Protective effect of interleukin-36 receptor antagonist on liver injury induced by concanavalin A in mice.

Abstract:

Objectives:Interleukin-36 receptor antagonist (IL-36Ra) is a new member of the IL-1 family that exhibits anti-inflammatory activity in a variety of inflammatory and immune diseases. Our purpose was to determine the effect of IL-36Ra on liver injury in a mouse hepatitis model induced by concanavalin A (ConA). Materials and Methods:Mice were treated with IL-36Ra DNA or pcDNA3.1 control plasmid using a hydrodynamic gene delivery approach. Results:Our data reveal that treatment with IL-36Ra decreased liver inflammation and serum level of aminotransferases. Furthermore, IL-36Ra reduced ConA-induced pro-inflammatory cytokines (interferon-γ, tumor necrosis factor-α, and IL-17A) production when compared to control plasmid. Conclusion:Our results demonstrated that IL-36Ra is a critical protector against ConA-induced liver injury.

journal_name

Iran J Basic Med Sci

authors

Peng X,Pan X,Tan J,Li Y,Li M

doi

10.22038/ijbms.2020.35614.8492

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

623-628

issue

5

eissn

2008-3866

issn

2008-3874

journal_volume

23

pub_type

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