Antifungal activity of Zataria multiflora essential oil-loaded solid lipid nanoparticles in-vitro condition.

Abstract:

OBJECTIVES:The aim of the present study was to prepare, characterize, and evaluate solid lipid nanoparticles (SLNs) containing Zataria multiflora essential oil (ZEO). MATERIALS AND METHODS:In this study, Z. multiflora essential oil-loaded solid lipid nanoparticles (ZE-SLNs) were prepared to improve its efficiency in controlling some fungal pathogens. SLNs containing Z. multiflora essential oil were prepared by high shear homogenization and ultra sound technique. ZEO-SLNs contained 0.03% ZEO in 5% of lipid phase (Glyceryl monostearate-GMS and Precirol® ATO 5). Tween 80 and Poloxamer 188 (2.5% w/v) were used as surfactant in the aqueous phase. The antifungal efficacy of ZE-SLNs and ZEO was compared under in vitro conditions. RESULTS:The particle size of ZE-SLNs was around 255.5±3 nm with PDI of 0.369±0.05 and zeta potential was about -37.8±0.8 mV. Encapsulation efficacy of ZE-SLNs in crystalline form was 84±0.92%. The results showed that the ZEO and ZE-SLNs had 54 and 79% inhibition on the growth of fungal pathogens, respectively. The minimum inhibitory concentration (MIC) under in vitro conditions for the ZEO on the fungal pathogens of Aspergillus ochraceus, Aspergillus niger, Aspergillus flavus, Alternaria solani, Rhizoctonia solani, and Rhizopus stolonifer was 300, 200, 300, 200, 200 and 200 ppm, respectively, for ZE-SLNs, it was 200, 200, 200, 100, 50 and 50 ppm. The antifungal efficacy of ZE-SLNs was significantly more than ZEO. CONCLUSION:Our results showed that the SLNs were suitable carriers for Z. multiflora essential oil in controlling the fungal pathogens and merits further investigation.

journal_name

Iran J Basic Med Sci

authors

Nasseri M,Golmohammadzadeh S,Arouiee H,Jaafari MR,Neamati H

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

1231-1237

issue

11

eissn

2008-3866

issn

2008-3874

journal_volume

19

pub_type

杂志文章
  • Effect of creatine supplementation on cognitive performance and apoptosis in a rat model of amyloid-beta-induced Alzheimer's disease.

    abstract:OBJECTIVES:Neuroprotective effect of creatine (Cr) against β-amyloid (Aβ) is reported in an in vitro study. This study investigated the effect of Cr supplementation on β-amyloid toxicity in vivo. MATERIALS AND METHODS:Thirty two, male Wistar rats were divided into 4 groups. During ten weeks of study, control group wen...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Alimohammadi-Kamalabadi M,Eshraghian M,Zarindast MR,Aliaghaei A,Pishva H

    更新日期:2016-11-01 00:00:00

  • Double edged effect of gum-resin of ferula assa-foetida on lifespan of neurons.

    abstract:OBJECTIVE(S):Based on knowledge from traditional herbal medicine, Ferula assa-foetida (asafoetida) has several therapeutic applications but there is less knowledge about its effect on neurons. MATERIALS AND METHODS:In order to evaluate neuronal differentiation, neuronal like cells were stained against neuronal specifi...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Homayouni Moghadam F,Vakili Zarch B,Shafiei M

    更新日期:2013-04-01 00:00:00

  • Effects of Lactobacillus acidophilus and Bifidobacterium bifidum probiotics on the serum biochemical parameters, and the vitamin D and leptin receptor genes on mice colon cancer.

    abstract:Objectives:The preclinical reports have shown that specific probiotics like Bifidobacterium bifidum (B. bifidum) and Lactobacillus acidophilus (L. acidophilus) can be applied as the biotherapeutic agents in the inhibition or therapy of colorectal cancer via the modification of gut bacteria. In the previous studies, we ...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/ijbms.2019.32624.7806

    authors: Ranji P,Agah S,Heydari Z,Rahmati-Yamchi M,Mohammad Alizadeh A

    更新日期:2019-06-01 00:00:00

  • Moisturizing effects of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) using deionized and magnetized water by in vivo and in vitro methods.

