Abstract:
OBJECTIVES:This study examined whether conjugated linoleic acid (CLA) supplementation affects insulin sensitivity and peroxisome proliferator-activated receptor gamma (PPAR-γ) and glucose transporter type 4 (GLUT-4) protein expressions in the skeletal muscles of rats during endurance exercise. MATERIALS AND METHODS:Sprague-Dawley male rats were randomly divided into HS (high-fat diet (HFD) sedentary group, n = 8), CS (1.0% CLA supplemented HFD sedentary group, n = 8), and CE (1.0% CLA supplemented HFD exercise group, n = 8). The rats in the CE swam for 60 min a day, 5 days a week for 8 weeks. RESULTS:The serum glucose and insulin contents and homeostasis model assessment of insulin resistance (HOMA-IR) value of the CS and CE were significantly decreased compared to those of the HS. The PPAR-γ protein expressions in the soleus muscle (SOM) and extensor digitorum longus muscle (EDL) were significantly higher in the CE than in the HS. In addition, the PPAR-γ protein expression in the SOM of the CS was significantly higher than that in the HS. On the other hand, the GLUT-4 protein expression of the SOM in the CE was significantly higher compared to that in the HS. However, there was no significant difference in GLUT-4 protein expression in the EDL among the groups. CONCLUSION:CLA supplementation with/without endurance exercise has role in improvement of insulin sensitivity. Moreover, when CLA supplementation was accompanied by endurance exercise, the PPAR-γ protein expression in SOM and EDL and the GLUT-4 protein expression in SOM were enhanced compared with the control group.
journal_name
Iran J Basic Med Scijournal_title
Iranian journal of basic medical sciencesauthors
Cho K,Song Y,Kwon Dsubject
Has Abstractpub_date
2016-01-01 00:00:00pages
20-7issue
1eissn
2008-3866issn
2008-3874journal_volume
19pub_type
杂志文章abstract:Objectives:Panax ginseng (PG) widely used for its various pharmacological activities, including effects on diabetes and its complications. This study aims to investigate the effect of PG on mortality-related hypomagnesemia, hyperlactatemia, metabolic acidosis, and other diabetes-induced abnormalities. Materials and Me...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/ijbms.2019.33223.7936
更新日期:2019-06-01 00:00:00
abstract::Nigella sativa is the miraculous plant having a lot of nutritional and medicinal benefits, and attracts large number of nutrition and pharmacological researchers. N. sativa seed composition shows that it is the blessing of nature and it contains and many bioactive compounds like thymoquinone, α-hederin, alkaloids, fla...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章,评审
doi:
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVES:Human Cytomegalovirus (HCMV) remains a major morbidity and mortality cause in immuno suppressed patients. Therefore, significant effort has been made towards the development of a vaccine. In this study, the expression of the pp65 and gB fusion peptides and Fc domain of mouse IgG2a as a novel delivery system ...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE(S):The effect of the extract of Crocus sativus and its constituent, safranal on inflammatory markers in sensitized guinea pigs was examined. MATERIALS AND METHODS:Ovalbumin (OA) sensitized guinea pigs were given drinking water alone (group S), or drinking water containing three concentrations of safranal, th...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2013-09-01 00:00:00
abstract:Objectives:Chemotherapies used to treat colon cancer might often fail due to the emergence of chemoresistance and side effects. Escherichia coli Nissle 1917 (EcN) is a beneficial probiotic, whose molecular mechanisms in the prevention of colon cancer are yet to be fully understood. The present study assessed the anti-c...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/ijbms.2020.43016.10115
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVES:Particulate matter (PM) exposure can promote cardiac ischemia and myocardial damage. The effects of PM10 on hemodynamic parameters, lipid peroxidation, and infarct size induced by ischemia-reperfusion injury and the protective effects of vanillic acid (VA) in isolated rat heart were investigated. MATERIALS ...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/IJBMS.2017.9007
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVES:Prostaglandins have been shown to mediate the gastro-protective effect of sodium hydrosulfide (NaHS) but effect of NaHS on mRNA expression of prostaglandin E2 receptors (EP1, 3-4; EPs) has not been investigated. Therefore, this study designed to evaluate the effect of NaHS on mRNA expression of EPs receptors...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/ijbms.2017.8237
