Anti-cancer properties of Escherichia coli Nissle 1917 against HT-29 colon cancer cells through regulation of Bax/Bcl-xL and AKT/PTEN signaling pathways.

abstract：:Cancer testis antigens (CTAs), a large family of tumor-associated and immunogenic antigens expressed in human tumors of various histological origins, are highly restricted to the testis and trophoblast. CTAs have been identified as potent targets for tumor-specific immunotherapeutic advances and have immensely lead to...

journal_title：Iranian journal of basic medical sciences

authors： Babatunde KA,Najafi A,Salehipour P,Modarressi MH,Mobasheri MB

更新日期：2017-09-01 00:00:00

abstract：Objectives:The present study evaluates the protective effects of myricitrin and its solid lipid nanoparticle (SLN) on diabetic nephropathy (DN) induced by streptozotocin-nicotinamide (STZ-NA) in mice. Materials and Methods:In this experimental study, 108 adult male NMRI mice were divided into 9 groups: control, vehicl...

journal_title：Iranian journal of basic medical sciences

authors： Ahangarpour A,Oroojan AA,Khorsandi L,Kouchak M,Badavi M

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE(S):Based on knowledge from traditional herbal medicine, Ferula assa-foetida (asafoetida) has several therapeutic applications but there is less knowledge about its effect on neurons. MATERIALS AND METHODS:In order to evaluate neuronal differentiation, neuronal like cells were stained against neuronal specifi...

journal_title：Iranian journal of basic medical sciences

authors： Homayouni Moghadam F,Vakili Zarch B,Shafiei M

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE(S):Spermatogonial Stem Cells (SSCs) maintain spermatogenesis throughout the life of the male. Because of the small number of SSCs in adult, enriching and culturing them is a crucial step prior to differentiation or transplantation. Maintenance of SSCs and transplantation or induction of in vitro spermio-genes...

journal_title：Iranian journal of basic medical sciences

authors： Rastegar T,Minaee MB,Habibi Roudkenar M,Raghardi Kashani I,Amidi F,Abolhasani F,Barbarestani M

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVES:Lead (Pb) is a toxic metal inducing many destructive effects leading to a broad range of physiological, biochemical, and neurological dysfunctions in humans and laboratory animals. MATERIALS AND METHODS:Here, we investigated the effect of chronic exposure to Pb (50 mg/l) on oxidative stress, hepatotoxicity,...

journal_title：Iranian journal of basic medical sciences

authors： Alya A,Ines DB,Montassar L,Najoua G,Saloua el F

更新日期：2015-10-01 00:00:00

abstract：Objectives:The present study aimed to determine and compare moisturizing and occlusion effects of different solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) using magnetized water and deionized water. Materials and Methods:SLN formulations were prepared using various lipids, including Tripalmiti...

journal_title：Iranian journal of basic medical sciences

authors： Sarhadi S,Gholizadeh M,Moghadasian T,Golmohammadzadeh S

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVES:The primary objective of this study was to determine whether local and imported cigarette brands used in , have elevated levels of metals or not. The produced data of cigarette brands are compared both with each other and with the existing brands in different countries. MATERIALS AND METHODS:In present stud...

journal_title：Iranian journal of basic medical sciences

authors： Pourkhabbaz A,Pourkhabbaz H

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE(S):Garlic (Allium sativum L. family Liliaceae) is well known in Iran and its leaves, flowers, and cloves have been used in traditional medicine for a long time. Research in recent decades has shown widespread pharmacological effects of A. sativum and its organosulfur compounds especially Allicin. Studies carr...

journal_title：Iranian journal of basic medical sciences

authors： Mikaili P,Maadirad S,Moloudizargari M,Aghajanshakeri S,Sarahroodi S

更新日期：2013-10-01 00:00:00

abstract：Objectives:Morbidity and mortality due to diabetes mellitus (DM) result in exorbitant psycho-economical costs, so there is a strong need to create new strategies and drugs for controlling DM. The aim of the current study was to investigate the anti-diabetic effect of the aqueous extract of Pterocarpus santalinus on str...

journal_title：Iranian journal of basic medical sciences

authors： El-Badawy RE,Ibrahim KA,Hassan NS,El-Sayed WM

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVES:HTLVI-1 is the first human retrovirus with limited endemic regions in the world. The epidemiological studies have shown that the genetic background and immune response to the virus have a significant role in HTLV-I-associated diseases. Among the genes are involved in HTLV-I infection, the role of human leuko...

journal_title：Iranian journal of basic medical sciences

authors： Tafreshian AR,Etemadi M,Farid-Hosseini R,Salhi M,Afshari JT

更新日期：2014-10-01 00:00:00

abstract：Objectives:Association of adolescent emotional stress (ES) with the incidence of cardiovascular disease (CVD) at older age was investigated. Materials and Methods:21 female rats were divided into three groups of 7 each; ES, foot-shock, and control. Chronic ES was induced by exposing the rats to witness foot-shock of t...

