Improvement in Memory and Brain Long-term Potentiation Deficits Due to Permanent Hypoperfusion/Ischemia by Grape Seed Extract in Rats.

abstract：Objectives:A growing body of evidence indicates that rhomboid domain containing 1 (RHBDD1) plays an important role in a variety of physiological and pathological processes, including tumorigenesis. We aimed to determine the function of RHBDD1 in breast cancer cells. Materials and Methods:In this study, we used the Onc...

journal_title：Iranian journal of basic medical sciences

authors： Huang C,Ji X,Peng Y,Wu M,Wu W,Luo Y,Cheng G,Zhu Y

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:Lupus nephritis (LN) is frequently associated with a poor long-term prognosis. Renal biopsy is the diagnostic method of choice in this condition. Urine biomarkers have been mentioned in the diagnosis of LN. The study(,)s purpose was to evaluate the performance of urinary monocyte chemoattractant protein 1(UM...

journal_title：Iranian journal of basic medical sciences

authors： Mirfeizi Z,Mahmoudi M,Naghibi M,Hatef M,Sharifipour F,Jokar M,Zeraati A,Shariati Sarabi Z,Azarian A

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVES:Amyotrophic lateral sclerosis (ALS), a fatal progressive neurodegenerative disorder, is the most common motor neuron disease in European populations. Approximately 10% of ALS cases are familial (FALS) and the other patients are considered as sporadic ALS (SALS). Among many ALS causing genes that have been id...

journal_title：Iranian journal of basic medical sciences

authors： Alavi A,Khani M,Nafissi S,Shamshiri H,Elahi E

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVES:Fabaceae is the third largest family of flowering plants. Lack of essential oils in the plants of this family can be considered as an advantage and can favor them in search for safe and antiepileptic medicines. The effects of Fabacea family plants including Ebenus stellata (E. stellata), Sophora alopecuroide...

journal_title：Iranian journal of basic medical sciences

authors： Khodaparast A,Sayyah M,Sardari S

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE(S):Adeno-associated virus type 2 (AAV2) vectors are widely used for both experimental and clinical gene therapy. A recent research has shown that the performance of these vectors can be greatly improved by substitution of specific surface-exposed tyrosine residues with phenylalanines. In this study, a fast an...

journal_title：Iranian journal of basic medical sciences

authors： Ahmadiankia N,Neshati V,Neshati Z,Swildens J,de Vries AA

更新日期：2013-07-01 00:00:00

abstract：Objectives:Interleukin-36 receptor antagonist (IL-36Ra) is a new member of the IL-1 family that exhibits anti-inflammatory activity in a variety of inflammatory and immune diseases. Our purpose was to determine the effect of IL-36Ra on liver injury in a mouse hepatitis model induced by concanavalin A (ConA). Materials...

journal_title：Iranian journal of basic medical sciences

authors： Peng X,Pan X,Tan J,Li Y,Li M

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVES:Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of multiple sclerosis. The aim of the present work is to investigate the protective effects of erythropoietin against cuprizone-induced oxidative stress. MATERIALS AND METHODS:...

journal_title：Iranian journal of basic medical sciences

authors： Kashani IR,Chavoshi H,Pasbakhsh P,Hassani M,Omidi A,Mahmoudi R,Beyer C,Zendedel A

更新日期：2017-08-01 00:00:00

abstract：Objectives:Methamphetamine (METH) is a powerful stimulant drug that directly affects the brain and induces neurological deficits. B12 is a water-soluble vitamin (vit) that is reported to attenuate neuronal degeneration. The goal of the present study is to investigate the effect of vitamin B12 on METH's neurodegenerativ...

journal_title：Iranian journal of basic medical sciences

authors： Moshiri M,Hosseiniyan SM,Moallem SA,Hadizadeh F,Jafarian AH,Ghadiri A,Hoseini T,Seifi M,Etemad L

更新日期：2018-04-01 00:00:00

abstract：Objectives:Resveratrol (RSV) is a naturally occurring plant polyphenol with cardioprotective, neuroprotective, immunoregulatory, and anticancer properties and is biologically effective against various diseases. This study aimed to investigate the chemopreventive effect of different doses of RSV against hepatocellular c...

journal_title：Iranian journal of basic medical sciences

authors： Karabekir SC,Özgörgülü A

更新日期：2020-01-01 00:00:00

abstract：Objectives:Cord blood (CB) is known as a valuable source of hematopoietic stem cells (HSC). Identifying strategies that enhance expansion and maintain engraftment and homing capacity of HSCs can improve transplant efficiency. In this study, we examined different culture conditions on ex vivo expansion and homing capaci...

