Abstract:
Objectives:Cholinergic neurons are important neurons in the Pedunculopontine tegmental nucleus (PPT). In this study, nicotinic receptor of the PPT in central cardiovascular regulation in the anesthetized rat was evaluated. Materials and Methods:Saline, acetylcholine (Ach; doses: 90 and 150 nmol), hexamethonium (Hexa; doses: 100 and 300 nmol) and higher doses of Hexa (300 nmol) + Ach (150 nmol) microinjected into the PPT. The femoral artery was cannulated and cardiovascular responses were continuously recorded by a power lab system. After injection of drugs, peak changes of mean arterial pressure (∆MAP), systolic blood pressure (∆SBP) and heart rate (∆HR) calculated and compared with saline group. Results:The ∆SBP and ∆MAP significantly decreased by two doses of Ach (P<0.05 to P<0.001) but ∆HR did not change. Two doses 100 (P<0.05) and 300 nmol (P<0.01) of Hexa significantly increased ∆HR but did not alter the ∆MAP or ∆SBP. Co-injection of Hexa + Ach significantly strengthened the ∆HR induced by Hexa alone (P<0.01) but did not affect ∆MAP or ∆SBP. Conclusion:These results indicate that nicotinic receptor of the PPT has an inhibitory effect on ∆HR with no significant effect on ∆MAP or ∆SBP.
journal_name
Iran J Basic Med Scijournal_title
Iranian journal of basic medical sciencesauthors
Nikyar T,Hosseini M,Niazmand S,Shafei MNdoi
10.22038/IJBMS.2018.25616.6319subject
Has Abstractpub_date
2018-04-01 00:00:00pages
376-381issue
4eissn
2008-3866issn
2008-3874pii
IJBMS-21-376journal_volume
21pub_type
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
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journal_title:Iranian journal of basic medical sciences
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更新日期:2018-08-01 00:00:00
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更新日期:2020-05-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
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doi:
更新日期:2014-01-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2014-03-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
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更新日期:2013-06-01 00:00:00
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更新日期:2017-09-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2012-03-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2014-05-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2013-07-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2014-02-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2015-01-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2016-05-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2013-04-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2016-08-01 00:00:00
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pub_type: 杂志文章
doi:10.22038/ijbms.2020.44948.10482
更新日期:2020-06-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章,评审
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更新日期:2013-10-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2014-11-01 00:00:00
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doi:
更新日期:2016-09-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2014-07-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
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更新日期:2019-08-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/ijbms.2017.8101
更新日期:2017-01-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2016-11-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
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更新日期:2019-05-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2012-07-01 00:00:00
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journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/ijbms.2019.31226.7521
更新日期:2019-03-01 00:00:00