Investigation on metabolism of cisplatin resistant ovarian cancer using a genome scale metabolic model and microarray data.

abstract：OBJECTIVE(S):The effect of prolonged overtraining on cytokine kinetics was compared with moderate exercise in the present study. MATERIALS AND METHODS:Male Wistar rats were randomly divided into control sedentary (C), moderate trained (MT), (V=20 m/min, 30 min/day for 6 days a week, 8 weeks), overtrained (OT) (V=25 m/...

journal_title：Iranian journal of basic medical sciences

authors： Gholamnezhad Z,Boskabady MH,Hosseini M,Sankian M,Khajavi Rad A

更新日期：2014-01-01 00:00:00

abstract：:The study of tumor viruses paves the way for understanding the mechanisms of virus pathogenesis, including those involved in establishing infection and dissemination in the host tumor affecting immune-compromised patients. The processes ranging from viral infection to progressing malignancy are slow and usually insuff...

journal_title：Iranian journal of basic medical sciences

authors： Ahmadi Ghezeldasht S,Shirdel A,Assarehzadegan MA,Hassannia T,Rahimi H,Miri R,Rezaee SA

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVES:Bone marrow mesenchymal stem cells (MSCs) play an important role in bone health. Cadmium causes osteoporosis, but the exact mechanisms of its effect on MSCs are not known. MATERIALS AND METHODS:Rats were treated with cadmium chloride (40 mg/l) in drinking water for six weeks, and then the biochemical and mo...

journal_title：Iranian journal of basic medical sciences

authors： Abnosi MH,Golami S

更新日期：2017-03-01 00:00:00

abstract：Objectives:In this study, we investigated the protective effects of piperine on lead acetate-induced renal damage in rat kidney tissue. Materials and Methods:Forty male rats were divided into 5 groups: negative control (rats were given aquadest daily), positive control (rats were given lead acetate 30 mg/kg BW orally ...

journal_title：Iranian journal of basic medical sciences

authors： Sudjarwo SA,Eraiko K,Sudjarwo GW,Koerniasari

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE(S):Adeno-associated virus type 2 (AAV2) vectors are widely used for both experimental and clinical gene therapy. A recent research has shown that the performance of these vectors can be greatly improved by substitution of specific surface-exposed tyrosine residues with phenylalanines. In this study, a fast an...

journal_title：Iranian journal of basic medical sciences

authors： Ahmadiankia N,Neshati V,Neshati Z,Swildens J,de Vries AA

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVES:Hepatitis C is a major cause of liver failure worldwide. Current therapies applied for this disease are not fully effective and produce side effects in most cases. Non-structural protein 3 helicase (NS3) of HCV is one of the key enzymes in viral replication and infection. Therefore, this region is a promisin...

journal_title：Iranian journal of basic medical sciences

authors： Sadri M,Farajollahi MM,Sharifi Z

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVES:Due to unsatisfactory response or intolerable side effects of current drugs, treatment of essential tremor remains inadequate. Thus, we aimed to investigate the protective and therapeutic effects of aqueous and ethanolic extracts of Crocus sativus (saffron), and its active consistent, safranal, on the harmal...

journal_title：Iranian journal of basic medical sciences

authors： Amin B,Malekzadeh M,Heidari MR,Hosseinzadeh H

更新日期：2015-05-01 00:00:00

abstract：Objectives:The present study investigated the prevalence of genes encoding for exotoxins, adhesion and biofilm factors in Staphylococcus aureus isolates obtained from samples in a referral burn hospital in Tehran, Iran. Materials and Methods:S. aureus isolates obtained from patients, personnel and surfaces in the ward...

journal_title：Iranian journal of basic medical sciences

authors： Mir Z,Nodeh Farahani N,Abbasian S,Alinejad F,Sattarzadeh M,Pouriran R,Dahmardehei M,Mirzaii M,Khoramrooz SS,Darban-Sarokhalil D

更新日期：2019-11-01 00:00:00

abstract：:Thromboangiitis obliterans (TAO) is a thrombotic-occlusive as well as an inflammatory peripheral vascular disease with unknown etiology. Recent evidence has supported the immunopathogenesis of the disease, however, the factors contributing to the altered immune function and vascular tissue inflammation are still uncle...

journal_title：Iranian journal of basic medical sciences

authors： Shapouri-Moghaddam A,Saeed Modaghegh MH,Rahimi HR,Ehteshamfar SM,Tavakol Afshari J

更新日期：2019-03-01 00:00:00

abstract：Objectives:We investigated the role of nitric oxide (NO) in the protective effects of remote ischemic per-conditioning (rIPerC) on renal ischemia/reperfusion (I/R) injury in male rats. Materials and Methods:I/R treatment consisted of 45 min bilateral renal artery ischemia and 24 hr reperfusion interval. rIPerC was per...

journal_title：Iranian journal of basic medical sciences

authors： Gholampour F,Khangah L,Vatanparast J,Karbalaei-Heidari HR,Owji SM,Bahaoddini A