    abstract:Objectives:The present study aimed to determine and compare moisturizing and occlusion effects of different solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) using magnetized water and deionized water. Materials and Methods:SLN formulations were prepared using various lipids, including Tripalmiti...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/IJBMS.2020.39587.9397

    authors: Sarhadi S,Gholizadeh M,Moghadasian T,Golmohammadzadeh S

    更新日期:2020-03-01 00:00:00

  • The effect of intrathecal delivery of bone marrow stromal cells on hippocampal neurons in rat model of Alzheimer's disease.

    abstract:OBJECTIVES:Intracerebral injection of bone marrow stromal cells (BMSCs) is being investigated as a therapeutic tool to prevent Alzheimer's disease (AD). Our aim was to investigate the effects of BMSCs by intrathecal injection in AD rat model. MATERIALS AND METHODS:BMSCs were obtained from the bone marrow of Wistar rat...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Eftekharzadeh M,Nobakht M,Alizadeh A,Soleimani M,Hajghasem M,Kordestani Shargh B,Karkuki Osguei N,Behnam B,Samadikuchaksaraei A

    更新日期:2015-05-01 00:00:00

  • Combination of stem cell mobilized by granulocyte-colony stimulating factor and human umbilical cord matrix stem cell: therapy of traumatic brain injury in rats.

    abstract:OBJECTIVES:Clinical studies of treating traumatic brain injury (TBI) with autologous adult stem cells led us to examine the impression of a combination therapy. This was performed by intravenous injection of human umbilical cord matrix stem cell (hUCMSC-Wharton(,)s jelly stem cell) with bone marrow cell mobilized by gr...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Bakhtiary M,Marzban M,Mehdizadeh M,Joghataei MT,Khoei S,Tondar M,Mahabadi VP,Laribi B,Ebrahimi A,Hashemian SJ,Modiry N,Mehrabi S

    更新日期:2011-07-01 00:00:00

  • A Comparative Study of Serum Level of Vascular Cell Adhesion Molecule-1 (sVCAM-1), Intercellular Adhesion Molecule-1(ICAM-1) and High Sensitive C - reactive protein (hs-CRP) in Normal and Pre-eclamptic Pregnancies.

    abstract:OBJECTIVE(S):Pre-eclampsia is characterized by hypertension, dyslipidemia, and increased systemic inflammatory response and has been associated with an increased maternal risk of cardiovascular disease later in life. Endothelial dysfunction is thought to be a central pathogenic feature in pre-eclampsia on the basis of ...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Farzadnia M,Ayatollahi H,Hasan-Zade M,Rahimi HR

    更新日期:2013-05-01 00:00:00

  • Aloe vera toxic effects: expression of inducible nitric oxide synthase (iNOS) in testis of Wistar rat.

    abstract:OBJECTIVES:Nitric oxide (NO), a product of inducible nitric oxide synthase (iNOS), contributes in germ cell apoptosis. This study was aimed to evaluate the effects of Aloe vera gel (AVG) on male Wistar rat reproductive organ, serum NO level, and expression of iNOS gene in leydig cells. MATERIALS AND METHODS:Adult male...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Asgharzade S,Rafieian-Kopaei M,Mirzaeian A,Reiisi S,Salimzadeh L

    更新日期:2015-10-01 00:00:00

  • Improvement of Expression of α6 and β1 Integrins by the Co-culture of Adult Mouse Spermatogonial Stem Cells with SIM Mouse Embryonic Fibroblast Cells (STO) and Growth Factors.

    abstract:OBJECTIVE(S):Spermatogonial Stem Cells (SSCs) maintain spermatogenesis throughout the life of the male. Because of the small number of SSCs in adult, enriching and culturing them is a crucial step prior to differentiation or transplantation. Maintenance of SSCs and transplantation or induction of in vitro spermio-genes...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Rastegar T,Minaee MB,Habibi Roudkenar M,Raghardi Kashani I,Amidi F,Abolhasani F,Barbarestani M

    更新日期:2013-02-01 00:00:00

  • The association between inflammatory markers and obesity-related factors in Tehranian adults: Tehran lipid and glucose study.

