatunde KA,Najafi A,Salehipour P,Modarressi MH,Mobasheri MB

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVE(S):Atherosclerosis is a chronic immune-inflammatory disease that generally leads to ischemic heart disease. Ghrelin has several modulatory effects on cardiovascular system. In this study, we investigated the effect of ghrelin on aortic intima-media thickness, size and the number of adipocyte cells in obese an...

journal_title：Iranian journal of basic medical sciences

authors： Tahergorabi Z,Rashidi B,Khazaei M

更新日期：2013-08-01 00:00:00

abstract：Objectives:Mycobacterium tuberculosis (M. tuberculosis), an intracellular pathogen, causes 1.5 million deaths globally. Bacilli Calmette-Guérin (BCG) is commonly administered to protect people against M. tuberculosis infection; however, there are some obstacles with this first-generation vaccine. DNA vaccines, the thir...

journal_title：Iranian journal of basic medical sciences

authors： Dalirfardouei R,Tafaghodi M,Meshkat Z,Najafi A,Gholoobi A,Nabavinia MS,Sajedifar S,Meshkat M,Badiee A,Ramezani M,Varasteh AR,Naderinasab M

更新日期：2020-06-01 00:00:00

abstract：Objectives:Several lines of evidence showed that minocycline possesses antioxidant and anti-inflammatory properties. This study aimed to demonstrate the effects of minocycline in rats subjected to chronic constriction injury (CCI). Materials and Methods:In this study four groups (n = 6-8) of rats were used as follows:...

journal_title：Iranian journal of basic medical sciences

authors： Abbaszadeh A,Darabi S,Hasanvand A,Amini-Khoei H,Abbasnezhad A,Choghakhori R,Aaliehpour A

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVES:Previous studies showed that skeletal muscle microcirculation was reduced in chronic heart failure. The aim of this study was to investigate the effects of endurance training on capillary and arteriolar density of fast and slow twitch muscles in rats with chronic heart failure. MATERIALS AND METHODS:Four we...

journal_title：Iranian journal of basic medical sciences

authors： Ranjbar K,Ardakanizade M,Nazem F

更新日期：2017-01-01 00:00:00

abstract：Objectives:The preclinical reports have shown that specific probiotics like Bifidobacterium bifidum (B. bifidum) and Lactobacillus acidophilus (L. acidophilus) can be applied as the biotherapeutic agents in the inhibition or therapy of colorectal cancer via the modification of gut bacteria. In the previous studies, we ...

journal_title：Iranian journal of basic medical sciences

authors： Ranji P,Agah S,Heydari Z,Rahmati-Yamchi M,Mohammad Alizadeh A

更新日期：2019-06-01 00:00:00

abstract：:Nigella sativa is the miraculous plant having a lot of nutritional and medicinal benefits, and attracts large number of nutrition and pharmacological researchers. N. sativa seed composition shows that it is the blessing of nature and it contains and many bioactive compounds like thymoquinone, α-hederin, alkaloids, fla...

journal_title：Iranian journal of basic medical sciences

authors： Shafiq H,Ahmad A,Masud T,Kaleem M

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVES:Seed of Cucumis sativus Linn. is one of the herbal remedies has been traditionally used for diabetes mellitus treatment. We studied the effect of hydroalcoholic and buthanolic extract obtained from C. sativus seeds in a model of streptozotocin (STZ)-induced diabetic (type I) rats. MATERIALS AND METHODS:Norm...

journal_title：Iranian journal of basic medical sciences

authors： Minaiyan M,Zolfaghari B,Kamal A

更新日期：2011-09-01 00:00:00

abstract：Objectives:Traumatic brain injury (TBI) is one of the main causes of intellectual and cognitive disabilities. Clinically, it is essential to limit the development of cognitive impairment after TBI. In the present study, the neuroprotective effects of gallic acid (GA) on neurological score, memory, long-term potentiatio...

journal_title：Iranian journal of basic medical sciences

authors： Mirshekar MA,Sarkaki A,Farbood Y,Gharib Naseri MK,Badavi M,Mansouri MT,Haghparast A

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to investigate the relationship between insulin resistance (IR) and leptin (LEP) gene polymorphisms in peritoneal dialysis (PD) patients. MATERIALS AND METHODS:From July 1, 2011 to August 1, 2011, patients who received chronic PD were chosen and divided into three groups (DM, high H...

journal_title：Iranian journal of basic medical sciences

authors： Cao L,Mou S,Fang W,Qi C,Chang X,Gu L,Qian J,Ni Z

更新日期：2015-09-01 00:00:00

abstract：Objectives:Weight gain and metabolic disturbances such as dyslipidemia, are frequent side effects of second-generation antipsychotics, including olanzapine. This study examined the metabolic effects of chronic olanzapine exposure. In addition, we investigated the hepatic fatty acid effects of olanzapine in female C57BL...

journal_title：Iranian journal of basic medical sciences

authors： Hou PH,Chang GR,Chen CP,Lin YL,Chao IS,Shen TT,Mao FC

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:In previous studies, researchers observed that doxepin could improve cognitive processes and has protective effects on the central nervous system. Thus, this study was designed to analyze the effects of doxepin on β-amyloid (Aβ)-induced memory impairment and neuronal toxicity in rat and to explore the underl...

journal_title：Iranian journal of basic medical sciences

authors： Bu J,Zu H

更新日期：2017-09-01 00:00:00