更新日期：2018-06-01 00:00:00

abstract：Objectives:This study aimed to investigate the glucose and lipid metabolism improving effect of the total flavonoids from Selaginella tamariscina (Beauv.) Spring (TFST) on db/db mice, and to study its mechanism of action. Materials and Methods:The db/db mice were divided into 5 groups: the normal group (NC), the diabe...

journal_title：Iranian journal of basic medical sciences

authors： Wang X,Feng A,Yuan P,Fu Y,Bai Z,Zhou N,Zheng X

更新日期：2020-10-01 00:00:00

abstract：Objectives:The present study evaluates the protective effects of myricitrin and its solid lipid nanoparticle (SLN) on diabetic nephropathy (DN) induced by streptozotocin-nicotinamide (STZ-NA) in mice. Materials and Methods:In this experimental study, 108 adult male NMRI mice were divided into 9 groups: control, vehicl...

journal_title：Iranian journal of basic medical sciences

authors： Ahangarpour A,Oroojan AA,Khorsandi L,Kouchak M,Badavi M

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVES:Amyotrophic lateral sclerosis (ALS), a fatal progressive neurodegenerative disorder, is the most common motor neuron disease in European populations. Approximately 10% of ALS cases are familial (FALS) and the other patients are considered as sporadic ALS (SALS). Among many ALS causing genes that have been id...

journal_title：Iranian journal of basic medical sciences

authors： Alavi A,Khani M,Nafissi S,Shamshiri H,Elahi E

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVES:Production of extended-spectrum beta-lactamases (ESBLs) by enteric bacteria continues to be a major problem in hospitals and community. ESBLs producing bacteria cause many serious infections including urinary tract infections, peritonitis, cholangitis and intra-abdominal abscess. The aim of this study was to...

journal_title：Iranian journal of basic medical sciences

authors： Zaniani FR,Meshkat Z,Naderi Nasab M,Khaje-Karamadini M,Ghazvini K,Rezaee A,Esmaily H,Nabavinia MS,Darban Hoseini M

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:Clinical studies of treating traumatic brain injury (TBI) with autologous adult stem cells led us to examine the impression of a combination therapy. This was performed by intravenous injection of human umbilical cord matrix stem cell (hUCMSC-Wharton(,)s jelly stem cell) with bone marrow cell mobilized by gr...

journal_title：Iranian journal of basic medical sciences

authors： Bakhtiary M,Marzban M,Mehdizadeh M,Joghataei MT,Khoei S,Tondar M,Mahabadi VP,Laribi B,Ebrahimi A,Hashemian SJ,Modiry N,Mehrabi S

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVES:Cyclooxygenases (COXs) are known to play some roles in physiological mechanisms related to learning and memory. Since sodium salicylate is an inhibitor of COX, we have evaluated the effect of peripheral and intra-hippocampal administration of sodium salicylate on spatial learning and memory in male rats. MA...

journal_title：Iranian journal of basic medical sciences

authors： Azimi L,Pourmotabbed A,Ghadami MR,Nedaei SE,Pourmotabbed T

更新日期：2012-03-01 00:00:00

abstract：Objectives:Prompt detection of extended-spectrum β-lactamases (ESBL) and carbapenemase-producing enterobacteriaceae is crucial for infection prevention and control strategies. The present study aimed to characterize the ESBL and carbapenemase genes among Enterobacter isolates from an Iranian inpatient population. Mate...

journal_title：Iranian journal of basic medical sciences

authors： Khashei R,Edalati Sarvestani F,Malekzadegan Y,Motamedifar M

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:Pseudomonas aeruginosa is a Gram-negative and aerobic rod bacterium that displays mucoid and non-mucoid phenotype. Mucoid strains secrete alginate, which is the main agent of biofilms in chronic P. aeruginosa infections, show high resistance to antibiotics; consequently, the biological disruption of mucoid P...

journal_title：Iranian journal of basic medical sciences

authors： Ghadam P,Akhlaghi F,Ali AA

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE(S):Gingivitis is an inflammatory disease that affects tooth-supporting tissues and is caused by a microbe-immune response. The aim of this study was to evaluate the effects of omega-3 fatty acids on immune system regulation and the prevention and treatment of gingivitis using an animal model. MATERIALS AND M...

journal_title：Iranian journal of basic medical sciences

authors： Araghizadeh N,Paknejad M,Alaeddini M,Minaii B,Abdollahi M,Khorasanie R

更新日期：2014-02-01 00:00:00

abstract：UNLABELLED:Objective(s ): Targeting the neuropeptide systems has been shown to be useful for the development of more effective antipsychotic drugs. Neurotensin, an endogenous neuropeptide, appears to be involved in the mechanism of action of antipsychotics. However, the available data provide conflicting results and th...