journal_title：Iranian journal of basic medical sciences

authors： Mohammadali F,Abroun S,Atashi A

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVES:Asthma results from the interaction between genetic and environmental factors. ADAM33 gene on chromosome 20p13 is associated with asthma and airway hyperresponsiveness. MATERIALS AND METHODS:This is a case-control study, where four SNPs S1 (rs3918396), T1 (rs2280091), T2 (rs2280090), V4 (rs2787094) of ADAM3...

journal_title：Iranian journal of basic medical sciences

authors： Karimi MR,Faridhosseini R,Abbaszadegan MR,Azad FJ,Shirkani A,Riyahi A,Montazar M,Gholamin M

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVES:Pharmacological studies showed that the extracts of Jin Yin Hua and its active constituents have lipid lowering, antipyretic, hepatoprotective, cytoprotective, antimicrobial, antibiotic, antioxidative, antiviral, and anti-inflammatory effects. The purpose of the present study was to investigate the protectiv...

journal_title：Iranian journal of basic medical sciences

authors： Wang C,Wang G,Liu H,Hou YL

更新日期：2016-01-01 00:00:00

abstract：Objectives:Bacteriophages are infectious replicating entities that are under consideration as antimicrobial bioagents to control bacterial infections. As an alternative or supplement to antibiotics, bacteriophages can be used to circumvent the resistance to existing antibiotics. The aim of this study was to assess the ...

journal_title：Iranian journal of basic medical sciences

authors： Moradpour Z,Yousefi N,Sadeghi D,Ghasemian A

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVES:Many cancer cells show significant resistance to drugs that kill drug sensitive cancer cells and non-tumor cells and such resistance might be a consequence of the difference in metabolism. Therefore, studying the metabolism of drug resistant cancer cells and comparison with drug sensitive and normal cell lin...

journal_title：Iranian journal of basic medical sciences

authors： Motamedian E,Ghavami G,Sardari S

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVES:Prostaglandins have been shown to mediate the gastro-protective effect of sodium hydrosulfide (NaHS) but effect of NaHS on mRNA expression of prostaglandin E2 receptors (EP1, 3-4; EPs) has not been investigated. Therefore, this study designed to evaluate the effect of NaHS on mRNA expression of EPs receptors...

journal_title：Iranian journal of basic medical sciences

authors： Mard SA,Mahini S,Dianat M,Farbood Y

更新日期：2017-02-01 00:00:00

abstract：:Thromboangiitis obliterans (TAO) is a thrombotic-occlusive as well as an inflammatory peripheral vascular disease with unknown etiology. Recent evidence has supported the immunopathogenesis of the disease, however, the factors contributing to the altered immune function and vascular tissue inflammation are still uncle...

journal_title：Iranian journal of basic medical sciences

authors： Shapouri-Moghaddam A,Saeed Modaghegh MH,Rahimi HR,Ehteshamfar SM,Tavakol Afshari J

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:Acquisition of TNF-α resistance plays role in the onset and growth of malignant tumors. Previous studies have demonstrated that MCF-7 cell line and its doxorubicin resistant variant MCF-7/Adr are resistant against the cytotoxic effects of TNF-α. In this study, we investigated the role of Akt activation in re...

journal_title：Iranian journal of basic medical sciences

authors： Ghandadi M,Mohammadi A,Behravan J,Abnous K,Haj-Ali N,Gharaee ME,Mosaffa F

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVES:In the present study, we evaluated immunological and immunomodulatory properties of royal jelly (RJ) in 2,4,6 trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats. MATERIALS AND METHODS:Eighteen adult female Wistar albino rats were divided into three groups of six animals each: a control group that ...

journal_title：Iranian journal of basic medical sciences

authors： Karaca T,Uz YH,Demirtas S,Karaboga I,Can G

更新日期：2015-04-01 00:00:00

abstract：Objectives:The main goal of the current research was to examine the effects of Berberine (BBR) on apoptotic signaling and hippocampal oxidative stress induced by common carotid artery occlusion. Materials and Methods:Chronic cerebral hypoperfusion (CCH) model was created by occluding the two common carotid arteries (t...

journal_title：Iranian journal of basic medical sciences

authors： Pirmoradi Z,Yadegari M,Moradi A,Khojasteh F,Zare Mehrjerdi F

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVES:Valproic acid (VPA) has proven to be as one of the most promising useful drug with anticancer properties. In this study, we investigate the VPA effects on E-cadherin expression in HeLa, TC1, MKN45, and HCT116 cell lines. This study assesses the effects of VPA on human papillomavirus E7 expression in HPV posi...

journal_title：Iranian journal of basic medical sciences

authors： Faghihloo E,Akbari A,Adjaminezhad-Fard F,Mokhtari-Azad T

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVES:Seed of Cucumis sativus Linn. is one of the herbal remedies has been traditionally used for diabetes mellitus treatment. We studied the effect of hydroalcoholic and buthanolic extract obtained from C. sativus seeds in a model of streptozotocin (STZ)-induced diabetic (type I) rats. MATERIALS AND METHODS:Norm...