    abstract:OBJECTIVES:Obesity considered being a low-grade inflammatory disease. The objective of this study was to examine the association between inflammatory markers (IM) including C-reactive protein (hs-CRP), Interleukin-6 (IL-6), and homocystein (Hcy) and obesity-related factors (e.g. BMI, waist, hip) in adult participants o...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Faam B,Zarkesh M,Daneshpour MS,Azizi F,Hedayati M

    更新日期:2014-08-01 00:00:00

  • Molecular mechanisms regulating immune responses in thromboangiitis obliterans: A comprehensive review.

    abstract::Thromboangiitis obliterans (TAO) is a thrombotic-occlusive as well as an inflammatory peripheral vascular disease with unknown etiology. Recent evidence has supported the immunopathogenesis of the disease, however, the factors contributing to the altered immune function and vascular tissue inflammation are still uncle...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章,评审

    doi:10.22038/ijbms.2019.31119.7513

    authors: Shapouri-Moghaddam A,Saeed Modaghegh MH,Rahimi HR,Ehteshamfar SM,Tavakol Afshari J

    更新日期:2019-03-01 00:00:00

  • Evaluation of HTLV-I and HCV Prevalence in Non-Hodgkin's Lymphoma.

    abstract:OBJECTIVE(S):Non-Hodgkin's lymphoma (NHL) is a lymphoproliferative malignancy in which cells undergo microscopic changes with unknown etiology, and risk factors such as age, sex, genetic and environmental factors are involved. The relationship between the presence of infectious agents and the development of lymphoproli...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Rastin M,Khoee AR,Tabasi N,Sheikh A,Ziaolhagh S,Esmaeeli E,Zamani S,Khazaee M,Mahmoudi M

    更新日期:2013-03-01 00:00:00

  • Gestational diabetes influences retinal Muller cells in rat's offspring.

    abstract:OBJECTIVES:The Muller cell is the principal glial cell of the vertebrate retina. The expression of Glial fibrillary acidic protein (GFAP) in the Muller cells was used as a cellular marker for retinal damage. This study was done to evaluate the effect of gestational diabetes on retinal Muller cells in rat's offspring. ...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/ijbms.2017.8251

    authors: Tabasi A,Ghafari S,Mehdizadeh M,Shekari MA,Golalipour MJ

    更新日期:2017-02-01 00:00:00

  • Apoptotic and proliferative activity of mouse gastric mucosa following oral administration of fumonisin B1.

    abstract:OBJECTIVES:Fumonisins are a group of toxic and carcinogenic mycotoxins, which contaminate the grains and their products. The aim of this study was to examine the apoptotic and proliferative activity of mouse gastric mucosa following administration of fumonisin B1 (FB1). MATERIALS AND METHODS:Twenty-nine female mice di...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Alizadeh AM,Mohammadghasemi F,Zendehdel K,Kamyabi-Moghaddam Z,Tavassoli A,Amini-Najafi F,Khosravi A

    更新日期:2015-01-01 00:00:00

  • Synergistic bactericidal activity of a naturally isolated phage and ampicillin against urinary tract infecting Escherichia coli O157.

    abstract:Objectives:Bacteriophages are infectious replicating entities that are under consideration as antimicrobial bioagents to control bacterial infections. As an alternative or supplement to antibiotics, bacteriophages can be used to circumvent the resistance to existing antibiotics. The aim of this study was to assess the ...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/IJBMS.2019.37561.8989

    authors: Moradpour Z,Yousefi N,Sadeghi D,Ghasemian A

    更新日期:2020-02-01 00:00:00

  • Nephroprotective effects of Feijoa Sellowiana leaves extract on renal injury induced by acute dose of ecstasy (MDMA) in mice.

    abstract:OBJECTIVE(S):Because of the high total phenolic contents of Feijoa sellowiana, its nephroprotective effect was determined in 3,4-methylene dioxymethamphetamine (MDMA) treated mice. MATERIALS AND METHODS:Animals received 10, 20 and 40 mg/kg doses of aqueous or methanol extract of F. sellowiana leaves, intra-peritoneall...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Karami M,Karimian Nokabadi F,Ebrahimzadeh MA,Naghshvar F

    更新日期:2014-01-01 00:00:00

  • Differential gene expression by lithium chloride induction of adipose-derived stem cells into neural phenotype cells.