journal_title：Iranian journal of basic medical sciences

authors： Hassanzadeh P,Rostami F

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVES:The utilization of molecular techniques in the epidemiology of tuberculosis have provided an opportunity for using effective markers to trace the transmission of the disease. The purpose of this study was to compare the genetic patterns of Mycobacterium tuberculosis by three methods of RFLP technique. MATER...

journal_title：Iranian journal of basic medical sciences

authors： Farazi A,Jabbariasl M,Tadayon K,Mossavar N,Keshavarz R,Hoseini SD

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVES:Solid dispersion formulation is the most promising strategy to improve oral bioavailability of poorly water soluble drugs. The aim of this study was to compare the effect of polyvinylpyrrolidone K30 (PVP) and poloxamer-188 (PLX) as carrier in solid dispersion formulations of celecoxib (CLX). MATERIALS AND M...

journal_title：Iranian journal of basic medical sciences

authors： Homayouni A,Sadeghi F,Nokhodchi A,Varshosaz J,Garekani HA

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVES:Determination of stages of colon cancer is done by biopsy usually after surgery. Metabolomics is the study of all the metabolites using LC-MS and 1HNMR spectroscopy with chemometric techniques. The stages of colon cancer were detected from patients' sera using 1HNMR. MATERIALS AND METHODS:Five ml blood was ...

journal_title：Iranian journal of basic medical sciences

authors： Vahabi F,Sadeghi S,Arjmand M,Mirkhani F,Hosseini E,Mehrabanfar M,Hajhosseini R,Iravani A,Bayat P,Zamani Z

更新日期：2017-07-01 00:00:00

abstract：Objectives:Renal ischemia-reperfusion injury (IRI) as a severe condition of acute kidney injury (AKI) is the most common clinical problem with high mortality rates of 35-60% deaths in hospital. Mesenchymal stem cells (MSC) due to unique regenerative characteristics are ideal candidates for the treatment of the ischemic...

journal_title：Iranian journal of basic medical sciences

authors： Havakhah S,Sankian M,Kazemzadeh GH,Sadri K,Bidkhori HR,Naderi-Meshkin H,Ebrahimzadeh Bideskan A,Niazmand S,Bahrami AR,Khajavi Rad A

更新日期：2018-08-01 00:00:00

abstract：UNLABELLED:Objective(s) : Although bacteria and molds are the pioneering microorganisms for production of many enzymes, yet yeasts provide safe and reliable sources of enzymes with applications in food and feed. MATERIALS AND METHODS:Single xylanase producer yeast was isolated from plant residues based on formation of...

journal_title：Iranian journal of basic medical sciences

authors： Nasr S,Soudi MR,Hatef Salmanian A,Ghadam P

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVES:Opioids and cannabinoids are two important compounds that have been shown to influence the activity of magnocellular neurons (MCNs) of supraoptic nucleus (SON). The interaction between opioidergic and cannabinoidergic systems in various structures of the brain and spinal cord is now well established, but not...

journal_title：Iranian journal of basic medical sciences

authors： Yousefpour M,Naderi N,Motamedi F

更新日期：2016-06-01 00:00:00

abstract：:Cancer testis antigens (CTAs), a large family of tumor-associated and immunogenic antigens expressed in human tumors of various histological origins, are highly restricted to the testis and trophoblast. CTAs have been identified as potent targets for tumor-specific immunotherapeutic advances and have immensely lead to...

journal_title：Iranian journal of basic medical sciences

authors： Babatunde KA,Najafi A,Salehipour P,Modarressi MH,Mobasheri MB

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVE(S):Spermatogonial Stem Cells (SSCs) maintain spermatogenesis throughout the life of the male. Because of the small number of SSCs in adult, enriching and culturing them is a crucial step prior to differentiation or transplantation. Maintenance of SSCs and transplantation or induction of in vitro spermio-genes...

journal_title：Iranian journal of basic medical sciences

authors： Rastegar T,Minaee MB,Habibi Roudkenar M,Raghardi Kashani I,Amidi F,Abolhasani F,Barbarestani M

更新日期：2013-02-01 00:00:00

abstract：Objectives:Cholinergic neurons are important neurons in the Pedunculopontine tegmental nucleus (PPT). In this study, nicotinic receptor of the PPT in central cardiovascular regulation in the anesthetized rat was evaluated. Materials and Methods:Saline, acetylcholine (Ach; doses: 90 and 150 nmol), hexamethonium (Hexa; ...

journal_title：Iranian journal of basic medical sciences

authors： Nikyar T,Hosseini M,Niazmand S,Shafei MN

更新日期：2018-04-01 00:00:00

abstract：Objectives:Morbidity and mortality due to diabetes mellitus (DM) result in exorbitant psycho-economical costs, so there is a strong need to create new strategies and drugs for controlling DM. The aim of the current study was to investigate the anti-diabetic effect of the aqueous extract of Pterocarpus santalinus on str...

journal_title：Iranian journal of basic medical sciences

authors： El-Badawy RE,Ibrahim KA,Hassan NS,El-Sayed WM

更新日期：2019-08-01 00:00:00