journal_title：Iranian journal of basic medical sciences

authors： Mousavi MS,Imani A,Meknatkhah S,Riazi G

更新日期：2019-10-01 00:00:00

abstract：Objectives:Eupafolin, a major active component of Eupatorium perfoliatum L., has anti-inflammatory and anti-oxidant properties. Lipopolysaccharide (LPS) is responsible for myocardial depression. A line of evidences revealed that LPS induces autophagy in cardiomyocytes injury. This study aims to evaluate the effects of ...

journal_title：Iranian journal of basic medical sciences

authors： Gao Y,Zhang Y,Fan Y

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVES:Fabaceae is the third largest family of flowering plants. Lack of essential oils in the plants of this family can be considered as an advantage and can favor them in search for safe and antiepileptic medicines. The effects of Fabacea family plants including Ebenus stellata (E. stellata), Sophora alopecuroide...

journal_title：Iranian journal of basic medical sciences

authors： Khodaparast A,Sayyah M,Sardari S

更新日期：2012-05-01 00:00:00

abstract：Objectives:Copper (Cu) is an essential dietary supplement in animal feeds, which plays an important role in maintaining the balance of all living organisms. Copper nanoparticles (nCu) participate in catalysing activities of multiple antioxidant/defensive enzymes and exerts pro-inflammatory and pro-apoptotic effects on ...

journal_title：Iranian journal of basic medical sciences

authors： Hien LTT,Trang PTT,Phuong PC,Tam PT,Xuan NT

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVES:MicroRNAs (miRNAs) are a class of short RNAs that control the biological processes including cell proliferation, apoptosis and development. Aberrant expression of miRNAs was determined in the different stages of tumor development and metastasis. To study the effect of silibinin on miRNAs expression, we evalu...

journal_title：Iranian journal of basic medical sciences

authors： Zadeh MM,Ranji N,Motamed N

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVES:Eukaryotic translation initiation factor 4E (eIF4E) is overexpressed in cervical cancer (CC). However, the molecular mechanisms are unclear. This study aimed to investigate the molecular mechanism of eIF4E gene overexpression in CC. MATERIALS AND METHODS:The human papillomavirus (HPV) type 18 E7 and eIF4E m...

journal_title：Iranian journal of basic medical sciences

authors： Pang T,Wang S,Gao M,Kang H,Zhao Y,Yao Y,Hu X

更新日期：2015-07-01 00:00:00

abstract：Objectives:Charcot-Marie Tooth disease (CMT) is one of the main inherited causes of motor and sensory neuropathies with variable expressivity and age-of onset. Although more than 70 genes have been identified for CMT, more studies are needed to discover other genes involved in CMT. Introduction of whole exome sequencin...

journal_title：Iranian journal of basic medical sciences

authors： Tahmasebi-Birgani M,Hajjari M,Golchin N,Shalbafan B,Mohammadi-Asl J,Sadeghian F

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE(S):In the current study, the effects of selected folk medicinal herbs were evaluated in D-galactose-induced aging in male mice. MATERIALS AND METHODS:Male BALB/c mice were randomly divided into 12 groups composing sham, control, and treated groups. Aging was induced by administration of D-galactose (500 mg/k...

journal_title：Iranian journal of basic medical sciences

authors： Mohammadirad A,Aghamohammadali-Sarraf F,Badiei S,Faraji Z,Hajiaghaee R,Baeeri M,Gholami M,Abdollahi M

更新日期：2013-11-01 00:00:00

abstract：Objectives:Periodontal diseases are among prevalent oral health problems which may ultimately lead to severe complications in oral cavity. Herbal products can be designed as single or multicomponent preparations for better oral health. This study aims to review current clinical trials on the effectiveness of herbal pro...

journal_title：Iranian journal of basic medical sciences

authors： Safiaghdam H,Oveissi V,Bahramsoltani R,Farzaei MH,Rahimi R

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE(S):Drug resistant Acinetobacter baumannii have emerged as a major problem in many hospitals and intensive care units. Various types of extended spectrum beta-lactamases (ESBLs) are responsible for resistance to beta-lactam antibiotics in different parts of the world. The objective of this study was to determi...

journal_title：Iranian journal of basic medical sciences

authors： Farajnia S,Azhari F,Alikhani MY,Hosseini MK,Peymani A,Sohrabi N

更新日期：2013-06-01 00:00:00

abstract：Objective:The role of growth factors, including vascular endothelial growth factor of activated omentum on mitosis is clearly known, though not on all the aspects of in vitro oocyte maturation. This study was designed to assess the effect of activated-omental extract (AOE) on in vitro maturation (IVM) of rat cumulus-oo...