journal_title：Iranian journal of basic medical sciences

authors： Minaiyan M,Zolfaghari B,Kamal A

更新日期：2011-09-01 00:00:00

abstract：Objectives:Weight gain and metabolic disturbances such as dyslipidemia, are frequent side effects of second-generation antipsychotics, including olanzapine. This study examined the metabolic effects of chronic olanzapine exposure. In addition, we investigated the hepatic fatty acid effects of olanzapine in female C57BL...

journal_title：Iranian journal of basic medical sciences

authors： Hou PH,Chang GR,Chen CP,Lin YL,Chao IS,Shen TT,Mao FC

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:Intracerebral injection of bone marrow stromal cells (BMSCs) is being investigated as a therapeutic tool to prevent Alzheimer's disease (AD). Our aim was to investigate the effects of BMSCs by intrathecal injection in AD rat model. MATERIALS AND METHODS:BMSCs were obtained from the bone marrow of Wistar rat...

journal_title：Iranian journal of basic medical sciences

authors： Eftekharzadeh M,Nobakht M,Alizadeh A,Soleimani M,Hajghasem M,Kordestani Shargh B,Karkuki Osguei N,Behnam B,Samadikuchaksaraei A

更新日期：2015-05-01 00:00:00

abstract：Objectives:Copper (Cu) is an essential dietary supplement in animal feeds, which plays an important role in maintaining the balance of all living organisms. Copper nanoparticles (nCu) participate in catalysing activities of multiple antioxidant/defensive enzymes and exerts pro-inflammatory and pro-apoptotic effects on ...

journal_title：Iranian journal of basic medical sciences

authors： Hien LTT,Trang PTT,Phuong PC,Tam PT,Xuan NT

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE(S):In the current study, the effects of selected folk medicinal herbs were evaluated in D-galactose-induced aging in male mice. MATERIALS AND METHODS:Male BALB/c mice were randomly divided into 12 groups composing sham, control, and treated groups. Aging was induced by administration of D-galactose (500 mg/k...

journal_title：Iranian journal of basic medical sciences

authors： Mohammadirad A,Aghamohammadali-Sarraf F,Badiei S,Faraji Z,Hajiaghaee R,Baeeri M,Gholami M,Abdollahi M

更新日期：2013-11-01 00:00:00

abstract：:Cancer testis antigens (CTAs), a large family of tumor-associated and immunogenic antigens expressed in human tumors of various histological origins, are highly restricted to the testis and trophoblast. CTAs have been identified as potent targets for tumor-specific immunotherapeutic advances and have immensely lead to...

journal_title：Iranian journal of basic medical sciences

authors： Babatunde KA,Najafi A,Salehipour P,Modarressi MH,Mobasheri MB

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVES:Neuroprotective effect of creatine (Cr) against β-amyloid (Aβ) is reported in an in vitro study. This study investigated the effect of Cr supplementation on β-amyloid toxicity in vivo. MATERIALS AND METHODS:Thirty two, male Wistar rats were divided into 4 groups. During ten weeks of study, control group wen...

journal_title：Iranian journal of basic medical sciences

authors： Alimohammadi-Kamalabadi M,Eshraghian M,Zarindast MR,Aliaghaei A,Pishva H

更新日期：2016-11-01 00:00:00

abstract：Objectives:The monitoring of cancer treatment response to chemotherapy is considered an essential strategy for follow-up of patients. The aim of this study was to evaluate the use of 99mTc-glucarate as a radiotracer for in vivo quantification and visualization of necrotic area and therapeutic effect of paclitaxel in ov...

journal_title：Iranian journal of basic medical sciences

authors： Sadeghi H,Rahmanian N,Amiri FT,Amirfakhrian H,Abedi SM,Hosseinimehr SJ

更新日期：2018-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disease and the leading cause of dementia worldwide. Epidemiological studies support the important role of diet in prevention and improvement of AD. In Traditional Persian Medicine (TPM), there is multiple dietary guidelines to prevent and alleviate dementia and memory i...

journal_title：Iranian journal of basic medical sciences

authors： Iranshahy M,Javadi B

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVES:This study aimed to evaluate the protective effects of total flavonoid extract from Coreopsis tinctoria Nutt. (CTF) against myocardial ischemia/reperfusion injury (MIRI) using an isolated Langendorff rat heart model. MATERIALS AND METHODS:Left ventricular developed pressure (LVDP) and the maximum rate of ri...

journal_title：Iranian journal of basic medical sciences

authors： Zhang Y,Yuan C,Fang H,Li J,Su S,Chen W

更新日期：2016-09-01 00:00:00