Abstract：
Objectives:Morbidity and mortality due to diabetes mellitus (DM) result in exorbitant psycho-economical costs, so there is a strong need to create new strategies and drugs for controlling DM. The aim of the current study was to investigate the anti-diabetic effect of the aqueous extract of Pterocarpus santalinus on streptozotocin (STZ)-induced DM as compared to glustin. Materials and Methods:Thirty male rats were divided into five groups of six rats each as follows: control; the second group, received the aqueous plant extract (250 mg/kg) orally and daily for three weeks; the third group, was intraperitoneally injected with a single dose of 65 mg/kg of STZ and sacrificed after four weeks; the fourth and fifth groups, were injected with STZ, then after one week these were treated orally with either plant extract or with 3 mg/kg of glustin for three weeks, then sacrificed. Results:HPLC analysis of the plant aqueous extract showed that it contains many polyphenols and flavonoids. Treatment with STZ resulted in significant reductions in body weight, insulin level, and the expression of Fetuin-A and IRS-1. It also caused significant elevations in glucose, HOMA-IR, glycated hemoglobin, urea, and the expression of JNK and SIRT-1. STZ also caused an extensive β-cell degranulation and decreased cellular density. The aqueous extract of red sandalwood was able to abrogate the deleterious effects caused by STZ and improved the histological architecture of pancreas. Conclusion:The aqueous extract of P. santalinus ameliorates diabetes mellitus via anti-inflammatory pathways and enhancement of insulin function.
journal_name
Iran J Basic Med Scijournal_title
Iranian journal of basic medical sciencesauthors
El-Badawy RE,Ibrahim KA,Hassan NS,El-Sayed WMdoi
10.22038/ijbms.2019.34998.8325subject
Has Abstractpub_date
2019-08-01 00:00:00pages
932-939issue
8eissn
2008-3866issn
2008-3874journal_volume
22pub_type
杂志文章abstract：:Alzheimer's disease (AD) is a neurodegenerative disease and the leading cause of dementia worldwide. Epidemiological studies support the important role of diet in prevention and improvement of AD. In Traditional Persian Medicine (TPM), there is multiple dietary guidelines to prevent and alleviate dementia and memory i...
journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章,评审
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abstract：OBJECTIVES:The purpose of the current study was to assess the feasibility of microspheres from biocompatible polymer for oral bioavailability (BA) enhancement of potent sulfonamide- type loop diuretic- Furosemide - which used in the treatment of congestive heart failure, caused edema, cirrhosis, renal disease and as an...
journal_title：Iranian journal of basic medical sciences
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：10.22038/IJBMS.2017.24707.6138
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：10.22038/IJBMS.2018.24280.6064
更新日期：2018-02-01 00:00:00
abstract：Objectives:Panax ginseng (PG) widely used for its various pharmacological activities, including effects on diabetes and its complications. This study aims to investigate the effect of PG on mortality-related hypomagnesemia, hyperlactatemia, metabolic acidosis, and other diabetes-induced abnormalities. Materials and Me...
journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：10.22038/ijbms.2019.33223.7936
更新日期：2019-06-01 00:00:00
abstract：OBJECTIVES:Primary or adult type hypolactasia, the most common enzyme deficiency in the world, is due to reduced lactase activity in the intestinal cell after weaning. Lactase non-persistence is inherited as an autosomal recessive trait. A DNA variant, single nucleotide polymorphism C/T-13910 which is located on 13910 ...
journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
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更新日期：2015-02-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：Objectives:Eupafolin, a major active component of Eupatorium perfoliatum L., has anti-inflammatory and anti-oxidant properties. Lipopolysaccharide (LPS) is responsible for myocardial depression. A line of evidences revealed that LPS induces autophagy in cardiomyocytes injury. This study aims to evaluate the effects of ...
journal_title：Iranian journal of basic medical sciences
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更新日期：2019-11-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：
更新日期：2016-08-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：10.22038/IJBMS.2019.13989
更新日期：2019-12-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：
更新日期：2014-11-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：
更新日期：2014-07-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：
更新日期：2013-03-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
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更新日期：2018-03-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：10.22038/ijbms.2017.8088
更新日期：2017-01-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：
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更新日期：2018-07-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
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doi：
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journal_title：Iranian journal of basic medical sciences
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doi：
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：
更新日期：2014-09-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：
更新日期：2013-09-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：10.22038/IJBMS.2017.9274
更新日期：2017-09-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：
更新日期：2014-06-01 00:00:00
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：
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journal_title：Iranian journal of basic medical sciences
pub_type： 杂志文章
doi：10.22038/ijbms.2020.35614.8492
更新日期：2020-05-01 00:00:00