更新日期:2017-02-01 00:00:00
abstract:Objectives:Cholinergic neurons are important neurons in the Pedunculopontine tegmental nucleus (PPT). In this study, nicotinic receptor of the PPT in central cardiovascular regulation in the anesthetized rat was evaluated. Materials and Methods:Saline, acetylcholine (Ach; doses: 90 and 150 nmol), hexamethonium (Hexa; ...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/IJBMS.2018.25616.6319
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE(S):Carotenoids which are naturally synthesized by fungi such as yeasts can act as an antioxidant which is closely related to their ability to decrease the risk of a variety of degenerative diseases. In recent years, the increase of demand for carotenoids obtained from natural sources has promoted major effort...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2013-10-01 00:00:00
abstract:Objectives:The present study aimed to determine and compare moisturizing and occlusion effects of different solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) using magnetized water and deionized water. Materials and Methods:SLN formulations were prepared using various lipids, including Tripalmiti...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/IJBMS.2020.39587.9397
更新日期:2020-03-01 00:00:00
abstract:Objectives:Heparin-binding hemagglutinin (HBHA), a mycobacterial cell surface protein, mediates adhesion to nonphagocytic cells and the dissemination of Mycobacterium tuberculosis (M. tuberculosis) from the site of primary infection. Superior expression systems are required to obtain abundant M. tuberculosis proteins f...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/IJBMS.2018.24280.6064
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE(S):In the current study, the effects of selected folk medicinal herbs were evaluated in D-galactose-induced aging in male mice. MATERIALS AND METHODS:Male BALB/c mice were randomly divided into 12 groups composing sham, control, and treated groups. Aging was induced by administration of D-galactose (500 mg/k...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVES:To clarify the protective effects of Cichorium glandulosum (CG) extracts on thioacetamide (TAA)-induced rat hepatic fibrosis. MATERIALS AND METHODS:The dry roots of CG were smashed and percolated with 95% ethanol, and the residual was prepared into petroleum ether extract (CG-V), ethyl acetate extract (CG-V...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVES:Similar characteristics of molecular pathways between cellular reprogramming events and tumorigenesis have been accentuated in recent years. Reprogramming-related transcription factors, also known as Yamanaka factors (OCT4, SOX2, KLF4, and c-MYC), are also well-known oncogenes promoting cancer initiation, pr...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVES:Lupus nephritis (LN) is frequently associated with a poor long-term prognosis. Renal biopsy is the diagnostic method of choice in this condition. Urine biomarkers have been mentioned in the diagnosis of LN. The study(,)s purpose was to evaluate the performance of urinary monocyte chemoattractant protein 1(UM...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2012-11-01 00:00:00
abstract:Objectives:Traumatic brain injury (TBI) is one of the main causes of intellectual and cognitive disabilities. Clinically, it is essential to limit the development of cognitive impairment after TBI. In the present study, the neuroprotective effects of gallic acid (GA) on neurological score, memory, long-term potentiatio...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/IJBMS.2018.29639.7165
更新日期:2018-10-01 00:00:00
abstract:Objective:The role of growth factors, including vascular endothelial growth factor of activated omentum on mitosis is clearly known, though not on all the aspects of in vitro oocyte maturation. This study was designed to assess the effect of activated-omental extract (AOE) on in vitro maturation (IVM) of rat cumulus-oo...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/IJBMS.2017.9622
更新日期:2017-12-01 00:00:00
abstract:Objectives:Inflammation is involved in various forms of pulmonary arterial hypertension (PAH). Although the pathophysiology of PAH remains uncertain, NF-κB and p38 mitogen-activated protein kinase (p38 MAPK) has been reported to be associated with many inflammatory mediators of PAH. This study aimed to evaluate the eff...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/ijbms.2018.25399.6280
更新日期:2018-03-01 00:00:00
abstract:Objectives:Recent evidence has shown underlying roles of gut dysbiosis and metabolic endotoxemia in obesity and its complications. Despite the large number of experimental and clinical researches performed on gut microbiota and obesity, no bibliometrics' study has been conducted so far. We aimed to assess the trend of ...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章,评审