journal_title：Iranian journal of basic medical sciences

authors： Mesbah F,Pracha AD,Talaei-Khozani T,Bahmanpour S

更新日期：2017-12-01 00:00:00

abstract：Objectives:Precision-cut tissue slices are considered an organotypic 3D model widely used in biomedical research. The comet assay is an important screening test for early genotoxicity risk assessment that is mainly applied on in vitro models. The aim of the present study was to provide a 3D organ system for determinati...

journal_title：Iranian journal of basic medical sciences

authors： Carranza-Torres IE,Viveros-Valdez E,Guzmán-Delgado NE,García-Davis S,Morán-Martínez J,Betancourt-Martínez ND,Balderas-Rentería I,Carranza-Rosales P

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVES:Naringin has been reported to regulate bone metabolism. However, its effect on osteogenesis remains unclear. The aim was to investigate the effect of naringin on osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs) through the activation of the ERK signaling pathway in osteogenic d...

journal_title：Iranian journal of basic medical sciences

authors： Wang H,Li C,Li J,Zhu Y,Jia Y,Zhang Y,Zhang X,Li W,Cui L,Li W,Liu Y

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVES:Due to unsatisfactory response or intolerable side effects of current drugs, treatment of essential tremor remains inadequate. Thus, we aimed to investigate the protective and therapeutic effects of aqueous and ethanolic extracts of Crocus sativus (saffron), and its active consistent, safranal, on the harmal...

journal_title：Iranian journal of basic medical sciences

authors： Amin B,Malekzadeh M,Heidari MR,Hosseinzadeh H

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVES:In previous studies, researchers observed that doxepin could improve cognitive processes and has protective effects on the central nervous system. Thus, this study was designed to analyze the effects of doxepin on β-amyloid (Aβ)-induced memory impairment and neuronal toxicity in rat and to explore the underl...

journal_title：Iranian journal of basic medical sciences

authors： Bu J,Zu H

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVES:Lipocalin 2 (Lcn2) is a 25-kDa glycoprotein that has initially been extracted from neutrophil granules. Expression of Lcn2 is induced under various pathophysiological conditions. It is also known as an early marker of kidney and heart injury. High-level expression of recombinant Lcn2 neutrophil gelatinase-as...

journal_title：Iranian journal of basic medical sciences

authors： Rouhbakhsh M,Halabian R,Masroori N,Mohammadi Pour M,Bahmani P,Mohammadi Roush A,Jahanian-Najafabadi A,Habibi Roudkenar M

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE(S):Because of the high total phenolic contents of Feijoa sellowiana, its nephroprotective effect was determined in 3,4-methylene dioxymethamphetamine (MDMA) treated mice. MATERIALS AND METHODS:Animals received 10, 20 and 40 mg/kg doses of aqueous or methanol extract of F. sellowiana leaves, intra-peritoneall...

journal_title：Iranian journal of basic medical sciences

authors： Karami M,Karimian Nokabadi F,Ebrahimzadeh MA,Naghshvar F

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE(S):Cerebral hypoperfusion/ischemia (CHI) is a neurological disease where impaired hippocampus electrical activity and cognition caused by a serial pathophysiological events. This study aimed to evaluate the effects of chronic oral administration of grape seed extract (GSE) on passive avoidance memory and long...

journal_title：Iranian journal of basic medical sciences

authors： Sarkaki A,Rafieirad M,Hossini SE,Farbood Y,Motamedi F,Mansouri SM,Naghizadeh B

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVES:To clarify the protective effects of Cichorium glandulosum (CG) extracts on thioacetamide (TAA)-induced rat hepatic fibrosis. MATERIALS AND METHODS:The dry roots of CG were smashed and percolated with 95% ethanol, and the residual was prepared into petroleum ether extract (CG-V), ethyl acetate extract (CG-V...

journal_title：Iranian journal of basic medical sciences

authors： Qin D,Nie Y,Wen Z

更新日期：2014-11-01 00:00:00

abstract：Objectives:Renal ischemia-reperfusion injury (IRI) as a severe condition of acute kidney injury (AKI) is the most common clinical problem with high mortality rates of 35-60% deaths in hospital. Mesenchymal stem cells (MSC) due to unique regenerative characteristics are ideal candidates for the treatment of the ischemic...

journal_title：Iranian journal of basic medical sciences

authors： Havakhah S,Sankian M,Kazemzadeh GH,Sadri K,Bidkhori HR,Naderi-Meshkin H,Ebrahimzadeh Bideskan A,Niazmand S,Bahrami AR,Khajavi Rad A

更新日期：2018-08-01 00:00:00