    abstract:Objectives:Adipose-derived stem cells (ADSCs), with suitable and easy access, are multipotential cells that have the ability for differentiation into other mesodermal and transdifferentiate into neural phenotype cells. In this study, Lithium chloride (LiCl) was used for in vitro transdifferentiation of rat ADSCs into n...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/ijbms.2020.41582.9820

    authors: Farrokhfar S,Tiraihi T,Movahedin M,Azizi H

    更新日期:2020-04-01 00:00:00

  • Protective effects of piperine on lead acetate induced-nephrotoxicity in rats.

    abstract:Objectives:In this study, we investigated the protective effects of piperine on lead acetate-induced renal damage in rat kidney tissue. Materials and Methods:Forty male rats were divided into 5 groups: negative control (rats were given aquadest daily), positive control (rats were given lead acetate 30 mg/kg BW orally ...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/IJBMS.2017.9487

    authors: Sudjarwo SA,Eraiko K,Sudjarwo GW,Koerniasari

    更新日期:2017-11-01 00:00:00

  • Anti-aging effects of some selected Iranian folk medicinal herbs-biochemical evidences.

    abstract:OBJECTIVE(S):In the current study, the effects of selected folk medicinal herbs were evaluated in D-galactose-induced aging in male mice. MATERIALS AND METHODS:Male BALB/c mice were randomly divided into 12 groups composing sham, control, and treated groups. Aging was induced by administration of D-galactose (500 mg/k...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Mohammadirad A,Aghamohammadali-Sarraf F,Badiei S,Faraji Z,Hajiaghaee R,Baeeri M,Gholami M,Abdollahi M

    更新日期:2013-11-01 00:00:00

  • Worldwide trends in scientific publications on association of gut microbiota with obesity.

    abstract:Objectives:Recent evidence has shown underlying roles of gut dysbiosis and metabolic endotoxemia in obesity and its complications. Despite the large number of experimental and clinical researches performed on gut microbiota and obesity, no bibliometrics' study has been conducted so far. We aimed to assess the trend of ...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章,评审

    doi:10.22038/ijbms.2018.30203.7281

    authors: Ejtahed HS,Tabatabaei-Malazy O,Soroush AR,Hasani-Ranjbar S,Siadat SD,Raes J,Larijani B

    更新日期:2019-01-01 00:00:00

  • Preparation and characterization of celecoxib solid dispersions; comparison of poloxamer-188 and PVP-K30 as carriers.

    abstract:OBJECTIVES:Solid dispersion formulation is the most promising strategy to improve oral bioavailability of poorly water soluble drugs. The aim of this study was to compare the effect of polyvinylpyrrolidone K30 (PVP) and poloxamer-188 (PLX) as carrier in solid dispersion formulations of celecoxib (CLX). MATERIALS AND M...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Homayouni A,Sadeghi F,Nokhodchi A,Varshosaz J,Garekani HA

    更新日期:2014-05-01 00:00:00

  • Changes in expression of klotho affect physiological processes, diseases, and cancer.

    abstract::Klotho (KL) encodes a single-pass transmembrane protein and is predominantly expressed in the kidney, parathyroid glands, and choroid plexus. Genetic studies on the KL gene have revealed that DNA hypermethylation is one of the major risk factors for aging, diseases, and cancer. Besides, KL exerts anti-inflammatory and...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章,评审

    doi:

    authors: Xuan NT,Hai NV

    更新日期:2018-01-01 00:00:00

  • Effect of Crocus sativus extracts and its active constituent safranal on the harmaline-induced tremor in mice.

    abstract:OBJECTIVES:Due to unsatisfactory response or intolerable side effects of current drugs, treatment of essential tremor remains inadequate. Thus, we aimed to investigate the protective and therapeutic effects of aqueous and ethanolic extracts of Crocus sativus (saffron), and its active consistent, safranal, on the harmal...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Amin B,Malekzadeh M,Heidari MR,Hosseinzadeh H

    更新日期:2015-05-01 00:00:00

  • Staging of colorectal cancer using serum metabolomics with 1HNMR Spectroscopy.