doi:10.22038/ijbms.2018.30203.7281
更新日期:2019-01-01 00:00:00
abstract::Thromboangiitis obliterans (TAO) is a thrombotic-occlusive as well as an inflammatory peripheral vascular disease with unknown etiology. Recent evidence has supported the immunopathogenesis of the disease, however, the factors contributing to the altered immune function and vascular tissue inflammation are still uncle...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章,评审
doi:10.22038/ijbms.2019.31119.7513
更新日期:2019-03-01 00:00:00
abstract:Objectives:The present study evaluates the protective effects of myricitrin and its solid lipid nanoparticle (SLN) on diabetic nephropathy (DN) induced by streptozotocin-nicotinamide (STZ-NA) in mice. Materials and Methods:In this experimental study, 108 adult male NMRI mice were divided into 9 groups: control, vehicl...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/IJBMS.2019.13989
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVES:Tadalafil can restore endothelial function and treat atherosclerosis. However, the effect of tadalafil on transplant arteriosclerosis remains unclear. In this study, we explore the effects of tadalafil on allograft vasculopathy. MATERIALS AND METHODS:Male Brow-Norway rats supplied aorta grafts for Male Lewi...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2015-09-01 00:00:00
abstract:Objectives:The main goal of the current research was to examine the effects of Berberine (BBR) on apoptotic signaling and hippocampal oxidative stress induced by common carotid artery occlusion. Materials and Methods:Chronic cerebral hypoperfusion (CCH) model was created by occluding the two common carotid arteries (t...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/ijbms.2018.31225.7534
更新日期:2019-02-01 00:00:00
abstract::Klotho (KL) encodes a single-pass transmembrane protein and is predominantly expressed in the kidney, parathyroid glands, and choroid plexus. Genetic studies on the KL gene have revealed that DNA hypermethylation is one of the major risk factors for aging, diseases, and cancer. Besides, KL exerts anti-inflammatory and...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章,评审
doi:
更新日期:2018-01-01 00:00:00
abstract:Objectives:The aims of the present study were to investigate the expression of calcium sensing receptor (CaSR) at different times in acute myocardial infarction (AMI) rat myocardial tissue after mouse embryonic stem cells (mESCs) transplantation treatment and to assess its effects on apoptosis and oxidative stress of c...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/ijbms.2020.47436.10916
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVES:Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of multiple sclerosis. The aim of the present work is to investigate the protective effects of erythropoietin against cuprizone-induced oxidative stress. MATERIALS AND METHODS:...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/IJBMS.2017.9110
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVES:Chemoresistance remains the main causes of treatment failure and mortality in cancer patients. There is an urgent need to investigate novel approaches to improve current therapeutic modalities and increase cancer patients' survival. Induction of drug efflux due to overexpression of P-glycoproteins is conside...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2016-03-01 00:00:00
abstract:UNLABELLED:Objective(s) : Although bacteria and molds are the pioneering microorganisms for production of many enzymes, yet yeasts provide safe and reliable sources of enzymes with applications in food and feed. MATERIALS AND METHODS:Single xylanase producer yeast was isolated from plant residues based on formation of...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the methylation status and mRNA expression levels of P15, death-associated protein kinase (DAPK), and suppressor of cytokine signaling-1 (SOCS1) genes in multiple myeloma (MM). MATERIALS AND METHODS:The bone marrow samples of 54 MM patients were collected and the met...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:
更新日期:2016-07-01 00:00:00
abstract:Objectives:Osteonecrosis of the jaw, as an exposed necrotic bone in the oral cavity, is one of the adverse effects of bisphosphonates, which have an affinity for bone minerals. This study investigates the cytotoxic effects of alendronate (ALN) as a nitrogen-containing bisphosphonate, on human dental pulp stem cells (hD...
journal_title:Iranian journal of basic medical sciences
pub_type: 杂志文章
doi:10.22038/IJBMS.2018.22877.5816
更新日期:2018-09-01 00:00:00