    abstract:OBJECTIVES:Determination of stages of colon cancer is done by biopsy usually after surgery. Metabolomics is the study of all the metabolites using LC-MS and 1HNMR spectroscopy with chemometric techniques. The stages of colon cancer were detected from patients' sera using 1HNMR. MATERIALS AND METHODS:Five ml blood was ...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/IJBMS.2017.9022

    authors: Vahabi F,Sadeghi S,Arjmand M,Mirkhani F,Hosseini E,Mehrabanfar M,Hajhosseini R,Iravani A,Bayat P,Zamani Z

    更新日期:2017-07-01 00:00:00

  • Effect of berberine chloride on caspase-3 dependent apoptosis and antioxidant capacity in the hippocampus of the chronic cerebral hypoperfusion rat model.

    abstract:Objectives:The main goal of the current research was to examine the effects of Berberine (BBR) on apoptotic signaling and hippocampal oxidative stress induced by common carotid artery occlusion. Materials and Methods:Chronic cerebral hypoperfusion (CCH) model was created by occluding the two common carotid arteries (t...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/ijbms.2018.31225.7534

    authors: Pirmoradi Z,Yadegari M,Moradi A,Khojasteh F,Zare Mehrjerdi F

    更新日期:2019-02-01 00:00:00

  • Gallic acid protects the liver in rats against injuries induced by transient ischemia-reperfusion through regulating microRNAs expressions.

    abstract:Objectives:Gallic acid (GA) is a highly effective antioxidant, which its beneficial effects are well known, but its impact on expression of microRNAs (miRs) following hepatic ischemia-reperfusion (I/R) is not well recognized. Therefore, the current research was designed to specify the beneficial effect of GA on miRs (1...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/ijbms.2018.31589.7605

    authors: Akbari G,Savari F,Mard SA,Rezaie A,Moradi M

    更新日期:2019-04-01 00:00:00

  • Crocin Bleaching Assay Using Purified Di-gentiobiosyl Crocin (-crocin) from Iranian Saffron.

    abstract:OBJECTIVES:Crocin bleaching assay (CBA) is a new method for determination of antioxidant capacity. In CBA, addition of hydrogen to the conjugated double bonds of crocin results in reduction of crocin and increase in the absorbance at 440 nm, which is considered as a measure of antioxidant potential. Here CBA method was...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Bathaie SZ,Shams A,Moghadas Zadeh Kermani F

    更新日期:2011-09-01 00:00:00

  • Effects of nano-copper on maize yield and inflammatory response in mice.

    abstract:Objectives:Copper (Cu) is an essential dietary supplement in animal feeds, which plays an important role in maintaining the balance of all living organisms. Copper nanoparticles (nCu) participate in catalysing activities of multiple antioxidant/defensive enzymes and exerts pro-inflammatory and pro-apoptotic effects on ...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.22038/ijbms.2019.35787.8526

    authors: Hien LTT,Trang PTT,Phuong PC,Tam PT,Xuan NT

    更新日期:2019-07-01 00:00:00

  • Evaluation of alpha- amylase inhibition by Urtica dioica and Juglans regia extracts.

    abstract:OBJECTIVES:One strategy for the treatment of diabetes is inhibition of pancreatic α- amylase. Plants contains different chemical constituents with potential for inhibition of α-amylase and hence maybe used as therapeutic. MATERIALS AND METHODS:Urtica dioica and Juglans regia Linn were tested for α-amylase inhibition. ...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Rahimzadeh M,Jahanshahi S,Moein S,Moein MR

    更新日期:2014-06-01 00:00:00

  • Evaluation of immune response after moderate and overtraining exercise in wistar rat.

    abstract:OBJECTIVE(S):The effect of prolonged overtraining on cytokine kinetics was compared with moderate exercise in the present study. MATERIALS AND METHODS:Male Wistar rats were randomly divided into control sedentary (C), moderate trained (MT), (V=20 m/min, 30 min/day for 6 days a week, 8 weeks), overtrained (OT) (V=25 m/...

    journal_title:Iranian journal of basic medical sciences

    pub_type: 杂志文章

    doi:

    authors: Gholamnezhad Z,Boskabady MH,Hosseini M,Sankian M,Khajavi Rad A

    更新日期:2014-01-01 00:00:00